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Showing 25 to 36 of 236 entries
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Activation of 5-HT 1b/d receptor restores the cognitive function by reducing glutamate release, deposition of β-amyloid and TLR-4 pathway in the brain of scopolamine-induced dementia in rat.

The Journal of pharmacy and pharmacology

Tripathi AS, Bansod P, Swathi KP.
PMID: 34244776
J Pharm Pharmacol. 2021 Dec 07;73(12):1592-1598. doi: 10.1093/jpp/rgab095.

OBJECTIVES: This study evaluates the effect of 5-HT 1b/d agonist on cognitive function in scopolamine (SPN)-induced dementia in the rat.METHODS: Dementia was induced by administration of SPN 2 mg/kg/day, intraperitoneally, for a duration of 21 days. The effect of...

Pharmacokinetics and brain distribution studies of 6-hydroxykynurenic acid and its structural modified compounds.

The Journal of pharmacy and pharmacology

Shen Z, Hu H, Pan J, Xu M, Ou F, He K, Zeng K, Yao J, Wang R, Lou Y, Zeng S.
PMID: 34586411
J Pharm Pharmacol. 2022 Jan 05;74(1):22-31. doi: 10.1093/jpp/rgab132.

OBJECTIVES: 6-Hydroxykynurenic acid (6-HKA) is an organic acid component in extracts of Ginkgo biloba leaves and acts as a major contributor to neurorestorative effects, while its oral bioavailability was low. Therefore, using prodrug method to improve the bioavailability and...

Corrigendum to: Remimazolam alleviates neuropathic pain via regulating bradykinin receptor B1 and autophagy.

The Journal of pharmacy and pharmacology

Xie H, Lu F, Liu W, Wang E, Wang L, Zhong M.
PMID: 34190314
J Pharm Pharmacol. 2021 Jun 30; doi: 10.1093/jpp/rgab101. Epub 2021 Jun 30.

No abstract available.

The potential protective effect of the Polygonum hydropiper L against the development of fructose-induced oxidative stress and metabolic disorders in male Sprague-Dawely rats.

The Journal of pharmacy and pharmacology

Batool A, Saleem M, Alamgeer, Mushtaq MN, Alotaibi NH, Alharbi KS, Bukhari SNA.
PMID: 34165561
J Pharm Pharmacol. 2021 Jun 22; doi: 10.1093/jpp/rgab071. Epub 2021 Jun 22.

OBJECTIVES: Polygnum hydropiper L (Polygonaceae) is commonly known as smart weed. This study was designed to assess the effect of aqueous methanolic extract of P. hydropiper on oxidative stress and metabolic changes in fructose-induced hypertensive rats.METHODS: Male Sprague-Dawely rats...

An in-vitro comparative study of the binding of caspofungin and micafungin to plasma proteins.

The Journal of pharmacy and pharmacology

Yamasaki K, Sakurama K, Nishi K, Tsukigawa K, Seo H, Otagiri M, Taguchi K.
PMID: 34791369
J Pharm Pharmacol. 2021 Nov 16; doi: 10.1093/jpp/rgab157. Epub 2021 Nov 16.

OBJECTIVES: Echinocandins are widely used for the treatment of invasive fungal diseases. While they bind strongly to plasma proteins, our knowledge of this process is not sufficient to permit their pharmacokinetics and pharmacodynamics targets to be discussed. In this...

The relationship of telmisartan with sclerostin in the osteoporosis model induced by ovariectomy in rats.

The Journal of pharmacy and pharmacology

Kutlu Z, Bilen A, Celik M, Maman A, Gulaboglu M, Kul A, Celik Z, Halici Z.
PMID: 34874446
J Pharm Pharmacol. 2021 Dec 07;73(12):1693-1702. doi: 10.1093/jpp/rgab123.

OBJECTIVES: Our aim is to explain the relationship between Ang II and Scl in osteoporotic (OP) rats and the contribution of Scl in the antiosteoporotic effect mechanism of angiotensin receptor blockers (ARB).METHODS: This study consists of two sub-studies conducted...

HDAC9 exacerbates myocardial infarction via inactivating Nrf2 pathways.

The Journal of pharmacy and pharmacology

Liu F, Di Y, Ma W, Kang X, Li X, Ji Z.
PMID: 33963859
J Pharm Pharmacol. 2021 May 08; doi: 10.1093/jpp/rgab065. Epub 2021 May 08.

OBJECTIVES: Myocardial infarction (MI) is the leading cause of death worldwide. Histone deacetylases (HDACs) collectively participate in the initiation and progression of heart diseases, including MI. This study aimed to investigate the roles of histone deacetylase 9 (HDAC9) in...

The Protective Effect of Natural Compounds on Doxorubicin-Induced Cardiotoxicity via Nicotinamide Adenine Dinucleotide Phosphate Oxidase Inhibition.

The Journal of pharmacy and pharmacology

Yousefian M, Hosseinzadeh H, Hayes AW, Hadizadeh F, Karimi G.
PMID: 34562089
J Pharm Pharmacol. 2021 Sep 25; doi: 10.1093/jpp/rgab109. Epub 2021 Sep 25.

OBJECTIVES: Doxorubicin (DOX) is widely prescribed for the treatment of several human cancers. Unfortunately, cumulative doses of DOX are the main cause of myocardial dysfunction. Although preclinical and pharmaceutical studies were performed to investigate the potential of natural compounds...

Synthesis of 3,3-dimethyl-6-oxopyrano[3,4-c]pyridines and their antiplatelet and vasodilatory activity.

The Journal of pharmacy and pharmacology

Sirakanyan SN, Hrubša M, Spinelli D, Dias P, Kartsev V, Carazo A, Hovakimyan AA, Pourová J, Hakobyan EK, Karlíčková J, Parvin S, Fadraersada J, Macáková K, Geronikaki A, Mladěnka P.
PMID: 34106261
J Pharm Pharmacol. 2021 Jun 09; doi: 10.1093/jpp/rgab075. Epub 2021 Jun 09.

OBJECTIVES: Both pyridine and pyrano derivatives have been previously shown to possess biologically relevant activity. In this study, we report the incorporation of these two scaffolds into one molecule.METHODS: The designed 3,3-dimethyl-6-oxopyrano[3,4-c]pyridines were synthesized by the acylation of enamine...

Corrigendum to: Magnesium isoglycyrrhizinate prevents cadmium-induced activation of JNK and apoptotic hepatocyte death by reversing ROS-inactivated PP2A.

The Journal of pharmacy and pharmacology

Chen X, Wang X, Yang L, Xu H, Wu Y, Wu J, Chen L, Xu C.
PMID: 34718703
J Pharm Pharmacol. 2021 Dec 07;73(12):1726. doi: 10.1093/jpp/rgab149.

No abstract available.

Development of 3D printed drug-eluting contact lenses.

The Journal of pharmacy and pharmacology

Mohamdeen YMG, Tabriz AG, Tighsazzadeh M, Nandi U, Khalaj R, Andreadis I, Boateng JS, Douroumis D.
PMID: 34928372
J Pharm Pharmacol. 2021 Dec 20; doi: 10.1093/jpp/rgab173. Epub 2021 Dec 20.

OBJECTIVES: The aim of the work was to introduce 3D printing technology for the design and fabrication of drug-eluting contact lenses (DECL) for the treatment of glaucoma. The development of 3D printed lenses can effectively overcome drawbacks of existing...

Comparative beneficial effects of nebivolol and nebivolol/valsartan combination against mitochondrial dysfunction in angiotensin II-induced pathology in H9c2 cardiomyoblasts.

The Journal of pharmacy and pharmacology

Gul R, Alsalman N, Bazighifan A, Alfadda AA.
PMID: 34453839
J Pharm Pharmacol. 2021 Oct 07;73(11):1520-1529. doi: 10.1093/jpp/rgab124.

OBJECTIVES: Considering the complementary nature of signalling mechanisms and the therapeutic effects of nebivolol, a β1-adrenoreceptor antagonist, and valsartan, an angiotensin receptor blocker (ARB), here we aimed to investigate whether nebivolol/valsartan combination would complement the cardioprotective effects of nebivolol...

Showing 25 to 36 of 236 entries