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Showing 25 to 36 of 1213 entries
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Patient preference and ease of use for different coagulation factor VIII reconstitution device scenarios: a cross-sectional survey in five European countries.

Patient preference and adherence

Cimino E, Linari S, Malerba M, Halimeh S, Biondo F, Westfeld M.
PMID: 25525348
Patient Prefer Adherence. 2014 Dec 12;8:1713-20. doi: 10.2147/PPA.S64709. eCollection 2014.

INTRODUCTION: Hemophilia A treatment involves replacing the deficient coagulation factor VIII. This process may involve multiple steps that might create a barrier to adherence. A new dual-chamber syringe (DCS; FuseNGo(®)) was recently introduced with the aim of simplifying reconstitution.AIM:...

Impacts of leukocyte filtration and irradiation on coagulation factors in fresh frozen plasma.

Experimental and therapeutic medicine

Li DY, Zhang HW, Feng QZ, Zhao H.
PMID: 25574241
Exp Ther Med. 2015 Feb;9(2):598-602. doi: 10.3892/etm.2014.2126. Epub 2014 Dec 10.

This study aimed to compare and analyze the changes in the coagulation factors in fresh frozen plasma (FFP) prior to and following leukocyte filtration and irradiation. In total, 30 bags of FFP from healthy donors were processed: One-third of...

Early prophylaxis in children with severe haemophilia A: clinical and ultrasound imaging outcomes.

Haemophilia : the official journal of the World Federation of Hemophilia

Altisent C, Martorell M, Crespo A, Casas L, Torrents C, Parra R.
PMID: 26315845
Haemophilia. 2016 Mar;22(2):218-224. doi: 10.1111/hae.12792. Epub 2015 Aug 28.

AIM: This observational study was undertaken with the aim to describe the characteristics and evaluate the outcomes of prophylactic treatment in children with severe haemophilia A (HA) treated at our centre.METHODS: Twenty-five patients aged 4-19 years with severe HA,...

Portal Vein Thrombosis in the Setting of Newly Diagnosed Cushing's Syndrome.

Journal of investigative medicine high impact case reports

McDow AD, Gurung A, Poola R, Fratianni C, Garfinkel M, Jakoby MG.
PMID: 28491882
J Investig Med High Impact Case Rep. 2017 Apr 10;5(2):2324709617703672. doi: 10.1177/2324709617703672. eCollection 2017.

The hallmark manifestations of Cushing's syndrome (CS) are well known, but hypercoagulability is perhaps least recognized. Patients with CS are at increased risk of both spontaneous and postoperative thromboembolism, with the significant majority of events occurring in the lower...

The Utilization of Rehabilitation in Patients with Hemophilia A in Taiwan: A Nationwide Population-Based Study.

PloS one

Chen CM, Yang YH, Chang CH, Chen CC, Chen PC.
PMID: 27690229
PLoS One. 2016 Sep 30;11(9):e0164009. doi: 10.1371/journal.pone.0164009. eCollection 2016.

INTRODUCTION: Rehabilitation plays an important role in the physical health of patients with hemophilia. However, comprehensive information regarding the utilization of rehabilitation for such patients remains scarce.AIM: This population-based study aimed to examine the characteristics, trends, and most important...

Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat.

Journal of toxicology

Rasmussen CE, Nowak J, Larsen JM, Moore E, Bell D, Liu KC, Sorensen NS, Kappers WA, Krogh-Meibom T, Offenberg H.
PMID: 28458688
J Toxicol. 2017;2017:8496246. doi: 10.1155/2017/8496246. Epub 2017 Mar 28.

Turoctocog alfa pegol (N8-GP) is a glycoPEGylated human recombinant factor VIII for the treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) technology, is well-established. Conducting long-term toxicity studies in animals using human proteins can...

Immunomagnetic separation as a final purification step of liver endothelial cells.

In vitro cellular & developmental biology. Animal

Gomez DE, Hartzler JL, Corbitt RH, Nason AM, Thorgeirsson UP.
PMID: 27519745
In Vitro Cell Dev Biol Anim. 1993 Jun;29(6):451-5. doi: 10.1007/BF02639378.

We describe a fast and reproducible method that can be used as a final step in obtaining pure populations of liver endothelial cells. This method employs endothelial cell specific lectin covalently bound to magnetic polystyrene beads (Dynabeads). Evonymus europaeus...

Circulatory contributors to the phenotype in hereditary hemorrhagic telangiectasia.

Frontiers in genetics

Shovlin CL.
PMID: 25914716
Front Genet. 2015 Apr 09;6:101. doi: 10.3389/fgene.2015.00101. eCollection 2015.

Hereditary hemorrhagic telangiectasia (HHT) is mechanistically and therapeutically challenging, not only because of the molecular and cellular perturbations that generate vascular abnormalities, but also the modifications to circulatory physiology that result, and are likely to exacerbate vascular injury. First,...

Malignant Hepatic Epithelioid Hemangioendothelioma with Villaret Syndrome.

Journal of clinical and experimental hepatology

Pavan H, Varghese J, Harika K, Vij M, Jayanthi V, Rela M.
PMID: 28348474
J Clin Exp Hepatol. 2017 Mar;7(1):68-70. doi: 10.1016/j.jceh.2016.09.006. Epub 2016 Sep 15.

Malignant hepatic epithelioid hemangioendothelioma is a rare, vascular tumor of the liver with peak incidence in the middle age with a female preponderance and of unknown etiology. Majority of the tumors are asymptomatic. The gold standard for diagnosis of...

Symptomatic Acquired Haemophilia Due to Circulating Antibodies Against Both Factor VIII and IX in a Non-haemophiliac Patient.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Damodar S, Bhat P, Balasubramaniam S.
PMID: 25332547
Indian J Hematol Blood Transfus. 2014 Sep;30:90-2. doi: 10.1007/s12288-013-0270-3. Epub 2013 May 24.

Acquired haemophilia is a very rare condition, occurring in less than 2 per million populations. This condition is caused commonly by acquired antibodies against factor VIII and rarely by antibodies against factor IX. Here we describe an extremely rare...

Salvage therapy with high dose Intravenous Immunoglobulins in acquired Von Willebrand Syndrome and unresponsive severe intestinal bleeding.

Experimental hematology & oncology

Cugno M, Tedeschi A, Siboni SM, Stufano F, Depetri F, Franchi F, Griffini S, Peyvandi F.
PMID: 24926417
Exp Hematol Oncol. 2014 Jun 04;3:15. doi: 10.1186/2162-3619-3-15. eCollection 2014.

A 91-year-old woman affected with acquired Von Willebrand (VW) syndrome and intestinal angiodysplasias presented with severe gastrointestinal bleeding (hemoglobin 5 g/dl). Despite replacement therapy with VW factor/factor VIII concentrate qid, bleeding did not stop (eleven packed red blood cell...

Alpha interferon for hepatitis C virus infection in haemophilic patients.

Haemophilia : the official journal of the World Federation of Hemophilia

Telfer P, Devereux H, Colvin B, Hayden S, Dusheiko G, Lee C.
PMID: 27214222
Haemophilia. 1995 Jan;1(1):54-8. doi: 10.1111/j.1365-2516.1995.tb00040.x.

We have conducted a controlled trial in 20 haemophilic patients in which intravenous recombinant interferon alpha-2a, 3 mega units thrice weekly, was used to treat chronic hepatitis C infection. The study endpoints included complete and paritial normalization of serum...

Showing 25 to 36 of 1213 entries