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Showing 13 to 24 of 183 entries
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Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer.

Cancers

Legras A, Pécuchet N, Imbeaud S, Pallier K, Didelot A, Roussel H, Gibault L, Fabre E, Le Pimpec-Barthes F, Laurent-Puig P, Blons H.
PMID: 28771186
Cancers (Basel). 2017 Aug 03;9(8). doi: 10.3390/cancers9080101.

Despite major advances, non-small cell lung cancer (NSCLC) remains the major cause of cancer-related death in developed countries. Metastasis and drug resistance are the main factors contributing to relapse and death. Epithelial-to-mesenchymal transition (EMT) is a complex molecular and...

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Legras A, Pécuchet N, Imbeaud S, et al. Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer. Cancers (Basel). 2017;9(8)doi: 10.3390/cancers9080101.
Legras, A., Pécuchet, N., Imbeaud, S., Pallier, K., Didelot, A., Roussel, H., Gibault, L., Fabre, E., Le Pimpec-Barthes, F., Laurent-Puig, P., & Blons, H. (2017). Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer. Cancers, 9(8), . https://doi.org/10.3390/cancers9080101
Legras, Antoine, et al. "Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer." Cancers vol. 9,8 (2017). doi: https://doi.org/10.3390/cancers9080101
Legras A, Pécuchet N, Imbeaud S, Pallier K, Didelot A, Roussel H, Gibault L, Fabre E, Le Pimpec-Barthes F, Laurent-Puig P, Blons H. Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer. Cancers (Basel). 2017 Aug 03;9(8). doi: 10.3390/cancers9080101. PMID: 28771186; PMCID: PMC5575604.
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Stationary Rossby waves dominate subduction of anthropogenic carbon in the Southern Ocean.

Scientific reports

Langlais CE, Lenton A, Matear R, Monselesan D, Legresy B, Cougnon E, Rintoul S.
PMID: 29213120
Sci Rep. 2017 Dec 06;7(1):17076. doi: 10.1038/s41598-017-17292-3.

The Southern Ocean has taken up more than 40% of the total anthropogenic carbon (C

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Langlais CE, Lenton A, Matear R, et al. Stationary Rossby waves dominate subduction of anthropogenic carbon in the Southern Ocean. Sci Rep. 2017;7(1):17076doi: 10.1038/s41598-017-17292-3.
Langlais, C. E., Lenton, A., Matear, R., Monselesan, D., Legresy, B., Cougnon, E., & Rintoul, S. (2017). Stationary Rossby waves dominate subduction of anthropogenic carbon in the Southern Ocean. Scientific reports, 7(1), 17076. https://doi.org/10.1038/s41598-017-17292-3
Langlais, C E, et al. "Stationary Rossby waves dominate subduction of anthropogenic carbon in the Southern Ocean." Scientific reports vol. 7,1 (2017): 17076. doi: https://doi.org/10.1038/s41598-017-17292-3
Langlais CE, Lenton A, Matear R, Monselesan D, Legresy B, Cougnon E, Rintoul S. Stationary Rossby waves dominate subduction of anthropogenic carbon in the Southern Ocean. Sci Rep. 2017 Dec 06;7(1):17076. doi: 10.1038/s41598-017-17292-3. PMID: 29213120; PMCID: PMC5719014.
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Introduction to Special Issue: ADHD Research in a Canadian Context.

Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent

Toplak ME, LeGris J.
PMID: 32194646
J Can Acad Child Adolesc Psychiatry. 2020 Mar;29(1):2-3. Epub 2020 Mar 01.

No abstract available.

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Toplak ME, LeGris J. Introduction to Special Issue: ADHD Research in a Canadian Context. J Can Acad Child Adolesc Psychiatry. 2020;29(1):2-3
Toplak, M. E., & LeGris, J. (2020). Introduction to Special Issue: ADHD Research in a Canadian Context. Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent, 29(1), 2-3.
Toplak, Maggie E, and LeGris, Jeannette. "Introduction to Special Issue: ADHD Research in a Canadian Context." Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent vol. 29,1 (2020): 2-3.
Toplak ME, LeGris J. Introduction to Special Issue: ADHD Research in a Canadian Context. J Can Acad Child Adolesc Psychiatry. 2020 Mar;29(1):2-3. Epub 2020 Mar 01. PMID: 32194646; PMCID: PMC7065564.
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Dynamic magnetic resonance imaging in unilateral diaphragm eventration: knowledge improvement before and after plication.

Journal of thoracic disease

Le Pimpec-Barthes F, Hernigou A, Mazzella A, Legras A, Rivera C, Bouacida I, Arame A, Badia A, Das Neves Pereira JC, Morelot-Panzini C, Similowski T, Riquet M, Vilfaillot A, Mangiameli G.
PMID: 31559052
J Thorac Dis. 2019 Aug;11(8):3467-3475. doi: 10.21037/jtd.2019.07.79.

BACKGROUND: The assessment before surgical plication for unilateral hemidiaphragm (HD) eventration is not clearly defined and no precise criteria exist to really understand which patient is operated with which results depending on the technique used. The goal of this...

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Le Pimpec-Barthes F, Hernigou A, Mazzella A, et al. Dynamic magnetic resonance imaging in unilateral diaphragm eventration: knowledge improvement before and after plication. J Thorac Dis. 2019;11(8):3467-3475doi: 10.21037/jtd.2019.07.79.
Le Pimpec-Barthes, F., Hernigou, A., Mazzella, A., Legras, A., Rivera, C., Bouacida, I., Arame, A., Badia, A., Das Neves Pereira, J. C., Morelot-Panzini, C., Similowski, T., Riquet, M., Vilfaillot, A., & Mangiameli, G. (2019). Dynamic magnetic resonance imaging in unilateral diaphragm eventration: knowledge improvement before and after plication. Journal of thoracic disease, 11(8), 3467-3475. https://doi.org/10.21037/jtd.2019.07.79
Le Pimpec-Barthes, Francoise, et al. "Dynamic magnetic resonance imaging in unilateral diaphragm eventration: knowledge improvement before and after plication." Journal of thoracic disease vol. 11,8 (2019): 3467-3475. doi: https://doi.org/10.21037/jtd.2019.07.79
Le Pimpec-Barthes F, Hernigou A, Mazzella A, Legras A, Rivera C, Bouacida I, Arame A, Badia A, Das Neves Pereira JC, Morelot-Panzini C, Similowski T, Riquet M, Vilfaillot A, Mangiameli G. Dynamic magnetic resonance imaging in unilateral diaphragm eventration: knowledge improvement before and after plication. J Thorac Dis. 2019 Aug;11(8):3467-3475. doi: 10.21037/jtd.2019.07.79. PMID: 31559052; PMCID: PMC6753452.
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Surfactin Stimulated by Pectin Molecular Patterns and Root Exudates Acts as a Key Driver of the .

mBio

Hoff G, Arguelles Arias A, Boubsi F, Pršić J, Meyer T, Ibrahim HMM, Steels S, Luzuriaga P, Legras A, Franzil L, Lequart-Pillon M, Rayon C, Osorio V, de Pauw E, Lara Y, Deboever E, de Coninck B, Jacques P, Deleu M, Petit E, Van Wuytswinkel O, Ongena M.
PMID: 34724831
mBio. 2021 Nov 02;e0177421. doi: 10.1128/mBio.01774-21. Epub 2021 Nov 02.

Bacillus velezensis is considered as a model species belonging to the so-called Bacillus subtilis complex that evolved typically to dwell in the soil rhizosphere niche and establish an intimate association with plant roots. This bacterium provides protection to its...

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Hoff G, Arguelles Arias A, Boubsi F, et al. Surfactin Stimulated by Pectin Molecular Patterns and Root Exudates Acts as a Key Driver of the . mBio. 2021;e0177421doi: 10.1128/mBio.01774-21.
Hoff, G., Arguelles Arias, A., Boubsi, F., Pršić, J., Meyer, T., Ibrahim, H. M. M., Steels, S., Luzuriaga, P., Legras, A., Franzil, L., Lequart-Pillon, M., Rayon, C., Osorio, V., de Pauw, E., Lara, Y., Deboever, E., de Coninck, B., Jacques, P., Deleu, M., Petit, E., Van Wuytswinkel, O., & Ongena, M. (2021). Surfactin Stimulated by Pectin Molecular Patterns and Root Exudates Acts as a Key Driver of the . mBio, e0177421. https://doi.org/10.1128/mBio.01774-21
Hoff, Grégory, et al. "Surfactin Stimulated by Pectin Molecular Patterns and Root Exudates Acts as a Key Driver of the ." mBio vol. (2021): e0177421. doi: https://doi.org/10.1128/mBio.01774-21
Hoff G, Arguelles Arias A, Boubsi F, Pršić J, Meyer T, Ibrahim HMM, Steels S, Luzuriaga P, Legras A, Franzil L, Lequart-Pillon M, Rayon C, Osorio V, de Pauw E, Lara Y, Deboever E, de Coninck B, Jacques P, Deleu M, Petit E, Van Wuytswinkel O, Ongena M. Surfactin Stimulated by Pectin Molecular Patterns and Root Exudates Acts as a Key Driver of the . mBio. 2021 Nov 02;e0177421. doi: 10.1128/mBio.01774-21. Epub 2021 Nov 02. PMID: 34724831; PMCID: PMC8561381.
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Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.

The Journal of experimental medicine

Cova G, Taroni C, Deau MC, Cai Q, Mittelheisser V, Philipps M, Jung M, Cerciat M, Le Gras S, Thibault-Carpentier C, Jost B, Carlsson L, Thornton AM, Shevach EM, Kirstetter P, Kastner P, Chan S.
PMID: 34459852
J Exp Med. 2021 Oct 04;218(10). doi: 10.1084/jem.20202317. Epub 2021 Aug 30.

Our understanding of cell fate decisions in hematopoietic stem cells is incomplete. Here, we show that the transcription factor Helios is highly expressed in murine hematopoietic stem and progenitor cells (HSPCs), where it is required to suppress the separation...

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Cova G, Taroni C, Deau MC, et al. Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells. J Exp Med. 2021;218(10)doi: 10.1084/jem.20202317.
Cova, G., Taroni, C., Deau, M. C., Cai, Q., Mittelheisser, V., Philipps, M., Jung, M., Cerciat, M., Le Gras, S., Thibault-Carpentier, C., Jost, B., Carlsson, L., Thornton, A. M., Shevach, E. M., Kirstetter, P., Kastner, P., & Chan, S. (2021). Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells. The Journal of experimental medicine, 218(10), . https://doi.org/10.1084/jem.20202317
Cova, Giovanni, et al. "Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells." The Journal of experimental medicine vol. 218,10 (2021). doi: https://doi.org/10.1084/jem.20202317
Cova G, Taroni C, Deau MC, Cai Q, Mittelheisser V, Philipps M, Jung M, Cerciat M, Le Gras S, Thibault-Carpentier C, Jost B, Carlsson L, Thornton AM, Shevach EM, Kirstetter P, Kastner P, Chan S. Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells. J Exp Med. 2021 Oct 04;218(10). doi: 10.1084/jem.20202317. Epub 2021 Aug 30. PMID: 34459852; PMCID: PMC8406645.
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Successful Control of Hypoglycemia with Pasireotide LAR in a Patient with Inappropriate Insulin Secretion.

Clinical pharmacology : advances and applications

Rouland A, Bouillet B, Legris P, Simoneau I, Petit JM, Vergès B.
PMID: 33574715
Clin Pharmacol. 2021 Feb 05;13:33-37. doi: 10.2147/CPAA.S278978. eCollection 2021.

INTRODUCTION: Inappropriate insulin secretion could be due to several diseases. Nesidioblastosis is characterized by diffuse hyperplasia of pancreatic beta cells, causing organic hypoglycemia. No pancreatic lesions are found on the imaging of patients with this condition. Diazoxide is used...

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Rouland A, Bouillet B, Legris P, et al. Successful Control of Hypoglycemia with Pasireotide LAR in a Patient with Inappropriate Insulin Secretion. Clin Pharmacol. 2021;13:33-37doi: 10.2147/CPAA.S278978.
Rouland, A., Bouillet, B., Legris, P., Simoneau, I., Petit, J. M., & Vergès, B. (2021). Successful Control of Hypoglycemia with Pasireotide LAR in a Patient with Inappropriate Insulin Secretion. Clinical pharmacology : advances and applications, 1333-37. https://doi.org/10.2147/CPAA.S278978
Rouland, Alexia, et al. "Successful Control of Hypoglycemia with Pasireotide LAR in a Patient with Inappropriate Insulin Secretion." Clinical pharmacology : advances and applications vol. 13 (2021): 33-37. doi: https://doi.org/10.2147/CPAA.S278978
Rouland A, Bouillet B, Legris P, Simoneau I, Petit JM, Vergès B. Successful Control of Hypoglycemia with Pasireotide LAR in a Patient with Inappropriate Insulin Secretion. Clin Pharmacol. 2021 Feb 05;13:33-37. doi: 10.2147/CPAA.S278978. eCollection 2021. PMID: 33574715; PMCID: PMC7872904.
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Clinical pharmacology and dosing regimen optimization of neonatal opioid withdrawal syndrome treatments.

Clinical and translational science

Tang F, Ng CM, Bada HS, Leggas M.
PMID: 33650314
Clin Transl Sci. 2021 Jul;14(4):1231-1249. doi: 10.1111/cts.12994. Epub 2021 May 01.

In this paper, we review the management of neonatal opioid withdrawal syndrome (NOWS) and clinical pharmacology of primary treatment agents in NOWS, including morphine, methadone, buprenorphine, clonidine, and phenobarbital. Pharmacologic treatment strategies in NOWS have been mostly empirical, and...

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Tang F, Ng CM, Bada HS, et al. Clinical pharmacology and dosing regimen optimization of neonatal opioid withdrawal syndrome treatments. Clin Transl Sci. 2021;14(4):1231-1249doi: 10.1111/cts.12994.
Tang, F., Ng, C. M., Bada, H. S., & Leggas, M. (2021). Clinical pharmacology and dosing regimen optimization of neonatal opioid withdrawal syndrome treatments. Clinical and translational science, 14(4), 1231-1249. https://doi.org/10.1111/cts.12994
Tang, Fei, et al. "Clinical pharmacology and dosing regimen optimization of neonatal opioid withdrawal syndrome treatments." Clinical and translational science vol. 14,4 (2021): 1231-1249. doi: https://doi.org/10.1111/cts.12994
Tang F, Ng CM, Bada HS, Leggas M. Clinical pharmacology and dosing regimen optimization of neonatal opioid withdrawal syndrome treatments. Clin Transl Sci. 2021 Jul;14(4):1231-1249. doi: 10.1111/cts.12994. Epub 2021 May 01. PMID: 33650314; PMCID: PMC8301571.
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Reperfusion therapy for acute ischemic stroke in older people: An observational real-life study.

Journal of the American Geriatrics Society

Sudre J, Venditti L, Ancelet C, Chassin O, Sarov M, Smadja D, Chausson N, Lun F, Laine O, Duron E, Verny C, Spelle L, Rouquette A, Legris N, Denier C.
PMID: 34374987
J Am Geriatr Soc. 2021 Nov;69(11):3167-3176. doi: 10.1111/jgs.17394. Epub 2021 Aug 10.

BACKGROUND: While randomized clinical trials have shown the benefit of thrombolysis and endovascular thrombectomy (EVT) in patients with acute ischemic stroke (AIS), we aimed to describe in a real-life study the differences between older (>80 years old) and younger...

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Sudre J, Venditti L, Ancelet C, et al. Reperfusion therapy for acute ischemic stroke in older people: An observational real-life study. J Am Geriatr Soc. 2021;69(11):3167-3176doi: 10.1111/jgs.17394.
Sudre, J., Venditti, L., Ancelet, C., Chassin, O., Sarov, M., Smadja, D., Chausson, N., Lun, F., Laine, O., Duron, E., Verny, C., Spelle, L., Rouquette, A., Legris, N., & Denier, C. (2021). Reperfusion therapy for acute ischemic stroke in older people: An observational real-life study. Journal of the American Geriatrics Society, 69(11), 3167-3176. https://doi.org/10.1111/jgs.17394
Sudre, Justine, et al. "Reperfusion therapy for acute ischemic stroke in older people: An observational real-life study." Journal of the American Geriatrics Society vol. 69,11 (2021): 3167-3176. doi: https://doi.org/10.1111/jgs.17394
Sudre J, Venditti L, Ancelet C, Chassin O, Sarov M, Smadja D, Chausson N, Lun F, Laine O, Duron E, Verny C, Spelle L, Rouquette A, Legris N, Denier C. Reperfusion therapy for acute ischemic stroke in older people: An observational real-life study. J Am Geriatr Soc. 2021 Nov;69(11):3167-3176. doi: 10.1111/jgs.17394. Epub 2021 Aug 10. PMID: 34374987.
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A human liver chimeric mouse model for non-alcoholic fatty liver disease.

JHEP reports : innovation in hepatology

Bissig-Choisat B, Alves-Bezerra M, Zorman B, Ochsner SA, Barzi M, Legras X, Yang D, Borowiak M, Dean AM, York RB, Galvan NTN, Goss J, Lagor WR, Moore DD, Cohen DE, McKenna NJ, Sumazin P, Bissig KD.
PMID: 34036256
JHEP Rep. 2021 Mar 21;3(3):100281. doi: 10.1016/j.jhepr.2021.100281. eCollection 2021 Jun.

BACKGROUND & AIMS: The accumulation of neutral lipids within hepatocytes underlies non-alcoholic fatty liver disease (NAFLD), which affects a quarter of the world's population and is associated with hepatitis, cirrhosis, and hepatocellular carcinoma. Despite insights gained from both human...

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Bissig-Choisat B, Alves-Bezerra M, Zorman B, et al. A human liver chimeric mouse model for non-alcoholic fatty liver disease. JHEP Rep. 2021;3(3):100281doi: 10.1016/j.jhepr.2021.100281.
Bissig-Choisat, B., Alves-Bezerra, M., Zorman, B., Ochsner, S. A., Barzi, M., Legras, X., Yang, D., Borowiak, M., Dean, A. M., York, R. B., Galvan, N. T. N., Goss, J., Lagor, W. R., Moore, D. D., Cohen, D. E., McKenna, N. J., Sumazin, P., & Bissig, K. D. (2021). A human liver chimeric mouse model for non-alcoholic fatty liver disease. JHEP reports : innovation in hepatology, 3(3), 100281. https://doi.org/10.1016/j.jhepr.2021.100281
Bissig-Choisat, Beatrice, et al. "A human liver chimeric mouse model for non-alcoholic fatty liver disease." JHEP reports : innovation in hepatology vol. 3,3 (2021): 100281. doi: https://doi.org/10.1016/j.jhepr.2021.100281
Bissig-Choisat B, Alves-Bezerra M, Zorman B, Ochsner SA, Barzi M, Legras X, Yang D, Borowiak M, Dean AM, York RB, Galvan NTN, Goss J, Lagor WR, Moore DD, Cohen DE, McKenna NJ, Sumazin P, Bissig KD. A human liver chimeric mouse model for non-alcoholic fatty liver disease. JHEP Rep. 2021 Mar 21;3(3):100281. doi: 10.1016/j.jhepr.2021.100281. eCollection 2021 Jun. PMID: 34036256; PMCID: PMC8138774.
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Correction: Ikaros antagonizes DNA binding by STAT5 in pre-B cells.

PloS one

Heizmann B, Le Gras S, Simand C, Marchal P, Chan S, Kastner P.
PMID: 33513189
PLoS One. 2021 Jan 29;16(1):e0246570. doi: 10.1371/journal.pone.0246570. eCollection 2021.

[This corrects the article DOI: 10.1371/journal.pone.0242211.].

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Heizmann B, Le Gras S, Simand C, et al. Correction: Ikaros antagonizes DNA binding by STAT5 in pre-B cells. PLoS One. 2021;16(1):e0246570doi: 10.1371/journal.pone.0246570.
Heizmann, B., Le Gras, S., Simand, C., Marchal, P., Chan, S., & Kastner, P. (2021). Correction: Ikaros antagonizes DNA binding by STAT5 in pre-B cells. PloS one, 16(1), e0246570. https://doi.org/10.1371/journal.pone.0246570
Heizmann, Beate, et al. "Correction: Ikaros antagonizes DNA binding by STAT5 in pre-B cells." PloS one vol. 16,1 (2021): e0246570. doi: https://doi.org/10.1371/journal.pone.0246570
Heizmann B, Le Gras S, Simand C, Marchal P, Chan S, Kastner P. Correction: Ikaros antagonizes DNA binding by STAT5 in pre-B cells. PLoS One. 2021 Jan 29;16(1):e0246570. doi: 10.1371/journal.pone.0246570. eCollection 2021. PMID: 33513189; PMCID: PMC7845949.
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Rituximab in combination with adapted-dose of ifosfamide and etoposide as salvage treatment in elderly refractory/relapsed diffuse large B-cell lymphoma patients non-candidate for high dose therapy: a retrospective study.

Leukemia & lymphoma

Aussedat G, Maucort-Boulch D, Rey P, Safar V, Karlin L, Elsensohn MH, Bachy E, Lebras L, Favier B, Vantard N, Ghergus D, Golfier C, Sesques P, Lazareth A, Lequeu H, Ferrant E, Salles G, Nicolas-Virelizier E, Ghesquieres H.
PMID: 34720034
Leuk Lymphoma. 2021 Oct 31;1-9. doi: 10.1080/10428194.2021.1998483. Epub 2021 Oct 31.

We retrospectively reviewed for 72 relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) patients ineligible for autologous stem-cell transplantation (ASCT) treated between 2004 and 2017, efficacy and safety profile of rituximab (375 mg/m

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Aussedat G, Maucort-Boulch D, Rey P, et al. Rituximab in combination with adapted-dose of ifosfamide and etoposide as salvage treatment in elderly refractory/relapsed diffuse large B-cell lymphoma patients non-candidate for high dose therapy: a retrospective study. Leuk Lymphoma. 2021;1-9doi: 10.1080/10428194.2021.1998483.
Aussedat, G., Maucort-Boulch, D., Rey, P., Safar, V., Karlin, L., Elsensohn, M. H., Bachy, E., Lebras, L., Favier, B., Vantard, N., Ghergus, D., Golfier, C., Sesques, P., Lazareth, A., Lequeu, H., Ferrant, E., Salles, G., Nicolas-Virelizier, E., & Ghesquieres, H. (2021). Rituximab in combination with adapted-dose of ifosfamide and etoposide as salvage treatment in elderly refractory/relapsed diffuse large B-cell lymphoma patients non-candidate for high dose therapy: a retrospective study. Leukemia & lymphoma, 1-9. https://doi.org/10.1080/10428194.2021.1998483
Aussedat, Guillaume, et al. "Rituximab in combination with adapted-dose of ifosfamide and etoposide as salvage treatment in elderly refractory/relapsed diffuse large B-cell lymphoma patients non-candidate for high dose therapy: a retrospective study." Leukemia & lymphoma vol. (2021): 1-9. doi: https://doi.org/10.1080/10428194.2021.1998483
Aussedat G, Maucort-Boulch D, Rey P, Safar V, Karlin L, Elsensohn MH, Bachy E, Lebras L, Favier B, Vantard N, Ghergus D, Golfier C, Sesques P, Lazareth A, Lequeu H, Ferrant E, Salles G, Nicolas-Virelizier E, Ghesquieres H. Rituximab in combination with adapted-dose of ifosfamide and etoposide as salvage treatment in elderly refractory/relapsed diffuse large B-cell lymphoma patients non-candidate for high dose therapy: a retrospective study. Leuk Lymphoma. 2021 Oct 31;1-9. doi: 10.1080/10428194.2021.1998483. Epub 2021 Oct 31. PMID: 34720034.
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