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Showing 169 to 178 of 178 entries
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Alcohol-related changes in behaviors and characteristics from the baseline to the randomization session for treatment and non-treatment seeking participants with alcohol use disorder.

The American journal of drug and alcohol abuse

Goodyear K, Vasaturo-Kolodner TR, Kenna GA, Swift RM, Leggio L, Haass-Koffler CL.
PMID: 34582281
Am J Drug Alcohol Abuse. 2021 Nov 02;47(6):760-768. doi: 10.1080/00952990.2021.1961799. Epub 2021 Sep 28.

BACKGROUND: Participants who are enrolled in randomized controlled trials (RCTs) may be more motivated to change their behaviors after being enrolled in a study and that motivation may vary by treatment status.OBJECTIVES: The objectives of this secondary analysis were...

Searchlight: automated bulk RNA-seq exploration and visualisation using dynamically generated R scripts.

BMC bioinformatics

Cole JJ, Faydaci BA, McGuinness D, Shaw R, Maciewicz RA, Robertson NA, Goodyear CS.
PMID: 34412594
BMC Bioinformatics. 2021 Aug 19;22(1):411. doi: 10.1186/s12859-021-04321-2.

BACKGROUND: Once bulk RNA-seq data has been processed, i.e. aligned and then expression and differential tables generated, there remains the essential process where the biology is explored, visualized and interpreted. Without the use of a visualisation and interpretation pipeline...

Participant factors that contribute to magnetic resonance imaging motion artifacts in children with mild traumatic brain injury or orthopedic injury.

Brain imaging and behavior

Ware AL, Shukla A, Guo S, Onicas A, Geeraert BL, Goodyear BG, Yeates KO, Lebel C.
PMID: 34694520
Brain Imaging Behav. 2021 Oct 25; doi: 10.1007/s11682-021-00582-w. Epub 2021 Oct 25.

Motion can compromise image quality and confound results, especially in pediatric research. This study evaluated qualitative and quantitative approaches to motion artifacts detection and correction, and whether motion artifacts relate to injury history, age, or sex in children with...

Apremilast Inhibits Inflammatory Osteoclastogenesis.

Rheumatology (Oxford, England)

Degboé Y, Sunzini F, Sood S, Bozec A, Sokolova MV, Zekovic A, McInnes IB, Schett G, Goodyear CS.
PMID: 33788924
Rheumatology (Oxford). 2021 Mar 31; doi: 10.1093/rheumatology/keab315. Epub 2021 Mar 31.

BACKGROUND: Psoriatic arthritis (PsA) is associated with bone erosion and inflammation-induced bone loss, which are mediated by osteoclasts and modulated by inflammatory cytokines. Apremilast (a selective phosphodiesterase 4 inhibitor) is efficacious in PsA and acts by inhibiting cytokine production....

Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health.

Cell metabolism

Kusuyama J, Alves-Wagner AB, Conlin RH, Makarewicz NS, Albertson BG, Prince NB, Kobayashi S, Kozuka C, Møller M, Bjerre M, Fuglsang J, Miele E, Middelbeek RJW, Xiudong Y, Xia Y, Garneau L, Bhattacharjee J, Aguer C, Patti ME, Hirshman MF, Jessen N, Hatta T, Ovesen PG, Adamo KB, Nozik-Grayck E, Goodyear LJ.
PMID: 33770509
Cell Metab. 2021 May 04;33(5):939-956.e8. doi: 10.1016/j.cmet.2021.03.004. Epub 2021 Mar 25.

Poor maternal diet increases the risk of obesity and type 2 diabetes in offspring, adding to the ever-increasing prevalence of these diseases. In contrast, we find that maternal exercise improves the metabolic health of offspring, and here, we demonstrate...

Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity.

JCI insight

Kenyon EJ, Kirkwood NK, Kitcher SR, Goodyear RJ, Derudas M, Cantillon DM, Baxendale S, de la Vega de León A, Mahieu VN, Osgood RT, Wilson CD, Bull JC, Waddell SJ, Whitfield TT, Ward SE, Kros CJ, Richardson GP.
PMID: 33735112
JCI Insight. 2021 Apr 08;6(7). doi: 10.1172/jci.insight.145704.

To identify small molecules that shield mammalian sensory hair cells from the ototoxic side effects of aminoglycoside antibiotics, 10,240 compounds were initially screened in zebrafish larvae, selecting for those that protected lateral-line hair cells against neomycin and gentamicin. When...

Long-Term Outcomes of NRG Oncology/RTOG 0529: A Phase 2 Evaluation of Dose-Painted Intensity Modulated Radiation Therapy in Combination With 5-Fluorouracil and Mitomycin-C for the Reduction of Acute Morbidity in Anal Canal Cancer.

International journal of radiation oncology, biology, physics

Kachnic LA, Winter KA, Myerson RJ, Goodyear MD, Abitbol AA, Streeter OE, Augspurger ME, Schefter TE, Katz AW, Fisher BJ, Henke LE, Narayan S, Crane CH.
PMID: 34400269
Int J Radiat Oncol Biol Phys. 2022 Jan 01;112(1):146-157. doi: 10.1016/j.ijrobp.2021.08.008. Epub 2021 Aug 14.

PURPOSE: A multi-institutional phase 2 trial assessed long-term outcomes of dose-painted intensity modulated radiation therapy (IMRT) with 5-fluorouracil (5FU) and mitomycin-C (MMC) for anal canal cancer.METHODS AND MATERIALS: T2-4N0-3M0 anal cancers received 5FU (1000 mg/mRESULTS: Of 52 patients, 54%...

Examining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: An A-CAP study.

NeuroImage. Clinical

Shukla A, Ware AL, Guo S, Goodyear B, Beauchamp MH, Zemek R, Craig W, Doan Q, Beaulieu C, Yeates KO, Lebel C.
PMID: 34911193
Neuroimage Clin. 2021;32:102887. doi: 10.1016/j.nicl.2021.102887. Epub 2021 Nov 19.

BACKGROUND: Pediatric mild traumatic brain injury (mTBI) affects millions of children annually. Diffusion tensor imaging (DTI) is sensitive to axonal injuries and white matter microstructure and has been used to characterize the brain changes associated with mild traumatic brain...

Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study.

Neurobiology of stress

Jenz ST, Goodyear CD, TSgt Graves PR, Goldstein S, Shia MR, Redei EE.
PMID: 33912629
Neurobiol Stress. 2021 Apr 09;14:100323. doi: 10.1016/j.ynstr.2021.100323. eCollection 2021 May.

In highly stressful environments, individuals with diverging stress-reactivity can perform differently. Identification of blood markers of stress-reactivity is of major significance to help human performance during stress. Candidate transcripts were identified between stressed and non-stressed strains of rats' blood...

Smart MALT: lymphoma with a superior predilection.

Orbit (Amsterdam, Netherlands)

Goodyear K, Roelofs KA, Rootman DB.
PMID: 33719902
Orbit. 2021 Mar 09;1. doi: 10.1080/01676830.2021.1888304. Epub 2021 Mar 09.

No abstract available.

Showing 169 to 178 of 178 entries