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Nelfinavir Induces Cytotoxicity towards High-Grade Serous Ovarian Cancer Cells, Involving Induction of the Unfolded Protein Response, Modulation of Protein Synthesis, DNA Damage, Lysosomal Impairment, and Potentiation of Toxicity Caused by Proteasome Inhibition.

Cancers

Subeha MR, Goyeneche AA, Bustamante P, Lisio MA, Burnier JV, Telleria CM.
PMID: 35008264
Cancers (Basel). 2021 Dec 26;14(1). doi: 10.3390/cancers14010099.

High-grade serous ovarian cancer (HGSOC) is a significant cause of mortality among women worldwide. Traditional treatment consists of platinum-based therapy; however, rapid development of platinum resistance contributes to lower life expectancy, warranting newer therapies to supplement the current platinum-based...

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Subeha MR, Goyeneche AA, Bustamante P, et al. Nelfinavir Induces Cytotoxicity towards High-Grade Serous Ovarian Cancer Cells, Involving Induction of the Unfolded Protein Response, Modulation of Protein Synthesis, DNA Damage, Lysosomal Impairment, and Potentiation of Toxicity Caused by Proteasome Inhibition. Cancers (Basel). 2021;14(1)doi: 10.3390/cancers14010099.
Subeha, M. R., Goyeneche, A. A., Bustamante, P., Lisio, M. A., Burnier, J. V., & Telleria, C. M. (2021). Nelfinavir Induces Cytotoxicity towards High-Grade Serous Ovarian Cancer Cells, Involving Induction of the Unfolded Protein Response, Modulation of Protein Synthesis, DNA Damage, Lysosomal Impairment, and Potentiation of Toxicity Caused by Proteasome Inhibition. Cancers, 14(1), . https://doi.org/10.3390/cancers14010099
Subeha, Mahbuba R, et al. "Nelfinavir Induces Cytotoxicity towards High-Grade Serous Ovarian Cancer Cells, Involving Induction of the Unfolded Protein Response, Modulation of Protein Synthesis, DNA Damage, Lysosomal Impairment, and Potentiation of Toxicity Caused by Proteasome Inhibition." Cancers vol. 14,1 (2021). doi: https://doi.org/10.3390/cancers14010099
Subeha MR, Goyeneche AA, Bustamante P, Lisio MA, Burnier JV, Telleria CM. Nelfinavir Induces Cytotoxicity towards High-Grade Serous Ovarian Cancer Cells, Involving Induction of the Unfolded Protein Response, Modulation of Protein Synthesis, DNA Damage, Lysosomal Impairment, and Potentiation of Toxicity Caused by Proteasome Inhibition. Cancers (Basel). 2021 Dec 26;14(1). doi: 10.3390/cancers14010099. PMID: 35008264.
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Internal Medicine Residents' Views About Care Transitions: Results of an Educational Intervention.

Journal of medical education and curricular development

Sheikh F, Gathecha E, Arbaje AI, Christmas C.
PMID: 33786377
J Med Educ Curric Dev. 2021 Jan 20;8:2382120520988590. doi: 10.1177/2382120520988590. eCollection 2021.

PROBLEM: Suboptimal care transitions can lead to re-hospitalizations.INTERVENTION: We developed a 2-week "Transitions of Care Curriculum" to train first-year internal medicine residents to improve their knowledge and skills to deliver optimal transitional care. Our objective was to use reflective...

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Sheikh F, Gathecha E, Arbaje AI, et al. Internal Medicine Residents' Views About Care Transitions: Results of an Educational Intervention. J Med Educ Curric Dev. 2021;8:2382120520988590doi: 10.1177/2382120520988590.
Sheikh, F., Gathecha, E., Arbaje, A. I., & Christmas, C. (2021). Internal Medicine Residents' Views About Care Transitions: Results of an Educational Intervention. Journal of medical education and curricular development, 82382120520988590. https://doi.org/10.1177/2382120520988590
Sheikh, Fatima, et al. "Internal Medicine Residents' Views About Care Transitions: Results of an Educational Intervention." Journal of medical education and curricular development vol. 8 (2021): 2382120520988590. doi: https://doi.org/10.1177/2382120520988590
Sheikh F, Gathecha E, Arbaje AI, Christmas C. Internal Medicine Residents' Views About Care Transitions: Results of an Educational Intervention. J Med Educ Curric Dev. 2021 Jan 20;8:2382120520988590. doi: 10.1177/2382120520988590. eCollection 2021. PMID: 33786377; PMCID: PMC7960894.
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Skin autofluorescence is associated with higher risk of cardiovascular events in Chinese adults with type 2 diabetes: A prospective cohort study from the Hong Kong Diabetes Biobank.

Journal of diabetes and its complications

Jin Q, Lau ESH, Luk AOY, Ozaki R, Chow EYK, Cheng F, So T, Yeung T, Loo KM, Lim CKP, Kong APS, Jenkins AJ, Chan JCN, Ma RCW.
PMID: 34384706
J Diabetes Complications. 2021 Oct;35(10):108015. doi: 10.1016/j.jdiacomp.2021.108015. Epub 2021 Aug 04.

AIMS: To investigate association between skin autofluorescence (SAF) and cardiovascular events (CVE) and assess its predictive value in Chinese adults with type 2 diabetes (T2D).MATERIALS AND METHODS: SAF was measured non-invasively in 3806 Chinese adults with T2D between 2016...

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Jin Q, Lau ESH, Luk AOY, et al. Skin autofluorescence is associated with higher risk of cardiovascular events in Chinese adults with type 2 diabetes: A prospective cohort study from the Hong Kong Diabetes Biobank. J Diabetes Complications. 2021;35(10):108015doi: 10.1016/j.jdiacomp.2021.108015.
Jin, Q., Lau, E. S. H., Luk, A. O. Y., Ozaki, R., Chow, E. Y. K., Cheng, F., So, T., Yeung, T., Loo, K. M., Lim, C. K. P., Kong, A. P. S., Jenkins, A. J., Chan, J. C. N., Ma, R. C. W. (2021). Skin autofluorescence is associated with higher risk of cardiovascular events in Chinese adults with type 2 diabetes: A prospective cohort study from the Hong Kong Diabetes Biobank. Journal of diabetes and its complications, 35(10), 108015. https://doi.org/10.1016/j.jdiacomp.2021.108015
Jin, Qiao, et al. "Skin autofluorescence is associated with higher risk of cardiovascular events in Chinese adults with type 2 diabetes: A prospective cohort study from the Hong Kong Diabetes Biobank." Journal of diabetes and its complications vol. 35,10 (2021): 108015. doi: https://doi.org/10.1016/j.jdiacomp.2021.108015
Jin Q, Lau ESH, Luk AOY, Ozaki R, Chow EYK, Cheng F, So T, Yeung T, Loo KM, Lim CKP, Kong APS, Jenkins AJ, Chan JCN, Ma RCW. Skin autofluorescence is associated with higher risk of cardiovascular events in Chinese adults with type 2 diabetes: A prospective cohort study from the Hong Kong Diabetes Biobank. J Diabetes Complications. 2021 Oct;35(10):108015. doi: 10.1016/j.jdiacomp.2021.108015. Epub 2021 Aug 04. PMID: 34384706.
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[No title available]

Frontiers in oncology

Ombredane AS, Silva VRP, Andrade LR, Pinheiro WO, Simonelly M, Oliveira JV, Pinheiro AC, Gonçalves GF, Felice GJ, Garcia MP, Campos PM, Luz GVS, Joanitti GA.
PMID: 33767985
Front Oncol. 2021 Mar 09;11:612903. doi: 10.3389/fonc.2021.612903. eCollection 2021.

Breast cancer is one of the most prevalent types of malignant tumors in the world, resulting in a high incidence of death. The development of new molecules and technologies aiming to apply more effective and safer therapy strategies has...

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Ombredane AS, Silva VRP, Andrade LR, et al. . Front Oncol. 2021;11:612903doi: 10.3389/fonc.2021.612903.
Ombredane, A. S., Silva, V. R. P., Andrade, L. R., Pinheiro, W. O., Simonelly, M., Oliveira, J. V., Pinheiro, A. C., Gonçalves, G. F., Felice, G. J., Garcia, M. P., Campos, P. M., Luz, G. V. S., & Joanitti, G. A. (2021). . Frontiers in oncology, 11612903. https://doi.org/10.3389/fonc.2021.612903
Ombredane, Alicia S, et al. "." Frontiers in oncology vol. 11 (2021): 612903. doi: https://doi.org/10.3389/fonc.2021.612903
Ombredane AS, Silva VRP, Andrade LR, Pinheiro WO, Simonelly M, Oliveira JV, Pinheiro AC, Gonçalves GF, Felice GJ, Garcia MP, Campos PM, Luz GVS, Joanitti GA. . Front Oncol. 2021 Mar 09;11:612903. doi: 10.3389/fonc.2021.612903. eCollection 2021. PMID: 33767985; PMCID: PMC7986721.
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What Are Models of Care? A Systematic Search and Narrative Review to Guide Development of Care Models for Premature Ovarian Insufficiency.

Seminars in reproductive medicine

Jones AR, Tay CT, Melder A, Vincent AJ, Teede H.
PMID: 33684948
Semin Reprod Med. 2020 Sep;38(4):323-330. doi: 10.1055/s-0041-1726131. Epub 2021 Mar 08.

No specific model of care (MoC) is recommended for premature ovarian insufficiency (POI), despite awareness that POI is associated with comorbidities requiring multidisciplinary care. This article aims to explore the definitions and central components of MoC in health settings,...

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Jones AR, Tay CT, Melder A, et al. What Are Models of Care? A Systematic Search and Narrative Review to Guide Development of Care Models for Premature Ovarian Insufficiency. Semin Reprod Med. 2021;38(4):323-330doi: 10.1055/s-0041-1726131.
Jones, A. R., Tay, C. T., Melder, A., Vincent, A. J., & Teede, H. (2020). What Are Models of Care? A Systematic Search and Narrative Review to Guide Development of Care Models for Premature Ovarian Insufficiency. Seminars in reproductive medicine, 38(4), 323-330. https://doi.org/10.1055/s-0041-1726131
Jones, Alicia R, et al. "What Are Models of Care? A Systematic Search and Narrative Review to Guide Development of Care Models for Premature Ovarian Insufficiency." Seminars in reproductive medicine vol. 38,4 (2020): 323-330. doi: https://doi.org/10.1055/s-0041-1726131
Jones AR, Tay CT, Melder A, Vincent AJ, Teede H. What Are Models of Care? A Systematic Search and Narrative Review to Guide Development of Care Models for Premature Ovarian Insufficiency. Semin Reprod Med. 2020 Sep;38(4):323-330. doi: 10.1055/s-0041-1726131. Epub 2021 Mar 08. PMID: 33684948.
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Genome-Wide Survey for Microdeletions or -Duplications in 155 Patients with Lower Urinary Tract Obstructions (LUTO).

Genes

Schierbaum LM, Schneider S, Herms S, Sivalingam S, Fabian J, Reutter H, Weber S, Merz WM, Tkaczyk M, Miklaszewska M, Sikora P, Szmigielska A, Krzemien G, Zachwieja K, Szczepanska M, Taranta-Janusz K, Kroll P, Polok M, Zaniew M, Hilger AC.
PMID: 34573432
Genes (Basel). 2021 Sep 20;12(9). doi: 10.3390/genes12091449.

Lower urinary tract obstruction (LUTO) is, in most cases, caused by anatomical blockage of the bladder outlet. The most common form are posterior urethral valves (PUVs), a male-limited phenotype. Here, we surveyed the genome of 155 LUTO patients to...

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Schierbaum LM, Schneider S, Herms S, et al. Genome-Wide Survey for Microdeletions or -Duplications in 155 Patients with Lower Urinary Tract Obstructions (LUTO). Genes (Basel). 2021;12(9)doi: 10.3390/genes12091449.
Schierbaum, L. M., Schneider, S., Herms, S., Sivalingam, S., Fabian, J., Reutter, H., Weber, S., Merz, W. M., Tkaczyk, M., Miklaszewska, M., Sikora, P., Szmigielska, A., Krzemien, G., Zachwieja, K., Szczepanska, M., Taranta-Janusz, K., Kroll, P., Polok, M., Zaniew, M., & Hilger, A. C. (2021). Genome-Wide Survey for Microdeletions or -Duplications in 155 Patients with Lower Urinary Tract Obstructions (LUTO). Genes, 12(9), . https://doi.org/10.3390/genes12091449
Schierbaum, Luca M, et al. "Genome-Wide Survey for Microdeletions or -Duplications in 155 Patients with Lower Urinary Tract Obstructions (LUTO)." Genes vol. 12,9 (2021). doi: https://doi.org/10.3390/genes12091449
Schierbaum LM, Schneider S, Herms S, Sivalingam S, Fabian J, Reutter H, Weber S, Merz WM, Tkaczyk M, Miklaszewska M, Sikora P, Szmigielska A, Krzemien G, Zachwieja K, Szczepanska M, Taranta-Janusz K, Kroll P, Polok M, Zaniew M, Hilger AC. Genome-Wide Survey for Microdeletions or -Duplications in 155 Patients with Lower Urinary Tract Obstructions (LUTO). Genes (Basel). 2021 Sep 20;12(9). doi: 10.3390/genes12091449. PMID: 34573432; PMCID: PMC8468665.
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ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia.

Molecular therapy. Methods & clinical development

Ilyinskii PO, Michaud AM, Rizzo GL, Roy CJ, Leung SS, Elkins SL, Capela T, Chowdhury A, Li L, Chandler RJ, Manoli I, Andres-Mateos E, Johnston LPM, Vandenberghe LH, Venditti CP, Kishimoto TK.
PMID: 34485611
Mol Ther Methods Clin Dev. 2021 Jul 16;22:279-292. doi: 10.1016/j.omtm.2021.06.015. eCollection 2021 Sep 10.

A major barrier to adeno-associated virus (AAV) gene therapy is the inability to re-dose patients due to formation of vector-induced neutralizing antibodies (Nabs). Tolerogenic nanoparticles encapsulating rapamycin (ImmTOR) provide long-term and specific suppression of adaptive immune responses, allowing for...

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Ilyinskii PO, Michaud AM, Rizzo GL, et al. ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia. Mol Ther Methods Clin Dev. 2021;22:279-292doi: 10.1016/j.omtm.2021.06.015.
Ilyinskii, P. O., Michaud, A. M., Rizzo, G. L., Roy, C. J., Leung, S. S., Elkins, S. L., Capela, T., Chowdhury, A., Li, L., Chandler, R. J., Manoli, I., Andres-Mateos, E., Johnston, L. P. M., Vandenberghe, L. H., Venditti, C. P., & Kishimoto, T. K. (2021). ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia. Molecular therapy. Methods & clinical development, 22279-292. https://doi.org/10.1016/j.omtm.2021.06.015
Ilyinskii, Petr O, et al. "ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia." Molecular therapy. Methods & clinical development vol. 22 (2021): 279-292. doi: https://doi.org/10.1016/j.omtm.2021.06.015
Ilyinskii PO, Michaud AM, Rizzo GL, Roy CJ, Leung SS, Elkins SL, Capela T, Chowdhury A, Li L, Chandler RJ, Manoli I, Andres-Mateos E, Johnston LPM, Vandenberghe LH, Venditti CP, Kishimoto TK. ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia. Mol Ther Methods Clin Dev. 2021 Jul 16;22:279-292. doi: 10.1016/j.omtm.2021.06.015. eCollection 2021 Sep 10. PMID: 34485611; PMCID: PMC8399083.
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Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Byrne KT, Betts CB, Mick R, Sivagnanam S, Bajor DL, Laheru DA, Chiorean EG, O'Hara MH, Liudahl SM, Newcomb C, Alanio C, Ferreira AP, Park BS, Ohtani T, Huffman AP, Väyrynen SA, Dias Costa A, Kaiser JC, Lacroix AM, Redlinger C, Stern M, Nowak JA, Wherry EJ, Cheever MA, Wolpin BM, Furth EE, Jaffee EM, Coussens LM, Vonderheide RH.
PMID: 34112709
Clin Cancer Res. 2021 Aug 15;27(16):4574-4586. doi: 10.1158/1078-0432.CCR-21-1047. Epub 2021 Jun 10.

PURPOSE: CD40 activation is a novel clinical opportunity for cancer immunotherapy. Despite numerous active clinical trials with agonistic CD40 monoclonal antibodies (mAb), biological effects and treatment-related modulation of the tumor microenvironment (TME) remain poorly understood.PATIENTS AND METHODS: Here, we...

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Byrne KT, Betts CB, Mick R, et al. Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer. Clin Cancer Res. 2021;27(16):4574-4586doi: 10.1158/1078-0432.CCR-21-1047.
Byrne, K. T., Betts, C. B., Mick, R., Sivagnanam, S., Bajor, D. L., Laheru, D. A., Chiorean, E. G., O'Hara, M. H., Liudahl, S. M., Newcomb, C., Alanio, C., Ferreira, A. P., Park, B. S., Ohtani, T., Huffman, A. P., Väyrynen, S. A., Dias Costa, A., Kaiser, J. C., Lacroix, A. M., Redlinger, C., Stern, M., Nowak, J. A., Wherry, E. J., Cheever, M. A., Wolpin, B. M., Furth, E. E., Jaffee, E. M., Coussens, L. M., & Vonderheide, R. H. (2021). Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 27(16), 4574-4586. https://doi.org/10.1158/1078-0432.CCR-21-1047
Byrne, Katelyn T, et al. "Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 27,16 (2021): 4574-4586. doi: https://doi.org/10.1158/1078-0432.CCR-21-1047
Byrne KT, Betts CB, Mick R, Sivagnanam S, Bajor DL, Laheru DA, Chiorean EG, O'Hara MH, Liudahl SM, Newcomb C, Alanio C, Ferreira AP, Park BS, Ohtani T, Huffman AP, Väyrynen SA, Dias Costa A, Kaiser JC, Lacroix AM, Redlinger C, Stern M, Nowak JA, Wherry EJ, Cheever MA, Wolpin BM, Furth EE, Jaffee EM, Coussens LM, Vonderheide RH. Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer. Clin Cancer Res. 2021 Aug 15;27(16):4574-4586. doi: 10.1158/1078-0432.CCR-21-1047. Epub 2021 Jun 10. PMID: 34112709; PMCID: PMC8667686.
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Theoretical foundations and a research agenda to validate measures of intercultural effort.

Dowd AliciaC, Sawatzky Misty, Korn Randi.
UIID-AD: 1642
2011;35:17-44. doi: 10.1353/rhe.2011.0033.

The concept of "student effort" is foundational to such commonly used assessments of institutional effectiveness as the National Survey of Student Engagement (NSSE) and the Community College Survey of Student Engagement (CCSSE). However, the current measure of student effort...

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Dowd AliciaC, Sawatzky Misty, Korn Randi. Theoretical foundations and a research agenda to validate measures of intercultural effort. 2011;35:17-44doi: 10.1353/rhe.2011.0033.
Dowd, A. l. i. c. i. a. C., Sawatzky, M. i. s. t. y., & Korn, R. a. n. d. i. (2011). Theoretical foundations and a research agenda to validate measures of intercultural effort. 3517-44. https://doi.org/10.1353/rhe.2011.0033
Dowd, Alicia C, et al. "Theoretical foundations and a research agenda to validate measures of intercultural effort." vol. 35 (2011): 17-44. doi: https://doi.org/10.1353/rhe.2011.0033
Dowd AliciaC, Sawatzky Misty, Korn Randi. Theoretical foundations and a research agenda to validate measures of intercultural effort. 2011;35:17-44. doi: 10.1353/rhe.2011.0033. UIID-AD: 1642.
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Showing 1765 to 1773 of 1773 entries