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Showing 25 to 36 of 171 entries
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TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.

JCI insight

de Mattos Barbosa MG, Lefferts AR, Huynh D, Liu H, Zhang Y, Fu B, Barnes J, Samaniego M, Bram RJ, Geha RS, Shikanov A, Prak ETL, Farkash EA, Platt JL, Cascalho M.
PMID: 34283811
JCI Insight. 2021 Sep 08;6(17). doi: 10.1172/jci.insight.150483.

Host genes define the severity of inflammation and immunity but specific loci doing so are unknown. Here we show that TNF receptor superfamily member 13B (TNFRSF13B) variants, which enhance defense against certain pathogens, also control immune-mediated injury of transplants,...

The Transfer of Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma.

Cancers

Faict S, Oudaert I, D'Auria L, Dehairs J, Maes K, Vlummens P, De Veirman K, De Bruyne E, Fostier K, Vande Broek I, Schots R, Vanderkerken K, Swinnen JV, Menu E.
PMID: 31756922
Cancers (Basel). 2019 Nov 20;11(12). doi: 10.3390/cancers11121823.

Multiple myeloma (MM) is well-known for the development of drug resistance, leading to relapse. Therefore, finding novel treatment strategies remains necessary. By performing a lipidomics assay on MM patient plasma, we aimed to identify new targets. We observed a...

A nano based approach to alleviate cisplatin induced nephrotoxicity.

International journal of immunopathology and pharmacology

Anees LM, Abdel-Hamid GR, Elkady AA.
PMID: 34915755
Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211066441. doi: 10.1177/20587384211066441.

BACKGROUND AND OBJECTIVE: Cisplatin, an effective drug against cancer, commonly induces nephrotoxicity; limiting its therapeutic efficacy and application. In this study, Cisplatin NanoComposite (Cis NC) was formulated successfully from irradiated chitosan coated Cisplatin and MgO nanoparticles (CHIT/Cis/MgO NPs) to...

Impact Toughness of Hybrid Carbon Fiber-PLA/ABS Laminar Composite Produced through Fused Filament Fabrication.

Polymers

Ahmed H, Hussain G, Gohar S, Ali A, Alkahtani M.
PMID: 34577956
Polymers (Basel). 2021 Sep 10;13(18). doi: 10.3390/polym13183057.

Nowadays, the components of carbon fiber-reinforced polymer composites (an important material) are directly produced with 3D printing technology, especially Fused Filament Fabrication (FFF). However, such components suffer from poor toughness. The main aim of this research is to overcome...

Therapeutic Potential of TLR8 Agonist GS-9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators.

Hepatology (Baltimore, Md.)

Amin OE, Colbeck EJ, Daffis S, Khan S, Ramakrishnan D, Pattabiraman D, Chu R, Micolochick Steuer H, Lehar S, Peiser L, Palazzo A, Frey C, Davies J, Javanbakht H, Rosenberg WMC, Fletcher SP, Maini MK, Pallett LJ.
PMID: 33368377
Hepatology. 2021 Jul;74(1):55-71. doi: 10.1002/hep.31695. Epub 2021 Jun 20.

BACKGROUND AND AIMS: GS-9688 (selgantolimod) is a toll-like receptor 8 agonist in clinical development for the treatment of chronic hepatitis B (CHB). Antiviral activity of GS-9688 has previously been evaluated in vitro in HBV-infected hepatocytes and in vivo in...

TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.

JCI insight

de Mattos Barbosa MG, Lefferts AR, Huynh D, Liu H, Zhang Y, Fu B, Barnes J, Samaniego M, Bram RJ, Geha RS, Shikanov A, Prak ETL, Farkash EA, Platt JL, Cascalho M.
PMID: 34283811
JCI Insight. 2021 Sep 08;6(17). doi: 10.1172/jci.insight.150483.

Host genes define the severity of inflammation and immunity but specific loci doing so are unknown. Here we show that TNF receptor superfamily member 13B (TNFRSF13B) variants, which enhance defense against certain pathogens, also control immune-mediated injury of transplants,...

Application of metabolomics in drug resistant breast cancer research.

Metabolites

Shajahan-Haq AN, Cheema MS, Clarke R.
PMID: 25693144
Metabolites. 2015 Feb 16;5(1):100-18. doi: 10.3390/metabo5010100.

The metabolic profiles of breast cancer cells are different from normal mammary epithelial cells. Breast cancer cells that gain resistance to therapeutic interventions can reprogram their endogenous metabolism in order to adapt and proliferate despite high oxidative stress and...

Improvement in the Prognosis of Patients With Acute Myocardial Infarction in the 1990s Compared With the Prethrombolytic Era: An Analysis by Age Subgroups.

The American journal of geriatric cardiology

Gottlieb S, Goldbourt U, Boyko V, Barbash G, Mandelzweig L, Behar S.
PMID: 11416352
Am J Geriatr Cardiol. 1995 Nov;4(6):17-31.

The number of elderly patients experiencing myocardial infarction (MI) is growing rapidly, and their hospital mortality rate remains high, although mortality after acute MI declined in the 1990s. The in-hospital and first-year mortality rates in 5,839 patients with acute...

Allergy, a disease of the internal and external environments.

Current opinion in immunology

Geha RS.
PMID: 11102762
Curr Opin Immunol. 2000 Dec;12(6):615-7. doi: 10.1016/s0952-7915(00)00152-7.

No abstract available.

Bioassay Directed Isolation, Biological Evaluation and in Silico Studies of New Isolates from .

Antioxidants (Basel, Switzerland)

Saleem F, Mehmood R, Mehar S, Khan MTJ, Khan ZU, Ashraf M, Ali MS, Abdullah I, Froeyen M, Mirza MU, Ahmad S.
PMID: 31331076
Antioxidants (Basel). 2019 Jul 19;8(7). doi: 10.3390/antiox8070231.

Members of genus

The Future Comes Early for Medical Educators.

Journal of general internal medicine

Minter DJ, Geha R, Manesh R, Dhaliwal G.
PMID: 32875502
J Gen Intern Med. 2021 May;36(5):1400-1403. doi: 10.1007/s11606-020-06128-y. Epub 2020 Sep 01.

Many experts have foretold of a digital transformation in medical education. Yet, until recently, day-to-day practices for frontline clinician-educators, who cherish close physical and intellectual contact between the patient, learner, and teacher, have remained largely unchanged. The COVID-19 pandemic...

More Is Less.

Journal of hospital medicine

Chan H, Nematollahi S, Manesh R, Geha RM, Minter DJ.
PMID: 32966193
J Hosp Med. 2021 Apr;16(4):239-243. doi: 10.12788/jhm.3488.

No abstract available.

Showing 25 to 36 of 171 entries