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Jackson VE, Latourelle JC, Wain LV, et al. Meta-analysis of exome array data identifies six novel genetic loci for lung function. Wellcome Open Res. 2018;3:4doi: 10.12688/wellcomeopenres.12583.3.
Jackson, V. E., Latourelle, J. C., Wain, L. V., Smith, A. V., Grove, M. L., Bartz, T. M., Obeidat, M., Province, M. A., Gao, W., Qaiser, B., Porteous, D. J., Cassano, P. A., Ahluwalia, T. S., Grarup, N., Li, J., Altmaier, E., Marten, J., Harris, S. E., Manichaikul, A., Pottinger, T. D., Li-Gao, R., Lind-Thomsen, A., Mahajan, A., Lahousse, L., Imboden, M., Teumer, A., Prins, B., Lyytikäinen, L. P., Eiriksdottir, G., Franceschini, N., Sitlani, C. M., Brody, J. A., Bossé, Y., Timens, W., Kraja, A., Loukola, A., Tang, W., Liu, Y., Bork-Jensen, J., Justesen, J. M., Linneberg, A., Lange, L. A., Rawal, R., Karrasch, S., Huffman, J. E., Smith, B. H., Davies, G., Burkart, K. M., Mychaleckyj, J. C., Bonten, T. N., Enroth, S., Lind, L., Brusselle, G. G., Kumar, A., Stubbe, B., Kähönen, M., Wyss, A. B., Psaty, B. M., Heckbert, S. R., Hao, K., Rantanen, T., Kritchevsky, S. B., Lohman, K., Skaaby, T., Pisinger, C., Hansen, T., Schulz, H., Polasek, O., Campbell, A., Starr, J. M., Rich, S. S., Mook-Kanamori, D. O., Johansson, �. �., Ingelsson, E., Uitterlinden, A. G., Weiss, S., Raitakari, O. T., Gudnason, V., North, K. E., Gharib, S. A., Sin, D. D., Taylor, K. D., O'Connor, G. T., Kaprio, J., Harris, T. B., Pederson, O., Vestergaard, H., Wilson, J. G., Strauch, K., Hayward, C., Kerr, S., Deary, I. J., Barr, R. G., de Mutsert, R., Gyllensten, U., Morris, A. P., Ikram, M. A., Probst-Hensch, N., Gläser, S., Zeggini, E., Lehtimäki, T., Strachan, D. P., Dupuis, J., Morrison, A. C., Hall, I. P., Tobin, M. D., & London, S. J. (2018). Meta-analysis of exome array data identifies six novel genetic loci for lung function. Wellcome open research, 34. https://doi.org/10.12688/wellcomeopenres.12583.3
Jackson, Victoria E, et al. "Meta-analysis of exome array data identifies six novel genetic loci for lung function." Wellcome open research vol. 3 (2018): 4. doi: https://doi.org/10.12688/wellcomeopenres.12583.3
Jackson VE, Latourelle JC, Wain LV, Smith AV, Grove ML, Bartz TM, Obeidat M, Province MA, Gao W, Qaiser B, Porteous DJ, Cassano PA, Ahluwalia TS, Grarup N, Li J, Altmaier E, Marten J, Harris SE, Manichaikul A, Pottinger TD, Li-Gao R, Lind-Thomsen A, Mahajan A, Lahousse L, Imboden M, Teumer A, Prins B, Lyytikäinen LP, Eiriksdottir G, Franceschini N, Sitlani CM, Brody JA, Bossé Y, Timens W, Kraja A, Loukola A, Tang W, Liu Y, Bork-Jensen J, Justesen JM, Linneberg A, Lange LA, Rawal R, Karrasch S, Huffman JE, Smith BH, Davies G, Burkart KM, Mychaleckyj JC, Bonten TN, Enroth S, Lind L, Brusselle GG, Kumar A, Stubbe B, Kähönen M, Wyss AB, Psaty BM, Heckbert SR, Hao K, Rantanen T, Kritchevsky SB, Lohman K, Skaaby T, Pisinger C, Hansen T, Schulz H, Polasek O, Campbell A, Starr JM, Rich SS, Mook-Kanamori DO, Johansson Å, Ingelsson E, Uitterlinden AG, Weiss S, Raitakari OT, Gudnason V, North KE, Gharib SA, Sin DD, Taylor KD, O'Connor GT, Kaprio J, Harris TB, Pederson O, Vestergaard H, Wilson JG, Strauch K, Hayward C, Kerr S, Deary IJ, Barr RG, de Mutsert R, Gyllensten U, Morris AP, Ikram MA, Probst-Hensch N, Gläser S, Zeggini E, Lehtimäki T, Strachan DP, Dupuis J, Morrison AC, Hall IP, Tobin MD, London SJ. Meta-analysis of exome array data identifies six novel genetic loci for lung function. Wellcome Open Res. 2018 Jan 12;3:4. doi: 10.12688/wellcomeopenres.12583.3. eCollection 2018. PMID: 30175238; PMCID: PMC6081985.
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Wellcome Open Res. 2018 Jan 12;3:4. doi: 10.12688/wellcomeopenres.12583.3. eCollection 2018.

Meta-analysis of exome array data identifies six novel genetic loci for lung function.

Wellcome open research

Victoria E Jackson, Jeanne C Latourelle, Louise V Wain, Albert V Smith, Megan L Grove, Traci M Bartz, Ma'en Obeidat, Michael A Province, Wei Gao, Beenish Qaiser, David J Porteous, Patricia A Cassano, Tarunveer S Ahluwalia, Niels Grarup, Jin Li, Elisabeth Altmaier, Jonathan Marten, Sarah E Harris, Ani Manichaikul, Tess D Pottinger, Ruifang Li-Gao, Allan Lind-Thomsen, Anubha Mahajan, Lies Lahousse, Medea Imboden, Alexander Teumer, Bram Prins, Leo-Pekka Lyytikäinen, Gudny Eiriksdottir, Nora Franceschini, Colleen M Sitlani, Jennifer A Brody, Yohan Bossé, Wim Timens, Aldi Kraja, Anu Loukola, Wenbo Tang, Yongmei Liu, Jette Bork-Jensen, Johanne M Justesen, Allan Linneberg, Leslie A Lange, Rajesh Rawal, Stefan Karrasch, Jennifer E Huffman, Blair H Smith, Gail Davies, Kristin M Burkart, Josyf C Mychaleckyj, Tobias N Bonten, Stefan Enroth, Lars Lind, Guy G Brusselle, Ashish Kumar, Beate Stubbe, Mika Kähönen, Annah B Wyss, Bruce M Psaty, Susan R Heckbert, Ke Hao, Taina Rantanen, Stephen B Kritchevsky, Kurt Lohman, Tea Skaaby, Charlotta Pisinger, Torben Hansen, Holger Schulz, Ozren Polasek, Archie Campbell, John M Starr, Stephen S Rich, Dennis O Mook-Kanamori, Åsa Johansson, Erik Ingelsson, André G Uitterlinden, Stefan Weiss, Olli T Raitakari, Vilmundur Gudnason, Kari E North, Sina A Gharib, Don D Sin, Kent D Taylor, George T O'Connor, Jaakko Kaprio, Tamara B Harris, Oluf Pederson, Henrik Vestergaard, James G Wilson, Konstantin Strauch, Caroline Hayward, Shona Kerr, Ian J Deary, R Graham Barr, Renée de Mutsert, Ulf Gyllensten, Andrew P Morris, M Arfan Ikram, Nicole Probst-Hensch, Sven Gläser, Eleftheria Zeggini, Terho Lehtimäki, David P Strachan, Josée Dupuis, Alanna C Morrison, Ian P Hall, Martin D Tobin, Stephanie J London

Affiliations

  1. Department of Health Sciences, University of Leicester, Leicester, UK.
  2. Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
  3. National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
  4. Icelandic Heart Association, 201 Kopavogur, Iceland.
  5. University of Iceland, 101 Reykjavik, Iceland.
  6. Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
  7. Cardiovascular Health Research Unit, Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, 98101, USA.
  8. The University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.
  9. Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
  10. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  11. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Helsinki, Finland.
  12. Centre for Genomic & Experimental Medicine, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  13. Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
  14. Department of Healthcare Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York City, NY, USA.
  15. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
  16. Steno Diabetes Center Copenhagen, Gentofte, 2820, Denmark.
  17. Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
  18. Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
  19. Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh , EH4 2XU, UK.
  20. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  21. Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  22. Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
  23. Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
  24. Department of Preventive Medicine - Division of Health and Biomedical Informatics, Northwestern University - Feinberg School of Medicine, Chicago, IL, USA.
  25. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, Netherlands.
  26. Department of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, SE-75108 Uppsala, Sweden.
  27. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  28. Respiratory Medicine, Ghent University Hospital, Ghent, BE9000, Belgium.
  29. Bioanalysis, Ghent University, Ghent, BE9000, Belgium.
  30. Swiss Tropical and Public Health Institute, Basel, Switzerland.
  31. University of Basel, Basel, Switzerland.
  32. Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
  33. Human Genetics, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
  34. Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
  35. Department of Clinical Chemistry, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland.
  36. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC 27514, USA.
  37. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.
  38. Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada.
  39. Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, NL9713 GZ, Netherlands.
  40. Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
  41. Boehringer Ingelheim , Danbury, CT, USA.
  42. Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
  43. Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.
  44. Department of Clinical Experimental Research, Rigshospitalet, 2600 Glostrup, Denmark.
  45. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
  46. Department of Medicine, Division of Bioinformatics and Personalized Medicine, University of Colorado Denver, Aurora, CO, USA.
  47. Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
  48. Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany.
  49. Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
  50. Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  51. Department of Pulmonology, Leiden University Medical Center, Leiden, 2333 ZA, Netherlands.
  52. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2333 ZA, Netherlands.
  53. Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.
  54. Epidemiology, Erasmus Medical Center, Rotterdam, 3000CA, Netherlands.
  55. Respiratory Medicine, Erasmus Medical Center, Rotterdam, 3000CA, Netherlands.
  56. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  57. Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany.
  58. Department of Clinical Physiology, Tampere University Hospital, Tampere, 33521, Finland.
  59. Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
  60. Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Dept of Health and Human Services, Research Triangle Park, NC, 27709, USA.
  61. Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, 98101, USA.
  62. Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
  63. Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, 98101, USA.
  64. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574, USA.
  65. Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574, USA.
  66. Department of Health Sciences, University of Jyväskylä, Jyväskylä, Fl-40014, Finland.
  67. Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  68. Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany.
  69. Faculty of Medicine, University of Split, Split, Croatia.
  70. Alzheimer Scotland Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  71. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  72. Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  73. Internal Medicine, Erasmus Medical Center, Rotterdam, 3000CA, Netherlands.
  74. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.
  75. DZHK (German Centre for Cardiovascular Research), partner site: Greifswald, Greifswald, Germany.
  76. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.
  77. Research Centre of Applied and Preventative Cardiovascular Medicine, University of Turku, Turku, 20014, Finland.
  78. Department of Epidemiology and Carolina Center for Genome Science, University of North Carolina, Chapel Hill, NC, 27514, USA.
  79. Computational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Department of Medicine, University of Washington, Seattle, WA, 98109, USA.
  80. Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
  81. Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
  82. Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
  83. National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, 01702, USA.
  84. Department of Health, University of Helsinki, Helsinki, FI-00014, Finland.
  85. Department of Public Health, National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
  86. National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
  87. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
  88. Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
  89. Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, 81377, Germany.
  90. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA.
  91. Department of Biostatistics, University of Liverpool, Liverpool, L69 3GL, UK.
  92. Radiology, Erasmus Medical Center, Rotterdam, 3000CA, Netherlands.
  93. Neurology, Erasmus Medical Center, Rotterdam, 3000CA, Netherlands.
  94. Department of Internal Medicine - Pulmonary Diseases, Vivantes Klinikum Spandau Berlin, Berlin, 13585, Germany.
  95. Population Health Research Institute, St George's, University of London, London, SW17 0RE, UK.
  96. NIHR Nottingham Biomedical Research Centre and Division of Respiratory Medicine, University of Nottingham, Nottingham, NG7 2UH, UK.

PMID: 30175238 PMCID: PMC6081985 DOI: 10.12688/wellcomeopenres.12583.3

[No abstract available.]

Keywords: COPD; GWAS; Lung function; exome array; respiratory

Conflict of interest statement

No competing interests were disclosed.

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