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Kawada T, Li M, Zheng C, et al. Acute Effects of Vagotomy on Baroreflex Equilibrium Diagram in Rats with Chronic Heart Failure. Clin Med Insights Cardiol. 2016;10:139-47doi: 10.4137/CMC.S38443.
Kawada, T., Li, M., Zheng, C., & Sugimachi, M. (2016). Acute Effects of Vagotomy on Baroreflex Equilibrium Diagram in Rats with Chronic Heart Failure. Clinical Medicine Insights. Cardiology, 10139-47. https://doi.org/10.4137/CMC.S38443
Kawada, Toru, et al. "Acute Effects of Vagotomy on Baroreflex Equilibrium Diagram in Rats with Chronic Heart Failure." Clinical Medicine Insights. Cardiology vol. 10 (2016): 139-47. doi: https://doi.org/10.4137/CMC.S38443
Kawada T, Li M, Zheng C, Sugimachi M. Acute Effects of Vagotomy on Baroreflex Equilibrium Diagram in Rats with Chronic Heart Failure. Clin Med Insights Cardiol. 2016 Aug 28;10:139-47. doi: 10.4137/CMC.S38443. eCollection 2016. PMID: 27594790; PMCID: PMC5003122.
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Clin Med Insights Cardiol. 2016 Aug 28;10:139-47. doi: 10.4137/CMC.S38443. eCollection 2016.

Acute Effects of Vagotomy on Baroreflex Equilibrium Diagram in Rats with Chronic Heart Failure.

Clinical Medicine Insights. Cardiology

Toru Kawada, Meihua Li, Can Zheng, Masaru Sugimachi

Affiliations

  1. Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.

PMID: 27594790 PMCID: PMC5003122 DOI: 10.4137/CMC.S38443

Abstract

The arterial baroreflex system can be divided into the neural arc, from pressure input to efferent sympathetic nerve activity (SNA), and the peripheral arc, from SNA to arterial pressure (AP). Plotting the neural and peripheral arcs on a pressure-SNA plane yields a baroreflex equilibrium diagram. We examined the effects of vagotomy on the open-loop static characteristics of the carotid sinus baroreflex in normal control rats (NC, n = 10) and rats with heart failure after myocardial infarction (MI, n = 10). In the NC group, vagotomy shifted the neural arc toward higher SNA and decreased the slope of the peripheral arc. Consequently, the operating-point SNA increased without a significant change in the operating-point AP on the baroreflex equilibrium diagram. These vagotomy-induced effects were not observed in the MI group, suggesting a loss of vagal modulation of the carotid sinus baroreflex function in heart failure.

Keywords: arterial pressure; carotid sinus baroreflex; equilibrium diagram; myocardial infarction; open-loop analysis; sympathetic nerve activity

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