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Bugay DE. Solid-state nuclear magnetic resonance spectroscopy: theory and pharmaceutical applications. Pharm Res. 1993;10(3):317-27doi: 10.1023/a:1018967717781.
Bugay, D. E. (1993). Solid-state nuclear magnetic resonance spectroscopy: theory and pharmaceutical applications. Pharmaceutical research, 10(3), 317-27. https://doi.org/10.1023/a:1018967717781
Bugay, D E. "Solid-state nuclear magnetic resonance spectroscopy: theory and pharmaceutical applications." Pharmaceutical research vol. 10,3 (1993): 317-27. doi: https://doi.org/10.1023/a:1018967717781
Bugay DE. Solid-state nuclear magnetic resonance spectroscopy: theory and pharmaceutical applications. Pharm Res. 1993 Mar;10(3):317-27. doi: 10.1023/a:1018967717781. PMID: 8464803.
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Pharm Res. 1993 Mar;10(3):317-27. doi: 10.1023/a:1018967717781.

Solid-state nuclear magnetic resonance spectroscopy: theory and pharmaceutical applications.

Pharmaceutical research

D E Bugay

Affiliations

  1. Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey 08903-0191.

PMID: 8464803 DOI: 10.1023/a:1018967717781

Abstract

The theory of solid-state nuclear magnetic resonance (NMR) spectroscopy is reviewed, with specific discussions of magnetic interactions in the solid state. Each magnetic interaction (Zeeman, dipole-dipole, chemical-shift, spin-spin, and quadrupolar) is addressed and manifestations of these interactions in the solid state NMR spectrum are explained. The techniques of high-power decoupling, magic-angle spinning, and cross-polarization, used to acquire highly resolved solid-state NMR spectra, are also illustrated. Application of solid-state NMR to pharmaceutical problem solving and methods development is then briefly reviewed.

References

  1. J Pharm Pharmacol. 1989 Oct;41(10 ):665-9 - PubMed
  2. Pharm Res. 1990 Feb;7(2):147-53 - PubMed
  3. Pharm Res. 1990 Feb;7(2):184-7 - PubMed
  4. J Pharm Sci. 1969 Aug;58(8):911-29 - PubMed
  5. Pharm Res. 1991 Feb;8(2):148-55 - PubMed
  6. Pharm Res. 1991 Aug;8(8):963-73 - PubMed
  7. Drugs. 1990 Dec;40(6):800-28 - PubMed
  8. J Pharm Sci. 1985 May;74(5):565-8 - PubMed
  9. J Pharm Sci. 1986 Jun;75(6):596-600 - PubMed
  10. J Pharm Sci. 1991 Apr;80(4):357-62 - PubMed

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