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Carboxylesterases from bacterial enrichment culture degrade strobilurin fungicides.

The Science of the total environment

Wang W, Zhao Z, Yan H, Zhang H, Li QX, Liu X.
PMID: 34979227
Sci Total Environ. 2021 Dec 31;152751. doi: 10.1016/j.scitotenv.2021.152751. Epub 2021 Dec 31.

Strobilurin fungicides are a class of persistent fungicides frequently detected in the environment. Microbes can effectively degrade strobilurins, but the mechanisms are complex and diverse. Compared with isolated strains, bacterial consortia are more robust in terms of the degradation...

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Wang W, Zhao Z, Yan H, et al. Carboxylesterases from bacterial enrichment culture degrade strobilurin fungicides. Sci Total Environ. 2021;152751doi: 10.1016/j.scitotenv.2021.152751.
Wang, W., Zhao, Z., Yan, H., Zhang, H., Li, Q. X., & Liu, X. (2021). Carboxylesterases from bacterial enrichment culture degrade strobilurin fungicides. The Science of the total environment, 152751. https://doi.org/10.1016/j.scitotenv.2021.152751
Wang, Weijun, et al. "Carboxylesterases from bacterial enrichment culture degrade strobilurin fungicides." The Science of the total environment vol. (2021): 152751. doi: https://doi.org/10.1016/j.scitotenv.2021.152751
Wang W, Zhao Z, Yan H, Zhang H, Li QX, Liu X. Carboxylesterases from bacterial enrichment culture degrade strobilurin fungicides. Sci Total Environ. 2021 Dec 31;152751. doi: 10.1016/j.scitotenv.2021.152751. Epub 2021 Dec 31. PMID: 34979227.
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Anthracycline-formaldehyde conjugates and their targeted prodrugs.

Topics in current chemistry

Koch TH, Barthel BL, Kalet BT, Rudnicki DL, Post GC, Burkhart DJ.
PMID: 23605631
Top Curr Chem. 2008;283:141-70. doi: 10.1007/128_2007_4.

The sequence of research leading to a proposal for anthracycline cross-linking of DNA is presented.The clinical anthracycline antitumor drugs are anthraquinones, and as such are redox active. Their redoxchemistry leads to induction of oxidative stress and drug metabolites. An...

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Koch TH, Barthel BL, Kalet BT, et al. Anthracycline-formaldehyde conjugates and their targeted prodrugs. Top Curr Chem. 2008;283:141-70doi: 10.1007/128_2007_4.
Koch, T. H., Barthel, B. L., Kalet, B. T., Rudnicki, D. L., Post, G. C., & Burkhart, D. J. (2008). Anthracycline-formaldehyde conjugates and their targeted prodrugs. Topics in current chemistry, 283141-70. https://doi.org/10.1007/128_2007_4
Koch, Tad H, et al. "Anthracycline-formaldehyde conjugates and their targeted prodrugs." Topics in current chemistry vol. 283 (2008): 141-70. doi: https://doi.org/10.1007/128_2007_4
Koch TH, Barthel BL, Kalet BT, Rudnicki DL, Post GC, Burkhart DJ. Anthracycline-formaldehyde conjugates and their targeted prodrugs. Top Curr Chem. 2008;283:141-70. doi: 10.1007/128_2007_4. PMID: 23605631.
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Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation.

Drug metabolism and disposition: the biological fate of chemicals

Parvez MM, Basit A, Jariwala PB, Gáborik Z, Kis E, Heyward S, Redinbo MR, Prasad B.
PMID: 34074730
Drug Metab Dispos. 2021 Aug;49(8):683-693. doi: 10.1124/dmd.121.000476. Epub 2021 Jun 01.

The anticancer drug irinotecan shows serious dose-limiting gastrointestinal toxicity regardless of intravenous dosing. Although enzymes and transporters involved in irinotecan disposition are known, quantitative contributions of these mechanisms in complex in vivo disposition of irinotecan are poorly understood. We...

Cite
Parvez MM, Basit A, Jariwala PB, et al. Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation. Drug Metab Dispos. 2021;49(8):683-693doi: 10.1124/dmd.121.000476.
Parvez, M. M., Basit, A., Jariwala, P. B., Gáborik, Z., Kis, E., Heyward, S., Redinbo, M. R., & Prasad, B. (2021). Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation. Drug metabolism and disposition: the biological fate of chemicals, 49(8), 683-693. https://doi.org/10.1124/dmd.121.000476
Parvez, Md Masud, et al. "Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation." Drug metabolism and disposition: the biological fate of chemicals vol. 49,8 (2021): 683-693. doi: https://doi.org/10.1124/dmd.121.000476
Parvez MM, Basit A, Jariwala PB, Gáborik Z, Kis E, Heyward S, Redinbo MR, Prasad B. Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation. Drug Metab Dispos. 2021 Aug;49(8):683-693. doi: 10.1124/dmd.121.000476. Epub 2021 Jun 01. PMID: 34074730; PMCID: PMC8407663.
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Carboxylesterases from bacterial enrichment culture degrade strobilurin fungicides.

The Science of the total environment

Wang W, Zhao Z, Yan H, Zhang H, Li QX, Liu X.
PMID: 34979227
Sci Total Environ. 2021 Dec 31;814:152751. doi: 10.1016/j.scitotenv.2021.152751. Epub 2021 Dec 31.

Strobilurin fungicides are a class of persistent fungicides frequently detected in the environment. Microbes can effectively degrade strobilurins, but the mechanisms are complex and diverse. Compared with isolated strains, bacterial consortia are more robust in terms of the degradation...

Cite
Wang W, Zhao Z, Yan H, et al. Carboxylesterases from bacterial enrichment culture degrade strobilurin fungicides. Sci Total Environ. 2021;814:152751doi: 10.1016/j.scitotenv.2021.152751.
Wang, W., Zhao, Z., Yan, H., Zhang, H., Li, Q. X., & Liu, X. (2021). Carboxylesterases from bacterial enrichment culture degrade strobilurin fungicides. The Science of the total environment, 814152751. https://doi.org/10.1016/j.scitotenv.2021.152751
Wang, Weijun, et al. "Carboxylesterases from bacterial enrichment culture degrade strobilurin fungicides." The Science of the total environment vol. 814 (2021): 152751. doi: https://doi.org/10.1016/j.scitotenv.2021.152751
Wang W, Zhao Z, Yan H, Zhang H, Li QX, Liu X. Carboxylesterases from bacterial enrichment culture degrade strobilurin fungicides. Sci Total Environ. 2021 Dec 31;814:152751. doi: 10.1016/j.scitotenv.2021.152751. Epub 2021 Dec 31. PMID: 34979227.
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Neuroligin 3 from common cutworm enhances the GABA-induced current of recombinant SlRDL1 channel.

Pest management science

Wang Y, Zhang YC, Zhang KX, Jia ZQ, Tang T, Zheng LL, Liu D, Zhao CQ.
PMID: 34619015
Pest Manag Sci. 2022 Feb;78(2):603-611. doi: 10.1002/ps.6669. Epub 2021 Oct 21.

BACKGROUND: Neuroligin (NLG) protein is a nerve cell adhesion molecule and plays a key role in the precision apposition of presynaptic domains on inhibitory and excitatory synapses. Existing studies mainly focused on the function of NLG3 against the excitatory...

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Wang Y, Zhang YC, Zhang KX, et al. Neuroligin 3 from common cutworm enhances the GABA-induced current of recombinant SlRDL1 channel. Pest Manag Sci. 2021;78(2):603-611doi: 10.1002/ps.6669.
Wang, Y., Zhang, Y. C., Zhang, K. X., Jia, Z. Q., Tang, T., Zheng, L. L., Liu, D., & Zhao, C. Q. (2022). Neuroligin 3 from common cutworm enhances the GABA-induced current of recombinant SlRDL1 channel. Pest management science, 78(2), 603-611. https://doi.org/10.1002/ps.6669
Wang, Ying, et al. "Neuroligin 3 from common cutworm enhances the GABA-induced current of recombinant SlRDL1 channel." Pest management science vol. 78,2 (2022): 603-611. doi: https://doi.org/10.1002/ps.6669
Wang Y, Zhang YC, Zhang KX, Jia ZQ, Tang T, Zheng LL, Liu D, Zhao CQ. Neuroligin 3 from common cutworm enhances the GABA-induced current of recombinant SlRDL1 channel. Pest Manag Sci. 2022 Feb;78(2):603-611. doi: 10.1002/ps.6669. Epub 2021 Oct 21. PMID: 34619015.
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Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication.

International journal of molecular sciences

Sobolev VE, Sokolova MO, Jenkins RO, Goncharov NV.
PMID: 34948422
Int J Mol Sci. 2021 Dec 20;22(24). doi: 10.3390/ijms222413625.

The delayed effects of acute intoxication by organophosphates (OPs) are poorly understood, and the various experimental animal models often do not take into account species characteristics. The principal biochemical feature of rodents is the presence of carboxylesterase in blood...

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Sobolev VE, Sokolova MO, Jenkins RO, et al. Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication. Int J Mol Sci. 2021;22(24)doi: 10.3390/ijms222413625.
Sobolev, V. E., Sokolova, M. O., Jenkins, R. O., & Goncharov, N. V. (2021). Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication. International journal of molecular sciences, 22(24), . https://doi.org/10.3390/ijms222413625
Sobolev, Vladislav E, et al. "Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication." International journal of molecular sciences vol. 22,24 (2021). doi: https://doi.org/10.3390/ijms222413625
Sobolev VE, Sokolova MO, Jenkins RO, Goncharov NV. Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication. Int J Mol Sci. 2021 Dec 20;22(24). doi: 10.3390/ijms222413625. PMID: 34948422.
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A whole transcriptomic approach provides novel insights into the molecular basis of organophosphate and pyrethroid resistance in Anopheles arabiensis from Ethiopia.

Insect biochemistry and molecular biology

Messenger LA, Impoinvil LM, Derilus D, Yewhalaw D, Irish S, Lenhart A.
PMID: 34562591
Insect Biochem Mol Biol. 2021 Dec;139:103655. doi: 10.1016/j.ibmb.2021.103655. Epub 2021 Sep 23.

The development of insecticide resistance in malaria vectors is of increasing concern in Ethiopia because of its potential implications for vector control failure. To better elucidate the specificity of resistance mechanisms and to facilitate the design of control strategies...

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Messenger LA, Impoinvil LM, Derilus D, et al. A whole transcriptomic approach provides novel insights into the molecular basis of organophosphate and pyrethroid resistance in Anopheles arabiensis from Ethiopia. Insect Biochem Mol Biol. 2021;139:103655doi: 10.1016/j.ibmb.2021.103655.
Messenger, L. A., Impoinvil, L. M., Derilus, D., Yewhalaw, D., Irish, S., & Lenhart, A. (2021). A whole transcriptomic approach provides novel insights into the molecular basis of organophosphate and pyrethroid resistance in Anopheles arabiensis from Ethiopia. Insect biochemistry and molecular biology, 139103655. https://doi.org/10.1016/j.ibmb.2021.103655
Messenger, Louisa A, et al. "A whole transcriptomic approach provides novel insights into the molecular basis of organophosphate and pyrethroid resistance in Anopheles arabiensis from Ethiopia." Insect biochemistry and molecular biology vol. 139 (2021): 103655. doi: https://doi.org/10.1016/j.ibmb.2021.103655
Messenger LA, Impoinvil LM, Derilus D, Yewhalaw D, Irish S, Lenhart A. A whole transcriptomic approach provides novel insights into the molecular basis of organophosphate and pyrethroid resistance in Anopheles arabiensis from Ethiopia. Insect Biochem Mol Biol. 2021 Dec;139:103655. doi: 10.1016/j.ibmb.2021.103655. Epub 2021 Sep 23. PMID: 34562591.
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Multiple transcriptomic profiling: potential novel metabolism-related genes predict prepubertal testis damage caused by DEHP exposure.

Environmental science and pollution research international

Kang L, Chen J, Wang J, Zhao T, Wei Y, Wu Y, Han L, Zheng X, Shen L, Long C, Wei G, Wu S.
PMID: 34595713
Environ Sci Pollut Res Int. 2021 Sep 30; doi: 10.1007/s11356-021-16701-5. Epub 2021 Sep 30.

The toxic effect of di(2-ethylhexyl) phthalate (DEHP) on prepubertal testes was examined in this study. We treated 3-week-old male mice with 4.8 mg/kg/day (milligram/kilogram/day) (no observed adverse effect level), 30 mg/kg/day (high exposure dose relative to humans), 100 mg/kg/day...

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Kang L, Chen J, Wang J, et al. Multiple transcriptomic profiling: potential novel metabolism-related genes predict prepubertal testis damage caused by DEHP exposure. Environ Sci Pollut Res Int. 2021;doi: 10.1007/s11356-021-16701-5.
Kang, L., Chen, J., Wang, J., Zhao, T., Wei, Y., Wu, Y., Han, L., Zheng, X., Shen, L., Long, C., Wei, G., & Wu, S. (2021). Multiple transcriptomic profiling: potential novel metabolism-related genes predict prepubertal testis damage caused by DEHP exposure. Environmental science and pollution research international, . https://doi.org/10.1007/s11356-021-16701-5
Kang, Lian, et al. "Multiple transcriptomic profiling: potential novel metabolism-related genes predict prepubertal testis damage caused by DEHP exposure." Environmental science and pollution research international vol. (2021). doi: https://doi.org/10.1007/s11356-021-16701-5
Kang L, Chen J, Wang J, Zhao T, Wei Y, Wu Y, Han L, Zheng X, Shen L, Long C, Wei G, Wu S. Multiple transcriptomic profiling: potential novel metabolism-related genes predict prepubertal testis damage caused by DEHP exposure. Environ Sci Pollut Res Int. 2021 Sep 30; doi: 10.1007/s11356-021-16701-5. Epub 2021 Sep 30. PMID: 34595713.
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Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation.

Drug metabolism and disposition: the biological fate of chemicals

Parvez MM, Basit A, Jariwala PB, Gáborik Z, Kis E, Heyward S, Redinbo MR, Prasad B.
PMID: 34074730
Drug Metab Dispos. 2021 Aug;49(8):683-693. doi: 10.1124/dmd.121.000476. Epub 2021 Jun 01.

The anticancer drug irinotecan shows serious dose-limiting gastrointestinal toxicity regardless of intravenous dosing. Although enzymes and transporters involved in irinotecan disposition are known, quantitative contributions of these mechanisms in complex in vivo disposition of irinotecan are poorly understood. We...

Cite
Parvez MM, Basit A, Jariwala PB, et al. Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation. Drug Metab Dispos. 2021;49(8):683-693doi: 10.1124/dmd.121.000476.
Parvez, M. M., Basit, A., Jariwala, P. B., Gáborik, Z., Kis, E., Heyward, S., Redinbo, M. R., & Prasad, B. (2021). Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation. Drug metabolism and disposition: the biological fate of chemicals, 49(8), 683-693. https://doi.org/10.1124/dmd.121.000476
Parvez, Md Masud, et al. "Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation." Drug metabolism and disposition: the biological fate of chemicals vol. 49,8 (2021): 683-693. doi: https://doi.org/10.1124/dmd.121.000476
Parvez MM, Basit A, Jariwala PB, Gáborik Z, Kis E, Heyward S, Redinbo MR, Prasad B. Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation. Drug Metab Dispos. 2021 Aug;49(8):683-693. doi: 10.1124/dmd.121.000476. Epub 2021 Jun 01. PMID: 34074730; PMCID: PMC8407663.
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Expression Levels of Detoxification Enzyme Genes from .

Insects

Dai L, Gao H, Chen H.
PMID: 34680695
Insects. 2021 Oct 11;12(10). doi: 10.3390/insects12100926.

Bark beetles overcome the toxic terpenoids produced by pine trees by both detoxifying and converting them into a pheromone system. Detoxification enzymes such as cytochrome P450s, glutathione S-transferases, and carboxylesterases are involved in the ability of

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Dai L, Gao H, Chen H. Expression Levels of Detoxification Enzyme Genes from . Insects. 2021;12(10)doi: 10.3390/insects12100926.
Dai, L., Gao, H., & Chen, H. (2021). Expression Levels of Detoxification Enzyme Genes from . Insects, 12(10), . https://doi.org/10.3390/insects12100926
Dai, Lulu, et al. "Expression Levels of Detoxification Enzyme Genes from ." Insects vol. 12,10 (2021). doi: https://doi.org/10.3390/insects12100926
Dai L, Gao H, Chen H. Expression Levels of Detoxification Enzyme Genes from . Insects. 2021 Oct 11;12(10). doi: 10.3390/insects12100926. PMID: 34680695; PMCID: PMC8541301.
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Molecular and functional characterization of three novel carboxylesterases in the detoxification of permethrin in the mosquito, Culex quinquefasciatus.

Insect science

Gong Y, Li M, Li T, Liu N.
PMID: 34048147
Insect Sci. 2021 May 28; doi: 10.1111/1744-7917.12927. Epub 2021 May 28.

Carboxylesterases (CarEs) belong to a super family of multifunctional enzymes associated with the degradation of endogenous and exogenous compounds. Many insect CarEs are known to play important roles in catalyzing the hydrolysis of organophosphates (OPs), carbamates, and synthetic pyrethroids...

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Gong Y, Li M, Li T, et al. Molecular and functional characterization of three novel carboxylesterases in the detoxification of permethrin in the mosquito, Culex quinquefasciatus. Insect Sci. 2021;doi: 10.1111/1744-7917.12927.
Gong, Y., Li, M., Li, T., & Liu, N. (2021). Molecular and functional characterization of three novel carboxylesterases in the detoxification of permethrin in the mosquito, Culex quinquefasciatus. Insect science, . https://doi.org/10.1111/1744-7917.12927
Gong, Youhui, et al. "Molecular and functional characterization of three novel carboxylesterases in the detoxification of permethrin in the mosquito, Culex quinquefasciatus." Insect science vol. (2021). doi: https://doi.org/10.1111/1744-7917.12927
Gong Y, Li M, Li T, Liu N. Molecular and functional characterization of three novel carboxylesterases in the detoxification of permethrin in the mosquito, Culex quinquefasciatus. Insect Sci. 2021 May 28; doi: 10.1111/1744-7917.12927. Epub 2021 May 28. PMID: 34048147.
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Assessment of drug-drug interaction and optimization in capecitabine and irinotecan combination regimen using a physiologically based pharmacokinetic model.

Journal of pharmaceutical sciences

Sakai S, Kobuchi S, Ito Y, Sakaeda T.
PMID: 34965386
J Pharm Sci. 2021 Dec 26; doi: 10.1016/j.xphs.2021.12.021. Epub 2021 Dec 26.

Capecitabine and irinotecan (CPT-11) combination regimen (XELIRI) is used for colorectal cancer treatment. Capecitabine is metabolized to 5-fluorouracil (5-FU) by three enzymes, including carboxylesterase (CES). CES can also convert CPT-11 to 7-ethyl-10-hydroxycamptotecin (SN-38). CES is involved in the metabolic...

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Sakai S, Kobuchi S, Ito Y, et al. Assessment of drug-drug interaction and optimization in capecitabine and irinotecan combination regimen using a physiologically based pharmacokinetic model. J Pharm Sci. 2021;doi: 10.1016/j.xphs.2021.12.021.
Sakai, S., Kobuchi, S., Ito, Y., & Sakaeda, T. (2021). Assessment of drug-drug interaction and optimization in capecitabine and irinotecan combination regimen using a physiologically based pharmacokinetic model. Journal of pharmaceutical sciences, . https://doi.org/10.1016/j.xphs.2021.12.021
Sakai, Shuhei, et al. "Assessment of drug-drug interaction and optimization in capecitabine and irinotecan combination regimen using a physiologically based pharmacokinetic model." Journal of pharmaceutical sciences vol. (2021). doi: https://doi.org/10.1016/j.xphs.2021.12.021
Sakai S, Kobuchi S, Ito Y, Sakaeda T. Assessment of drug-drug interaction and optimization in capecitabine and irinotecan combination regimen using a physiologically based pharmacokinetic model. J Pharm Sci. 2021 Dec 26; doi: 10.1016/j.xphs.2021.12.021. Epub 2021 Dec 26. PMID: 34965386.
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Showing 25 to 36 of 275 entries