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Kawada T, Li M, Sata Y, et al. Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats. Clin Med Insights Cardiol. 2015;9:1-9doi: 10.4137/CMC.S18759.
Kawada, T., Li, M., Sata, Y., Zheng, C., Turner, M. J., Shimizu, S., & Sugimachi, M. (2015). Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats. Clinical Medicine Insights. Cardiology, 91-9. https://doi.org/10.4137/CMC.S18759
Kawada, Toru, et al. "Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats." Clinical Medicine Insights. Cardiology vol. 9 (2015): 1-9. doi: https://doi.org/10.4137/CMC.S18759
Kawada T, Li M, Sata Y, Zheng C, Turner MJ, Shimizu S, Sugimachi M. Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats. Clin Med Insights Cardiol. 2015 Feb 03;9:1-9. doi: 10.4137/CMC.S18759. eCollection 2015. PMID: 25698884; PMCID: PMC4319654.
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Clin Med Insights Cardiol. 2015 Feb 03;9:1-9. doi: 10.4137/CMC.S18759. eCollection 2015.

Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats.

Clinical Medicine Insights. Cardiology

Toru Kawada, Meihua Li, Yusuke Sata, Can Zheng, Michael J Turner, Shuji Shimizu, Masaru Sugimachi

Affiliations

  1. Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.
  2. Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan. ; Department of Artificial Organ Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

PMID: 25698884 PMCID: PMC4319654 DOI: 10.4137/CMC.S18759

Abstract

A baroreflex equilibrium diagram describes the relation between input pressure and sympathetic nerve activity (SNA) and that between SNA and arterial pressure (AP). To calibrate the SNA axis (abscissa) of the baroreflex equilibrium diagram, the AP response to intravenous bolus injections of phenylephrine (0.2-50 μg/kg) or norepinephrine (NE, 0.02-5 μg/kg) was examined in normal control rats (NC, n = 9) and rats with chronic heart failure (CHF, n = 6). The maximum slope of the dose-effect curve was significantly smaller in the CHF group than in the NC group (57.3 ± 5.2 vs 80.9 ± 6.3 mmHg/decade for phenylephrine, 60.2 ± 7.8 vs 80.4 ± 5.9 mmHg/decade for NE; P < 0.01). The CHF/NC ratio of the maximum slope was used to calibrate SNA. While the calibrated baroreflex equilibrium diagram showed increased maximum SNA and operating-point SNA in CHF rats compared with NC rats, the magnitude of increase was smaller than that expected from the excess plasma NE concentration in CHF rats. Plasma NE concentration in the CHF group could be disproportionally high relative to SNA.

Keywords: arterial pressure; carotid sinus baroreflex; norepinephrine; open-loop analysis; phenylephrine

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