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Cytotechnology. 2017 Feb;69(1):39-56. doi: 10.1007/s10616-016-0036-5. Epub 2016 Nov 29.

Selection of chemically defined media for CHO cell fed-batch culture processes.

Cytotechnology

Xiao Pan, Mathieu Streefland, Ciska Dalm, René H Wijffels, Dirk E Martens

Affiliations

  1. Bioprocess Engineering, Wageningen University, PO Box 16, 6700 AA, Wageningen, The Netherlands. [email protected].
  2. Bioprocess Engineering, Wageningen University, PO Box 16, 6700 AA, Wageningen, The Netherlands.
  3. Synthon Biopharmaceuticals BV, Upstream Process Development, PO Box 7071, 6503 GN, Nijmegen, The Netherlands.
  4. Faculty of Biosciences and Aquaculture, Nord University, 8049, Bodø, Norway.

PMID: 27900626 PMCID: PMC5264622 DOI: 10.1007/s10616-016-0036-5

Abstract

Two CHO cell clones derived from the same parental CHO

Keywords: Antibody production; Cell culture medium; Chinese hamster ovary (CHO) cell; Fed-batch; Metabolite profile; Phase transition

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