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In vivo interferon system assessed by 2'-5' oligoadenylate synthetase activity in chronic hepatitis C virus patients treated with pegylated interferon and ribavirin.

Hepatology research : the official journal of the Japan Society of Hepatology

Shindo M, Hamada K, Morikawa T, Harano Y, Nakajima T, Okuno T.
PMID: 18713278
Hepatol Res. 2008 Dec;38(12):1213-20. doi: 10.1111/j.1872-034X.2008.00397.x. Epub 2008 Aug 18.

AIM: 2',5' oligoadenylate synthetase (2-5AS), an enzyme induced by interferon, is an accurate indicator of the antiviral effect of interferon. We measured it during pegylated interferon based therapies in patients with chronic hepatitis C virus (HCV) in order to...

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Shindo M, Hamada K, Morikawa T, et al. In vivo interferon system assessed by 2'-5' oligoadenylate synthetase activity in chronic hepatitis C virus patients treated with pegylated interferon and ribavirin. Hepatol Res. 2008;38(12):1213-20doi: 10.1111/j.1872-034X.2008.00397.x.
Shindo, M., Hamada, K., Morikawa, T., Harano, Y., Nakajima, T., & Okuno, T. (2008). In vivo interferon system assessed by 2'-5' oligoadenylate synthetase activity in chronic hepatitis C virus patients treated with pegylated interferon and ribavirin. Hepatology research : the official journal of the Japan Society of Hepatology, 38(12), 1213-20. https://doi.org/10.1111/j.1872-034X.2008.00397.x
Shindo, Michiko, et al. "In vivo interferon system assessed by 2'-5' oligoadenylate synthetase activity in chronic hepatitis C virus patients treated with pegylated interferon and ribavirin." Hepatology research : the official journal of the Japan Society of Hepatology vol. 38,12 (2008): 1213-20. doi: https://doi.org/10.1111/j.1872-034X.2008.00397.x
Shindo M, Hamada K, Morikawa T, Harano Y, Nakajima T, Okuno T. In vivo interferon system assessed by 2'-5' oligoadenylate synthetase activity in chronic hepatitis C virus patients treated with pegylated interferon and ribavirin. Hepatol Res. 2008 Dec;38(12):1213-20. doi: 10.1111/j.1872-034X.2008.00397.x. Epub 2008 Aug 18. PMID: 18713278.
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Loss of (2'-5')oligoadenylate synthetase activity by production of antisense RNA results in lack of protection by interferon from viral infections.

Proceedings of the National Academy of Sciences of the United States of America

[No authors listed]
PMID: 3309945
Proc Natl Acad Sci U S A. 1987 Oct;84(19):6740. doi: 10.1073/pnas.84.19.6740.
Free PMC Article

No abstract available.

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Loss of (2'-5')oligoadenylate synthetase activity by production of antisense RNA results in lack of protection by interferon from viral infections. Proc Natl Acad Sci U S A. 1987;84(19):6740doi: 10.1073/pnas.84.19.6740.
(1987). Loss of (2'-5')oligoadenylate synthetase activity by production of antisense RNA results in lack of protection by interferon from viral infections. Proceedings of the National Academy of Sciences of the United States of America, 84(19), 6740. https://doi.org/10.1073/pnas.84.19.6740
"Loss of (2'-5')oligoadenylate synthetase activity by production of antisense RNA results in lack of protection by interferon from viral infections." Proceedings of the National Academy of Sciences of the United States of America vol. 84,19 (1987): 6740. doi: https://doi.org/10.1073/pnas.84.19.6740
Loss of (2'-5')oligoadenylate synthetase activity by production of antisense RNA results in lack of protection by interferon from viral infections. Proc Natl Acad Sci U S A. 1987 Oct;84(19):6740. doi: 10.1073/pnas.84.19.6740. PMID: 3309945; PMCID: PMC299159.
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Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals.

Frontiers in immunology

Rong E, Wang X, Chen H, Yang C, Hu J, Liu W, Wang Z, Chen X, Zheng H, Pu J, Sun H, Smith J, Burt DW, Liu J, Li N, Huang Y.
PMID: 29973937
Front Immunol. 2018 Jun 20;9:1398. doi: 10.3389/fimmu.2018.01398. eCollection 2018.

Host cells develop the OAS/RNase L [2'-5'-oligoadenylate synthetase (OAS)/ribonuclease L] system to degrade cellular and viral RNA, and/or the OASL/RIG-I (2'-5'-OAS like/retinoic acid inducible protein I) system to enhance RIG-I-mediated IFN induction, thus providing the first line of defense...

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Rong E, Wang X, Chen H, et al. Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals. Front Immunol. 2018;9:1398doi: 10.3389/fimmu.2018.01398.
Rong, E., Wang, X., Chen, H., Yang, C., Hu, J., Liu, W., Wang, Z., Chen, X., Zheng, H., Pu, J., Sun, H., Smith, J., Burt, D. W., Liu, J., Li, N., & Huang, Y. (2018). Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals. Frontiers in immunology, 91398. https://doi.org/10.3389/fimmu.2018.01398
Rong, Enguang, et al. "Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals." Frontiers in immunology vol. 9 (2018): 1398. doi: https://doi.org/10.3389/fimmu.2018.01398
Rong E, Wang X, Chen H, Yang C, Hu J, Liu W, Wang Z, Chen X, Zheng H, Pu J, Sun H, Smith J, Burt DW, Liu J, Li N, Huang Y. Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals. Front Immunol. 2018 Jun 20;9:1398. doi: 10.3389/fimmu.2018.01398. eCollection 2018. PMID: 29973937; PMCID: PMC6019448.
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Molecular Cloning and Identification of the 2'-5' Oligoadenylate Synthetase 2 Gene in Chinese Domestic Pigs Through Bioinformatics Analysis, and Determination of Its Antiviral Activity Against Porcine Reproductive and Respiratory Syndrome Virus Infection.

Indian journal of microbiology

Wang R, Ma H, Kang Y, Li C, Li H, Zhang E, Ji P, He J, Zhao M.
PMID: 30013278
Indian J Microbiol. 2018 Sep;58(3):332-344. doi: 10.1007/s12088-018-0731-3. Epub 2018 Apr 26.

An interferon-mediated antiviral protein, 2'-5' oligoadenylate synthetase 2, plays an important role in the antiviral response of interferons. In this study, 2'-5' oligoadenylate synthetase 2 genes were cloned from Chinese domestic pigs. Bioinformatics analysis revealed that the 2024-bp long...

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Wang R, Ma H, Kang Y, et al. Molecular Cloning and Identification of the 2'-5' Oligoadenylate Synthetase 2 Gene in Chinese Domestic Pigs Through Bioinformatics Analysis, and Determination of Its Antiviral Activity Against Porcine Reproductive and Respiratory Syndrome Virus Infection. Indian J Microbiol. 2018;58(3):332-344doi: 10.1007/s12088-018-0731-3.
Wang, R., Ma, H., Kang, Y., Li, C., Li, H., Zhang, E., Ji, P., He, J., & Zhao, M. (2018). Molecular Cloning and Identification of the 2'-5' Oligoadenylate Synthetase 2 Gene in Chinese Domestic Pigs Through Bioinformatics Analysis, and Determination of Its Antiviral Activity Against Porcine Reproductive and Respiratory Syndrome Virus Infection. Indian journal of microbiology, 58(3), 332-344. https://doi.org/10.1007/s12088-018-0731-3
Wang, Ruining, et al. "Molecular Cloning and Identification of the 2'-5' Oligoadenylate Synthetase 2 Gene in Chinese Domestic Pigs Through Bioinformatics Analysis, and Determination of Its Antiviral Activity Against Porcine Reproductive and Respiratory Syndrome Virus Infection." Indian journal of microbiology vol. 58,3 (2018): 332-344. doi: https://doi.org/10.1007/s12088-018-0731-3
Wang R, Ma H, Kang Y, Li C, Li H, Zhang E, Ji P, He J, Zhao M. Molecular Cloning and Identification of the 2'-5' Oligoadenylate Synthetase 2 Gene in Chinese Domestic Pigs Through Bioinformatics Analysis, and Determination of Its Antiviral Activity Against Porcine Reproductive and Respiratory Syndrome Virus Infection. Indian J Microbiol. 2018 Sep;58(3):332-344. doi: 10.1007/s12088-018-0731-3. Epub 2018 Apr 26. PMID: 30013278; PMCID: PMC6023816.
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In silico identification of potential inhibitors against human 2'-5'- oligoadenylate synthetase (OAS) proteins.

Computational biology and chemistry

Gonzalez KJ, Moncada-Giraldo DM, Gutierrez JB.
PMID: 32004971
Comput Biol Chem. 2020 Apr;85:107211. doi: 10.1016/j.compbiolchem.2020.107211. Epub 2020 Jan 22.

As part of the type I IFN signaling, the 2'-5'- oligoadenylate synthetase (OAS) proteins have been involved in the progression of several non-viral diseases. Notably, OAS has been correlated with immune-modulatory functions that promote chronic inflammatory conditions, autoimmune disorders,...

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Gonzalez KJ, Moncada-Giraldo DM, Gutierrez JB. In silico identification of potential inhibitors against human 2'-5'- oligoadenylate synthetase (OAS) proteins. Comput Biol Chem. 2020;85:107211doi: 10.1016/j.compbiolchem.2020.107211.
Gonzalez, K. J., Moncada-Giraldo, D. M., & Gutierrez, J. B. (2020). In silico identification of potential inhibitors against human 2'-5'- oligoadenylate synthetase (OAS) proteins. Computational biology and chemistry, 85107211. https://doi.org/10.1016/j.compbiolchem.2020.107211
Gonzalez, Karen J, et al. "In silico identification of potential inhibitors against human 2'-5'- oligoadenylate synthetase (OAS) proteins." Computational biology and chemistry vol. 85 (2020): 107211. doi: https://doi.org/10.1016/j.compbiolchem.2020.107211
Gonzalez KJ, Moncada-Giraldo DM, Gutierrez JB. In silico identification of potential inhibitors against human 2'-5'- oligoadenylate synthetase (OAS) proteins. Comput Biol Chem. 2020 Apr;85:107211. doi: 10.1016/j.compbiolchem.2020.107211. Epub 2020 Jan 22. PMID: 32004971.
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Comprehensive analysis of prognostic immune-related genes associated with the tumor microenvironment of pancreatic ductal adenocarcinoma.

Oncology letters

Yan S, Fang J, Zhu Y, Xie Y, Fang F.
PMID: 33133266
Oncol Lett. 2020 Dec;20(6):366. doi: 10.3892/ol.2020.12228. Epub 2020 Oct 15.

Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with a specific tumor immune microenvironment (TIME). Therefore, investigating prognostic immune-related genes (IRGs) that are closely associated with TIME to predict PDAC clinical outcomes is necessary. In the present study, 459...

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Yan S, Fang J, Zhu Y, et al. Comprehensive analysis of prognostic immune-related genes associated with the tumor microenvironment of pancreatic ductal adenocarcinoma. Oncol Lett. 2020;20(6):366doi: 10.3892/ol.2020.12228.
Yan, S., Fang, J., Zhu, Y., Xie, Y., & Fang, F. (2020). Comprehensive analysis of prognostic immune-related genes associated with the tumor microenvironment of pancreatic ductal adenocarcinoma. Oncology letters, 20(6), 366. https://doi.org/10.3892/ol.2020.12228
Yan, Shibai, et al. "Comprehensive analysis of prognostic immune-related genes associated with the tumor microenvironment of pancreatic ductal adenocarcinoma." Oncology letters vol. 20,6 (2020): 366. doi: https://doi.org/10.3892/ol.2020.12228
Yan S, Fang J, Zhu Y, Xie Y, Fang F. Comprehensive analysis of prognostic immune-related genes associated with the tumor microenvironment of pancreatic ductal adenocarcinoma. Oncol Lett. 2020 Dec;20(6):366. doi: 10.3892/ol.2020.12228. Epub 2020 Oct 15. PMID: 33133266; PMCID: PMC7590433.
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Effects of Co-Administration of Icariin and .

Neuropsychiatric disease and treatment

Zhang T, Dong K, Xiao L, Li G, Zhang Z.
PMID: 33061388
Neuropsychiatr Dis Treat. 2020 Sep 22;16:2169-2179. doi: 10.2147/NDT.S253972. eCollection 2020.

OBJECTIVE: We investigated the effect of icariin (ICA) combined with METHODS: Transgenic mice were treated with icariin and PNS. The Morris water maze (MWM) was used to assess spatial memory, and the gut microbiota and differential protein expression in...

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Zhang T, Dong K, Xiao L, et al. Effects of Co-Administration of Icariin and . Neuropsychiatr Dis Treat. 2020;16:2169-2179doi: 10.2147/NDT.S253972.
Zhang, T., Dong, K., Xiao, L., Li, G., & Zhang, Z. (2020). Effects of Co-Administration of Icariin and . Neuropsychiatric disease and treatment, 162169-2179. https://doi.org/10.2147/NDT.S253972
Zhang, Ting, et al. "Effects of Co-Administration of Icariin and ." Neuropsychiatric disease and treatment vol. 16 (2020): 2169-2179. doi: https://doi.org/10.2147/NDT.S253972
Zhang T, Dong K, Xiao L, Li G, Zhang Z. Effects of Co-Administration of Icariin and . Neuropsychiatr Dis Treat. 2020 Sep 22;16:2169-2179. doi: 10.2147/NDT.S253972. eCollection 2020. PMID: 33061388; PMCID: PMC7519864.
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Protein kinase expression as a predictive factor for interferon response in chronic hepatitis C patients.

Journal of advanced research

Mohamed AA, Amin MA, Ragab MM, Ismail SA, Baki AA.
PMID: 25685478
J Adv Res. 2014 Jan;5(1):117-23. doi: 10.1016/j.jare.2013.01.002. Epub 2013 Mar 14.

Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. Currently, combined pegylated interferon and ribavirin therapy are the standard treatment. The biological activity of interferon (IFN) is mediated by the induction of intracellular antiviral proteins, such as...

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Mohamed AA, Amin MA, Ragab MM, et al. Protein kinase expression as a predictive factor for interferon response in chronic hepatitis C patients. J Adv Res. 2013;5(1):117-23doi: 10.1016/j.jare.2013.01.002.
Mohamed, A. A., Amin, M. A., Ragab, M. M., Ismail, S. A., & Baki, A. A. (2014). Protein kinase expression as a predictive factor for interferon response in chronic hepatitis C patients. Journal of advanced research, 5(1), 117-23. https://doi.org/10.1016/j.jare.2013.01.002
Mohamed, Amal A, et al. "Protein kinase expression as a predictive factor for interferon response in chronic hepatitis C patients." Journal of advanced research vol. 5,1 (2014): 117-23. doi: https://doi.org/10.1016/j.jare.2013.01.002
Mohamed AA, Amin MA, Ragab MM, Ismail SA, Baki AA. Protein kinase expression as a predictive factor for interferon response in chronic hepatitis C patients. J Adv Res. 2014 Jan;5(1):117-23. doi: 10.1016/j.jare.2013.01.002. Epub 2013 Mar 14. PMID: 25685478; PMCID: PMC4294718.
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Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation.

Evidence-based complementary and alternative medicine : eCAM

Kim SK, Kim J, Ko E, Kim H, Hwang DS, Lee S, Baek Y, Min BI, Nam S, Bae H.
PMID: 21799680
Evid Based Complement Alternat Med. 2011;2011:508689. doi: 10.1093/ecam/nep222. Epub 2011 Jun 05.

Clinical evidence indicates that electroacupuncture (EA) is effective for allergic disorder. Recent animal studies have shown that EA treatment reduces levels of IgE and Th2 cytokines in BALB/c mice immunized with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH). The hypothalamus, a...

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Kim SK, Kim J, Ko E, et al. Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation. Evid Based Complement Alternat Med. 2011;2011:508689doi: 10.1093/ecam/nep222.
Kim, S. K., Kim, J., Ko, E., Kim, H., Hwang, D. S., Lee, S., Baek, Y., Min, B. I., Nam, S., & Bae, H. (2011). Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation. Evidence-based complementary and alternative medicine : eCAM, 2011508689. https://doi.org/10.1093/ecam/nep222
Kim, Sun Kwang, et al. "Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation." Evidence-based complementary and alternative medicine : eCAM vol. 2011 (2011): 508689. doi: https://doi.org/10.1093/ecam/nep222
Kim SK, Kim J, Ko E, Kim H, Hwang DS, Lee S, Baek Y, Min BI, Nam S, Bae H. Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation. Evid Based Complement Alternat Med. 2011;2011:508689. doi: 10.1093/ecam/nep222. Epub 2011 Jun 05. PMID: 21799680; PMCID: PMC3136536.
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Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death.

The EMBO journal

Kondratova A, Cheon H, Dong B, Holvey-Bates EG, Hasipek M, Taran I, Gaughan C, Jha BK, Silverman RH, Stark GR.
PMID: 33058249
EMBO J. 2020 Oct 15;39(20):e106593. doi: 10.15252/embj.2020106593.

No abstract available.

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Kondratova A, Cheon H, Dong B, et al. Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death. EMBO J. 2020;39(20):e106593doi: 10.15252/embj.2020106593.
Kondratova, A., Cheon, H., Dong, B., Holvey-Bates, E. G., Hasipek, M., Taran, I., Gaughan, C., Jha, B. K., Silverman, R. H., & Stark, G. R. (2020). Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death. The EMBO journal, 39(20), e106593. https://doi.org/10.15252/embj.2020106593
Kondratova, Anna, et al. "Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death." The EMBO journal vol. 39,20 (2020): e106593. doi: https://doi.org/10.15252/embj.2020106593
Kondratova A, Cheon H, Dong B, Holvey-Bates EG, Hasipek M, Taran I, Gaughan C, Jha BK, Silverman RH, Stark GR. Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death. EMBO J. 2020 Oct 15;39(20):e106593. doi: 10.15252/embj.2020106593. PMID: 33058249; PMCID: PMC7560197.
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Global Mapping of H3K4 Trimethylation (H3K4me3) and Transcriptome Analysis Reveal Genes Involved in the Response to Epidemic Diarrhea Virus Infections in Pigs.

Animals : an open access journal from MDPI

Wang H, Yang L, Qu H, Feng H, Wu S, Bao W.
PMID: 31382472
Animals (Basel). 2019 Aug 02;9(8). doi: 10.3390/ani9080523.

Porcine epidemic diarrhea virus (PEDV) is currently detected as the main pathogen causing severe diarrhea in pig farms. The phenotypic alterations induced by pathogenic infections are usually tightly linked with marked changes in epigenetic modification and gene expression. We...

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Wang H, Yang L, Qu H, et al. Global Mapping of H3K4 Trimethylation (H3K4me3) and Transcriptome Analysis Reveal Genes Involved in the Response to Epidemic Diarrhea Virus Infections in Pigs. Animals (Basel). 2019;9(8)doi: 10.3390/ani9080523.
Wang, H., Yang, L., Qu, H., Feng, H., Wu, S., & Bao, W. (2019). Global Mapping of H3K4 Trimethylation (H3K4me3) and Transcriptome Analysis Reveal Genes Involved in the Response to Epidemic Diarrhea Virus Infections in Pigs. Animals : an open access journal from MDPI, 9(8), . https://doi.org/10.3390/ani9080523
Wang, Haifei, et al. "Global Mapping of H3K4 Trimethylation (H3K4me3) and Transcriptome Analysis Reveal Genes Involved in the Response to Epidemic Diarrhea Virus Infections in Pigs." Animals : an open access journal from MDPI vol. 9,8 (2019). doi: https://doi.org/10.3390/ani9080523
Wang H, Yang L, Qu H, Feng H, Wu S, Bao W. Global Mapping of H3K4 Trimethylation (H3K4me3) and Transcriptome Analysis Reveal Genes Involved in the Response to Epidemic Diarrhea Virus Infections in Pigs. Animals (Basel). 2019 Aug 02;9(8). doi: 10.3390/ani9080523. PMID: 31382472; PMCID: PMC6719071.
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Identification and characterization of biomarkers and their functions for docetaxel-resistant prostate cancer cells.

Oncology letters

Deng L, Gu X, Zeng T, Xu F, Dong Z, Liu C, Chao H.
PMID: 31452801
Oncol Lett. 2019 Sep;18(3):3236-3248. doi: 10.3892/ol.2019.10623. Epub 2019 Jul 16.

Docetaxel treatment is a standard chemotherapy strategy for castration-resistant prostate cancer (CRPC), and patients with CRPC eventually develop resistance to treatment. However, little is understood regarding the underlying mechanism of resistance. The present study aimed to identify the underlying...

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Deng L, Gu X, Zeng T, et al. Identification and characterization of biomarkers and their functions for docetaxel-resistant prostate cancer cells. Oncol Lett. 2019;18(3):3236-3248doi: 10.3892/ol.2019.10623.
Deng, L., Gu, X., Zeng, T., Xu, F., Dong, Z., Liu, C., & Chao, H. (2019). Identification and characterization of biomarkers and their functions for docetaxel-resistant prostate cancer cells. Oncology letters, 18(3), 3236-3248. https://doi.org/10.3892/ol.2019.10623
Deng, Leihong, et al. "Identification and characterization of biomarkers and their functions for docetaxel-resistant prostate cancer cells." Oncology letters vol. 18,3 (2019): 3236-3248. doi: https://doi.org/10.3892/ol.2019.10623
Deng L, Gu X, Zeng T, Xu F, Dong Z, Liu C, Chao H. Identification and characterization of biomarkers and their functions for docetaxel-resistant prostate cancer cells. Oncol Lett. 2019 Sep;18(3):3236-3248. doi: 10.3892/ol.2019.10623. Epub 2019 Jul 16. PMID: 31452801; PMCID: PMC6676406.
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