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Showing 25 to 36 of 50 entries
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Serum Nonesterified Fatty Acids and Incident Stroke: The CHS.

Journal of the American Heart Association

Huang NK, Biggs ML, Matthan NR, Djoussé L, Longstreth WT, Mukamal KJ, Siscovick DS, Lichtenstein AH.
PMID: 34755529
J Am Heart Assoc. 2021 Nov 16;10(22):e022725. doi: 10.1161/JAHA.121.022725. Epub 2021 Nov 10.

Background Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies. We evaluated the associations between incident stroke and serum concentrations of nonesterified saturated, monounsaturated, polyunsaturated, and

Ophthalmic conditions associated with dementia risk: The Cardiovascular Health Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Hwang PH, Longstreth WT, Thielke SM, Francis CE, Carone M, Kuller LH, Fitzpatrick AL.
PMID: 33788406
Alzheimers Dement. 2021 Sep;17(9):1442-1451. doi: 10.1002/alz.12313. Epub 2021 Mar 31.

INTRODUCTION: Ophthalmic conditions and dementia appear to overlap and may share common pathways, but research has not differentiated dementia subtypes.METHODS: Diagnoses of cataracts, age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma were based on medical histories and International...

Longitudinal Plasma Measures of Trimethylamine N-Oxide and Risk of Atherosclerotic Cardiovascular Disease Events in Community-Based Older Adults.

Journal of the American Heart Association

Lee Y, Nemet I, Wang Z, Lai HTM, de Oliveira Otto MC, Lemaitre RN, Fretts AM, Sotoodehnia N, Budoff M, DiDonato JA, McKnight B, Tang WHW, Psaty BM, Siscovick DS, Hazen SL, Mozaffarian D.
PMID: 34398665
J Am Heart Assoc. 2021 Sep 07;10(17):e020646. doi: 10.1161/JAHA.120.020646. Epub 2021 Aug 16.

Background Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of dietary choline, L-carnitine, and phosphatidylcholine-rich foods. On the basis of experimental studies and patients with prevalent disease, elevated plasma TMAO may increase risk of atherosclerotic cardiovascular disease (ASCVD). TMAO...

Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Zeki Al Hazzouri A, Vittinghoff E, Hoang T, Golden SH, Fitzpatrick AL, Zhang A, Grasset L, Yaffe K.
PMID: 33984188
Alzheimers Dement. 2021 Nov;17(11):1798-1807. doi: 10.1002/alz.12367. Epub 2021 May 13.

INTRODUCTION: To examine the independent association of body mass index (BMI) in early adulthood with dementia incidence among men and women.METHODS: We studied 5104 older adults from the Cardiovascular Health Study (CHS) and the Health, Aging, and Body Composition...

Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Zhang X, Farrell JJ, Tong T, Hu J, Zhu C, Wang LS, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA.
PMID: 34152079
Alzheimers Dement. 2021 Jun 20; doi: 10.1002/alz.12396. Epub 2021 Jun 20.

INTRODUCTION: Findings regarding the association between mitochondrial DNA (mtDNA) variants and Alzheimer's disease (AD) are inconsistent.METHODS: We developed a pipeline for accurate assembly and variant calling in mitochondrial genomes embedded within whole exome sequences (WES) from 10,831 participants from...

Epigenetic Age and the Risk of Incident Atrial Fibrillation.

Circulation

Roberts JD, Vittinghoff E, Lu AT, Alonso A, Wang B, Sitlani CM, Mohammadi-Shemirani P, Fornage M, Kornej J, Brody JA, Arking DE, Lin H, Heckbert SR, Prokic I, Ghanbari M, Skanes AC, Bartz TM, Perez MV, Taylor KD, Lubitz SA, Ellinor PT, Lunetta KL, Pankow JS, Paré G, Sotoodehnia N, Benjamin EJ, Horvath S, Marcus GM.
PMID: 34587750
Circulation. 2021 Dec 14;144(24):1899-1911. doi: 10.1161/CIRCULATIONAHA.121.056456. Epub 2021 Sep 30.

BACKGROUND: The most prominent risk factor for atrial fibrillation (AF) is chronological age; however, underlying mechanisms are unexplained. Algorithms using epigenetic modifications to the human genome effectively predict chronological age. Chronological and epigenetic predicted ages may diverge in a...

Epigenetic Age and the Risk of Incident Atrial Fibrillation.

Circulation

Roberts JD, Vittinghoff E, Lu AT, Alonso A, Wang B, Sitlani CM, Mohammadi-Shemirani P, Fornage M, Kornej J, Brody JA, Arking DE, Lin H, Heckbert SR, Prokic I, Ghanbari M, Skanes AC, Bartz TM, Perez MV, Taylor KD, Lubitz SA, Ellinor PT, Lunetta KL, Pankow JS, Paré G, Sotoodehnia N, Benjamin EJ, Horvath S, Marcus GM.
PMID: 34587750
Circulation. 2021 Dec 14;144(24):1899-1911. doi: 10.1161/CIRCULATIONAHA.121.056456. Epub 2021 Sep 30.

BACKGROUND: The most prominent risk factor for atrial fibrillation (AF) is chronological age; however, underlying mechanisms are unexplained. Algorithms using epigenetic modifications to the human genome effectively predict chronological age. Chronological and epigenetic predicted ages may diverge in a...

Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation.

Circulation. Genomic and precision medicine

Yang Y, Bartz TM, Brown MR, Guo X, Zilhão NR, Trompet S, Weiss S, Yao J, Brody JA, Defilippi CR, Hoogeveen RC, Lin HJ, Gudnason V, Ballantyne CM, Dörr M, Jukema JW, Petersmann A, Psaty BM, Rotter JI, Boerwinkle E, Fornage M, Jun G, Yu B.
PMID: 34732054
Circ Genom Precis Med. 2021 Dec;14(6):e003460. doi: 10.1161/CIRCGEN.121.003460. Epub 2021 Nov 04.

BACKGROUND: Elevated cardiac troponin levels in blood are associated with increased risk of cardiovascular diseases and mortality. Cardiac troponin levels are heritable, but their genetic architecture remains elusive.METHODS: We conducted a transethnic genome-wide association analysis on high-sensitivity cTnT (cardiac...

Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease.

Annals of clinical and translational neurology

Vardarajan BN, Barral S, Jaworski J, Beecham GW, Blue E, Tosto G, Reyes-Dumeyer D, Medrano M, Lantigua R, Naj A, Thornton T, DeStefano A, Martin E, Wang LS, Brown L, Bush W, van Duijn C, Goate A, Farrer L, Haines JL, Boerwinkle E, Schellenberg G, Wijsman E, Pericak-Vance MA, Mayeux R, Wang LS.
PMID: 29688227
Ann Clin Transl Neurol. 2018 Mar 13;5(4):406-417. doi: 10.1002/acn3.537. eCollection 2018 Apr.

OBJECTIVE: To identify rare causal variants underlying known loci that segregate with late-onset Alzheimer's disease (LOAD) in multiplex families.METHODS: We analyzed whole genome sequences (WGS) from 351 members of 67 Caribbean Hispanic (CH) families from Dominican Republic and New...

Gene Set Enrichment Analsyes Identify Pathways Involved in Genetic Risk for Diabetic Retinopathy.

American journal of ophthalmology

Sobrin L, Susarla G, Stanwyck L, Rouhana JM, Li A, Pollack S, Igo RP, Jensen RA, Li X, Ng MCY, Smith AV, Kuo JZ, Taylor KD, Freedman BI, Bowden DW, Penman A, Chen CJ, Craig JE, Adler SG, Chew EY, Cotch MF, Yaspan B, Mitchell P, Wang JJ, Klein BEK, Wong TY, Rotter JI, Burdon KP, Iyengar SK, Segrè AV.
PMID: 34166655
Am J Ophthalmol. 2022 Jan;233:111-123. doi: 10.1016/j.ajo.2021.06.014. Epub 2021 Jun 21.

To identify functionally related genes associated with diabetic retinopathy (DR) risk using gene set enrichment analyses applied to genome-wide association study meta-analyses.METHODS: We analyzed DR GWAS meta-analyses performed on 3246 Europeans and 2611 African Americans with type 2 diabetes....

Meta-analysis of exome array data identifies six novel genetic loci for lung function.

Wellcome open research

Jackson VE, Latourelle JC, Wain LV, Smith AV, Grove ML, Bartz TM, Obeidat M, Province MA, Gao W, Qaiser B, Porteous DJ, Cassano PA, Ahluwalia TS, Grarup N, Li J, Altmaier E, Marten J, Harris SE, Manichaikul A, Pottinger TD, Li-Gao R, Lind-Thomsen A, Mahajan A, Lahousse L, Imboden M, Teumer A, Prins B, Lyytikäinen LP, Eiriksdottir G, Franceschini N, Sitlani CM, Brody JA, Bossé Y, Timens W, Kraja A, Loukola A, Tang W, Liu Y, Bork-Jensen J, Justesen JM, Linneberg A, Lange LA, Rawal R, Karrasch S, Huffman JE, Smith BH, Davies G, Burkart KM, Mychaleckyj JC, Bonten TN, Enroth S, Lind L, Brusselle GG, Kumar A, Stubbe B, Kähönen M, Wyss AB, Psaty BM, Heckbert SR, Hao K, Rantanen T, Kritchevsky SB, Lohman K, Skaaby T, Pisinger C, Hansen T, Schulz H, Polasek O, Campbell A, Starr JM, Rich SS, Mook-Kanamori DO, Johansson Å, Ingelsson E, Uitterlinden AG, Weiss S, Raitakari OT, Gudnason V, North KE, Gharib SA, Sin DD, Taylor KD, O'Connor GT, Kaprio J, Harris TB, Pederson O, Vestergaard H, Wilson JG, Strauch K, Hayward C, Kerr S, Deary IJ, Barr RG, de Mutsert R, Gyllensten U, Morris AP, Ikram MA, Probst-Hensch N, Gläser S, Zeggini E, Lehtimäki T, Strachan DP, Dupuis J, Morrison AC, Hall IP, Tobin MD, London SJ.
PMID: 30175238
Wellcome Open Res. 2018 Jan 12;3:4. doi: 10.12688/wellcomeopenres.12583.3. eCollection 2018.

No abstract available.

Depressive Symptoms Imputed Across the Life Course Are Associated with Cognitive Impairment and Cognitive Decline.

Journal of Alzheimer's disease : JAD

Brenowitz WD, Zeki Al Hazzouri A, Vittinghoff E, Golden SH, Fitzpatrick AL, Yaffe K.
PMID: 34420969
J Alzheimers Dis. 2021;83(3):1379-1389. doi: 10.3233/JAD-210588.

BACKGROUND: Depressive symptoms may increase risk for dementia, but findings are controversial because late-life depression may be a prodromal dementia symptom. Life course data on depression and dementia risk may clarify this association; however, data is limited.OBJECTIVE: To impute...

Showing 25 to 36 of 50 entries