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Showing 301 to 306 of 306 entries
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A rat model to investigate quality of recovery after abdominal surgery.

Pain reports

Cata JP, Patiño M, Lacagnina MJ, Li J, Gorur A, Agudelo-Jimenez R, Wei B, Hagberg CA, Dougherty PM, Shureiqi I, Yang P, Grace PM.
PMID: 34235345
Pain Rep. 2021 Jun 30;6(2):e943. doi: 10.1097/PR9.0000000000000943. eCollection 2021.

INTRODUCTION: Major advances in therapies to optimize recovery after surgery have been limited by the lack of an animal model that can mimic major domains of postoperative sickness behavior in humans. We hypothesized that the integration of commonly impaired...

T2-Pseudonormalization and Microstructural Characterization in Advanced Stages of Late-infantile Metachromatic Leukodystrophy.

Clinical neuroradiology

Martin P, Hagberg GE, Schultz T, Harzer K, Klose U, Bender B, Nägele T, Scheffler K, Krägeloh-Mann I, Groeschel S.
PMID: 33226437
Clin Neuroradiol. 2021 Dec;31(4):969-980. doi: 10.1007/s00062-020-00975-2. Epub 2020 Nov 23.

PURPOSE: T2-weighted signal hyperintensities in white matter (WM) are a diagnostic finding in brain magnetic resonance imaging (MRI) of patients with metachromatic leukodystrophy (MLD). In our systematic investigation of the evolution of T2-hyperintensities in patients with the late-infantile form,...

Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce.

Nature medicine

Li Q, Hagberg CE, Silva Cascales H, Lang S, Hyvönen MT, Salehzadeh F, Chen P, Alexandersson I, Terezaki E, Harms MJ, Kutschke M, Arifen N, Krämer N, Aouadi M, Knibbe C, Boucher J, Thorell A, Spalding KL.
PMID: 34608330
Nat Med. 2021 Nov;27(11):1941-1953. doi: 10.1038/s41591-021-01501-8. Epub 2021 Oct 04.

Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an increase in both adipocyte progenitor differentiation and mature adipocyte cell size. Adipocytes,...

Diurnal variation in DLCO and non-standardized study procedures may cause a false positive safety signal in clinical trials.

Respiratory medicine

Kirla KT, Nemes S, Betts J, Kristensson C, Mo J, Asimus S, Sadiq MW, Redlich E, Koernicke T, Fuhr R, Brailsford W, Keen C, Hagberg A, Mäenpää J.
PMID: 34879298
Respir Med. 2021 Dec 02;191:106705. doi: 10.1016/j.rmed.2021.106705. Epub 2021 Dec 02.

Diffusing capacity for carbon monoxide (DLCO) was measured in a phase I single ascending dose study after inhalation of AZD8154 or placebo in healthy participants at baseline (DLCO

Simple holistic solution to Archie's-law puzzle in porous media.

Physical review. E

Balberg I.
PMID: 34271767
Phys Rev E. 2021 Jun;103(6):063005. doi: 10.1103/PhysRevE.103.063005.

In this paper, we account for the many critical exponents derived from the studies of the electrical conductivity in porous media by applying analysis of the well-known relation known as Archie's law. In spite of its seeming simplicity this...

Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain.

Genes & development

Zelco A, Börjesson V, de Kanter JK, Lebrero-Fernandez C, Lauschke VM, Rocha-Ferreira E, Nilsson G, Nair S, Svedin P, Bemark M, Hagberg H, Mallard C, Holstege FCP, Wang X.
PMID: 34301765
Genes Dev. 2021 Aug 01;35(15):1190-1207. doi: 10.1101/gad.348190.120. Epub 2021 Jul 22.

The meninges are important for brain development and pathology. Using single-cell RNA sequencing, we have generated the first comprehensive transcriptional atlas of neonatal mouse meningeal leukocytes under normal conditions and after perinatal brain injury. We identified almost all known...

Showing 301 to 306 of 306 entries