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Showing 1 to 12 of 37 entries
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In vivo Induction of Rabbit 2',5'-Oligoadenylate Synthetase.

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica

Feng YF, Yang KY.
PMID: 12219200
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1997;29(3):235-242.

By the study of in vivo induction of rabbit 2',5'-oligoadenylate synthetase (2',5'-OASE), it has been found that polyinosinic acid-polycytidylic acid (poly(I).poly(C)) can induce the formation of 2',5'-OASE only in rabbit peripheral blood mononuclear cells(PBMC), whereas New Castle disease virus...

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Feng YF, Yang KY. In vivo Induction of Rabbit 2',5'-Oligoadenylate Synthetase. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1997;29(3):235-242
Feng, Y. F., & Yang, K. Y. (1997). In vivo Induction of Rabbit 2',5'-Oligoadenylate Synthetase. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica, 29(3), 235-242.
Feng, Yun-Feng, and Yang, Kai-Yu. "In vivo Induction of Rabbit 2',5'-Oligoadenylate Synthetase." Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica vol. 29,3 (1997): 235-242.
Feng YF, Yang KY. In vivo Induction of Rabbit 2',5'-Oligoadenylate Synthetase. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1997;29(3):235-242. PMID: 12219200.
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Polymorphism of 2'-5'-oligoadenylate synthetase (.

Molecular biology

Barkhash AV, Babenko VN, Kobzev VF, Romaschenko AG, Voevoda MI.
PMID: 32214471
Mol Biol. 2010;44(6):875-882. doi: 10.1134/S002689331006004X. Epub 2010 Dec 04.

2'-5'-oligoadenylate synthetases are a family of interferon-induced enzymes playing an important role in antiviral defense in mammals. In the human genome, three genes encoding functional synthetases (

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Barkhash AV, Babenko VN, Kobzev VF, et al. Polymorphism of 2'-5'-oligoadenylate synthetase (. Mol Biol. 2010;44(6):875-882doi: 10.1134/S002689331006004X.
Barkhash, A. V., Babenko, V. N., Kobzev, V. F., Romaschenko, A. G., & Voevoda, M. I. (2010). Polymorphism of 2'-5'-oligoadenylate synthetase (. Molecular biology, 44(6), 875-882. https://doi.org/10.1134/S002689331006004X
Barkhash, A V, et al. "Polymorphism of 2'-5'-oligoadenylate synthetase (." Molecular biology vol. 44,6 (2010): 875-882. doi: https://doi.org/10.1134/S002689331006004X
Barkhash AV, Babenko VN, Kobzev VF, Romaschenko AG, Voevoda MI. Polymorphism of 2'-5'-oligoadenylate synthetase (. Mol Biol. 2010;44(6):875-882. doi: 10.1134/S002689331006004X. Epub 2010 Dec 04. PMID: 32214471; PMCID: PMC7088653.
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Role of STAT1 in the resistance of HBV to IFN-α.

Experimental and therapeutic medicine

Xu B, Tang B, Wei J.
PMID: 33850522
Exp Ther Med. 2021 Jun;21(6):550. doi: 10.3892/etm.2021.9982. Epub 2021 Mar 24.

The objective of the present study was to explore the mechanism of hepatitis B virus (HBV) resistance to interferon (IFN), and the role of signal transducer and activator of transcription 1 (STAT1). HepG2.2.15 cells were stimulated with a long-term...

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Xu B, Tang B, Wei J. Role of STAT1 in the resistance of HBV to IFN-α. Exp Ther Med. 2021;21(6):550doi: 10.3892/etm.2021.9982.
Xu, B., Tang, B., & Wei, J. (2021). Role of STAT1 in the resistance of HBV to IFN-α. Experimental and therapeutic medicine, 21(6), 550. https://doi.org/10.3892/etm.2021.9982
Xu, Bingfa, et al. "Role of STAT1 in the resistance of HBV to IFN-α." Experimental and therapeutic medicine vol. 21,6 (2021): 550. doi: https://doi.org/10.3892/etm.2021.9982
Xu B, Tang B, Wei J. Role of STAT1 in the resistance of HBV to IFN-α. Exp Ther Med. 2021 Jun;21(6):550. doi: 10.3892/etm.2021.9982. Epub 2021 Mar 24. PMID: 33850522; PMCID: PMC8027746.
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MicroRNA-221 inhibits human papillomavirus 16 E1-E2 mediated DNA replication through activating SOCS1/Type I IFN signaling pathway.

International journal of clinical and experimental pathology

Lu H, Gu X.
PMID: 31933969
Int J Clin Exp Pathol. 2019 May 01;12(5):1518-1528. eCollection 2019.

Human Papillomavirus (HPV) 16 infection has led to clinical disorders and is considered one of the important causes of human cervical cancer. Recently, microRNAs (miRNAs) have been proven to play an important role in many viral infections through regulating...

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Lu H, Gu X. MicroRNA-221 inhibits human papillomavirus 16 E1-E2 mediated DNA replication through activating SOCS1/Type I IFN signaling pathway. Int J Clin Exp Pathol. 2019;12(5):1518-1528
Lu, H., & Gu, X. (2019). MicroRNA-221 inhibits human papillomavirus 16 E1-E2 mediated DNA replication through activating SOCS1/Type I IFN signaling pathway. International journal of clinical and experimental pathology, 12(5), 1518-1528.
Lu, Haikong, and Gu, Xin. "MicroRNA-221 inhibits human papillomavirus 16 E1-E2 mediated DNA replication through activating SOCS1/Type I IFN signaling pathway." International journal of clinical and experimental pathology vol. 12,5 (2019): 1518-1528.
Lu H, Gu X. MicroRNA-221 inhibits human papillomavirus 16 E1-E2 mediated DNA replication through activating SOCS1/Type I IFN signaling pathway. Int J Clin Exp Pathol. 2019 May 01;12(5):1518-1528. eCollection 2019. PMID: 31933969; PMCID: PMC6947112.
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Early Pregnancy Induces Expression of STAT1, OAS1 and CXCL10 in Ovine Spleen.

Animals : an open access journal from MDPI

Wang Y, Han X, Zhang L, Cao N, Cao L, Yang L.
PMID: 31671580
Animals (Basel). 2019 Oct 30;9(11). doi: 10.3390/ani9110882.

Interferon-tau is a maternal recognition factor in ruminant species, and spleen plays an essential role in regulating innate and adaptive immune responses. However, it is not fully understood that early pregnancy induces expression of interferon stimulated genes (ISGs) in...

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Wang Y, Han X, Zhang L, et al. Early Pregnancy Induces Expression of STAT1, OAS1 and CXCL10 in Ovine Spleen. Animals (Basel). 2019;9(11)doi: 10.3390/ani9110882.
Wang, Y., Han, X., Zhang, L., Cao, N., Cao, L., & Yang, L. (2019). Early Pregnancy Induces Expression of STAT1, OAS1 and CXCL10 in Ovine Spleen. Animals : an open access journal from MDPI, 9(11), . https://doi.org/10.3390/ani9110882
Wang, Yujiao, et al. "Early Pregnancy Induces Expression of STAT1, OAS1 and CXCL10 in Ovine Spleen." Animals : an open access journal from MDPI vol. 9,11 (2019). doi: https://doi.org/10.3390/ani9110882
Wang Y, Han X, Zhang L, Cao N, Cao L, Yang L. Early Pregnancy Induces Expression of STAT1, OAS1 and CXCL10 in Ovine Spleen. Animals (Basel). 2019 Oct 30;9(11). doi: 10.3390/ani9110882. PMID: 31671580; PMCID: PMC6912697.
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A Comparative Study of Different Types of Rabbit 2',5'-Oligoadenylate Synthetase.

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica

Feng YF, Yang KY.
PMID: 12219201
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1997;29(3):243-250.

Only one 2',5'-oligoadenylate synthetase (2',5'-OASE) with a mass of 110 kD is present in the NDV-induced rabbit reticulocytes, whereas two 2',5'-OASE isozymes with mass of 110 kD and 40 kD respectively exist in the NDV-treated rabbit spleen. The large...

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Feng YF, Yang KY. A Comparative Study of Different Types of Rabbit 2',5'-Oligoadenylate Synthetase. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1997;29(3):243-250
Feng, Y. F., & Yang, K. Y. (1997). A Comparative Study of Different Types of Rabbit 2',5'-Oligoadenylate Synthetase. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica, 29(3), 243-250.
Feng, Yun-Feng, and Yang, Kai-Yu. "A Comparative Study of Different Types of Rabbit 2',5'-Oligoadenylate Synthetase." Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica vol. 29,3 (1997): 243-250.
Feng YF, Yang KY. A Comparative Study of Different Types of Rabbit 2',5'-Oligoadenylate Synthetase. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1997;29(3):243-250. PMID: 12219201.
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A Modified Coupled Spectrophotometric Method to Detect 2-5 Oligoadenylate Synthetase Activity in Prostate Cell Lines.

Biological procedures online

Bhosle SM, Hunt A, Chaudhary J.
PMID: 26997919
Biol Proced Online. 2016 Mar 17;18:9. doi: 10.1186/s12575-016-0038-x. eCollection 2016.

BACKGROUND: 2'-5' oligoadenylate synthetases (OAS) are interferon inducible enzymes that polymerizes ATP to 2'-5'-linked oligomers of adenylate (2-5As). As part of the innate immune response, these enzymes are activated by viral double stranded RNA or mRNAs with significant double...

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Bhosle SM, Hunt A, Chaudhary J. A Modified Coupled Spectrophotometric Method to Detect 2-5 Oligoadenylate Synthetase Activity in Prostate Cell Lines. Biol Proced Online. 2016;18:9doi: 10.1186/s12575-016-0038-x.
Bhosle, S. M., Hunt, A., & Chaudhary, J. (2016). A Modified Coupled Spectrophotometric Method to Detect 2-5 Oligoadenylate Synthetase Activity in Prostate Cell Lines. Biological procedures online, 189. https://doi.org/10.1186/s12575-016-0038-x
Bhosle, Sushma M, et al. "A Modified Coupled Spectrophotometric Method to Detect 2-5 Oligoadenylate Synthetase Activity in Prostate Cell Lines." Biological procedures online vol. 18 (2016): 9. doi: https://doi.org/10.1186/s12575-016-0038-x
Bhosle SM, Hunt A, Chaudhary J. A Modified Coupled Spectrophotometric Method to Detect 2-5 Oligoadenylate Synthetase Activity in Prostate Cell Lines. Biol Proced Online. 2016 Mar 17;18:9. doi: 10.1186/s12575-016-0038-x. eCollection 2016. PMID: 26997919; PMCID: PMC4797170.
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Pattern recognition receptor-initiated innate immune responses in mouse prostatic epithelial cells‡.

Biology of reproduction

Yu X, Chen R, Wang F, Liu W, Zhang W, Gong M, Wu H, Liu A, Han R, Chen Y, Han D.
PMID: 33899078
Biol Reprod. 2021 Jul 02;105(1):113-127. doi: 10.1093/biolre/ioab076.

Three major pathogenic states of the prostate, including benign prostatic hyperplasia, prostate cancer, and prostatitis, are related to the local inflammation. However, the mechanisms underlying the initiation of prostate inflammation remain largely unknown. Given that the innate immune responses...

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Yu X, Chen R, Wang F, et al. Pattern recognition receptor-initiated innate immune responses in mouse prostatic epithelial cells‡. Biol Reprod. 2021;105(1):113-127doi: 10.1093/biolre/ioab076.
Yu, X., Chen, R., Wang, F., Liu, W., Zhang, W., Gong, M., Wu, H., Liu, A., Han, R., Chen, Y., & Han, D. (2021). Pattern recognition receptor-initiated innate immune responses in mouse prostatic epithelial cells‡. Biology of reproduction, 105(1), 113-127. https://doi.org/10.1093/biolre/ioab076
Yu, Xiaoqin, et al. "Pattern recognition receptor-initiated innate immune responses in mouse prostatic epithelial cells‡." Biology of reproduction vol. 105,1 (2021): 113-127. doi: https://doi.org/10.1093/biolre/ioab076
Yu X, Chen R, Wang F, Liu W, Zhang W, Gong M, Wu H, Liu A, Han R, Chen Y, Han D. Pattern recognition receptor-initiated innate immune responses in mouse prostatic epithelial cells‡. Biol Reprod. 2021 Jul 02;105(1):113-127. doi: 10.1093/biolre/ioab076. PMID: 33899078.
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OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s.

Allergy, asthma & immunology research

Chang Y, Kang JS, Jung K, Chung DH, Ha SJ, Kim YJ, Kim HY.
PMID: 34983110
Allergy Asthma Immunol Res. 2022 Jan;14(1):99-116. doi: 10.4168/aair.2022.14.1.99.

PURPOSE: Three observations drove this study. First, 2'-5'-oligoadenylate synthetase-like protein (OASL) is a negative regulator of type I interferon (IFN). Second, type I IFN plays a central role during virus infections and the pathogenesis of various diseases, including asthma....

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Chang Y, Kang JS, Jung K, et al. OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s. Allergy Asthma Immunol Res. 2022;14(1):99-116doi: 10.4168/aair.2022.14.1.99.
Chang, Y., Kang, J. S., Jung, K., Chung, D. H., Ha, S. J., Kim, Y. J., & Kim, H. Y. (2022). OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s. Allergy, asthma & immunology research, 14(1), 99-116. https://doi.org/10.4168/aair.2022.14.1.99
Chang, Yuna, et al. "OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s." Allergy, asthma & immunology research vol. 14,1 (2022): 99-116. doi: https://doi.org/10.4168/aair.2022.14.1.99
Chang Y, Kang JS, Jung K, Chung DH, Ha SJ, Kim YJ, Kim HY. OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s. Allergy Asthma Immunol Res. 2022 Jan;14(1):99-116. doi: 10.4168/aair.2022.14.1.99. PMID: 34983110.
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Characterization, expression pattern and antiviral activities of oligoadenylate synthetase in Chinese Giant Salamander, Andrias davidianus.

Developmental and comparative immunology

Zhang J, Li Y, Zhou Y, Jiang N, Fan Y, Lin G, Zeng L.
PMID: 35007654
Dev Comp Immunol. 2022 Jan 08;104347. doi: 10.1016/j.dci.2022.104347. Epub 2022 Jan 08.

The enzyme 2'-5'-oligoadenylate synthetase (OAS) is an antiviral protein induced by interferons (IFNs), which plays an important role in IFN-mediated antiviral signaling pathway. In this study, the OAS of Chinese Giant Salamander, Andrias davidianus (AdOAS) was identified for the...

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Zhang J, Li Y, Zhou Y, et al. Characterization, expression pattern and antiviral activities of oligoadenylate synthetase in Chinese Giant Salamander, Andrias davidianus. Dev Comp Immunol. 2022;104347doi: 10.1016/j.dci.2022.104347.
Zhang, J., Li, Y., Zhou, Y., Jiang, N., Fan, Y., Lin, G., & Zeng, L. (2022). Characterization, expression pattern and antiviral activities of oligoadenylate synthetase in Chinese Giant Salamander, Andrias davidianus. Developmental and comparative immunology, 104347. https://doi.org/10.1016/j.dci.2022.104347
Zhang, Jingjing, et al. "Characterization, expression pattern and antiviral activities of oligoadenylate synthetase in Chinese Giant Salamander, Andrias davidianus." Developmental and comparative immunology vol. (2022): 104347. doi: https://doi.org/10.1016/j.dci.2022.104347
Zhang J, Li Y, Zhou Y, Jiang N, Fan Y, Lin G, Zeng L. Characterization, expression pattern and antiviral activities of oligoadenylate synthetase in Chinese Giant Salamander, Andrias davidianus. Dev Comp Immunol. 2022 Jan 08;104347. doi: 10.1016/j.dci.2022.104347. Epub 2022 Jan 08. PMID: 35007654.
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Improved lentiviral vector titers from a multi-gene knockout packaging line.

Molecular therapy oncolytics

Han J, Tam K, Tam C, Hollis RP, Kohn DB.
PMID: 34938858
Mol Ther Oncolytics. 2021 Nov 20;23:582-592. doi: 10.1016/j.omto.2021.11.012. eCollection 2021 Dec 17.

Lentiviral vectors (LVs) are robust delivery vehicles for gene therapy as they can efficiently integrate transgenes into host cell genomes. However, LVs with lengthy or complex expression cassettes typically are produced at low titers and have reduced gene transfer...

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Han J, Tam K, Tam C, et al. Improved lentiviral vector titers from a multi-gene knockout packaging line. Mol Ther Oncolytics. 2021;23:582-592doi: 10.1016/j.omto.2021.11.012.
Han, J., Tam, K., Tam, C., Hollis, R. P., & Kohn, D. B. (2021). Improved lentiviral vector titers from a multi-gene knockout packaging line. Molecular therapy oncolytics, 23582-592. https://doi.org/10.1016/j.omto.2021.11.012
Han, Jiaying, et al. "Improved lentiviral vector titers from a multi-gene knockout packaging line." Molecular therapy oncolytics vol. 23 (2021): 582-592. doi: https://doi.org/10.1016/j.omto.2021.11.012
Han J, Tam K, Tam C, Hollis RP, Kohn DB. Improved lentiviral vector titers from a multi-gene knockout packaging line. Mol Ther Oncolytics. 2021 Nov 20;23:582-592. doi: 10.1016/j.omto.2021.11.012. eCollection 2021 Dec 17. PMID: 34938858; PMCID: PMC8660686.
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Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2.

PLoS neglected tropical diseases

Castillo JA, Giraldo DM, Hernandez JC, Smit JM, Rodenhuis-Zybert IA, Urcuqui-Inchima S.
PMID: 34634046
PLoS Negl Trop Dis. 2021 Oct 11;15(10):e0009873. doi: 10.1371/journal.pntd.0009873. eCollection 2021 Oct.

A dysregulated or exacerbated inflammatory response is thought to be the key driver of the pathogenesis of severe disease caused by the mosquito-borne dengue virus (DENV). Compounds that restrict virus replication and modulate the inflammatory response could thus serve...

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Castillo JA, Giraldo DM, Hernandez JC, et al. Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2. PLoS Negl Trop Dis. 2021;15(10):e0009873doi: 10.1371/journal.pntd.0009873.
Castillo, J. A., Giraldo, D. M., Hernandez, J. C., Smit, J. M., Rodenhuis-Zybert, I. A., & Urcuqui-Inchima, S. (2021). Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2. PLoS neglected tropical diseases, 15(10), e0009873. https://doi.org/10.1371/journal.pntd.0009873
Castillo, Jorge Andrés, et al. "Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2." PLoS neglected tropical diseases vol. 15,10 (2021): e0009873. doi: https://doi.org/10.1371/journal.pntd.0009873
Castillo JA, Giraldo DM, Hernandez JC, Smit JM, Rodenhuis-Zybert IA, Urcuqui-Inchima S. Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2. PLoS Negl Trop Dis. 2021 Oct 11;15(10):e0009873. doi: 10.1371/journal.pntd.0009873. eCollection 2021 Oct. PMID: 34634046; PMCID: PMC8530315.
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Showing 1 to 12 of 37 entries