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Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury.

Frontiers in molecular neuroscience

Wang YJ, Zuo ZX, Wu C, Liu L, Feng ZH, Li XY.
PMID: 28955200
Front Mol Neurosci. 2017 Sep 12;10:289. doi: 10.3389/fnmol.2017.00289. eCollection 2017.

The anterior cingulate cortex (ACC) is an important brain area for the regulation of neuropathic pain. The α

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Wang YJ, Zuo ZX, Wu C, et al. Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury. Front Mol Neurosci. 2017;10:289doi: 10.3389/fnmol.2017.00289.
Wang, Y. J., Zuo, Z. X., Wu, C., Liu, L., Feng, Z. H., & Li, X. Y. (2017). Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury. Frontiers in molecular neuroscience, 10289. https://doi.org/10.3389/fnmol.2017.00289
Wang, Yong-Jie, et al. "Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury." Frontiers in molecular neuroscience vol. 10 (2017): 289. doi: https://doi.org/10.3389/fnmol.2017.00289
Wang YJ, Zuo ZX, Wu C, Liu L, Feng ZH, Li XY. Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury. Front Mol Neurosci. 2017 Sep 12;10:289. doi: 10.3389/fnmol.2017.00289. eCollection 2017. PMID: 28955200; PMCID: PMC5600928.
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Are Alpha-2D Adrenoceptor Subtypes Involved in Rat Mydriasis Evoked by New Imidazoline Derivatives: Marsanidine and 7-Methylmarsanidine?.

Dose-response : a publication of International Hormesis Society

Raczak-Gutknecht J, Frąckowiak T, Nasal A, Kornicka A, Sączewski F, Kaliszan R.
PMID: 28491012
Dose Response. 2017 Apr 18;15(2):1559325817701213. doi: 10.1177/1559325817701213. eCollection 2017.

The imidazoline compounds may produce mydriasis after systemic administration to some species (rats, cats, and mice). In mydriatic activity of imidazolines, α

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Raczak-Gutknecht J, Frąckowiak T, Nasal A, et al. Are Alpha-2D Adrenoceptor Subtypes Involved in Rat Mydriasis Evoked by New Imidazoline Derivatives: Marsanidine and 7-Methylmarsanidine?. Dose Response. 2017;15(2):1559325817701213doi: 10.1177/1559325817701213.
Raczak-Gutknecht, J., Frąckowiak, T., Nasal, A., Kornicka, A., Sączewski, F., & Kaliszan, R. (2017). Are Alpha-2D Adrenoceptor Subtypes Involved in Rat Mydriasis Evoked by New Imidazoline Derivatives: Marsanidine and 7-Methylmarsanidine?. Dose-response : a publication of International Hormesis Society, 15(2), 1559325817701213. https://doi.org/10.1177/1559325817701213
Raczak-Gutknecht, Joanna, et al. "Are Alpha-2D Adrenoceptor Subtypes Involved in Rat Mydriasis Evoked by New Imidazoline Derivatives: Marsanidine and 7-Methylmarsanidine?." Dose-response : a publication of International Hormesis Society vol. 15,2 (2017): 1559325817701213. doi: https://doi.org/10.1177/1559325817701213
Raczak-Gutknecht J, Frąckowiak T, Nasal A, Kornicka A, Sączewski F, Kaliszan R. Are Alpha-2D Adrenoceptor Subtypes Involved in Rat Mydriasis Evoked by New Imidazoline Derivatives: Marsanidine and 7-Methylmarsanidine?. Dose Response. 2017 Apr 18;15(2):1559325817701213. doi: 10.1177/1559325817701213. eCollection 2017. PMID: 28491012; PMCID: PMC5405787.
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Induced hypotension in ambulatory functional endoscopic sinus surgery: A comparison between dexmedetomidine and clonidine as premedication. A prospective, double-blind, and randomized study.

Saudi journal of anaesthesia

Das A, Mukherje A, Chhaule S, Chattopadhyay S, Halder PS, Mitra T, Basunia SR, Mandal SK.
PMID: 26955315
Saudi J Anaesth. 2016 Jan-Mar;10(1):74-80. doi: 10.4103/1658-354X.169480.

BACKGROUND: Functional endoscopic sinus surgery (FESS) is the mainstay of a therapeutic technique for nasal pathologies. This study is to compare the ability of preoperative dexmedetomidine versus clonidine for producing controlled hypotensive anesthesia during FESS in adults in an...

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Das A, Mukherje A, Chhaule S, et al. Induced hypotension in ambulatory functional endoscopic sinus surgery: A comparison between dexmedetomidine and clonidine as premedication. A prospective, double-blind, and randomized study. Saudi J Anaesth. 2016;10(1):74-80doi: 10.4103/1658-354X.169480.
Das, A., Mukherje, A., Chhaule, S., Chattopadhyay, S., Halder, P. S., Mitra, T., Basunia, S. R., & Mandal, S. K. (2016). Induced hypotension in ambulatory functional endoscopic sinus surgery: A comparison between dexmedetomidine and clonidine as premedication. A prospective, double-blind, and randomized study. Saudi journal of anaesthesia, 10(1), 74-80. https://doi.org/10.4103/1658-354X.169480
Das, A, et al. "Induced hypotension in ambulatory functional endoscopic sinus surgery: A comparison between dexmedetomidine and clonidine as premedication. A prospective, double-blind, and randomized study." Saudi journal of anaesthesia vol. 10,1 (2016): 74-80. doi: https://doi.org/10.4103/1658-354X.169480
Das A, Mukherje A, Chhaule S, Chattopadhyay S, Halder PS, Mitra T, Basunia SR, Mandal SK. Induced hypotension in ambulatory functional endoscopic sinus surgery: A comparison between dexmedetomidine and clonidine as premedication. A prospective, double-blind, and randomized study. Saudi J Anaesth. 2016 Jan-Mar;10(1):74-80. doi: 10.4103/1658-354X.169480. PMID: 26955315; PMCID: PMC4760048.
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α2-Adrenoreceptor Constraint of Catecholamine Release and Blood Pressure Is Enhanced in Female Spontaneously Hypertensive Rats.

Frontiers in neuroscience

Berg T.
PMID: 27065790
Front Neurosci. 2016 Mar 30;10:130. doi: 10.3389/fnins.2016.00130. eCollection 2016.

UNLABELLED: α2-adrenoceptors (α2AR) lower central sympathetic output and peripheral catecholamine release, and may therefore prevent sympathetic hyperactivity and hypertension. The α2AR are dysfunctional in male spontaneously hypertensive rats (SHR). Premenopausal females are less hypertensive than males. The purpose of...

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Berg T. α2-Adrenoreceptor Constraint of Catecholamine Release and Blood Pressure Is Enhanced in Female Spontaneously Hypertensive Rats. Front Neurosci. 2016;10:130doi: 10.3389/fnins.2016.00130.
Berg, T. (2016). α2-Adrenoreceptor Constraint of Catecholamine Release and Blood Pressure Is Enhanced in Female Spontaneously Hypertensive Rats. Frontiers in neuroscience, 10130. https://doi.org/10.3389/fnins.2016.00130
Berg, Torill. "α2-Adrenoreceptor Constraint of Catecholamine Release and Blood Pressure Is Enhanced in Female Spontaneously Hypertensive Rats." Frontiers in neuroscience vol. 10 (2016): 130. doi: https://doi.org/10.3389/fnins.2016.00130
Berg T. α2-Adrenoreceptor Constraint of Catecholamine Release and Blood Pressure Is Enhanced in Female Spontaneously Hypertensive Rats. Front Neurosci. 2016 Mar 30;10:130. doi: 10.3389/fnins.2016.00130. eCollection 2016. PMID: 27065790; PMCID: PMC4812064.
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Effect of intrathecal clonidine versus fentanyl on bupivacaine spinal block in transurethral resection of prostate surgeries.

Anesthesia, essays and researches

Singh G, Aulakh GS, Aulakh NK, Singh RM, Bose A, Katayal S, Aulakh BS.
PMID: 26957693
Anesth Essays Res. 2016 Jan-Apr;10(1):65-70. doi: 10.4103/0259-1162.165513.

AIMS: Our study aimed at comparing the onset, degree and recovery time of sensory and motor block, the hemodynamic effects and postoperative pain relief using intrathecal bupivacaine alone, bupivacaine along with fentanyl and clonidine.MATERIALS AND METHODS: A total of...

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Singh G, Aulakh GS, Aulakh NK, et al. Effect of intrathecal clonidine versus fentanyl on bupivacaine spinal block in transurethral resection of prostate surgeries. Anesth Essays Res. 2016;10(1):65-70doi: 10.4103/0259-1162.165513.
Singh, G., Aulakh, G. S., Aulakh, N. K., Singh, R. M., Bose, A., Katayal, S., & Aulakh, B. S. (2016). Effect of intrathecal clonidine versus fentanyl on bupivacaine spinal block in transurethral resection of prostate surgeries. Anesthesia, essays and researches, 10(1), 65-70. https://doi.org/10.4103/0259-1162.165513
Singh, Gurpreet, et al. "Effect of intrathecal clonidine versus fentanyl on bupivacaine spinal block in transurethral resection of prostate surgeries." Anesthesia, essays and researches vol. 10,1 (2016): 65-70. doi: https://doi.org/10.4103/0259-1162.165513
Singh G, Aulakh GS, Aulakh NK, Singh RM, Bose A, Katayal S, Aulakh BS. Effect of intrathecal clonidine versus fentanyl on bupivacaine spinal block in transurethral resection of prostate surgeries. Anesth Essays Res. 2016 Jan-Apr;10(1):65-70. doi: 10.4103/0259-1162.165513. PMID: 26957693; PMCID: PMC4767068.
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Response to Combination Cholinergic/Noradrenergic Treatments in a Patient With Alzheimer's Disease.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Aisen PS, Bierer LM, Davidson M, Ryan TM, Kaminsky R, Davis KL.
PMID: 28530925
Am J Geriatr Psychiatry. 1993 Summer;1(3):244-248. doi: 10.1097/00019442-199300130-00009. Epub 2013 Jan 28.

A patient with probable Alzheimer's disease participated in four studies involving cholinergic and combination cholinergic/noradrenergic treatment regimens. This patient demonstrated clinically significant improvement only with the combination of physostigmine and clonidine. The implications of these findings are discussed with...

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Aisen PS, Bierer LM, Davidson M, et al. Response to Combination Cholinergic/Noradrenergic Treatments in a Patient With Alzheimer's Disease. Am J Geriatr Psychiatry. 2013;1(3):244-248doi: 10.1097/00019442-199300130-00009.
Aisen, P. S., Bierer, L. M., Davidson, M., Ryan, T. M., Kaminsky, R., & Davis, K. L. (1993). Response to Combination Cholinergic/Noradrenergic Treatments in a Patient With Alzheimer's Disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 1(3), 244-248. https://doi.org/10.1097/00019442-199300130-00009
Aisen, Paul S, et al. "Response to Combination Cholinergic/Noradrenergic Treatments in a Patient With Alzheimer's Disease." The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry vol. 1,3 (1993): 244-248. doi: https://doi.org/10.1097/00019442-199300130-00009
Aisen PS, Bierer LM, Davidson M, Ryan TM, Kaminsky R, Davis KL. Response to Combination Cholinergic/Noradrenergic Treatments in a Patient With Alzheimer's Disease. Am J Geriatr Psychiatry. 1993 Summer;1(3):244-248. doi: 10.1097/00019442-199300130-00009. Epub 2013 Jan 28. PMID: 28530925.
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Comparison of effects of intravenous clonidine and dexmedetomidine for blunting pressor response during laryngoscopy and tracheal intubation: A randomized control study.

Anesthesia, essays and researches

Sarkar A, Tripathi RK, Choubey S, Singh RB, Awasthi S.
PMID: 25886336
Anesth Essays Res. 2014 Sep-Dec;8(3):361-6. doi: 10.4103/0259-1162.143144.

CONTEXT: Laryngoscopy and endotracheal intubation activates the sympathetic nervous system, causing tachycardia and hypertension. Dexmedetomidine has an affinity for alpha2 receptors 8 times greater than that of clonidine. It diminishes norepinephrine release and inhibits sympathetic activity leading to decreased...

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Sarkar A, Tripathi RK, Choubey S, et al. Comparison of effects of intravenous clonidine and dexmedetomidine for blunting pressor response during laryngoscopy and tracheal intubation: A randomized control study. Anesth Essays Res. 2014;8(3):361-6doi: 10.4103/0259-1162.143144.
Sarkar, A., Tripathi, R. K., Choubey, S., Singh, R. B., & Awasthi, S. (2014). Comparison of effects of intravenous clonidine and dexmedetomidine for blunting pressor response during laryngoscopy and tracheal intubation: A randomized control study. Anesthesia, essays and researches, 8(3), 361-6. https://doi.org/10.4103/0259-1162.143144
Sarkar, Arindam, et al. "Comparison of effects of intravenous clonidine and dexmedetomidine for blunting pressor response during laryngoscopy and tracheal intubation: A randomized control study." Anesthesia, essays and researches vol. 8,3 (2014): 361-6. doi: https://doi.org/10.4103/0259-1162.143144
Sarkar A, Tripathi RK, Choubey S, Singh RB, Awasthi S. Comparison of effects of intravenous clonidine and dexmedetomidine for blunting pressor response during laryngoscopy and tracheal intubation: A randomized control study. Anesth Essays Res. 2014 Sep-Dec;8(3):361-6. doi: 10.4103/0259-1162.143144. PMID: 25886336; PMCID: PMC4258973.
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Effect of Addition of Fentanyl and Clonidine to Local Anesthetic Solution in Peribulbar Block.

Journal of pharmacology & pharmacotherapeutics

Nehra P, Oza V, Parmar V, Fumakiya P.
PMID: 28405129
J Pharmacol Pharmacother. 2017 Jan-Mar;8(1):3-7. doi: 10.4103/jpp.JPP_109_16.

OBJECTIVE: To compare the effect of addition of fentanyl and clonidine as adjuvants to bupivacaine and lignocaine in peribulbar block.METHODS: The study was conducted on 105 adult patients of either sex, of ASA grade I and II undergoing ophthalmic...

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Nehra P, Oza V, Parmar V, et al. Effect of Addition of Fentanyl and Clonidine to Local Anesthetic Solution in Peribulbar Block. J Pharmacol Pharmacother. 2017;8(1):3-7doi: 10.4103/jpp.JPP_109_16.
Nehra, P., Oza, V., Parmar, V., & Fumakiya, P. (2017). Effect of Addition of Fentanyl and Clonidine to Local Anesthetic Solution in Peribulbar Block. Journal of pharmacology & pharmacotherapeutics, 8(1), 3-7. https://doi.org/10.4103/jpp.JPP_109_16
Nehra, Poonam, et al. "Effect of Addition of Fentanyl and Clonidine to Local Anesthetic Solution in Peribulbar Block." Journal of pharmacology & pharmacotherapeutics vol. 8,1 (2017): 3-7. doi: https://doi.org/10.4103/jpp.JPP_109_16
Nehra P, Oza V, Parmar V, Fumakiya P. Effect of Addition of Fentanyl and Clonidine to Local Anesthetic Solution in Peribulbar Block. J Pharmacol Pharmacother. 2017 Jan-Mar;8(1):3-7. doi: 10.4103/jpp.JPP_109_16. PMID: 28405129; PMCID: PMC5370326.
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Pain Modulation and Autonomic Function: The Effect of Clonidine.

Pain medicine (Malden, Mass.)

Nahman-Averbuch H, Dayan L, Sprecher E, Hochberg U, Brill S, Yarnitsky D, Jacob G.
PMID: 26893118
Pain Med. 2016 Jul 01;17(7):1292-1301. doi: 10.1093/pm/pnv102.

OBJECTIVE: The α2-agonist clonidine is an analgesic agent, whose yet uncertain action may involve either increase in pain modulation efficiency, change in autonomic function, and/or decrease in anxiety level. The present study aimed to examine the effect of oral...

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Nahman-Averbuch H, Dayan L, Sprecher E, et al. Pain Modulation and Autonomic Function: The Effect of Clonidine. Pain Med. 2016;17(7):1292-1301doi: 10.1093/pm/pnv102.
Nahman-Averbuch, H., Dayan, L., Sprecher, E., Hochberg, U., Brill, S., Yarnitsky, D., & Jacob, G. (2016). Pain Modulation and Autonomic Function: The Effect of Clonidine. Pain medicine (Malden, Mass.), 17(7), 1292-1301. https://doi.org/10.1093/pm/pnv102
Nahman-Averbuch, Hadas, et al. "Pain Modulation and Autonomic Function: The Effect of Clonidine." Pain medicine (Malden, Mass.) vol. 17,7 (2016): 1292-1301. doi: https://doi.org/10.1093/pm/pnv102
Nahman-Averbuch H, Dayan L, Sprecher E, Hochberg U, Brill S, Yarnitsky D, Jacob G. Pain Modulation and Autonomic Function: The Effect of Clonidine. Pain Med. 2016 Jul 01;17(7):1292-1301. doi: 10.1093/pm/pnv102. PMID: 26893118.
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A Review of Pharmacological Management of Attention-Deficit/Hyperactivity Disorder.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Briars L, Todd T.
PMID: 27453697
J Pediatr Pharmacol Ther. 2016 May-Jun;21(3):192-206. doi: 10.5863/1551-6776-21.3.192.

Attention-deficit/hyperactivity disorder (ADHD) is a common psychological diagnosis in children. This disorder impacts children and adolescents in all areas of life, including academic performance, extracurricular activities, and social interactions. ADHD can continue into adulthood where unemployment and substance abuse...

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Briars L, Todd T. A Review of Pharmacological Management of Attention-Deficit/Hyperactivity Disorder. J Pediatr Pharmacol Ther. 2016;21(3):192-206doi: 10.5863/1551-6776-21.3.192.
Briars, L., & Todd, T. (2016). A Review of Pharmacological Management of Attention-Deficit/Hyperactivity Disorder. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 21(3), 192-206. https://doi.org/10.5863/1551-6776-21.3.192
Briars, Leslie, and Todd, Timothy. "A Review of Pharmacological Management of Attention-Deficit/Hyperactivity Disorder." The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG vol. 21,3 (2016): 192-206. doi: https://doi.org/10.5863/1551-6776-21.3.192
Briars L, Todd T. A Review of Pharmacological Management of Attention-Deficit/Hyperactivity Disorder. J Pediatr Pharmacol Ther. 2016 May-Jun;21(3):192-206. doi: 10.5863/1551-6776-21.3.192. PMID: 27453697; PMCID: PMC4956327.
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Effect of Magnesium Sulfate and Clonidine in Attenuating Hemodynamic Response to Pneumoperitoneum in Laparoscopic Cholecystectomy.

Anesthesia, essays and researches

Kamble SP, Bevinaguddaiah Y, Nagaraja DC, Pujar VS, Anandaswamy TC.
PMID: 28298759
Anesth Essays Res. 2017 Jan-Mar;11(1):67-71. doi: 10.4103/0259-1162.200228.

BACKGROUND: Pneumoperitoneum in laparoscopic procedures is associated with hemodynamic response, due to the release of catecholamines and vasopressin. Magnesium and clonidine have been used to attenuate such hemodynamic responses by inhibiting release of these mediators. We conducted this randomized,...

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Kamble SP, Bevinaguddaiah Y, Nagaraja DC, et al. Effect of Magnesium Sulfate and Clonidine in Attenuating Hemodynamic Response to Pneumoperitoneum in Laparoscopic Cholecystectomy. Anesth Essays Res. 2017;11(1):67-71doi: 10.4103/0259-1162.200228.
Kamble, S. P., Bevinaguddaiah, Y., Nagaraja, D. C., Pujar, V. S., & Anandaswamy, T. C. (2017). Effect of Magnesium Sulfate and Clonidine in Attenuating Hemodynamic Response to Pneumoperitoneum in Laparoscopic Cholecystectomy. Anesthesia, essays and researches, 11(1), 67-71. https://doi.org/10.4103/0259-1162.200228
Kamble, Shruthi P, et al. "Effect of Magnesium Sulfate and Clonidine in Attenuating Hemodynamic Response to Pneumoperitoneum in Laparoscopic Cholecystectomy." Anesthesia, essays and researches vol. 11,1 (2017): 67-71. doi: https://doi.org/10.4103/0259-1162.200228
Kamble SP, Bevinaguddaiah Y, Nagaraja DC, Pujar VS, Anandaswamy TC. Effect of Magnesium Sulfate and Clonidine in Attenuating Hemodynamic Response to Pneumoperitoneum in Laparoscopic Cholecystectomy. Anesth Essays Res. 2017 Jan-Mar;11(1):67-71. doi: 10.4103/0259-1162.200228. PMID: 28298759; PMCID: PMC5341635.
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Sedation options for the morbidly obese intensive care unit patient: a concise survey and an agenda for development.

Multidisciplinary respiratory medicine

Aantaa R, Tonner P, Conti G, Longrois D, Mantz J, Mulier JP.
PMID: 25883785
Multidiscip Respir Med. 2015 Mar 07;10(1):8. doi: 10.1186/s40248-015-0007-2. eCollection 2015.

BACKGROUND: We offer some perspectives and commentary on the sedation of obese patients in the intensive care unit (ICU).DISCUSSION: Sedation in morbidly obese patients should conform to the same broad principles now current in ICU practice. These include a...

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Aantaa R, Tonner P, Conti G, et al. Sedation options for the morbidly obese intensive care unit patient: a concise survey and an agenda for development. Multidiscip Respir Med. 2015;10(1):8doi: 10.1186/s40248-015-0007-2.
Aantaa, R., Tonner, P., Conti, G., Longrois, D., Mantz, J., & Mulier, J. P. (2015). Sedation options for the morbidly obese intensive care unit patient: a concise survey and an agenda for development. Multidisciplinary respiratory medicine, 10(1), 8. https://doi.org/10.1186/s40248-015-0007-2
Aantaa, Riku, et al. "Sedation options for the morbidly obese intensive care unit patient: a concise survey and an agenda for development." Multidisciplinary respiratory medicine vol. 10,1 (2015): 8. doi: https://doi.org/10.1186/s40248-015-0007-2
Aantaa R, Tonner P, Conti G, Longrois D, Mantz J, Mulier JP. Sedation options for the morbidly obese intensive care unit patient: a concise survey and an agenda for development. Multidiscip Respir Med. 2015 Mar 07;10(1):8. doi: 10.1186/s40248-015-0007-2. eCollection 2015. PMID: 25883785; PMCID: PMC4399437.
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