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Showing 25 to 36 of 253 entries
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Connecting copper and cancer: from transition metal signalling to metalloplasia.

Nature reviews. Cancer

Ge EJ, Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou QP, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LT, Van Aelst L, Xi D, Yuan P, Brady DC, Chang CJ.
PMID: 34764459
Nat Rev Cancer. 2021 Nov 11; doi: 10.1038/s41568-021-00417-2. Epub 2021 Nov 11.

Copper is an essential nutrient whose redox properties make it both beneficial and toxic to the cell. Recent progress in studying transition metal signalling has forged new links between researchers of different disciplines that can help translate basic research...

New classification of autoimmune neuropathies based on target antigens and involved domains of myelinated fibres.

Journal of neurology, neurosurgery, and psychiatry

Uncini A, Mathis S, Vallat JM.
PMID: 34373238
J Neurol Neurosurg Psychiatry. 2022 Jan;93(1):57-67. doi: 10.1136/jnnp-2021-326889. Epub 2021 Aug 09.

Autoimmune neuropathies are named by eponyms, by descriptive terminology or because of the presence of specific antibodies and are traditionally classified, on the basis of pathology and electrophysiology, as primary demyelinating or axonal. However, autoimmune disorders targeting specific molecules...

The complete mitochondrial genome of .

Mitochondrial DNA. Part B, Resources

Nardi F, Cucini C, Cardaioli E, Paoli F, Sabbatini Peverieri G, Roversi PF, Frati F, Carapelli A.
PMID: 34291166
Mitochondrial DNA B Resour. 2021 Jul 09;6(8):2307-2309. doi: 10.1080/23802359.2021.1948370. eCollection 2021.

The samurai wasp

Unburned Tobacco Cigarette Smoke Alters Rat Ultrastructural Lung Airways and DNA.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Vivarelli F, Canistro D, Cirillo S, Elias RJ, Granata S, Mussoni M, Burattini S, Falcieri E, Turrini E, Fimognari C, Buschini A, Lazzaretti M, Beghi S, Girotti S, Sangiorgi S, Bolelli L, Ghini S, Ferri EN, Fagiolino I, Franchi P, Lucarini M, Mercatante D, Rodriguez-Estrada MT, Lorenzini A, Marchionni S, Gabriele M, Longo V, Paolini M.
PMID: 34036368
Nicotine Tob Res. 2021 Nov 05;23(12):2127-2134. doi: 10.1093/ntr/ntab108.

INTRODUCTION: Recently, the Food and Drug Administration authorized the marketing of IQOS Tobacco Heating System as a Modified Risk Tobacco Product based on an electronic heat-not-burn technology that purports to reduce the risk.METHODS: Sprague-Dawley rats were exposed in a...

Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar.

PLoS neglected tropical diseases

Lieberman NAP, Lin MJ, Xie H, Shrestha L, Nguyen T, Huang ML, Haynes AM, Romeis E, Wang QQ, Zhang RL, Kou CX, Ciccarese G, Dal Conte I, Cusini M, Drago F, Nakayama SI, Lee K, Ohnishi M, Konda KA, Vargas SK, Eguiluz M, Caceres CF, Klausner JD, Mitjà O, Rompalo A, Mulcahy F, Hook EW, Lukehart SA, Casto AM, Roychoudhury P, DiMaio F, Giacani L, Greninger AL.
PMID: 34936652
PLoS Negl Trop Dis. 2021 Dec 22;15(12):e0010063. doi: 10.1371/journal.pntd.0010063. eCollection 2021 Dec.

In spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp. pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in significant morbidity and mortality and underscoring the urgency of developing an effective...

How I treat dysfibrinogenemia.

Blood

Casini A, de Moerloose P.
PMID: 33895794
Blood. 2021 Nov 25;138(21):2021-2030. doi: 10.1182/blood.2020010116.

Congenital dysfibrinogenemia (CD) is caused by structural changes in fibrinogen that modify its function. Diagnosis is based on discrepancy between decreased fibrinogen activity and normal fibrinogen antigen levels and is confirmed by genetic testing. CD is caused by monoallelic...

Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar.

PLoS neglected tropical diseases

Lieberman NAP, Lin MJ, Xie H, Shrestha L, Nguyen T, Huang ML, Haynes AM, Romeis E, Wang QQ, Zhang RL, Kou CX, Ciccarese G, Dal Conte I, Cusini M, Drago F, Nakayama SI, Lee K, Ohnishi M, Konda KA, Vargas SK, Eguiluz M, Caceres CF, Klausner JD, Mitjà O, Rompalo A, Mulcahy F, Hook EW, Lukehart SA, Casto AM, Roychoudhury P, DiMaio F, Giacani L, Greninger AL.
PMID: 34936652
PLoS Negl Trop Dis. 2021 Dec 22;15(12):e0010063. doi: 10.1371/journal.pntd.0010063. eCollection 2021 Dec.

In spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp. pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in significant morbidity and mortality and underscoring the urgency of developing an effective...

Microorganisms

Bulati M, Busà R, Carcione C, Iannolo G, Di Mento G, Cuscino N, Di Gesù R, Piccionello AP, Buscemi S, Carreca AP, Barbera F, Monaco F, Cardinale F, Conaldi PG, Douradinha B.
PMID: 34204279
Microorganisms. 2021 Jun 17;9(6). doi: 10.3390/microorganisms9061317.

Currently,

A ddRADseq Survey of the Genetic Diversity of Rye (.

Plants (Basel, Switzerland)

Adamo M, Blandino M, Capo L, Ravetto Enri S, Fusconi A, Lonati M, Mucciarelli M.
PMID: 34834778
Plants (Basel). 2021 Nov 09;10(11). doi: 10.3390/plants10112415.

Rye (

Fundamentals for a Systematic Approach to Mild and Moderate Inherited Bleeding Disorders: An EHA Consensus Report.

HemaSphere

Rodeghiero F, Pabinger I, Ragni M, Abdul-Kadir R, Berntorp E, Blanchette V, Bodó I, Casini A, Gresele P, Lassila R, Leebeek F, Lillicrap D, Mezzano D, Noris P, Srivastava A, Tosetto A, Windyga J, Zieger B, Makris M, Key N.
PMID: 31942541
Hemasphere. 2019 Sep 17;3(4):e286. doi: 10.1097/HS9.0000000000000286. eCollection 2019 Oct.

Healthy subjects frequently report minor bleedings that are frequently 'background noise' of normality rather than a true disorder. Nevertheless, unexpected or unusual bleeding may be alarming. Thus, the distinction between normal and pathologic bleeding is critical. Understanding the underlying...

From Inception to ConcePTION: Genesis of a Network to Support Better Monitoring and Communication of Medication Safety During Pregnancy and Breastfeeding.

Clinical pharmacology and therapeutics

Thurin NH, Pajouheshnia R, Roberto G, Dodd C, Hyeraci G, Bartolini C, Paoletti O, Nordeng H, Wallach-Kildemoes H, Ehrenstein V, Dudukina E, MacDonald T, De Paoli G, Loane M, Damase-Michel C, Beau AB, Droz-Perroteau C, Lassalle R, Bergman J, Swart K, Schink T, Cavero-Carbonell C, Barrachina-Bonet L, Gomez-Lumbreras A, Giner-Soriano M, Aragón M, Neville AJ, Puccini A, Pierini A, Ientile V, Trifirò G, Rissmann A, Leinonen MK, Martikainen V, Jordan S, Thayer D, Scanlon I, Georgiou ME, Cunnington M, Swertz M, Sturkenboom M, Gini R.
PMID: 34826340
Clin Pharmacol Ther. 2022 Jan;111(1):321-331. doi: 10.1002/cpt.2476. Epub 2021 Nov 26.

In 2019, the Innovative Medicines Initiative (IMI) funded the ConcePTION project-Building an ecosystem for better monitoring and communicating safety of medicines use in pregnancy and breastfeeding: validated and regulatory endorsed workflows for fast, optimised evidence generation-with the vision that...

Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations.

Metallomics : integrated biometal science

Pimpão C, Wragg D, Bonsignore R, Aikman B, Pedersen PA, Leoni S, Soveral G, Casini A.
PMID: 34468767
Metallomics. 2021 Sep 10;13(9). doi: 10.1093/mtomcs/mfab053.

The inhibition of glycerol permeation via human aquaporin-10 (hAQP10) by organometallic gold complexes has been studied by stopped-flow fluorescence spectroscopy, and its mechanism has been described using molecular modelling and atomistic simulations. The most effective hAQP10 inhibitors are cyclometalated...

Showing 25 to 36 of 253 entries