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Bacterial lipopolysaccharide induces a dose-dependent activation of neuroglia and loss of basal forebrain cholinergic cells in the rat brain.

Inflammation and cell signaling

Houdek HM, Larson J, Watt JA, Rosenberger TA.
PMID: 26052539
Inflamm Cell Signal. 2014;1(1). doi: 10.14800/ics.47.

In a rat model of neuroinflammation induced with a low-dose infusion lipopolysaccharide (5.0 ng/hr, LPS), we reported that brain arachidonic acid (ARA, 20:4

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Houdek HM, Larson J, Watt JA, et al. Bacterial lipopolysaccharide induces a dose-dependent activation of neuroglia and loss of basal forebrain cholinergic cells in the rat brain. Inflamm Cell Signal. 2014;1(1)doi: 10.14800/ics.47.
Houdek, H. M., Larson, J., Watt, J. A., & Rosenberger, T. A. (2014). Bacterial lipopolysaccharide induces a dose-dependent activation of neuroglia and loss of basal forebrain cholinergic cells in the rat brain. Inflammation and cell signaling, 1(1), . https://doi.org/10.14800/ics.47
Houdek, Heidi M, et al. "Bacterial lipopolysaccharide induces a dose-dependent activation of neuroglia and loss of basal forebrain cholinergic cells in the rat brain." Inflammation and cell signaling vol. 1,1 (2014). doi: https://doi.org/10.14800/ics.47
Houdek HM, Larson J, Watt JA, Rosenberger TA. Bacterial lipopolysaccharide induces a dose-dependent activation of neuroglia and loss of basal forebrain cholinergic cells in the rat brain. Inflamm Cell Signal. 2014;1(1). doi: 10.14800/ics.47. PMID: 26052539; PMCID: PMC4457330.
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Pressure/temperature fluid cell apparatus for the neutron powder diffractometer instrument: probing atomic structure in situ.

The Review of scientific instruments

Wang HW, Fanelli VR, Reiche HM, Larson E, Taylor MA, Xu H, Zhu J, Siewenie J, Page K.
PMID: 25554335
Rev Sci Instrum. 2014 Dec;85(12):125116. doi: 10.1063/1.4902838.

This contribution describes a new local structure compatible gas/liquid cell apparatus for probing disordered materials at high pressures and variable temperatures in the Neutron Powder Diffraction instrument at the Lujan Neutron Scattering Center, Los Alamos National Laboratory. The new...

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Wang HW, Fanelli VR, Reiche HM, et al. Pressure/temperature fluid cell apparatus for the neutron powder diffractometer instrument: probing atomic structure in situ. Rev Sci Instrum. 2014;85(12):125116doi: 10.1063/1.4902838.
Wang, H. W., Fanelli, V. R., Reiche, H. M., Larson, E., Taylor, M. A., Xu, H., Zhu, J., Siewenie, J., & Page, K. (2014). Pressure/temperature fluid cell apparatus for the neutron powder diffractometer instrument: probing atomic structure in situ. The Review of scientific instruments, 85(12), 125116. https://doi.org/10.1063/1.4902838
Wang, Hsiu-Wen, et al. "Pressure/temperature fluid cell apparatus for the neutron powder diffractometer instrument: probing atomic structure in situ." The Review of scientific instruments vol. 85,12 (2014): 125116. doi: https://doi.org/10.1063/1.4902838
Wang HW, Fanelli VR, Reiche HM, Larson E, Taylor MA, Xu H, Zhu J, Siewenie J, Page K. Pressure/temperature fluid cell apparatus for the neutron powder diffractometer instrument: probing atomic structure in situ. Rev Sci Instrum. 2014 Dec;85(12):125116. doi: 10.1063/1.4902838. PMID: 25554335.
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Sites of instability in the human TCF3 (E2A) gene adopt G-quadruplex DNA structures in vitro.

Frontiers in genetics

Williams JD, Fleetwood S, Berroyer A, Kim N, Larson ED.
PMID: 26029241
Front Genet. 2015 May 11;6:177. doi: 10.3389/fgene.2015.00177. eCollection 2015.

The formation of highly stable four-stranded DNA, called G-quadruplex (G4), promotes site-specific genome instability. G4 DNA structures fold from repetitive guanine sequences, and increasing experimental evidence connects G4 sequence motifs with specific gene rearrangements. The human transcription factor 3...

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Williams JD, Fleetwood S, Berroyer A, et al. Sites of instability in the human TCF3 (E2A) gene adopt G-quadruplex DNA structures in vitro. Front Genet. 2015;6:177doi: 10.3389/fgene.2015.00177.
Williams, J. D., Fleetwood, S., Berroyer, A., Kim, N., & Larson, E. D. (2015). Sites of instability in the human TCF3 (E2A) gene adopt G-quadruplex DNA structures in vitro. Frontiers in genetics, 6177. https://doi.org/10.3389/fgene.2015.00177
Williams, Jonathan D, et al. "Sites of instability in the human TCF3 (E2A) gene adopt G-quadruplex DNA structures in vitro." Frontiers in genetics vol. 6 (2015): 177. doi: https://doi.org/10.3389/fgene.2015.00177
Williams JD, Fleetwood S, Berroyer A, Kim N, Larson ED. Sites of instability in the human TCF3 (E2A) gene adopt G-quadruplex DNA structures in vitro. Front Genet. 2015 May 11;6:177. doi: 10.3389/fgene.2015.00177. eCollection 2015. PMID: 26029241; PMCID: PMC4426816.
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Education as a Complex System.

Systems research and behavioral science

Ghaffarzadegan N, Larson R, Hawley J.
PMID: 28522920
Syst Res Behav Sci. 2017 May-Jun;34(3):211-215. doi: 10.1002/sres.2405. Epub 2016 Jun 20.

No abstract available.

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Ghaffarzadegan N, Larson R, Hawley J. Education as a Complex System. Syst Res Behav Sci. 2016;34(3):211-215doi: 10.1002/sres.2405.
Ghaffarzadegan, N., Larson, R., & Hawley, J. (2017). Education as a Complex System. Systems research and behavioral science, 34(3), 211-215. https://doi.org/10.1002/sres.2405
Ghaffarzadegan, Navid, et al. "Education as a Complex System." Systems research and behavioral science vol. 34,3 (2017): 211-215. doi: https://doi.org/10.1002/sres.2405
Ghaffarzadegan N, Larson R, Hawley J. Education as a Complex System. Syst Res Behav Sci. 2017 May-Jun;34(3):211-215. doi: 10.1002/sres.2405. Epub 2016 Jun 20. PMID: 28522920; PMCID: PMC5431082.
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Childhood maltreatment and inflammation among pregnant women with gestational diabetes mellitus: A pilot study.

Obstetric medicine

Bublitz M, De La Monte S, Martin S, Larson L, Bourjeily G.
PMID: 29051779
Obstet Med. 2017 Sep;10(3):120-124. doi: 10.1177/1753495X17701320. Epub 2017 May 10.

BACKGROUND: Women with childhood maltreatment histories are at increased risk for adverse birth outcomes. Mechanisms explaining this link are poorly understood. Past research is limited by sampling pregnant women at low risk for adverse maternal and neonatal outcomes.METHODS: This...

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Bublitz M, De La Monte S, Martin S, et al. Childhood maltreatment and inflammation among pregnant women with gestational diabetes mellitus: A pilot study. Obstet Med. 2017;10(3):120-124doi: 10.1177/1753495X17701320.
Bublitz, M., De La Monte, S., Martin, S., Larson, L., & Bourjeily, G. (2017). Childhood maltreatment and inflammation among pregnant women with gestational diabetes mellitus: A pilot study. Obstetric medicine, 10(3), 120-124. https://doi.org/10.1177/1753495X17701320
Bublitz, Margaret, et al. "Childhood maltreatment and inflammation among pregnant women with gestational diabetes mellitus: A pilot study." Obstetric medicine vol. 10,3 (2017): 120-124. doi: https://doi.org/10.1177/1753495X17701320
Bublitz M, De La Monte S, Martin S, Larson L, Bourjeily G. Childhood maltreatment and inflammation among pregnant women with gestational diabetes mellitus: A pilot study. Obstet Med. 2017 Sep;10(3):120-124. doi: 10.1177/1753495X17701320. Epub 2017 May 10. PMID: 29051779; PMCID: PMC5637996.
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Alzheimer's disease genetic risk variants beyond .

Alzheimer's & dementia (Amsterdam, Netherlands)

Mez J, Marden JR, Mukherjee S, Walter S, Gibbons LE, Gross AL, Zahodne LB, Gilsanz P, Brewster P, Nho K, Crane PK, Larson EB, Glymour MM.
PMID: 28983503
Alzheimers Dement (Amst). 2017 Aug 14;8:188-195. doi: 10.1016/j.dadm.2017.07.002. eCollection 2017.

INTRODUCTION: We hypothesized that, like apolipoprotein E (METHODS: We used a weighted genetic risk score (GRS) from 21 non-RESULTS: Higher GRS predicted mortality (hazard ratio = 1.05; 95% confidence interval: 1.00-1.10, DISCUSSION: Non-

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Mez J, Marden JR, Mukherjee S, et al. Alzheimer's disease genetic risk variants beyond . Alzheimers Dement (Amst). 2017;8:188-195doi: 10.1016/j.dadm.2017.07.002.
Mez, J., Marden, J. R., Mukherjee, S., Walter, S., Gibbons, L. E., Gross, A. L., Zahodne, L. B., Gilsanz, P., Brewster, P., Nho, K., Crane, P. K., Larson, E. B., & Glymour, M. M. (2017). Alzheimer's disease genetic risk variants beyond . Alzheimer's & dementia (Amsterdam, Netherlands), 8188-195. https://doi.org/10.1016/j.dadm.2017.07.002
Mez, Jesse, et al. "Alzheimer's disease genetic risk variants beyond ." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 8 (2017): 188-195. doi: https://doi.org/10.1016/j.dadm.2017.07.002
Mez J, Marden JR, Mukherjee S, Walter S, Gibbons LE, Gross AL, Zahodne LB, Gilsanz P, Brewster P, Nho K, Crane PK, Larson EB, Glymour MM. Alzheimer's disease genetic risk variants beyond . Alzheimers Dement (Amst). 2017 Aug 14;8:188-195. doi: 10.1016/j.dadm.2017.07.002. eCollection 2017. PMID: 28983503; PMCID: PMC5604953.
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Microsatellites for Oenothera gayleana and O. hartwegii subsp. filifolia (Onagraceae), and their utility in section Calylophus.

Applications in plant sciences

Lewis EM, Fant JB, Moore MJ, Hastings AP, Larson EL, Agrawal AA, Skogen KA.
PMID: 26949578
Appl Plant Sci. 2016 Feb 09;4(2). doi: 10.3732/apps.1500107. eCollection 2016 Feb.

PREMISE OF THE STUDY: Eleven nuclear and four plastid microsatellite markers were screened for two gypsum endemic species, Oenothera gayleana and O. hartwegii subsp. filifolia, and tested for cross-amplification in the remaining 11 taxa within Oenothera sect. Calylophus (Onagraceae).METHODS...

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Lewis EM, Fant JB, Moore MJ, et al. Microsatellites for Oenothera gayleana and O. hartwegii subsp. filifolia (Onagraceae), and their utility in section Calylophus. Appl Plant Sci. 2016;4(2)doi: 10.3732/apps.1500107.
Lewis, E. M., Fant, J. B., Moore, M. J., Hastings, A. P., Larson, E. L., Agrawal, A. A., & Skogen, K. A. (2016). Microsatellites for Oenothera gayleana and O. hartwegii subsp. filifolia (Onagraceae), and their utility in section Calylophus. Applications in plant sciences, 4(2), . https://doi.org/10.3732/apps.1500107
Lewis, Emily M, et al. "Microsatellites for Oenothera gayleana and O. hartwegii subsp. filifolia (Onagraceae), and their utility in section Calylophus." Applications in plant sciences vol. 4,2 (2016). doi: https://doi.org/10.3732/apps.1500107
Lewis EM, Fant JB, Moore MJ, Hastings AP, Larson EL, Agrawal AA, Skogen KA. Microsatellites for Oenothera gayleana and O. hartwegii subsp. filifolia (Onagraceae), and their utility in section Calylophus. Appl Plant Sci. 2016 Feb 09;4(2). doi: 10.3732/apps.1500107. eCollection 2016 Feb. PMID: 26949578; PMCID: PMC4760750.
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THE EVOLUTION OF DIAPAUSE IN THE KILLIFISH FAMILY RIVULIDAE (ATHERINOMORPHA, CYPRINODONTIFORMES): A MOLECULAR PHYLOGENETIC AND BIOGEOGRAPHIC PERSPECTIVE.

Evolution; international journal of organic evolution

Hrbek T, Larson A.
PMID: 28565541
Evolution. 1999 Aug;53(4):1200-1216. doi: 10.1111/j.1558-5646.1999.tb04533.x.

Phylogenetic relationships within the family Rivulidae (order Cyprinodontiformes) are investigated using 1972 aligned base pairs of mitochondrial DNA (mtDNA) for samples representing 66 species. Genes analyzed include those encoding the 12S ribosomal RNA; transfer RNAs for valine, glutamine, methionine,...

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Hrbek T, Larson A. THE EVOLUTION OF DIAPAUSE IN THE KILLIFISH FAMILY RIVULIDAE (ATHERINOMORPHA, CYPRINODONTIFORMES): A MOLECULAR PHYLOGENETIC AND BIOGEOGRAPHIC PERSPECTIVE. Evolution. 1999;53(4):1200-1216doi: 10.1111/j.1558-5646.1999.tb04533.x.
Hrbek, T., & Larson, A. (1999). THE EVOLUTION OF DIAPAUSE IN THE KILLIFISH FAMILY RIVULIDAE (ATHERINOMORPHA, CYPRINODONTIFORMES): A MOLECULAR PHYLOGENETIC AND BIOGEOGRAPHIC PERSPECTIVE. Evolution; international journal of organic evolution, 53(4), 1200-1216. https://doi.org/10.1111/j.1558-5646.1999.tb04533.x
Hrbek, Tomas, and Larson, Allan. "THE EVOLUTION OF DIAPAUSE IN THE KILLIFISH FAMILY RIVULIDAE (ATHERINOMORPHA, CYPRINODONTIFORMES): A MOLECULAR PHYLOGENETIC AND BIOGEOGRAPHIC PERSPECTIVE." Evolution; international journal of organic evolution vol. 53,4 (1999): 1200-1216. doi: https://doi.org/10.1111/j.1558-5646.1999.tb04533.x
Hrbek T, Larson A. THE EVOLUTION OF DIAPAUSE IN THE KILLIFISH FAMILY RIVULIDAE (ATHERINOMORPHA, CYPRINODONTIFORMES): A MOLECULAR PHYLOGENETIC AND BIOGEOGRAPHIC PERSPECTIVE. Evolution. 1999 Aug;53(4):1200-1216. doi: 10.1111/j.1558-5646.1999.tb04533.x. PMID: 28565541.
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Self-reported race and ethnicity of US biobank participants compared to the US Census.

Journal of community genetics

Cohn EG, Hamilton N, Larson EL, Williams JK.
PMID: 28623623
J Community Genet. 2017 Jul;8(3):229-238. doi: 10.1007/s12687-017-0308-6. Epub 2017 Jun 16.

Precision medicine envisions a future of effective diagnosis, treatment, and prevention grounded in precise understandings of the genetic and environmental determinants of disease. Given that the original genome-wide association studies represented a predominately European White population, and that diversity...

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Cohn EG, Hamilton N, Larson EL, et al. Self-reported race and ethnicity of US biobank participants compared to the US Census. J Community Genet. 2017;8(3):229-238doi: 10.1007/s12687-017-0308-6.
Cohn, E. G., Hamilton, N., Larson, E. L., & Williams, J. K. (2017). Self-reported race and ethnicity of US biobank participants compared to the US Census. Journal of community genetics, 8(3), 229-238. https://doi.org/10.1007/s12687-017-0308-6
Cohn, Elizabeth Gross, et al. "Self-reported race and ethnicity of US biobank participants compared to the US Census." Journal of community genetics vol. 8,3 (2017): 229-238. doi: https://doi.org/10.1007/s12687-017-0308-6
Cohn EG, Hamilton N, Larson EL, Williams JK. Self-reported race and ethnicity of US biobank participants compared to the US Census. J Community Genet. 2017 Jul;8(3):229-238. doi: 10.1007/s12687-017-0308-6. Epub 2017 Jun 16. PMID: 28623623; PMCID: PMC5496846.
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MAVEN observations of the response of Mars to an interplanetary coronal mass ejection.

Science (New York, N.Y.)

Jakosky BM, Grebowsky JM, Luhmann JG, Connerney J, Eparvier F, Ergun R, Halekas J, Larson D, Mahaffy P, McFadden J, Mitchell DF, Schneider N, Zurek R, Bougher S, Brain D, Ma YJ, Mazelle C, Andersson L, Andrews D, Baird D, Baker D, Bell JM, Benna M, Chaffin M, Chamberlin P, Chaufray YY, Clarke J, Collinson G, Combi M, Crary F, Cravens T, Crismani M, Curry S, Curtis D, Deighan J, Delory G, Dewey R, DiBraccio G, Dong C, Dong Y, Dunn P, Elrod M, England S, Eriksson A, Espley J, Evans S, Fang X, Fillingim M, Fortier K, Fowler CM, Fox J, Gröller H, Guzewich S, Hara T, Harada Y, Holsclaw G, Jain SK, Jolitz R, Leblanc F, Lee CO, Lee Y, Lefevre F, Lillis R, Livi R, Lo D, Mayyasi M, McClintock W, McEnulty T, Modolo R, Montmessin F, Morooka M, Nagy A, Olsen K, Peterson W, Rahmati A, Ruhunusiri S, Russell CT, Sakai S, Sauvaud JA, Seki K, Steckiewicz M, Stevens M, Stewart AI, Stiepen A, Stone S, Tenishev V, Thiemann E, Tolson R, Toublanc D, Vogt M, Weber T, Withers P, Woods T, Yelle R.
PMID: 26542576
Science. 2015 Nov 06;350(6261):aad0210. doi: 10.1126/science.aad0210.

Coupling between the lower and upper atmosphere, combined with loss of gas from the upper atmosphere to space, likely contributed to the thin, cold, dry atmosphere of modern Mars. To help understand ongoing ion loss to space, the Mars...

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Jakosky BM, Grebowsky JM, Luhmann JG, et al. MAVEN observations of the response of Mars to an interplanetary coronal mass ejection. Science. 2015;350(6261):aad0210doi: 10.1126/science.aad0210.
Jakosky, B. M., Grebowsky, J. M., Luhmann, J. G., Connerney, J., Eparvier, F., Ergun, R., Halekas, J., Larson, D., Mahaffy, P., McFadden, J., Mitchell, D. F., Schneider, N., Zurek, R., Bougher, S., Brain, D., Ma, Y. J., Mazelle, C., Andersson, L., Andrews, D., Baird, D., Baker, D., Bell, J. M., Benna, M., Chaffin, M., Chamberlin, P., Chaufray, Y. Y., Clarke, J., Collinson, G., Combi, M., Crary, F., Cravens, T., Crismani, M., Curry, S., Curtis, D., Deighan, J., Delory, G., Dewey, R., DiBraccio, G., Dong, C., Dong, Y., Dunn, P., Elrod, M., England, S., Eriksson, A., Espley, J., Evans, S., Fang, X., Fillingim, M., Fortier, K., Fowler, C. M., Fox, J., Gröller, H., Guzewich, S., Hara, T., Harada, Y., Holsclaw, G., Jain, S. K., Jolitz, R., Leblanc, F., Lee, C. O., Lee, Y., Lefevre, F., Lillis, R., Livi, R., Lo, D., Mayyasi, M., McClintock, W., McEnulty, T., Modolo, R., Montmessin, F., Morooka, M., Nagy, A., Olsen, K., Peterson, W., Rahmati, A., Ruhunusiri, S., Russell, C. T., Sakai, S., Sauvaud, J. A., Seki, K., Steckiewicz, M., Stevens, M., Stewart, A. I., Stiepen, A., Stone, S., Tenishev, V., Thiemann, E., Tolson, R., Toublanc, D., Vogt, M., Weber, T., Withers, P., Woods, T., & Yelle, R. (2015). MAVEN observations of the response of Mars to an interplanetary coronal mass ejection. Science (New York, N.Y.), 350(6261), aad0210. https://doi.org/10.1126/science.aad0210
Jakosky, B M, et al. "MAVEN observations of the response of Mars to an interplanetary coronal mass ejection." Science (New York, N.Y.) vol. 350,6261 (2015): aad0210. doi: https://doi.org/10.1126/science.aad0210
Jakosky BM, Grebowsky JM, Luhmann JG, Connerney J, Eparvier F, Ergun R, Halekas J, Larson D, Mahaffy P, McFadden J, Mitchell DF, Schneider N, Zurek R, Bougher S, Brain D, Ma YJ, Mazelle C, Andersson L, Andrews D, Baird D, Baker D, Bell JM, Benna M, Chaffin M, Chamberlin P, Chaufray YY, Clarke J, Collinson G, Combi M, Crary F, Cravens T, Crismani M, Curry S, Curtis D, Deighan J, Delory G, Dewey R, DiBraccio G, Dong C, Dong Y, Dunn P, Elrod M, England S, Eriksson A, Espley J, Evans S, Fang X, Fillingim M, Fortier K, Fowler CM, Fox J, Gröller H, Guzewich S, Hara T, Harada Y, Holsclaw G, Jain SK, Jolitz R, Leblanc F, Lee CO, Lee Y, Lefevre F, Lillis R, Livi R, Lo D, Mayyasi M, McClintock W, McEnulty T, Modolo R, Montmessin F, Morooka M, Nagy A, Olsen K, Peterson W, Rahmati A, Ruhunusiri S, Russell CT, Sakai S, Sauvaud JA, Seki K, Steckiewicz M, Stevens M, Stewart AI, Stiepen A, Stone S, Tenishev V, Thiemann E, Tolson R, Toublanc D, Vogt M, Weber T, Withers P, Woods T, Yelle R. MAVEN observations of the response of Mars to an interplanetary coronal mass ejection. Science. 2015 Nov 06;350(6261):aad0210. doi: 10.1126/science.aad0210. PMID: 26542576.
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Statistical competencies for medical research learners: What is fundamental?.

Journal of clinical and translational science

Enders FT, Lindsell CJ, Welty LJ, Benn EKT, Perkins SM, Mayo MS, Rahbar MH, Kidwell KM, Thurston SW, Spratt H, Grambow SC, Larson J, Carter RE, Pollock BH, Oster RA.
PMID: 29082029
J Clin Transl Sci. 2017 Jun;1(3):146-152. doi: 10.1017/cts.2016.31. Epub 2017 May 09.

INTRODUCTION: It is increasingly essential for medical researchers to be literate in statistics, but the requisite degree of literacy is not the same for every statistical competency in translational research. Statistical competency can range from 'fundamental' (necessary for all)...

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Enders FT, Lindsell CJ, Welty LJ, et al. Statistical competencies for medical research learners: What is fundamental?. J Clin Transl Sci. 2017;1(3):146-152doi: 10.1017/cts.2016.31.
Enders, F. T., Lindsell, C. J., Welty, L. J., Benn, E. K. T., Perkins, S. M., Mayo, M. S., Rahbar, M. H., Kidwell, K. M., Thurston, S. W., Spratt, H., Grambow, S. C., Larson, J., Carter, R. E., Pollock, B. H., & Oster, R. A. (2017). Statistical competencies for medical research learners: What is fundamental?. Journal of clinical and translational science, 1(3), 146-152. https://doi.org/10.1017/cts.2016.31
Enders, Felicity T, et al. "Statistical competencies for medical research learners: What is fundamental?." Journal of clinical and translational science vol. 1,3 (2017): 146-152. doi: https://doi.org/10.1017/cts.2016.31
Enders FT, Lindsell CJ, Welty LJ, Benn EKT, Perkins SM, Mayo MS, Rahbar MH, Kidwell KM, Thurston SW, Spratt H, Grambow SC, Larson J, Carter RE, Pollock BH, Oster RA. Statistical competencies for medical research learners: What is fundamental?. J Clin Transl Sci. 2017 Jun;1(3):146-152. doi: 10.1017/cts.2016.31. Epub 2017 May 09. PMID: 29082029; PMCID: PMC5647667.
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Building a family network from genetic testing.

Molecular genetics & genomic medicine

Leppig KA, Thiese HA, Carrel D, Crosslin DR, Dorschner MO, Gordon AS, Hartzler A, Ralston J, Scrol A, Larson EB, Jarvik GP.
PMID: 28361098
Mol Genet Genomic Med. 2016 Dec 29;5(2):122-129. doi: 10.1002/mgg3.259. eCollection 2017 Mar.

BACKGROUND: Genetic testing has multigenerational and familial repercussions. However, the "trickle-down effect" of providing genetic counseling and testing to family members at risk after an initial identification of a pathogenic variant in a medically actionable gene has been poorly...

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Leppig KA, Thiese HA, Carrel D, et al. Building a family network from genetic testing. Mol Genet Genomic Med. 2016;5(2):122-129doi: 10.1002/mgg3.259.
Leppig, K. A., Thiese, H. A., Carrel, D., Crosslin, D. R., Dorschner, M. O., Gordon, A. S., Hartzler, A., Ralston, J., Scrol, A., Larson, E. B., & Jarvik, G. P. (2017). Building a family network from genetic testing. Molecular genetics & genomic medicine, 5(2), 122-129. https://doi.org/10.1002/mgg3.259
Leppig, Kathleen A, et al. "Building a family network from genetic testing." Molecular genetics & genomic medicine vol. 5,2 (2017): 122-129. doi: https://doi.org/10.1002/mgg3.259
Leppig KA, Thiese HA, Carrel D, Crosslin DR, Dorschner MO, Gordon AS, Hartzler A, Ralston J, Scrol A, Larson EB, Jarvik GP. Building a family network from genetic testing. Mol Genet Genomic Med. 2016 Dec 29;5(2):122-129. doi: 10.1002/mgg3.259. eCollection 2017 Mar. PMID: 28361098; PMCID: PMC5370219.
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