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Showing 13 to 24 of 116 entries
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Genetic Contributions to Multivariate Data-Driven Brain Networks Constructed via Source-Based Morphometry.

Cerebral cortex (New York, N.Y. : 1991)

Rodrigue AL, Alexander-Bloch AF, Knowles EEM, Mathias SR, Mollon J, Koenis MMG, Perrone-Bizzozero NI, Almasy L, Turner JA, Calhoun VD, Glahn DC.
PMID: 32318716
Cereb Cortex. 2020 Jul 30;30(9):4899-4913. doi: 10.1093/cercor/bhaa082.

Identifying genetic factors underlying neuroanatomical variation has been difficult. Traditional methods have used brain regions from predetermined parcellation schemes as phenotypes for genetic analyses, although these parcellations often do not reflect brain function and/or do not account for covariance...

Association of physical activity and sedentary behavior with type 2 diabetes and glycemic traits: a two-sample Mendelian randomization study.

BMJ open diabetes research & care

Meisinger C, Linseisen J, Leitzmann M, Baurecht H, Baumeister SE.
PMID: 33293297
BMJ Open Diabetes Res Care. 2020 Dec;8(2). doi: 10.1136/bmjdrc-2020-001896.

INTRODUCTION: Observational studies suggest that physical activity lowers and sedentary behavior increases the risk of type 2 diabetes. Despite of some supportive trial data for physical activity, it is largely unresolved whether these relations are causal or due to...

Super-variants identification for brain connectivity.

Human brain mapping

Li T, Hu J, Wang S, Zhang H.
PMID: 33236465
Hum Brain Mapp. 2021 Apr 01;42(5):1304-1312. doi: 10.1002/hbm.25294. Epub 2020 Nov 24.

Identifying genetic biomarkers for brain connectivity helps us understand genetic effects on brain function. The unique and important challenge in detecting associations between brain connectivity and genetic variants is that the phenotype is a matrix rather than a scalar....

COVID-19 and the UK Biobank-Opportunities and Challenges for Research and Collaboration With Other Large Population Studies.

Frontiers in cardiovascular medicine

Khanji MY, Aung N, Chahal CAA, Petersen SE.
PMID: 33195444
Front Cardiovasc Med. 2020 Aug 27;7:156. doi: 10.3389/fcvm.2020.00156. eCollection 2020.

Large population studies such as the UK Biobank provide great opportunities for understanding the pathophysiology, health impact and prognostic factors associated with COVID-19, a condition that has had significant impact on almost everyone around the world. We highlight the...

A unified framework for association and prediction from vertex-wise grey-matter structure.

Human brain mapping

Couvy-Duchesne B, Strike LT, Zhang F, Holtz Y, Zheng Z, Kemper KE, Yengo L, Colliot O, Wright MJ, Wray NR, Yang J, Visscher PM.
PMID: 32687259
Hum Brain Mapp. 2020 Oct 01;41(14):4062-4076. doi: 10.1002/hbm.25109. Epub 2020 Jul 20.

The recent availability of large-scale neuroimaging cohorts facilitates deeper characterisation of the relationship between phenotypic and brain architecture variation in humans. Here, we investigate the association (previously coined morphometricity) of a phenotype with all 652,283 vertex-wise measures of cortical...

Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women.

Circulation

Honigberg MC, Zekavat SM, Niroula A, Griffin GK, Bick AG, Pirruccello JP, Nakao T, Whitsel EA, Farland LV, Laurie C, Kooperberg C, Manson JE, Gabriel S, Libby P, Reiner AP, Ebert BL, Natarajan P.
PMID: 33161765
Circulation. 2021 Feb 02;143(5):410-423. doi: 10.1161/CIRCULATIONAHA.120.051775. Epub 2020 Nov 09.

BACKGROUND: Premature menopause is an independent risk factor for cardiovascular disease in women, but mechanisms underlying this association remain unclear. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of hematopoietic cells with leukemogenic mutations without detectable malignancy, is...

No statistical evidence for an effect of CCR5-∆32 on lifespan in the UK Biobank cohort.

Nature medicine

Maier R, Akbari A, Wei X, Patterson N, Nielsen R, Reich D.
PMID: 31873311
Nat Med. 2020 Feb;26(2):178-180. doi: 10.1038/s41591-019-0710-1. Epub 2019 Dec 23.

No abstract available.

The epidemiology of regular opioid use and its association with mortality: Prospective cohort study of 466 486 UK biobank participants.

EClinicalMedicine

Macfarlane GJ, Beasley M, Jones GT, Stannard C.
PMID: 32322808
EClinicalMedicine. 2020 Apr 18;21:100321. doi: 10.1016/j.eclinm.2020.100321. eCollection 2020 Apr.

BACKGROUND: Opioids have, at most, small benefits for non-cancer pain in the medium and long-term but there is good evidence that they cause harm. The current study describes the characteristics and clinical status of people taking regular opioids in...

The Impact of Periodontal Disease on Hospital Admission and Mortality During COVID-19 Pandemic.

Frontiers in medicine

Larvin H, Wilmott S, Wu J, Kang J.
PMID: 33330570
Front Med (Lausanne). 2020 Nov 23;7:604980. doi: 10.3389/fmed.2020.604980. eCollection 2020.

No abstract available.

The Health Impact of MAFLD, a Novel Disease Cluster of NAFLD, Is Amplified by the Integrated Effect of Fatty Liver Disease-Related Genetic Variants.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Liu Z, Suo C, Shi O, Lin C, Zhao R, Yuan H, Jin L, Zhang T, Chen X.
PMID: 33387670
Clin Gastroenterol Hepatol. 2020 Dec 30; doi: 10.1016/j.cgh.2020.12.033. Epub 2020 Dec 30.

BACKGROUND & AIMS: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly proposed disease category that derived from non-alcoholic fatty liver disease. The impact of MAFLD on health events has not been investigated.METHODS: UK Biobank participants were diagnosed for...

Association between herpes simplex virus 1 exposure and the risk of depression in UK Biobank.

Clinical and translational medicine

Ye J, Wen Y, Chu X, Li P, Cheng B, Cheng S, Liu L, Zhang L, Ma M, Qi X, Liang C, Kafle OP, Jia Y, Wu C, Wang S, Wang X, Ning Y, Zhang F.
PMID: 32564518
Clin Transl Med. 2020 Jun;10(2):e108. doi: 10.1002/ctm2.108. Epub 2020 Jun 20.

BACKGROUND: Herpes simplex virus-1 (HSV-1) infection is reported to be associated with depression. But limited efforts were made to investigate the relationship between HSV-1 infection and the risk of depression, especially from the genetic perspective.METHODS: In UK Biobank cohort,...

Quantifying the Polygenic Architecture of the Human Cerebral Cortex: Extensive Genetic Overlap between Cortical Thickness and Surface Area.

Cerebral cortex (New York, N.Y. : 1991)

van der Meer D, Frei O, Kaufmann T, Chen CH, Thompson WK, O'Connell KS, Monereo Sánchez J, Linden DEJ, Westlye LT, Dale AM, Andreassen OA.
PMID: 32483632
Cereb Cortex. 2020 Sep 03;30(10):5597-5603. doi: 10.1093/cercor/bhaa146.

The thickness of the cerebral cortical sheet and its surface area are highly heritable traits thought to have largely distinct polygenic architectures. Despite large-scale efforts, the majority of their genetic determinants remain unknown. Our ability to identify causal genetic...

Showing 13 to 24 of 116 entries