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Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice.

Scientific reports

López-Pérez A, Norlin S, Steneberg P, Remeseiro S, Edlund H, Hörnblad A.
PMID: 34949756
Sci Rep. 2021 Dec 23;11(1):24410. doi: 10.1038/s41598-021-03567-3.

AMP-activated protein kinase (AMPK) has an important role in cellular energy homeostasis and has emerged as a promising target for treatment of Type 2 Diabetes (T2D) due to its beneficial effects on insulin sensitivity and glucose homeostasis. O304 is...

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López-Pérez A, Norlin S, Steneberg P, et al. Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice. Sci Rep. 2021;11(1):24410doi: 10.1038/s41598-021-03567-3.
López-Pérez, A., Norlin, S., Steneberg, P., Remeseiro, S., Edlund, H., & Hörnblad, A. (2021). Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice. Scientific reports, 11(1), 24410. https://doi.org/10.1038/s41598-021-03567-3
López-Pérez, Ana, et al. "Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice." Scientific reports vol. 11,1 (2021): 24410. doi: https://doi.org/10.1038/s41598-021-03567-3
López-Pérez A, Norlin S, Steneberg P, Remeseiro S, Edlund H, Hörnblad A. Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice. Sci Rep. 2021 Dec 23;11(1):24410. doi: 10.1038/s41598-021-03567-3. PMID: 34949756; PMCID: PMC8702551.
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Enhanced Recovery of Microbial Genes and Genomes From a Marine Water Column Using Long-Read Metagenomics.

Frontiers in microbiology

Haro-Moreno JM, López-Pérez M, Rodriguez-Valera F.
PMID: 34512586
Front Microbiol. 2021 Aug 27;12:708782. doi: 10.3389/fmicb.2021.708782. eCollection 2021.

Third-generation sequencing has penetrated little in metagenomics due to the high error rate and dependence for assembly on short-read designed bioinformatics. However, second-generation sequencing metagenomics (mostly Illumina) suffers from limitations, particularly in the assembly of microbes with high microdiversity...

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Haro-Moreno JM, López-Pérez M, Rodriguez-Valera F. Enhanced Recovery of Microbial Genes and Genomes From a Marine Water Column Using Long-Read Metagenomics. Front Microbiol. 2021;12:708782doi: 10.3389/fmicb.2021.708782.
Haro-Moreno, J. M., López-Pérez, M., & Rodriguez-Valera, F. (2021). Enhanced Recovery of Microbial Genes and Genomes From a Marine Water Column Using Long-Read Metagenomics. Frontiers in microbiology, 12708782. https://doi.org/10.3389/fmicb.2021.708782
Haro-Moreno, Jose M, et al. "Enhanced Recovery of Microbial Genes and Genomes From a Marine Water Column Using Long-Read Metagenomics." Frontiers in microbiology vol. 12 (2021): 708782. doi: https://doi.org/10.3389/fmicb.2021.708782
Haro-Moreno JM, López-Pérez M, Rodriguez-Valera F. Enhanced Recovery of Microbial Genes and Genomes From a Marine Water Column Using Long-Read Metagenomics. Front Microbiol. 2021 Aug 27;12:708782. doi: 10.3389/fmicb.2021.708782. eCollection 2021. PMID: 34512586; PMCID: PMC8430335.
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Discovery of CH.

Astronomy and astrophysics

Cernicharo J, Agúndez M, Cabezas C, Marcelino N, Tercero B, Pardo JR, Gallego JD, Tercero F, López-Pérez JA, de Vicente P.
PMID: 33833468
Astron Astrophys. 2021 Mar 10;647. doi: 10.1051/0004-6361/202140434. eCollection 2021 Mar.

We present the discovery in TMC-1 of vinyl acetylene, CH

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Cernicharo J, Agúndez M, Cabezas C, et al. Discovery of CH. Astron Astrophys. 2021;647doi: 10.1051/0004-6361/202140434.
Cernicharo, J., Agúndez, M., Cabezas, C., Marcelino, N., Tercero, B., Pardo, J. R., Gallego, J. D., Tercero, F., López-Pérez, J. A., & de Vicente, P. (2021). Discovery of CH. Astronomy and astrophysics, 647. https://doi.org/10.1051/0004-6361/202140434
Cernicharo, J, et al. "Discovery of CH." Astronomy and astrophysics vol. 647 (2021). doi: https://doi.org/10.1051/0004-6361/202140434
Cernicharo J, Agúndez M, Cabezas C, Marcelino N, Tercero B, Pardo JR, Gallego JD, Tercero F, López-Pérez JA, de Vicente P. Discovery of CH. Astron Astrophys. 2021 Mar 10;647. doi: 10.1051/0004-6361/202140434. eCollection 2021 Mar. PMID: 33833468; PMCID: PMC7610549.
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Genomic Characterization of Imipenem- and Imipenem-Relebactam-Resistant Clinical Isolates of Pseudomonas aeruginosa.

mSphere

López-Pérez M, Haro-Moreno JM, Molina-Pardines C, Ventero MP, Rodríguez JC.
PMID: 34817240
mSphere. 2021 Dec 22;6(6):e0083621. doi: 10.1128/mSphere.00836-21. Epub 2021 Nov 24.

Pseudomonas aeruginosa is an opportunistic human pathogen and a major cause of nosocomial infections. The global spread of carbapenem-resistant strains is growing rapidly and has become a major public health challenge. Imipenem-relebactam (I/R) is a novel carbapenem-beta-lactamase inhibitor combination...

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López-Pérez M, Haro-Moreno JM, Molina-Pardines C, et al. Genomic Characterization of Imipenem- and Imipenem-Relebactam-Resistant Clinical Isolates of Pseudomonas aeruginosa. mSphere. 2021;6(6):e0083621doi: 10.1128/mSphere.00836-21.
López-Pérez, M., Haro-Moreno, J. M., Molina-Pardines, C., Ventero, M. P., & Rodríguez, J. C. (2021). Genomic Characterization of Imipenem- and Imipenem-Relebactam-Resistant Clinical Isolates of Pseudomonas aeruginosa. mSphere, 6(6), e0083621. https://doi.org/10.1128/mSphere.00836-21
López-Pérez, Mario, et al. "Genomic Characterization of Imipenem- and Imipenem-Relebactam-Resistant Clinical Isolates of Pseudomonas aeruginosa." mSphere vol. 6,6 (2021): e0083621. doi: https://doi.org/10.1128/mSphere.00836-21
López-Pérez M, Haro-Moreno JM, Molina-Pardines C, Ventero MP, Rodríguez JC. Genomic Characterization of Imipenem- and Imipenem-Relebactam-Resistant Clinical Isolates of Pseudomonas aeruginosa. mSphere. 2021 Dec 22;6(6):e0083621. doi: 10.1128/mSphere.00836-21. Epub 2021 Nov 24. PMID: 34817240; PMCID: PMC8612254.
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Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons.

Animals : an open access journal from MDPI

García-Mendívil L, Mediano DR, Hernaiz A, Sanz-Rubio D, Vázquez FJ, Marín B, López-Pérez Ó, Otero A, Badiola JJ, Zaragoza P, Ordovás L, Bolea R, Martín-Burriel I.
PMID: 33921147
Animals (Basel). 2021 Apr 15;11(4). doi: 10.3390/ani11041137.

Scrapie is a prion disease affecting sheep and goats and it is considered a prototype of transmissible spongiform encephalopathies (TSEs). Mesenchymal stem cells (MSCs) have been proposed as candidates for developing in vitro models of prion diseases. Murine MSCs...

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García-Mendívil L, Mediano DR, Hernaiz A, et al. Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons. Animals (Basel). 2021;11(4)doi: 10.3390/ani11041137.
García-Mendívil, L., Mediano, D. R., Hernaiz, A., Sanz-Rubio, D., Vázquez, F. J., Marín, B., López-Pérez, �. �., Otero, A., Badiola, J. J., Zaragoza, P., Ordovás, L., Bolea, R., & Martín-Burriel, I. (2021). Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons. Animals : an open access journal from MDPI, 11(4), . https://doi.org/10.3390/ani11041137
García-Mendívil, Laura, et al. "Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons." Animals : an open access journal from MDPI vol. 11,4 (2021). doi: https://doi.org/10.3390/ani11041137
García-Mendívil L, Mediano DR, Hernaiz A, Sanz-Rubio D, Vázquez FJ, Marín B, López-Pérez Ó, Otero A, Badiola JJ, Zaragoza P, Ordovás L, Bolea R, Martín-Burriel I. Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons. Animals (Basel). 2021 Apr 15;11(4). doi: 10.3390/ani11041137. PMID: 33921147; PMCID: PMC8071557.
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Cardiac amyloidosis: Description of a series of 143 cases.

Medicina clinica

Barge-Caballero G, Barge-Caballero E, López-Pérez M, Bilbao-Quesada R, González-Babarro E, Gómez-Otero I, López-López A, Gutiérrez-Feijoo M, Varela-Román A, González-Juanatey C, Díaz-Castro Ó, Crespo-Leiro MG.
PMID: 34996625
Med Clin (Barc). 2022 Jan 04; doi: 10.1016/j.medcli.2021.10.018. Epub 2022 Jan 04.

INTRODUCTION AND OBJECTIVES: Recently, there have been important advances in the diagnosis and treatment of cardiac amyloidosis (CA). Our aim was to provide an updated description of its 2 most frequent types: the transthyretin CA (ATTR-CA) and the light...

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Barge-Caballero G, Barge-Caballero E, López-Pérez M, et al. Amiloidosis cardiaca: descripción de una serie de 143 casos. Cardiac amyloidosis: Description of a series of 143 cases. Med Clin (Barc). 2022;doi: 10.1016/j.medcli.2021.10.018.
Barge-Caballero, G., Barge-Caballero, E., López-Pérez, M., Bilbao-Quesada, R., González-Babarro, E., Gómez-Otero, I., López-López, A., Gutiérrez-Feijoo, M., Varela-Román, A., González-Juanatey, C., Díaz-Castro, �. �., & Crespo-Leiro, M. G. (2022). Amiloidosis cardiaca: descripción de una serie de 143 casos. Cardiac amyloidosis: Description of a series of 143 cases. Medicina clinica, . https://doi.org/10.1016/j.medcli.2021.10.018
Barge-Caballero, Gonzalo, et al. "Amiloidosis cardiaca: descripción de una serie de 143 casos." Cardiac amyloidosis: Description of a series of 143 cases. Medicina clinica vol. (2022). doi: https://doi.org/10.1016/j.medcli.2021.10.018
Barge-Caballero G, Barge-Caballero E, López-Pérez M, Bilbao-Quesada R, González-Babarro E, Gómez-Otero I, López-López A, Gutiérrez-Feijoo M, Varela-Román A, González-Juanatey C, Díaz-Castro Ó, Crespo-Leiro MG. Amiloidosis cardiaca: descripción de una serie de 143 casos. Cardiac amyloidosis: Description of a series of 143 cases. Med Clin (Barc). 2022 Jan 04; doi: 10.1016/j.medcli.2021.10.018. Epub 2022 Jan 04. Spanish. PMID: 34996625.
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The Resistome and Mobilome of Multidrug-Resistant Staphylococcus sciuri C2865 Unveil a Transferable Trimethoprim Resistance Gene, Designated .

mSystems

Gómez-Sanz E, Haro-Moreno JM, Jensen SO, Roda-García JJ, López-Pérez M.
PMID: 34374564
mSystems. 2021 Aug 31;6(4):e0051121. doi: 10.1128/mSystems.00511-21. Epub 2021 Aug 10.

Methicillin-resistant Staphylococcus sciuri (MRSS) strain C2865 from a stranded dog in Nigeria was trimethoprim (TMP) resistant but lacked formerly described staphylococcal TMP-resistant dihydrofolate reductase genes (

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Gómez-Sanz E, Haro-Moreno JM, Jensen SO, et al. The Resistome and Mobilome of Multidrug-Resistant Staphylococcus sciuri C2865 Unveil a Transferable Trimethoprim Resistance Gene, Designated . mSystems. 2021;6(4):e0051121doi: 10.1128/mSystems.00511-21.
Gómez-Sanz, E., Haro-Moreno, J. M., Jensen, S. O., Roda-García, J. J., & López-Pérez, M. (2021). The Resistome and Mobilome of Multidrug-Resistant Staphylococcus sciuri C2865 Unveil a Transferable Trimethoprim Resistance Gene, Designated . mSystems, 6(4), e0051121. https://doi.org/10.1128/mSystems.00511-21
Gómez-Sanz, Elena, et al. "The Resistome and Mobilome of Multidrug-Resistant Staphylococcus sciuri C2865 Unveil a Transferable Trimethoprim Resistance Gene, Designated ." mSystems vol. 6,4 (2021): e0051121. doi: https://doi.org/10.1128/mSystems.00511-21
Gómez-Sanz E, Haro-Moreno JM, Jensen SO, Roda-García JJ, López-Pérez M. The Resistome and Mobilome of Multidrug-Resistant Staphylococcus sciuri C2865 Unveil a Transferable Trimethoprim Resistance Gene, Designated . mSystems. 2021 Aug 31;6(4):e0051121. doi: 10.1128/mSystems.00511-21. Epub 2021 Aug 10. PMID: 34374564; PMCID: PMC8407400.
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An MRPS12 mutation modifies aminoglycoside sensitivity caused by 12S rRNA mutations.

Frontiers in genetics

Emperador S, Pacheu-Grau D, Bayona-Bafaluy MP, Garrido-Pérez N, Martín-Navarro A, López-Pérez MJ, Montoya J, Ruiz-Pesini E.
PMID: 25642242
Front Genet. 2015 Jan 14;5:469. doi: 10.3389/fgene.2014.00469. eCollection 2014.

Several homoplasmic pathologic mutations in mitochondrial DNA, such as those causing Leber hereditary optic neuropathy or non-syndromic hearing loss, show incomplete penetrance. Therefore, other elements must modify their pathogenicity. Discovery of these modifying factors is not an easy task...

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Emperador S, Pacheu-Grau D, Bayona-Bafaluy MP, et al. An MRPS12 mutation modifies aminoglycoside sensitivity caused by 12S rRNA mutations. Front Genet. 2015;5:469doi: 10.3389/fgene.2014.00469.
Emperador, S., Pacheu-Grau, D., Bayona-Bafaluy, M. P., Garrido-Pérez, N., Martín-Navarro, A., López-Pérez, M. J., Montoya, J., & Ruiz-Pesini, E. (2014). An MRPS12 mutation modifies aminoglycoside sensitivity caused by 12S rRNA mutations. Frontiers in genetics, 5469. https://doi.org/10.3389/fgene.2014.00469
Emperador, Sonia, et al. "An MRPS12 mutation modifies aminoglycoside sensitivity caused by 12S rRNA mutations." Frontiers in genetics vol. 5 (2014): 469. doi: https://doi.org/10.3389/fgene.2014.00469
Emperador S, Pacheu-Grau D, Bayona-Bafaluy MP, Garrido-Pérez N, Martín-Navarro A, López-Pérez MJ, Montoya J, Ruiz-Pesini E. An MRPS12 mutation modifies aminoglycoside sensitivity caused by 12S rRNA mutations. Front Genet. 2015 Jan 14;5:469. doi: 10.3389/fgene.2014.00469. eCollection 2014. PMID: 25642242; PMCID: PMC4294204.
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Tunable 2D-gallium arsenide and graphene bandgaps in a graphene/GaAs heterostructure: an ab initio study.

Journal of physics. Condensed matter : an Institute of Physics journal

González-García A, López-Pérez W, González-Hernández R, Rodríguez JA, Milośević MV, Peeters FM.
PMID: 30840939
J Phys Condens Matter. 2019 Jul 03;31(26):265502. doi: 10.1088/1361-648X/ab0d70. Epub 2019 Mar 06.

The bandgap behavior of 2D-GaAs and graphene have been investigated with van der Waals heterostructured into a yet unexplored graphene/GaAs bilayer, under both uniaxial stress along c axis and different planar strain distributions. The 2D-GaAs bandgap nature changes from...

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González-García A, López-Pérez W, González-Hernández R, et al. Tunable 2D-gallium arsenide and graphene bandgaps in a graphene/GaAs heterostructure: an ab initio study. J Phys Condens Matter. 2019;31(26):265502doi: 10.1088/1361-648X/ab0d70.
González-García, A., López-Pérez, W., González-Hernández, R., Rodríguez, J. A., Milośević, M. V., & Peeters, F. M. (2019). Tunable 2D-gallium arsenide and graphene bandgaps in a graphene/GaAs heterostructure: an ab initio study. Journal of physics. Condensed matter : an Institute of Physics journal, 31(26), 265502. https://doi.org/10.1088/1361-648X/ab0d70
González-García, A, et al. "Tunable 2D-gallium arsenide and graphene bandgaps in a graphene/GaAs heterostructure: an ab initio study." Journal of physics. Condensed matter : an Institute of Physics journal vol. 31,26 (2019): 265502. doi: https://doi.org/10.1088/1361-648X/ab0d70
González-García A, López-Pérez W, González-Hernández R, Rodríguez JA, Milośević MV, Peeters FM. Tunable 2D-gallium arsenide and graphene bandgaps in a graphene/GaAs heterostructure: an ab initio study. J Phys Condens Matter. 2019 Jul 03;31(26):265502. doi: 10.1088/1361-648X/ab0d70. Epub 2019 Mar 06. PMID: 30840939.
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Ischemic strokes and foreign body in left atrium.

Revista clinica espanola

Redondo-Orts M, Serrano-Martínez JL, López-Pérez M, Conde-Baena P.
PMID: 26454614
Rev Clin Esp (Barc). 2016 Mar;216(2):108-9. doi: 10.1016/j.rce.2015.08.004. Epub 2015 Oct 09.

No abstract available.

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Redondo-Orts M, Serrano-Martínez JL, López-Pérez M, et al. Ischemic strokes and foreign body in left atrium. Rev Clin Esp (Barc). 2015;216(2):108-9doi: 10.1016/j.rce.2015.08.004.
Redondo-Orts, M., Serrano-Martínez, J. L., López-Pérez, M., & Conde-Baena, P. (2016). Ischemic strokes and foreign body in left atrium. Revista clinica espanola, 216(2), 108-9. https://doi.org/10.1016/j.rce.2015.08.004
Redondo-Orts, M, et al. "Ischemic strokes and foreign body in left atrium." Revista clinica espanola vol. 216,2 (2016): 108-9. doi: https://doi.org/10.1016/j.rce.2015.08.004
Redondo-Orts M, Serrano-Martínez JL, López-Pérez M, Conde-Baena P. Ischemic strokes and foreign body in left atrium. Rev Clin Esp (Barc). 2016 Mar;216(2):108-9. doi: 10.1016/j.rce.2015.08.004. Epub 2015 Oct 09. Spanish. PMID: 26454614.
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Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis.

The ISME journal

Sonnenschein EC, Nielsen KF, D'Alvise P, Porsby CH, Melchiorsen J, Heilmann J, Kalatzis PG, López-Pérez M, Bunk B, Spröer C, Middelboe M, Gram L.
PMID: 28117449
ISME J. 2017 Feb;11(2):588. doi: 10.1038/ismej.2016.125.

No abstract available.

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Sonnenschein EC, Nielsen KF, D'Alvise P, et al. Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis. ISME J. 2017;11(2):588doi: 10.1038/ismej.2016.125.
Sonnenschein, E. C., Nielsen, K. F., D'Alvise, P., Porsby, C. H., Melchiorsen, J., Heilmann, J., Kalatzis, P. G., López-Pérez, M., Bunk, B., Spröer, C., Middelboe, M., & Gram, L. (2017). Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis. The ISME journal, 11(2), 588. https://doi.org/10.1038/ismej.2016.125
Sonnenschein, Eva C, et al. "Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis." The ISME journal vol. 11,2 (2017): 588. doi: https://doi.org/10.1038/ismej.2016.125
Sonnenschein EC, Nielsen KF, D'Alvise P, Porsby CH, Melchiorsen J, Heilmann J, Kalatzis PG, López-Pérez M, Bunk B, Spröer C, Middelboe M, Gram L. Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis. ISME J. 2017 Feb;11(2):588. doi: 10.1038/ismej.2016.125. PMID: 28117449; PMCID: PMC5270566.
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Synthetic approaches to multifunctional indenes.

Beilstein journal of organic chemistry

Mesquida N, López-Pérez S, Dinarès I, Alcalde E.
PMID: 22238553
Beilstein J Org Chem. 2011;7:1739-44. doi: 10.3762/bjoc.7.204. Epub 2011 Dec 29.

The synthesis of multifunctional indenes with at least two different functional groups has not yet been extensively explored. Among the plausible synthetic routes to 3,5-disubstituted indenes bearing two different functional groups, such as the [3-(aminoethyl)inden-5-yl)]amines, a reasonable pathway involves...

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Mesquida N, López-Pérez S, Dinarès I, et al. Synthetic approaches to multifunctional indenes. Beilstein J Org Chem. 2011;7:1739-44doi: 10.3762/bjoc.7.204.
Mesquida, N., López-Pérez, S., Dinarès, I., & Alcalde, E. (2011). Synthetic approaches to multifunctional indenes. Beilstein journal of organic chemistry, 71739-44. https://doi.org/10.3762/bjoc.7.204
Mesquida, Neus, et al. "Synthetic approaches to multifunctional indenes." Beilstein journal of organic chemistry vol. 7 (2011): 1739-44. doi: https://doi.org/10.3762/bjoc.7.204
Mesquida N, López-Pérez S, Dinarès I, Alcalde E. Synthetic approaches to multifunctional indenes. Beilstein J Org Chem. 2011;7:1739-44. doi: 10.3762/bjoc.7.204. Epub 2011 Dec 29. PMID: 22238553; PMCID: PMC3252879.
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