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Showing 13 to 24 of 218 entries
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Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1.

Neuropsychiatric disease and treatment

Peri A, Serio M.
PMID: 19043524
Neuropsychiatr Dis Treat. 2008 Aug;4(4):817-24. doi: 10.2147/ndt.s3637.

Experimental evidence supports a protective role of estrogen in the brain. According to the fact that Alzheimer's disease (AD) is more common in postmenopausal women, estrogen treatment has been proposed. However, there is no general consensus on the beneficial...

Selective estrogen receptor modulators.

IDrugs : the investigational drugs journal

Rotella DP.
PMID: 16096913
IDrugs. 2000 Jun;3(6):589-90.

No abstract available.

Osteoporosis: understanding key risk factors and therapeutic options.

The Physician and sportsmedicine

Beck BR, Shoemaker MR.
PMID: 20086622
Phys Sportsmed. 2000 Feb;28(2):69-84. doi: 10.3810/psm.2000.02.695.

Bone loss throughout life is a normal consequence of aging; however, some people are more predisposed to developing osteoporosis and sustaining associated fractures than others. But the risk of osteoporosis can be reduced by: (1) maximizing skeletal mass during...

Bazedoxifene: the evolving role of third-generation selective estrogen-receptor modulators in the management of postmenopausal osteoporosis.

Therapeutic advances in musculoskeletal disease

Komm BS, Chines AA.
PMID: 22870492
Ther Adv Musculoskelet Dis. 2012 Feb;4(1):21-34. doi: 10.1177/1759720X11422602.

Osteoporosis is a significant public health concern, particularly for postmenopausal women. Current treatment options may not be appropriate for all women. Selective estrogen-receptor modulators (SERMs) are a class of molecules with tissue-selective activity. Bazedoxifene is currently in clinical development...

Lasofoxifene (CP-336,156), a novel selective estrogen receptor modulator, in preclinical studies.

Journal of the American Aging Association

Ke HZ, Brown TA, Thompson DD.
PMID: 23604900
J Am Aging Assoc. 2002 Apr;25(2):87-99. doi: 10.1007/s11357-002-0007-y.

Estrogen replacement therapy is reported to reduce the incidence of vertebral fractures in postmenopausal women, however, its compliance is limited because of side effects and safety concerns. Estrogen's side effects on breast and uterine tissues leading to the potential...

Influence of Supplementary Vitamin D on Bone Mineral Density When Used in Combination with Selective Estrogen Receptor Modulators.

Journal of menopausal medicine

Liu HJ, Kim SA, Shim DJ, Jung JM, Lee EJ.
PMID: 31497579
J Menopausal Med. 2019 Aug;25(2):94-99. doi: 10.6118/jmm.19193. Epub 2019 Jul 23.

OBJECTIVES: Vitamin D is regarded as one of the major nutrients that significantly influence bone metabolism. This study aims to look at the effect of supplementary vitamin D on bone mineral density (BMD) in female osteoporosis patients.METHODS: The retrospective...

Current medical treatment of estrogen receptor-positive breast cancer.

World journal of biological chemistry

Lumachi F, Santeufemia DA, Basso SM.
PMID: 26322178
World J Biol Chem. 2015 Aug 26;6(3):231-9. doi: 10.4331/wjbc.v6.i3.231.

Approximately 80% of breast cancers (BC) are estrogen receptor (ER)-positive and thus endocrine therapy (ET) should be considered complementary to surgery in the majority of patients. The advantages of oophorectomy, adrenalectomy and hypophysectomy in women with advanced BC have...

The guiding role of bone metabolism test in osteoporosis treatment.

American journal of clinical and experimental immunology

Zhang W, Yang GJ, Wu SX, Li DQ, Xu YB, Ma CH, Wang JL, Chen WW.
PMID: 29755856
Am J Clin Exp Immunol. 2018 Apr 05;7(2):40-49. eCollection 2018.

Osteoporosis (OP) and osteoporotic fractures are becoming a serious health care issue in the world. Calcium and vitamin D are the basic treatment for osteoporosis. Nonetheless, they do not effectively reduce the incidences of fracture. Currently approved treatments for...

Lifestyle Interventions for Breast Cancer Prevention.

Current breast cancer reports

Brown JC, Ligibel JA.
PMID: 30713591
Curr Breast Cancer Rep. 2018 Sep;10(3):202-208. doi: 10.1007/s12609-018-0281-z. Epub 2018 Jul 03.

One-in-eight women in the United States will develop breast cancer in her lifetime. Despite the established efficacy of selective estrogen receptor modulators and aromatase inhibitors in reducing the risk of developing hormone receptor positive breast cancer, use of these...

The impact of different strategies to handle missing data on both precision and bias in a drug safety study: a multidatabase multinational population-based cohort study.

Clinical epidemiology

Martín-Merino E, Calderón-Larrañaga A, Hawley S, Poblador-Plou B, Llorente-García A, Petersen I, Prieto-Alhambra D.
PMID: 29892204
Clin Epidemiol. 2018 Jun 05;10:643-654. doi: 10.2147/CLEP.S154914. eCollection 2018.

BACKGROUND: Missing data are often an issue in electronic medical records (EMRs) research. However, there are many ways that people deal with missing data in drug safety studies.AIM: To compare the risk estimates resulting from different strategies for the...

Dual targeting of estrogen receptor α and estrogen-related receptor α: a novel endocrine therapy for endometrial cancer.

OncoTargets and therapy

Mao X, Dong B, Gao M, Ruan G, Huang M, Braicu EI, Sehouli J, Sun P.
PMID: 31686835
Onco Targets Ther. 2019 Aug 20;12:6757-6767. doi: 10.2147/OTT.S216146. eCollection 2019.

BACKGROUND: Endometrial cancer (EC) is a hormone dependent carcinoma that may involve complex molecular mechanisms. Endocrine therapy by blocking the estrogen and estrogen receptor α (ERα) has been effective in breast cancer, while it is still controversial in EC....

Molecular mechanisms of estrogen action in female genital tract development.

Differentiation; research in biological diversity

Alderman MH, Taylor HS.
PMID: 33707128
Differentiation. 2021 Mar-Apr;118:34-40. doi: 10.1016/j.diff.2021.01.002. Epub 2021 Feb 24.

The development of the female reproductive tract can be divided into three parts consisting of Müllerian duct organogenesis, pre-sexual maturation organ development, and post-sexual maturation hormonal regulation. In primates, Müllerian duct organogenesis proceeds in an estrogen independent fashion based...

Showing 13 to 24 of 218 entries