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Showing 169 to 178 of 178 entries
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Salmonella "RecAmends" self-healing.

Cell host & microbe

Egan MS, Herrmann BI, Brodsky IE.
PMID: 34883061
Cell Host Microbe. 2021 Dec 08;29(12):1729-1731. doi: 10.1016/j.chom.2021.11.009.

Persistent bacteria contribute to antibiotic treatment failure, potentially fueling resistance. Persisters must survive host defenses while retaining infective capacity after antibiotic cessation. In this issue of Cell Host and Microbe, Hill et al. identify bacterial RecA as a DNA...

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling.

Proceedings of the National Academy of Sciences of the United States of America

Chen KW, Demarco B, Ramos S, Heilig R, Goris M, Grayczyk JP, Assenmacher CA, Radaelli E, Joannas LD, Henao-Mejia J, Tacchini-Cottier F, Brodsky IE, Broz P.
PMID: 34260403
Proc Natl Acad Sci U S A. 2021 Jul 13;118(28). doi: 10.1073/pnas.2101189118.

Injection of effector proteins to block host innate immune signaling is a common strategy used by many pathogenic organisms to establish an infection. For example, pathogenic

Nonfuel Antineutrino Contributions in the High Flux Isotope Reactor.

Physical review. C

Balantekin AB, Band HR, Bass CD, Bergeron DE, Berish D, Bowden NS, Brodsky JP, Bryan CD, Classen T, Conant AJ, Deichert G, Diwan MV, Dolinski MJ, Erickson A, Foust BT, Gaison JK, Galindo-Uribarri A, Gilbert CE, Hackett BT, Hans S, Hansell AB, Heeger KM, Heffron B, Jaffe DE, Ji X, Jones DC, Kyzylova O, Lane CE, Langford TJ, LaRosa J, Littlejohn BR, Lu X, Maricic J, Mendenhall MP, Milincic R, Mitchell I, Mueller PE, Mumm HP, Napolitano J, Neilson R, Nikkel JA, Norcini D, Nour S, Palomino-Gallo JL, Pushin DA, Qian X, Romero-Romero E, Rosero R, Surukuchi PT, Tyra MA, Varner RL, White C, Wilhelmi J, Woolverton A, Yeh M, Zhang A, Zhang C, Zhang X.
PMID: 33336123
Phys Rev C. 2020;101. doi: 10.1103/PhysRevC.101.054605.

Reactor neutrino experiments have seen major improvements in precision in recent years. With the experimental uncertainties becoming lower than those from theory, carefully considering all sources of

Patterns of Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 Among 1.6 Million Blood Donors: Impact of Vaccination, United States, December 2020-June 2021.

The Journal of infectious diseases

Dodd RY, Notari EP, Brodsky JP, Foster GA, Xu M, Saá P, Stramer SL.
PMID: 34626465
J Infect Dis. 2022 Jan 05;225(1):5-9. doi: 10.1093/infdis/jiab514.

From December 2020 to June 2021, 1654487 blood donors were tested for antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S1 protein, and 1028547 (62.17%) were reactive. A rapid increase in prevalence was due to vaccination. Among a...

Optimizing Robotic Hysterectomy for the Patient Who Is Morbidly Obese with a Surgical Safety Pathway.

Journal of minimally invasive gynecology

Smith MJ, Lee J, Brodsky AL, Figueroa MA, Stamm MH, Giard A, Luker N, Friedman S, Huncke T, Jain SK, Pothuri B.
PMID: 34139329
J Minim Invasive Gynecol. 2021 Dec;28(12):2052-2059.e3. doi: 10.1016/j.jmig.2021.06.005. Epub 2021 Jun 15.

STUDY OBJECTIVE: Obesity is a growing worldwide epidemic, and patients classified as obese undergoing gynecologic robotic surgery are at increased risk for surgical complications. This study aimed to evaluate the feasibility and outcomes of a surgical safety protocol known...

Improved correction of F508del-CFTR biogenesis with a folding facilitator and an inhibitor of protein ubiquitination.

Bioorganic & medicinal chemistry letters

Goeckeler-Fried JL, Aldrin Denny R, Joshi D, Hill C, Larsen MB, Chiang AN, Frizzell RA, Wipf P, Sorscher EJ, Brodsky JL.
PMID: 34246753
Bioorg Med Chem Lett. 2021 Sep 15;48:128243. doi: 10.1016/j.bmcl.2021.128243. Epub 2021 Jul 08.

A growing number of diseases are linked to the misfolding of integral membrane proteins, and many of these proteins are targeted for ubiquitin-proteasome-dependent degradation. One such substrate is a mutant form of the Cystic Fibrosis Transmembrane Conductance Regulator (F508del-CFTR)....

A defective viral genome strategy elicits broad protective immunity against respiratory viruses.

Cell

Xiao Y, Lidsky PV, Shirogane Y, Aviner R, Wu CT, Li W, Zheng W, Talbot D, Catching A, Doitsh G, Su W, Gekko CE, Nayak A, Ernst JD, Brodsky L, Brodsky E, Rousseau E, Capponi S, Bianco S, Nakamura R, Jackson PK, Frydman J, Andino R.
PMID: 34852237
Cell. 2021 Dec 09;184(25):6037-6051.e14. doi: 10.1016/j.cell.2021.11.023. Epub 2021 Nov 18.

RNA viruses generate defective viral genomes (DVGs) that can interfere with replication of the parental wild-type virus. To examine their therapeutic potential, we created a DVG by deleting the capsid-coding region of poliovirus. Strikingly, intraperitoneal or intranasal administration of...

Optimizing Robotic Hysterectomy for the Patient Who Is Morbidly Obese with a Surgical Safety Pathway.

Journal of minimally invasive gynecology

Smith MJ, Lee J, Brodsky AL, Figueroa MA, Stamm MH, Giard A, Luker N, Friedman S, Huncke T, Jain SK, Pothuri B.
PMID: 34139329
J Minim Invasive Gynecol. 2021 Dec;28(12):2052-2059.e3. doi: 10.1016/j.jmig.2021.06.005. Epub 2021 Jun 15.

STUDY OBJECTIVE: Obesity is a growing worldwide epidemic, and patients classified as obese undergoing gynecologic robotic surgery are at increased risk for surgical complications. This study aimed to evaluate the feasibility and outcomes of a surgical safety protocol known...

Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes.

The Journal of clinical endocrinology and metabolism

Rasouli N, Brodsky IG, Chatterjee R, Kim SH, Pratley RE, Staten MA, Pittas AG.
PMID: 34473295
J Clin Endocrinol Metab. 2022 Jan 01;107(1):230-240. doi: 10.1210/clinem/dgab649.

CONTEXT: Vitamin D regulates glucose homeostasis pathways, but effects of vitamin D supplementation on β-cell function remain unclear.OBJECTIVE: To investigate the effects of vitamin D3 supplementation on insulin sensitivity and β-cell function.METHODS: This is a prespecified secondary analysis of...

Where have all the midwives gone?.

The Journal of perinatal education

Brodsky PL.
PMID: 19436438
J Perinat Educ. 2008;17(4):48-51. doi: 10.1624/105812408X324912.

In past centuries, only women attended women in childbirth. Birthing women were in control, choosing who should attend them and where and how to give birth. Men were usually excluded unless they were needed for their strength and their...

Showing 169 to 178 of 178 entries