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Showing 13 to 24 of 162 entries
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Helping the chronic schizophrenic and their families in the community-intial observations.

Indian journal of psychiatry

Suman C, Baldev S, Murthy RS, Wig NN.
PMID: 22058448
Indian J Psychiatry. 1980 Jan;22(1):97-102.

There is a growing interest in the problems of mentally ill persons in the community in order to understand and organize services for them. Schizophrenia continues to form the most important problems in the community. The present prospective study...

Water intoxication in depression: a case report.

Indian journal of psychiatry

Mahla VP, Trehan V, Puri DK.
PMID: 21927494
Indian J Psychiatry. 1990 Oct;32(4):366-8.

Patient of "psychotic depression" who digested large quantity of water and subsequently developed grand mal seizure and serum sodium levels of less than 121 meq/litre is presented. The physiology of psychogenic polydypsia and related disorders is reviewed. The relation...

Unsymmetrical and Symmetrical Push-Pull Phenothiazines.

The Journal of organic chemistry

Rout Y, Gautam P, Misra R.
PMID: 28587457
J Org Chem. 2017 Jul 07;82(13):6840-6845. doi: 10.1021/acs.joc.7b00991. Epub 2017 Jun 13.

A series of unsymmetrical and symmetrical push-pull phenothiazines (3-7) were designed and synthesized by the Pd-catalyzed Sonogashira cross-coupling reaction and subsequent [2 + 2] cycloaddition-retroelectrocyclization reaction with tetracyanoethylene (TCNE) and 7,7,8,8-tetracyanoquinodimethane (TCNQ). The effect of systematic variation of the...

Influence of phenothiazines, phenazines and phenoxazine on cation transport in Candida albicans.

Journal of applied microbiology

Calahorra M, Sánchez NS, Peña A.
PMID: 30153370
J Appl Microbiol. 2018 Aug 28; doi: 10.1111/jam.14092. Epub 2018 Aug 28.

AIMS: (i) To analyse the increase in calcium ion uptake caused by several cationic dyes on Candida albicans, (ii) to postulate a mechanism, (iii) to define the effects of Zn ions on the phenomenon, and (iv) to propose the...

Electrochemical and ab initio investigations to design a new phenothiazine based organic redox polymeric material for metal-ion battery cathodes.

Physical chemistry chemical physics : PCCP

Godet-Bar T, Leprêtre JC, Le Bacq O, Sanchez JY, Deronzier A, Pasturel A.
PMID: 26355417
Phys Chem Chem Phys. 2015 Oct 14;17(38):25283-96. doi: 10.1039/c5cp01495f.

Different N-substituted phenothiazines have been synthesized and their electrochemical behavior has been investigated in CH3CN in order to design the best polyphenothiazine based cathodic material candidate for lithium batteries. These compounds exhibit two successive reversible one-electron oxidation processes. Ab...

The design and synthesis of an antibacterial phenothiazine-siderophore conjugate.

Beilstein journal of organic chemistry

Tarapdar A, Norris JKS, Sampson O, Mukamolova G, Hodgkinson JT.
PMID: 30410626
Beilstein J Org Chem. 2018 Oct 16;14:2646-2650. doi: 10.3762/bjoc.14.242. eCollection 2018.

Siderophore-antibiotic conjugates consist of an antibiotic covalently linked by a tether to a siderophore. Such conjugates can demonstrate enhanced uptake and internalisation to the bacterial cell resulting in significantly reduced MIC values and extended spectrum of activity. Phenothiazines are...

A double hetero[4]helicene composed of two phenothiazines: synthesis, structural properties, and cationic states.

Chemical communications (Cambridge, England)

Sakamaki D, Kumano D, Yashima E, Seki S.
PMID: 26459965
Chem Commun (Camb). 2015 Dec 18;51(97):17237-40. doi: 10.1039/c5cc07680c.

A novel double hetero[4]helicene consisting of two phenothiazines (1) has been synthesized. The racemization barrier of 1 is high enough for optical separation. We successfully obtained the single crystals of the radical cation salt of 1˙(+), whose torsion angles...

Electron-Rich Phenothiazine Congeners and Beyond: Synthesis and Electronic Properties of Isomeric Dithieno[1,4]thiazines.

Chemistry (Weinheim an der Bergstrasse, Germany)

May L, Müller TJJ.
PMID: 32017228
Chemistry. 2020 Sep 21;26(53):12111-12118. doi: 10.1002/chem.202000137. Epub 2020 Aug 31.

A series of isomeric dithieno[1,4]thiazines is accessible through an intermolecular-intramolecular Buchwald-Hartwig amination starting from dihalodithienyl sulfides. The electronic properties of dithieno[1,4]thiazine isomers differ conspicuously over a broad range depending on the thiophene-thiazine anellation: a large cathodic (340 mV) or...

Electron Transfer Reactivity of the Aqueous Iron(IV)-Oxo Complex. Outer-Sphere vs Proton-Coupled Electron Transfer.

Inorganic chemistry

Bataineh H, Pestovsky O, Bakac A.
PMID: 27320290
Inorg Chem. 2016 Jul 05;55(13):6719-24. doi: 10.1021/acs.inorgchem.6b00966. Epub 2016 Jun 18.

The kinetics of oxidation of organic and inorganic reductants by aqueous iron(IV) ions, Fe(IV)(H2O)5O(2+) (hereafter Fe(IV)aqO(2+)), are reported. The substrates examined include several water-soluble ferrocenes, hexachloroiridate(III), polypyridyl complexes M(NN)3(2+) (M = Os, Fe and Ru; NN = phenanthroline, bipyridine...

Malignant Ventricular Arrhythmias Resulting From Drug-Induced QTc Prolongation: A Retrospective Study.

Journal of clinical medicine research

De Vecchis R, Ariano C, Di Biase G, Noutsias M.
PMID: 29904445
J Clin Med Res. 2018 Jul;10(7):593-600. doi: 10.14740/jocmr3470w. Epub 2018 Jun 04.

BACKGROUND: Several drug classes (antiarrhythmics, antimicrobials, antidepressants, phenothiazines, opiates, prokinetics of digestive tract, etc.) have been related to ventricular hyperkinetic arrhythmias such as torsade de pointes (TdP). TdPs are usually heralded by an abnormal prolongation of heart rate-corrected QT...

Phenothiazines and phenoxazines: as electron transfer mediators for ferritin iron release.

Dalton transactions (Cambridge, England : 2003)

Koochana PK, Mohanty A, Subhadarshanee B, Satpati S, Naskar R, Dixit A, Behera RK.
PMID: 30778450
Dalton Trans. 2019 Mar 05;48(10):3314-3326. doi: 10.1039/c8dt04383c.

Intracellular ferritin stores iron as ferrihydrite and releases it for various cellular metabolic activities. The reductive approach, one of the possible mechanisms of iron mobilization from ferritin nanocages, requires electron transfer (ET) from reducing agent(s) to the protein encapsulated...

Recent Advances in the Medicinal Chemistry of Phenothiazines. New Anticancer and Antiprotozoal Agents.

Current medicinal chemistry

González-González A, Vazquez-Jimenez LK, Paz-González AD, Bolognesi ML, Rivera G.
PMID: 33820509
Curr Med Chem. 2021 Apr 05; doi: 10.2174/0929867328666210405120330. Epub 2021 Apr 05.

BACKGROUND: Molecules that have a phenothiazine scaffold have been considered versatile organic structures with a wide variety of biological activities: antipsychotic, anticancer, antibacterial, antifungal, antiviral, anti-inflammatory, antimalarial, and trypanocidal, among others. First discovered in the 19th century as a...

Showing 13 to 24 of 162 entries