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Showing 13 to 24 of 1422 entries
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Bacterial production in freshwater sediments: Cell specific versus system measures.

Microbial ecology

Fallon RD, Boylen CW.
PMID: 24196254
Microb Ecol. 1990 Jan;19(1):53-62. doi: 10.1007/BF02015053.

Estimates of bacterial production based on total trichloroacetic acid (TCA)-precipitable [methyl-(3)H]thymidine incorporation and frequency of dividing cell (FDC) techniques were compared to sediment respiration rates in Lake George, New York. Bacterial growth rates based on thymidine incorporation ranged from...

Crystal structure of ammonium 3'-azido-3'-de-oxy-thymidine-5'-amino-carbonyl-phospho-nate hemi-hydrate: an anti-HIV agent.

Acta crystallographica. Section E, Structure reports online

Jasko MV, Gurskaya GV, Kukhanova MK, Bushmarinov IS.
PMID: 25484756
Acta Crystallogr Sect E Struct Rep Online. 2014 Oct 24;70:396-9. doi: 10.1107/S1600536814022405. eCollection 2014 Nov 01.

The asymmetric unit of the title compound, NH4 (+)·C11H14N6O7P(-)·0.5H2O, contains one 3'-azido-3'-de-oxy-thymidine-5'amino-carbonyl-phospho-nate (ACP-AZT) anion, half of an NH4 (+) cation lying on a twofold rotation axis and in another position, occupied with equal probabilities of 0.5, an NH4 (+)...

Different effects of selenium on cyclic AMP metabolism in hepatoma cells and normal liver cells.

Biological trace element research

Yu SY, Wang LM.
PMID: 24263364
Biol Trace Elem Res. 1983 Feb;5(1):9-16. doi: 10.1007/BF02916922.

Sodium selenite administered to normal and hepatoma (HA)-bearing mice sc (2 mg/kg) or ip (1 mg/kg) led to a significant increase in cyclic AMP (cAMP) level and a decrease in cAMP phosphodiesterase (PDE) activity in HA cells. In contrast,...

Stimulatory and inhibitory regulation of DNA synthesis during spermatogenesis: studies in Squalus acanthias.

Fish physiology and biochemistry

Piferrer F, Redding M, Dubois W, Callard G.
PMID: 24202488
Fish Physiol Biochem. 1993 Jul;11(1):293-8. doi: 10.1007/BF00004578.

Spermatogenesis is a unique developmental sequence involving multiple cell to cell interactions and several categories of regulatory molecules. In contrast to conventional mammalian models in which testicular organization is highly complex, the testis of the dogfish shark Squalus acanthias...

Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks.

Experimental and therapeutic medicine

Suzuki N, Nakagawa F, Nukatsuka M, Fukushima M.
PMID: 22977515
Exp Ther Med. 2011 May;2(3):393-397. doi: 10.3892/etm.2011.244. Epub 2011 Mar 21.

TAS-102 is an oral anticancer drug composed of trifluorothymidine (TFT) and TPI (an inhibitor of thymidine phosphorylase that strongly inhibits the biodegradation of TFT). Similar to 5-fluorouracil (5FU) and 5-fluoro-2'-deoxyuridine (FdUrd), TFT also inhibits thymidylate synthase (TS), a rate-limiting...

Superior antitumor activity of trastuzumab combined with capecitabine plus oxaliplatin in a human epidermal growth factor receptor 2-positive human gastric cancer xenograft model.

Molecular and clinical oncology

Harada S, Yanagisawa M, Kaneko S, Yorozu K, Yamamoto K, Moriya Y, Harada N.
PMID: 26623038
Mol Clin Oncol. 2015 Sep;3(5):987-994. doi: 10.3892/mco.2015.609. Epub 2015 Jul 21.

In the treatment of human epidermal growth factor receptor 2 (HER2)-positive advanced gastric or gastroesophageal junction cancer, it has been reported that the combination of trastuzumab with capecitabine plus cisplatin, or with 5-fluorouracil (5-FU) plus cisplatin, significantly increased overall...

DNA replication in soybean protoplasts and suspension-cultured cells: Comparison of exponential and fluorodeoxyuridine synchronized cultures.

Planta

Cress DE, Jackson PJ, Kadouri A, Chu YE, Lark KG.
PMID: 24408461
Planta. 1978 Jan;143(3):241-53. doi: 10.1007/BF00391994.

Cell-suspension cultures of soybean (Glycine max (L.) Merr., line SB-1) have been used to study DNA replication. Cells or protoplasts incorporate either radioactive thymidine or 5-bromodeoxyuridine (BUdR) into DNA. The DNA has been extracted as large molecules which can...

Effect of amygdalin on proliferation of rat hepatic fat-storing cells and collagen production in vitro.

World journal of gastroenterology

Xu LM, Liu C, Liu P.
PMID: 27041958
World J Gastroenterol. 1997 Jun 15;3(2):103. doi: 10.3748/wjg.v3.i2.103.

AIM: To study the anti-fibrotic mechanism of amygdalin, a component of Semen Persicae, on fat-storing cells (FSC).METHODS: Livers of normal adult rats were perfused with Pronas E and collagenase in situ. FSC were isolated by centrifugation with 11% Metrizamide....

Validation of a semiconductor next-generation sequencing assay for the clinical genetic screening of CFTR.

Molecular genetics & genomic medicine

Trujillano D, Weiss ME, Köster J, Papachristos EB, Werber M, Kandaswamy KK, Marais A, Eichler S, Creed J, Baysal E, Jaber IY, Mehaney DA, Farra C, Rolfs A.
PMID: 26436105
Mol Genet Genomic Med. 2015 Sep;3(5):396-403. doi: 10.1002/mgg3.149. Epub 2015 Apr 16.

Genetic testing for cystic fibrosis and CFTR-related disorders mostly relies on laborious molecular tools that use Sanger sequencing to scan for mutations in the CFTR gene. We have explored a more efficient genetic screening strategy based on next-generation sequencing...

EPR Study of UV-Irradiated Thymidine Microcrystals Supports Radical Intermediates in Spore Photoproduct Formation.

The journal of physical chemistry. B

Hayes EC, Jian Y, Li L, Stoll S.
PMID: 27648491
J Phys Chem B. 2016 Oct 27;120(42):10923-10931. doi: 10.1021/acs.jpcb.6b06587. Epub 2016 Oct 17.

Spore photoproduct is a thymidine dimer formed when bacterial endospore DNA is exposed to ultraviolet (UV) radiation. The mechanism of formation of this thymidine dimer has been proposed to proceed through a radical-pair intermediate. The intermediate forms when a...

An expression vector inhibits gene expression in Xenopus embryos by antisense RNA.

Roux's archives of developmental biology : the official organ of the EDBO

Schmid M, Steinbeisser H, Epperlein HH, Trendelenburg MF, Lipps HJ.
PMID: 28305852
Rouxs Arch Dev Biol. 1992 Oct;201(6):340-345. doi: 10.1007/BF00365121.

An expression vector was constructed containing the entire bovine papilloma virus (BPV-1) genome and part of the a-actin gene of Xenopus laevis cloned in the antisense orientation into the neomycin resistance gene under the control of the herpes simplex...

[Distribution of mitoses and.

Wilhelm Roux's archives of developmental biology

Egelhaaf A, Berndt P, Küthe HW.
PMID: 28304935
Wilehm Roux Arch Dev Biol. 1975 Jun;178(2):185-202. doi: 10.1007/BF00848396.

1. During the first four days after pupation the eye anlage extends by cell proliferation from a dorsocaudal differentiation center. This extension is due to a peripheral growth zone and leads to a tripling of the eye area. During...

Showing 13 to 24 of 1422 entries