Oncotarget

Martin-Castillo B, Pernas S, Dorca J, Álvarez I, Martínez S, Pérez-Garcia JM, Batista-López N, Rodríguez-Sánchez CA, Amillano K, Domínguez S, Luque M, Stradella A, Morilla I, Viñas G, Cortés J, Cuyàs E, Verdura S, Fernández-Ochoa Á, Fernández-Arroyo S, Segura-Carretero A, Joven J, Pérez E, Bosch N, Garcia M, López-Bonet E, Saidani S, Buxó M, Menendez JA.
PMID: 30479698
Oncotarget. 2018 Nov 02;9(86):35687-35704. doi: 10.18632/oncotarget.26286. eCollection 2018 Nov 02.

The METTEN study assessed the efficacy, tolerability, and safety of adding metformin to neoadjuvant chemotherapy plus trastuzumab in early HER2-positive breast cancer (BC). Women with primary, non-metastatic HER2-positive BC were randomized (1:1) to receive metformin (850 mg twice-daily) for...

Cancer immunology research

Cabo M, Santana-Hernández S, Costa-Garcia M, Rea A, Lozano-Rodríguez R, Ataya M, Balaguer F, Juan M, Ochoa MC, Menéndez S, Comerma L, Rovira A, Berraondo P, Albanell J, Melero I, López-Botet M, Muntasell A.
PMID: 34580116
Cancer Immunol Res. 2021 Dec;9(12):1476-1490. doi: 10.1158/2326-6066.CIR-21-0030. Epub 2021 Sep 27.

Enhancing natural killer (NK) cell-based cancer immunotherapy by overcoming immunosuppression is an area of intensive research. Here, we have demonstrated that the anti-CD137 agonist urelumab can overcome TGFβ-mediated inhibition of human NK-cell proliferation and antitumor function. Transcriptomic, immunophenotypic, and...

Animals : an open access journal from MDPI

Benítez R, Núñez Y, Ayuso M, Isabel B, Fernández-Barroso MA, De Mercado E, Gómez-Izquierdo E, García-Casco JM, López-Bote C, Óvilo C.
PMID: 34944282
Animals (Basel). 2021 Dec 08;11(12). doi: 10.3390/ani11123505.

This experiment was conducted to investigate the effects of developmental stage, breed, and diet energy source on the genome-wide expression, meat quality traits, and tissue composition of

Methods (San Diego, Calif.)

Lopez-Botet M, Chambers WH.
PMID: 8812688
Methods. 1996 Apr;9(2):352-61. doi: 10.1006/meth.1996.0040.

Recognition of target cells by natural killer (NK) cells has been investigated using numerous approaches, but to date a clear understanding of the way(s) in which these effector cells interact with susceptible and nonsusceptible target cells or normal cells...

International journal of surgical pathology

Ortiz MR, Garijo G, Adrados M, López-Bonet E, Acero D, Bernadó L.
PMID: 11494016
Int J Surg Pathol. 2000 Oct;8(4):347-351. doi: 10.1177/106689690000800418.

We report the case of a 19-year-old woman who presented with a hepatic mass without cirrhosis. Light microscopy revealed a cholangiocarcinoma having both well-differentiated adenocarcinoma and lymphoepithelioma-like undifferentiated carcinoma components. By immunohistochemistry, the tumor showed strong and diffuse expression...

Meat science

Cava R, Ruiz J, López-Bote C, Martín L, García C, Ventanas J, Antequera T.
PMID: 22061308
Meat Sci. 1997 Feb;45(2):263-70. doi: 10.1016/s0309-1740(96)00102-7.

Thirty Iberian × Duroc pigs allotted in groups of ten animals were fed in three traditional different management systems ('Montanera' (MO), fed on acorns; 'Recebo' (RE), fed on acorns and a commercial diet; and 'Cebo' (CE), fed on a...

Oncology letters

Alonso-Ruano M, López-Bonet E, Huerta-Anaya MV, Vila-Camps E, Bernadó L, Tuca-Rodríguez F, Suarez-Pumariega P, Menendez JA.
PMID: 23419985
Oncol Lett. 2013 Feb;5(2):459-462. doi: 10.3892/ol.2012.1044. Epub 2012 Nov 23.

Neuroendocrine tumors (NETs) are frequently associated with second primary malignancies (SPMs). Earlier studies have demonstrated that NETs are highly associated with synchronous or metachronous gastrointestinal and genitourinary SPMs. We report, for the first time, a case of pure NE...

Frontiers in immunology

López-Botet M, Vilches C, Redondo-Pachón D, Muntasell A, Pupuleku A, Yélamos J, Pascual J, Crespo M.
PMID: 28261220
Front Immunol. 2017 Feb 16;8:166. doi: 10.3389/fimmu.2017.00166. eCollection 2017.

Allograft rejection constitutes a major complication of solid organ transplantation requiring prophylactic/therapeutic immunosuppression, which increases susceptibility of patients to infections and cancer. Beyond the pivotal role of alloantigen-specific T cells and antibodies in the pathogenesis of rejection, natural killer...

Immunity & ageing : I & A

Solana R, Tarazona R, Aiello AE, Akbar AN, Appay V, Beswick M, Bosch JA, Campos C, Cantisán S, Cicin-Sain L, Derhovanessian E, Ferrando-Martínez S, Frasca D, Fulöp T, Govind S, Grubeck-Loebenstein B, Hill A, Hurme M, Kern F, Larbi A, López-Botet M, Maier AB, McElhaney JE, Moss P, Naumova E, Nikolich-Zugich J, Pera A, Rector JL, Riddell N, Sanchez-Correa B, Sansoni P, Sauce D, van Lier R, Wang GC, Wills MR, Zieliński M, Pawelec G.
PMID: 23114110
Immun Ageing. 2012 Oct 31;9(1):23. doi: 10.1186/1742-4933-9-23.

Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or...

Oncoimmunology

Hardy-Werbin M, Arpí O, Taus A, Rocha P, Joseph-Pietras D, Nolan L, Danson S, Griffiths R, Lopez-Botet M, Rovira A, Albanell J, Ottensmeier CH, Arriola E.
PMID: 29308329
Oncoimmunology. 2017 Nov 27;7(2):e1395125. doi: 10.1080/2162402X.2017.1395125. eCollection 2018.

Small-cell lung cancer (SCLC) is often associated with paraneoplastic syndromes. To assess the role of anti-neuronal autoantibodies (NAAs) as biomarkers of treatment outcome, we assessed NAAs in serial samples from SCLC patients treated with chemoimmunotherapy compared to chemotherapy alone....

Meat science

Soto E, Hoz L, Ordóñez JA, Hierro E, Herranz B, López-Bote C, Cambero MI.
PMID: 22063028
Meat Sci. 2008 Aug;79(4):666-76. doi: 10.1016/j.meatsci.2007.10.031. Epub 2007 Nov 05.

The effect of growing pigs on free-range (FR) or in confinement with three different diets [acorn (A), acorn and grass (A-G) and formulated diet (FD)] on composition, volatile profile and sensory characteristics of dry-cured loin was studied. The FR,...

International journal of environmental research and public health

Sanvisens A, Puigdemont M, Rubió-Casadevall J, Vidal-Vila A, López-Bonet E, Martín-Romero F, Marcos-Gragera R.
PMID: 34948878
Int J Environ Res Public Health. 2021 Dec 16;18(24). doi: 10.3390/ijerph182413269.

INTRODUCTION: The recent COVID-19 pandemic has compromised socio-health care, with consequences for the diagnosis and follow-up of other pathologies. The aim of this study was to evaluate the impact of COVID-19 on cancer diagnosis in Girona, Spain.METHODOLOGY: Observational study...