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Gonzalez KJ, Moncada-Giraldo DM, Gutierrez JB. In silico identification of potential inhibitors against human 2'-5'- oligoadenylate synthetase (OAS) proteins. Comput Biol Chem. 2020;85:107211doi: 10.1016/j.compbiolchem.2020.107211.
Gonzalez, K. J., Moncada-Giraldo, D. M., & Gutierrez, J. B. (2020). In silico identification of potential inhibitors against human 2'-5'- oligoadenylate synthetase (OAS) proteins. Computational biology and chemistry, 85107211. https://doi.org/10.1016/j.compbiolchem.2020.107211
Gonzalez, Karen J, et al. "In silico identification of potential inhibitors against human 2'-5'- oligoadenylate synthetase (OAS) proteins." Computational biology and chemistry vol. 85 (2020): 107211. doi: https://doi.org/10.1016/j.compbiolchem.2020.107211
Gonzalez KJ, Moncada-Giraldo DM, Gutierrez JB. In silico identification of potential inhibitors against human 2'-5'- oligoadenylate synthetase (OAS) proteins. Comput Biol Chem. 2020 Apr;85:107211. doi: 10.1016/j.compbiolchem.2020.107211. Epub 2020 Jan 22. PMID: 32004971.
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Comput Biol Chem. 2020 Apr;85:107211. doi: 10.1016/j.compbiolchem.2020.107211. Epub 2020 Jan 22.

In silico identification of potential inhibitors against human 2'-5'- oligoadenylate synthetase (OAS) proteins.

Computational biology and chemistry

Karen J Gonzalez, Diego M Moncada-Giraldo, Juan B Gutierrez

Affiliations

  1. Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.
  2. Department of Mathematics, University of Texas at San Antonio, San Antonio, TX, 78249, USA. Electronic address: [email protected].

PMID: 32004971 DOI: 10.1016/j.compbiolchem.2020.107211

Abstract

As part of the type I IFN signaling, the 2'-5'- oligoadenylate synthetase (OAS) proteins have been involved in the progression of several non-viral diseases. Notably, OAS has been correlated with immune-modulatory functions that promote chronic inflammatory conditions, autoimmune disorders, cancer, and infectious diseases. In spite of this, OAS enzymes have been ignored as drug targets, and to date, there are no reports of compounds that can inhibit their activity. In this study, we have used homology modeling and virtual high-throughput screening to identify potential inhibitors of the human proteins OAS1, OAS2, and OAS3. Altogether, we have found 37 molecules that could exert a competitive inhibition in the ATP binding sites of OAS proteins, independently of the activation state of the enzyme. This latter characteristic, which might be crucial for a versatile inhibitor, was observed in compounds interacting with the residues Asp75, Asp77, Gln229, and Tyr230 in OAS1, and their equivalents in OAS2 and OAS3. Although there was little correlation between specific chemical fragments and their interactions, intermolecular contacts with OAS catalytic triad and other critical amino acids were mainly promoted by heterocycles with π electrons and hydrogen bond acceptors. In conclusion, this study provides a potential set of OAS inhibitors as well as valuable information for their design, development, and optimization.

Copyright © 2020 Elsevier Ltd. All rights reserved.

Keywords: 2’-5’- oligoadenylate synthetase (OAS); Docking; In-silico inhibition; Small drug-like molecules; Virtual screening

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this pa

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