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Aiewsakun P, Katzourakis A. Endogenous viruses: Connecting recent and ancient viral evolution. Virology. 2015;479:26-37doi: 10.1016/j.virol.2015.02.011.
Aiewsakun, P., & Katzourakis, A. (2015). Endogenous viruses: Connecting recent and ancient viral evolution. Virology, 47926-37. https://doi.org/10.1016/j.virol.2015.02.011
Aiewsakun, Pakorn, and Katzourakis, Aris. "Endogenous viruses: Connecting recent and ancient viral evolution." Virology vol. 479 (2015): 26-37. doi: https://doi.org/10.1016/j.virol.2015.02.011
Aiewsakun P, Katzourakis A. Endogenous viruses: Connecting recent and ancient viral evolution. Virology. 2015 May;479:26-37. doi: 10.1016/j.virol.2015.02.011. Epub 2015 Mar 12. PMID: 25771486.
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Virology. 2015 May;479:26-37. doi: 10.1016/j.virol.2015.02.011. Epub 2015 Mar 12.

Endogenous viruses: Connecting recent and ancient viral evolution.

Virology

Pakorn Aiewsakun, Aris Katzourakis

Affiliations

  1. Department of Zoology, University of Oxford, Oxford OX1 3PS, UK.
  2. Department of Zoology, University of Oxford, Oxford OX1 3PS, UK. Electronic address: [email protected].

PMID: 25771486 DOI: 10.1016/j.virol.2015.02.011

Abstract

The rapid rates of viral evolution allow us to reconstruct the recent history of viruses in great detail. This feature, however, also results in rapid erosion of evolutionary signal within viral molecular data, impeding studies of their deep history. Thus, the further back in time, the less accurate the inference becomes. Furthermore, reconstructing complex histories of transmission can be challenging, especially where extinct viral lineages are concerned. This problem has been partially solved by the discovery of viruses embedded in host genomes, known as endogenous viral elements (EVEs). Some of these endogenous viruses are derived from ancient relatives of extant viruses, allowing us to better examine ancient viral host range, geographical distribution and transmission routes. Moreover, our knowledge of viral evolutionary timescales and rate dynamics has also been greatly improved by their discovery, thereby bridging the gap between recent and ancient viral evolution.

Copyright © 2015 Elsevier Inc. All rights reserved.

Keywords: Endogenous viral element; Endogenous viruses; Genomics; Paleovirology; Virus evolution

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