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Showing 13 to 24 of 179 entries
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Three-Cornered Hat and Groslambert Covariance: A First Attempt to Assess the Uncertainty Domains.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control

Vernotte F, Lantz E.
PMID: 30596574
IEEE Trans Ultrason Ferroelectr Freq Control. 2019 Mar;66(3):643-653. doi: 10.1109/TUFFC.2018.2889703. Epub 2018 Dec 25.

The three-cornered hat method and the Groslambert covariance are very often used to estimate the frequency stability of each individual oscillator in a set of three oscillators by comparing them in pairs. However, no rigorous method to assess the...

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways.

Frontiers in pharmacology

Miner K, Labitzke K, Liu B, Wang P, Henckels K, Gaida K, Elliott R, Chen JJ, Liu L, Leith A, Trueblood E, Hensley K, Xia XZ, Homann O, Bennett B, Fiorino M, Whoriskey J, Yu G, Escobar S, Wong M, Born TL, Budelsky A, Comeau M, Smith D, Phillips J, Johnston JA, McGivern JG, Weikl K, Powers D, Kunzelmann K, Mohn D, Hochheimer A, Sullivan JK.
PMID: 30837866
Front Pharmacol. 2019 Feb 14;10:51. doi: 10.3389/fphar.2019.00051. eCollection 2019.

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. Antagonists of the Ca

Complication avoidance protocols in endoscopic pituitary adenoma surgery: a retrospective cohort study in 514 patients.

Pituitary

Thakur JD, Corlin A, Mallari RJ, Yawitz S, Eisenberg A, Sivakumar W, Griffiths C, Carrau RL, Rettinger S, Cohan P, Krauss H, Araque KA, Barkhoudarian G, Kelly DF.
PMID: 34215990
Pituitary. 2021 Dec;24(6):930-942. doi: 10.1007/s11102-021-01167-y. Epub 2021 Jul 02.

PURPOSE: To evaluate the impact of using consistent complication-avoidance protocols in patients undergoing endoscopic pituitary adenoma surgery including techniques for avoiding anosmia, epistaxis, carotid artery injury, hypopituitarism, cerebrospinal fluid leaks and meningitis.METHODS: All patients undergoing endoscopic adenoma resection from...

Regulation of ubiquitin and ubiquitin-like modifiers by phosphorylation.

The FEBS journal

Hepowit NL, Kolbe CC, Zelle SR, Latz E, MacGurn JA.
PMID: 34214249
FEBS J. 2021 Jul 02; doi: 10.1111/febs.16101. Epub 2021 Jul 02.

The regulatory influence of ubiquitin is vast, encompassing all cellular processes, by virtue of its central roles in protein degradation, membrane trafficking, and cell signaling. But how does ubiquitin, a 76 amino acid peptide, carry out such diverse, complex...

Fenofibrate Mitigates Hypertriglyceridemia in Nonalcoholic Steatohepatitis Patients Treated With Cilofexor/Firsocostat.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Lawitz EJ, Bhandari BR, Ruane PJ, Kohli A, Harting E, Ding D, Chuang JC, Huss RS, Chung C, Myers RP, Loomba R.
PMID: 34999207
Clin Gastroenterol Hepatol. 2022 Jan 06; doi: 10.1016/j.cgh.2021.12.044. Epub 2022 Jan 06.

BACKGROUND & AIMS: Patients with advanced fibrosis due to nonalcoholic steatohepatitis (NASH) are at high risk of morbidity and mortality. We previously found that a combination of the farnesoid X receptor agonist cilofexor (CILO) and the acetyl-CoA carboxylase (ACC)...

Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses.

Journal of extracellular vesicles

Budden CF, Gearing LJ, Kaiser R, Standke L, Hertzog PJ, Latz E.
PMID: 34377374
J Extracell Vesicles. 2021 Aug;10(10):e12127. doi: 10.1002/jev2.12127. Epub 2021 Aug 02.

Infectious organisms and damage of cells can activate inflammasomes, which mediate tissue inflammation and adaptive immunity. These mechanisms evolved to curb the spread of microbes and to induce repair of the damaged tissue. Chronic activation of inflammasomes, however, contributes...

BMS-986263 in patients with advanced hepatic fibrosis: 36-week results from a randomized, placebo-controlled phase 2 trial.

Hepatology (Baltimore, Md.)

Lawitz EJ, Shevell DE, Tirucherai GS, Du S, Chen W, Kavita U, Coste A, Poordad F, Karsdal M, Nielsen M, Goodman Z, Charles ED.
PMID: 34605045
Hepatology. 2021 Oct 04; doi: 10.1002/hep.32181. Epub 2021 Oct 04.

BACKGROUND AND AIMS: Hepatic fibrosis secondary to HCV infection can lead to cirrhosis and hepatic decompensation. Sustained virologic response (SVR) is possible with direct-acting antiviral drug regimens; however, patients with advanced fibrosis have an increased risk for HCC. Heat...

TeamSTEPPS Curricular-Wide Integration: Baccalaureate Nursing Students' Knowledge, Attitudes, and Perceptions.

Nurse educator

Ross JG, Latz E, Meakim CH, Mariani B.
PMID: 33767080
Nurse Educ. 2021 Nov-Dec 01;46(6):355-360. doi: 10.1097/NNE.0000000000000999.

BACKGROUND: To promote safe patient care, nurses must work collaboratively with members of the interprofessional health care team.PURPOSE: The purposes of this study were to explore the effect of a curricular-wide integration of TeamSTEPPS training on baccalaureate nursing students'...

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death.

Cellular & molecular immunology

Bertheloot D, Latz E, Franklin BS.
PMID: 33785842
Cell Mol Immunol. 2021 May;18(5):1106-1121. doi: 10.1038/s41423-020-00630-3. Epub 2021 Mar 30.

Cell death is a fundamental physiological process in all living organisms. Its roles extend from embryonic development, organ maintenance, and aging to the coordination of immune responses and autoimmunity. In recent years, our understanding of the mechanisms orchestrating cellular...

The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis.

Trends in molecular medicine

Verberk SGS, Kuiper KL, Lauterbach MA, Latz E, Van den Bossche J.
PMID: 34635427
Trends Mol Med. 2021 Dec;27(12):1095-1105. doi: 10.1016/j.molmed.2021.09.004. Epub 2021 Oct 08.

ATP-citrate lyase (Acly) is the target of the new class low-density lipoprotein-cholesterol (LDL-C)-lowering drug bempedoic acid (BA). Acly is a key metabolic enzyme synthesizing acetyl-CoA as the building block of cholesterol and fatty acids. Treatment with BA lowers circulating...

Treatment of 120 adult osteosarcoma patients with metachronous and synchronous metastases: A retrospective series of the French Sarcoma Group.

International journal of cancer

Lavit E, Aldea M, Piperno-Neumann S, Firmin N, Italiano A, Isambert N, Kurtz JE, Delcambre C, Lebrun V, Soibinet-Oudot P, Chevreau C, Bompas E, Le Maignan C, Boudou-Rouquette P, Le Cesne A, Mancini J, Blay JY, Duffaud F.
PMID: 34562271
Int J Cancer. 2021 Sep 25; doi: 10.1002/ijc.33823. Epub 2021 Sep 25.

Treatment options for metastatic osteosarcomas are scarce. Following failure of standard first line therapy, patients who relapse present a challenging treatment dilemma, and have a poor prognosis. Surgical removal of all metastases is essential. A retrospective analysis of patients...

Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes.

Nature immunology

Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG.
PMID: 34017127
Nat Immunol. 2021 Jul;22(7):928. doi: 10.1038/s41590-021-00960-y.

No abstract available.

Showing 13 to 24 of 179 entries