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Showing 13 to 24 of 283 entries
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Tunable Phospholipid Nanopatterns Mediated by Cholesterol with Sub-3 nm Domain Size.

Langmuir : the ACS journal of surfaces and colloids

Lee CC, Lin CS, Tung SH.
PMID: 30735047
Langmuir. 2019 Mar 05;35(9):3383-3390. doi: 10.1021/acs.langmuir.8b03075. Epub 2019 Feb 20.

The interactions between phospholipids and cholesterol have been extensively studied in the aqueous systems because of their vital functionalities in the cell membrane. In this study, instead of the self-assembly in water, we explored the microphase-separated structures of phospholipids...

UPLC-QTOF/MS-Based Lipidomic Profiling of Liver Qi-Stagnation and Spleen-Deficiency Syndrome in Patients with Hyperlipidemia.

Evidence-based complementary and alternative medicine : eCAM

Shenghua P, Shuyu T, Kunping L, Huixia Z, Xue X, Jiao G.
PMID: 30245731
Evid Based Complement Alternat Med. 2018 Aug 30;2018:4530849. doi: 10.1155/2018/4530849. eCollection 2018.

Hyperlipidemia is a common disease caused by abnormal plasma lipid metabolism. Lipidomics is a powerful and efficient technology to study the integration of disease and syndrome of Chinese medicine. This study investigated specific changes in lipid metabolites from hyperlipidemia...

Aggregation behaviour of a single-chain, phenylene-modified bolalipid and its miscibility with classical phospholipids.

Beilstein journal of organic chemistry

Drescher S, Garamus VM, Garvey CJ, Meister A, Blume A.
PMID: 28684979
Beilstein J Org Chem. 2017 May 23;13:995-1007. doi: 10.3762/bjoc.13.99. eCollection 2017.

In the present work, we describe the synthesis of a single-chain, phenylene-modified bolalipid with two phosphocholine headgroups, PC-C18pPhC18-PC, using a Sonogashira cross-coupling reaction as a key step. The aggregation behaviour was studied as a function of temperature using transmission...

Lecithin is the key material attribute in soy bean oil affecting filamentous bioprocesses.

AMB Express

Hofer A, Herwig C, Spadiut O.
PMID: 29858922
AMB Express. 2018 Jun 01;8(1):90. doi: 10.1186/s13568-018-0625-0.

Complex raw materials are widely used as supplements in biopharmaceutical production processes due to their positive effect on biomass growth and productivity at low cost. However, their use negatively impacts process reproducibility due to high lot-to-lot variability which contradicts...

A Lipidomics Study Reveals Lipid Signatures Associated with Early Allograft Dysfunction in Living Donor Liver Transplantation.

Journal of clinical medicine

Tsai HI, Lo CJ, Zheng CW, Lee CW, Lee WC, Lin JR, Shiao MS, Cheng ML, Yu HP.
PMID: 30597989
J Clin Med. 2018 Dec 29;8(1). doi: 10.3390/jcm8010030.

Liver transplantation has become the ultimate treatment for patients with end stage liver disease. However, early allograft dysfunction (EAD) has been associated with allograft loss or mortality after transplantation. We aim to utilize a metabolomic platform to identify novel...

Collision-induced dissociation of doubly-charged barium-cationized lipids generated from liquid samples by atmospheric pressure matrix-assisted laser desorption/ionization provides structurally diagnostic product ions.

Analytical and bioanalytical chemistry

Hale OJ, Cramer R.
PMID: 29264674
Anal Bioanal Chem. 2018 Feb;410(5):1435-1444. doi: 10.1007/s00216-017-0788-6. Epub 2017 Dec 20.

Obtaining structural information for lipids such as phosphatidylcholines, in particular the location of double bonds in their fatty acid constituents, is an ongoing challenge for mass spectrometry (MS) analysis. Here, we present a novel method utilizing the doping of...

Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10.

Frontiers in cellular neuroscience

Zakrzewicz A, Richter K, Agné A, Wilker S, Siebers K, Fink B, Krasteva-Christ G, Althaus M, Padberg W, Hone AJ, McIntosh JM, Grau V.
PMID: 28725182
Front Cell Neurosci. 2017 Jul 05;11:189. doi: 10.3389/fncel.2017.00189. eCollection 2017.

Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate (ATP)-dependent release of interleukin-1β (IL-1β) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of α7, α9 and/or α10 subunits. Furthermore, we identified phosphocholine (PC) and dipalmitoylphosphatidylcholine (DPPC)...

The Systemic Alterations of Lipids, Alanine-Glucose Cycle and Inter-Organ Amino Acid Metabolism in Swine Model Confirms the Role of Liver in Early Phase of Septic Shock.

Frontiers in physiology

Ferrario M, Brunelli L, Su F, Herpain A, Pastorelli R.
PMID: 30745875
Front Physiol. 2019 Jan 28;10:11. doi: 10.3389/fphys.2019.00011. eCollection 2019.

Septic shock is a medical emergency and is one of the main causes of mortality in critically ill patients. Given the pathophysiological complexity of sepsis spectrum and progression in clinical settings, animal models become essential tools to improve patient...

Morphologically compatible mass spectrometric analysis of lipids in cytological specimens.

Journal of the American Society of Cytopathology

Olson MT, Baxi A, ElNaggar M, Umbricht C, Yergey AL, Clarke W.
PMID: 31042535
J Am Soc Cytopathol. 2016 Jan - Feb;5(1):3-8. doi: 10.1016/j.jasc.2015.10.001. Epub 2015 Oct 22.

INTRODUCTION: Modern lipid analysis requires mass spectrometric techniques, though to date these have been developed and applied primarily to histological serial sections. As such, there has been little emphasis on using mass spectrometry in such a way that the...

In situ probing changes in fatty-acyl chain length and desaturation of lipids in cancerous areas using mass spectrometry imaging.

Journal of mass spectrometry : JMS

Guo L, Lai Z, Wang Y, Li Z.
PMID: 32776652
J Mass Spectrom. 2020 Jul 11;56(4):e4621. doi: 10.1002/jms.4621. Epub 2020 Jul 11.

Aberrant changes in the expression levels and structure of lipids may shape tumor microenvironment. In this study, we have performed mass spectrometry imaging and profiling analysis of 63 tissues of five types of cancer, namely, breast, colorectal, esophageal, lung,...

Sex-Specific Relationship between the Cardiorespiratory Fitness and Plasma Metabolite Patterns in Healthy Humans-Results of the KarMeN Study.

Metabolites

Kistner S, Döring M, Krüger R, Rist MJ, Weinert CH, Bunzel D, Merz B, Radloff K, Neumann R, Härtel S, Bub A.
PMID: 34357357
Metabolites. 2021 Jul 17;11(7). doi: 10.3390/metabo11070463.

Cardiorespiratory fitness (CRF) represents a strong predictor of all-cause mortality and is strongly influenced by regular physical activity (PA). However, the biological mechanisms involved in the body's adaptation to PA remain to be fully elucidated. The aim of this...

Anti-inflammatory and anti-thrombotic properties of lipid bioactives from the entomopathogenic fungus Beauveria bassiana.

Prostaglandins & other lipid mediators

Tsoupras A, Kouvelis VN, Pappas KM, Demopoulos CA, Typas MA.
PMID: 34923152
Prostaglandins Other Lipid Mediat. 2021 Dec 16;158:106606. doi: 10.1016/j.prostaglandins.2021.106606. Epub 2021 Dec 16.

In the present work the entomopathogenic fungus B. bassiana lipids were studied against the potent pro-inflammatory and thrombotic mediators implicated in several disorders, platelet-activating factor (PAF) and thrombin. Bioactivities of lipid extracts from B. bassiana cells and culture supernatants...

Showing 13 to 24 of 283 entries