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Xu J, Cong M, Park TJ, et al. Contribution of bone marrow-derived fibrocytes to liver fibrosis. Hepatobiliary Surg Nutr. 2015;4(1):34-47doi: 10.3978/j.issn.2304-3881.2015.01.01.
Xu, J., Cong, M., Park, T. J., Scholten, D., Brenner, D. A., & Kisseleva, T. (2015). Contribution of bone marrow-derived fibrocytes to liver fibrosis. Hepatobiliary surgery and nutrition, 4(1), 34-47. https://doi.org/10.3978/j.issn.2304-3881.2015.01.01
Xu, Jun, et al. "Contribution of bone marrow-derived fibrocytes to liver fibrosis." Hepatobiliary surgery and nutrition vol. 4,1 (2015): 34-47. doi: https://doi.org/10.3978/j.issn.2304-3881.2015.01.01
Xu J, Cong M, Park TJ, Scholten D, Brenner DA, Kisseleva T. Contribution of bone marrow-derived fibrocytes to liver fibrosis. Hepatobiliary Surg Nutr. 2015 Feb;4(1):34-47. doi: 10.3978/j.issn.2304-3881.2015.01.01. PMID: 25713803; PMCID: PMC4318956.
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Hepatobiliary Surg Nutr. 2015 Feb;4(1):34-47. doi: 10.3978/j.issn.2304-3881.2015.01.01.

Contribution of bone marrow-derived fibrocytes to liver fibrosis.

Hepatobiliary surgery and nutrition

Jun Xu, Min Cong, Tae Jun Park, David Scholten, David A Brenner, Tatiana Kisseleva

Affiliations

  1. 1 Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA ; 2 Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China ; 3 Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120752, Korea ; 4 Department of Medicine III, University Hospital Aachen, Aachen 52074, Germany ; 5 Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA.

PMID: 25713803 PMCID: PMC4318956 DOI: 10.3978/j.issn.2304-3881.2015.01.01

Abstract

Since the discovery of fibrocytes in 1994 by Dr. Bucala and colleagues, these bone marrow (BM)-derived collagen Type I producing CD45(+) cells remain the most fascinating cells of the hematopoietic system. Despite recent reports on the emerging contribution of fibrocytes to fibrosis of parenchymal and non-parenchymal organs and tissues, fibrocytes remain the most understudied pro-fibrogenic cellular population. In the past years fibrocytes were implicated in the pathogenesis of liver, skin, lung, and kidney fibrosis by giving rise to collagen type I producing cells/myofibroblasts. Hence, the role of fibrocytes in fibrosis is not well defined since different studies often contain controversial results on the number of fibrocytes recruited to the site of injury versus the number of fibrocyte-derived myofibroblasts in the same fibrotic organ. Furthermore, many studies were based on the in vitro characterization of fibrocytes formed after outgrowth of BM and/or peripheral blood cultures. Therefore, the fibrocyte function(s) still remain(s) lack of understanding, mostly due to (I) the lack of mouse models that can provide complimentary in vivo real-time and cell fate mapping studies of the dynamic differentiation of fibrocytes and their progeny into collagen type I producing cells (and/or possibly, other cell types of the hematopoietic system); (II) the complexity of hematopoietic cell differentiation pathways in response to various stimuli; (III) the high plasticity of hematopoietic cells. Here we summarize the current understanding of the role of CD45(+) collagen type I(+) BM-derived cells in the pathogenesis of liver injury. Based on data obtained from various organs undergoing fibrogenesis or other type of chronic injury, here we also discuss the most recent evidence supporting the critical role of fibrocytes in the mediation of pro-fibrogenic and/or pro-inflammatory responses.

Keywords: Fibrocytes; migration; myofibroblasts

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