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Mechanism and structure based design of inhibitors of AMP and adenosine deaminase.

Bioorganic & medicinal chemistry

Lindell SD, Maechling S, Klein R, Freigang J, Laber B, Blanazs L, Leonhardt M, Haupt S, Petry T, Sabina RL.
PMID: 34157570
Bioorg Med Chem. 2021 Aug 01;43:116272. doi: 10.1016/j.bmc.2021.116272. Epub 2021 Jun 10.

Inhibitors of the enzyme adenosine monophosphate deaminase (AMPD) show interesting levels of herbicidal activity. An enzyme mechanism-based approach has been used to design new inhibitors of AMPD starting from nebularine (6) and resulting in the synthesis of 2-deoxy isonebularine...

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Lindell SD, Maechling S, Klein R, et al. Mechanism and structure based design of inhibitors of AMP and adenosine deaminase. Bioorg Med Chem. 2021;43:116272doi: 10.1016/j.bmc.2021.116272.
Lindell, S. D., Maechling, S., Klein, R., Freigang, J., Laber, B., Blanazs, L., Leonhardt, M., Haupt, S., Petry, T., & Sabina, R. L. (2021). Mechanism and structure based design of inhibitors of AMP and adenosine deaminase. Bioorganic & medicinal chemistry, 43116272. https://doi.org/10.1016/j.bmc.2021.116272
Lindell, Stephen D, et al. "Mechanism and structure based design of inhibitors of AMP and adenosine deaminase." Bioorganic & medicinal chemistry vol. 43 (2021): 116272. doi: https://doi.org/10.1016/j.bmc.2021.116272
Lindell SD, Maechling S, Klein R, Freigang J, Laber B, Blanazs L, Leonhardt M, Haupt S, Petry T, Sabina RL. Mechanism and structure based design of inhibitors of AMP and adenosine deaminase. Bioorg Med Chem. 2021 Aug 01;43:116272. doi: 10.1016/j.bmc.2021.116272. Epub 2021 Jun 10. PMID: 34157570.
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The PanCareFollowUp Care Intervention: A European harmonised approach to person-centred guideline-based survivorship care after childhood, adolescent and young adult cancer.

European journal of cancer (Oxford, England : 1990)

van Kalsbeek RJ, Mulder RL, Haupt R, Muraca M, Hjorth L, Follin C, Kepak T, Kepakova K, Uyttebroeck A, Mangelschots M, Falck Winther J, Loonen JJ, Michel G, Bardi E, Elmerdahl Frederiksen L, den Hartogh J, Mader L, Roser K, Schneider C, Brown MC, Brunhofer M, Göttgens I, Hermens RPMG, Kienesberger A, Korevaar JC, Skinner R, van der Pal HJH, Kremer LCM.
PMID: 34953441
Eur J Cancer. 2021 Dec 22;162:34-44. doi: 10.1016/j.ejca.2021.10.035. Epub 2021 Dec 22.

BACKGROUND: Long-term follow-up (LTFU) care, although endorsed, is not available for the majority of adult survivors of childhood, adolescence and young adult (CAYA) cancer. Barriers to implementation include lack of time, knowledge, personnel and funding. Sustainable solutions are urgently...

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van Kalsbeek RJ, Mulder RL, Haupt R, et al. The PanCareFollowUp Care Intervention: A European harmonised approach to person-centred guideline-based survivorship care after childhood, adolescent and young adult cancer. Eur J Cancer. 2021;162:34-44doi: 10.1016/j.ejca.2021.10.035.
van Kalsbeek, R. J., Mulder, R. L., Haupt, R., Muraca, M., Hjorth, L., Follin, C., Kepak, T., Kepakova, K., Uyttebroeck, A., Mangelschots, M., Falck Winther, J., Loonen, J. J., Michel, G., Bardi, E., Elmerdahl Frederiksen, L., den Hartogh, J., Mader, L., Roser, K., Schneider, C., Brown, M. C., Brunhofer, M., Göttgens, I., Hermens, R. P. M. G., Kienesberger, A., Korevaar, J. C., Skinner, R., van der Pal, H. J. H., & Kremer, L. C. M. (2021). The PanCareFollowUp Care Intervention: A European harmonised approach to person-centred guideline-based survivorship care after childhood, adolescent and young adult cancer. European journal of cancer (Oxford, England : 1990), 16234-44. https://doi.org/10.1016/j.ejca.2021.10.035
van Kalsbeek, Rebecca J, et al. "The PanCareFollowUp Care Intervention: A European harmonised approach to person-centred guideline-based survivorship care after childhood, adolescent and young adult cancer." European journal of cancer (Oxford, England : 1990) vol. 162 (2021): 34-44. doi: https://doi.org/10.1016/j.ejca.2021.10.035
van Kalsbeek RJ, Mulder RL, Haupt R, Muraca M, Hjorth L, Follin C, Kepak T, Kepakova K, Uyttebroeck A, Mangelschots M, Falck Winther J, Loonen JJ, Michel G, Bardi E, Elmerdahl Frederiksen L, den Hartogh J, Mader L, Roser K, Schneider C, Brown MC, Brunhofer M, Göttgens I, Hermens RPMG, Kienesberger A, Korevaar JC, Skinner R, van der Pal HJH, Kremer LCM. The PanCareFollowUp Care Intervention: A European harmonised approach to person-centred guideline-based survivorship care after childhood, adolescent and young adult cancer. Eur J Cancer. 2021 Dec 22;162:34-44. doi: 10.1016/j.ejca.2021.10.035. Epub 2021 Dec 22. PMID: 34953441.
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The lack of retropatellar resurfacing at index surgery is significantly associated with failure in patients following patellofemoral inlay arthroplasty: a multi-center study of more than 260 patients.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Imhoff AB, Bartsch E, Becher C, Behrens P, Bode G, Cotic M, Diermeier T, Falk H, Feucht MJ, Haupt U, Hinterwimmer S, Holz J, Hutter R, Kaiser R, Knoblauch T, Nebelung W, Niemeyer P, O'Donnel T, Pagenstert G, Patzer T, Rose T, Rupp MC, Tischer T, Venjakob AJ, Vogt S, Pogorzelski J.
PMID: 33811265
Knee Surg Sports Traumatol Arthrosc. 2021 Apr 02; doi: 10.1007/s00167-021-06544-5. Epub 2021 Apr 02.

PURPOSE: To evaluate the clinical outcomes of patients with a minimum 2-year follow-up following contemporary patellofemoral inlay arthroplasty (PFIA) and to identify potential risk factors for failure in a multi-center study.METHODS: All patients who underwent implantation of PFIA between...

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Imhoff AB, Bartsch E, Becher C, et al. The lack of retropatellar resurfacing at index surgery is significantly associated with failure in patients following patellofemoral inlay arthroplasty: a multi-center study of more than 260 patients. Knee Surg Sports Traumatol Arthrosc. 2021;doi: 10.1007/s00167-021-06544-5.
Imhoff, A. B., Bartsch, E., Becher, C., Behrens, P., Bode, G., Cotic, M., Diermeier, T., Falk, H., Feucht, M. J., Haupt, U., Hinterwimmer, S., Holz, J., Hutter, R., Kaiser, R., Knoblauch, T., Nebelung, W., Niemeyer, P., O'Donnel, T., Pagenstert, G., Patzer, T., Rose, T., Rupp, M. C., Tischer, T., Venjakob, A. J., Vogt, S., & Pogorzelski, J. (2021). The lack of retropatellar resurfacing at index surgery is significantly associated with failure in patients following patellofemoral inlay arthroplasty: a multi-center study of more than 260 patients. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, . https://doi.org/10.1007/s00167-021-06544-5
Imhoff, Andreas B, et al. "The lack of retropatellar resurfacing at index surgery is significantly associated with failure in patients following patellofemoral inlay arthroplasty: a multi-center study of more than 260 patients." Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA vol. (2021). doi: https://doi.org/10.1007/s00167-021-06544-5
Imhoff AB, Bartsch E, Becher C, Behrens P, Bode G, Cotic M, Diermeier T, Falk H, Feucht MJ, Haupt U, Hinterwimmer S, Holz J, Hutter R, Kaiser R, Knoblauch T, Nebelung W, Niemeyer P, O'Donnel T, Pagenstert G, Patzer T, Rose T, Rupp MC, Tischer T, Venjakob AJ, Vogt S, Pogorzelski J. The lack of retropatellar resurfacing at index surgery is significantly associated with failure in patients following patellofemoral inlay arthroplasty: a multi-center study of more than 260 patients. Knee Surg Sports Traumatol Arthrosc. 2021 Apr 02; doi: 10.1007/s00167-021-06544-5. Epub 2021 Apr 02. PMID: 33811265.
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Hemophilia Gene Therapy Value Assessment: Methodological Challenges and Recommendations.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

Garrison LP, Pezalla E, Towse A, Yang H, Faust E, Wu EQ, Li N, Sawyer EK, Recht M.
PMID: 34711363
Value Health. 2021 Nov;24(11):1628-1633. doi: 10.1016/j.jval.2021.05.008. Epub 2021 Oct 03.

Gene therapy for hemophilia is designed to produce health gains for patients over many years. Rewarding that value creation on the basis of a one-time treatment implies a large upfront cost. This cost can only be justified by long-term...

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Garrison LP, Pezalla E, Towse A, et al. Hemophilia Gene Therapy Value Assessment: Methodological Challenges and Recommendations. Value Health. 2021;24(11):1628-1633doi: 10.1016/j.jval.2021.05.008.
Garrison, L. P., Pezalla, E., Towse, A., Yang, H., Faust, E., Wu, E. Q., Li, N., Sawyer, E. K., & Recht, M. (2021). Hemophilia Gene Therapy Value Assessment: Methodological Challenges and Recommendations. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 24(11), 1628-1633. https://doi.org/10.1016/j.jval.2021.05.008
Garrison, Louis P, et al. "Hemophilia Gene Therapy Value Assessment: Methodological Challenges and Recommendations." Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research vol. 24,11 (2021): 1628-1633. doi: https://doi.org/10.1016/j.jval.2021.05.008
Garrison LP, Pezalla E, Towse A, Yang H, Faust E, Wu EQ, Li N, Sawyer EK, Recht M. Hemophilia Gene Therapy Value Assessment: Methodological Challenges and Recommendations. Value Health. 2021 Nov;24(11):1628-1633. doi: 10.1016/j.jval.2021.05.008. Epub 2021 Oct 03. PMID: 34711363.
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Van der Pauw device used to investigate the thermoelectric power factor.

The Review of scientific instruments

Haupt S, Edler F, Bartel M, Pernau HF.
PMID: 33261461
Rev Sci Instrum. 2020 Nov 01;91(11):115102. doi: 10.1063/5.0019005.

In this paper, we describe a measuring system based on the Van der Pauw principle with four calibrated type S thermocouples. By means of this system, we conducted traceable measurements of the absolute Seebeck coefficients and the electrical conductivity...

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Haupt S, Edler F, Bartel M, et al. Van der Pauw device used to investigate the thermoelectric power factor. Rev Sci Instrum. 2020;91(11):115102doi: 10.1063/5.0019005.
Haupt, S., Edler, F., Bartel, M., & Pernau, H. F. (2020). Van der Pauw device used to investigate the thermoelectric power factor. The Review of scientific instruments, 91(11), 115102. https://doi.org/10.1063/5.0019005
Haupt, Sebastian, et al. "Van der Pauw device used to investigate the thermoelectric power factor." The Review of scientific instruments vol. 91,11 (2020): 115102. doi: https://doi.org/10.1063/5.0019005
Haupt S, Edler F, Bartel M, Pernau HF. Van der Pauw device used to investigate the thermoelectric power factor. Rev Sci Instrum. 2020 Nov 01;91(11):115102. doi: 10.1063/5.0019005. PMID: 33261461.
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Showing 349 to 353 of 353 entries