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Showing 13 to 24 of 25 entries
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The Journal of pediatrics

Samyn M, Hensel K, Hadzic N, Mieli-Vergani G.
PMID: 34530024
J Pediatr. 2022 Jan;240:317-318. doi: 10.1016/j.jpeds.2021.09.011. Epub 2021 Sep 13.

No abstract available.

Antibodies to soluble liver antigen and alpha-enolase in patients with autoimmune hepatitis.

Journal of autoimmune diseases

Bogdanos DP, Gilbert D, Bianchi I, Leoni S, Mitry RR, Ma Y, Mieli-Vergani G, Vergani D.
PMID: 15679947
J Autoimmune Dis. 2004 Nov 19;1(1):4. doi: 10.1186/1740-2557-1-4.

BACKGROUND: Antibodies to a cytosolic soluble liver antigen (SLA) are specifically detected in patients with autoimmune hepatitis (AIH). The target of anti-SLA has been identified as a ~50 kDa UGA serine tRNA-associated protein complex (tRNP(Ser)Sec), through the screening of...

Contemporary issues and future directions in autoimmune hepatitis.

Expert review of gastroenterology & hepatology

Liberal R, Mieli-Vergani G, Vergani D.
PMID: 27215278
Expert Rev Gastroenterol Hepatol. 2016 Oct;10(10):1163-1174. doi: 10.1080/17474124.2016.1193004. Epub 2016 Jun 03.

INTRODUCTION: Autoimmune hepatitis (AIH) is a severe life-threatening hepatopathy of unknown etiology, affecting both pediatric and adult populations, and characterised by inflammatory liver histology, circulating non-organ-specific autoantibodies, and hypergammaglobulinaemia. AIH is a very heterogeneous disease with a variety of...

Update on Autoimmune Hepatitis.

Journal of clinical and translational hepatology

Liberal R, Vergani D, Mieli-Vergani G, Downer JT.
PMID: 26357634
J Clin Transl Hepatol. 2015 Mar;3(1):42-52. doi: 10.14218/JCTH.2014.00032. Epub 2015 Mar 15.

Autoimmune hepatitis (AIH), a liver disorder affecting both children and adults, is characterized by inflammatory liver histology, elevated transaminase levels, circulating nonorganspecific autoantibodies, and increased levels of immunoglobulin G, in the absence of a known etiology. Two types of...

Autoimmune hepatitis: Diagnostic criteria and serological testing.

Clinical liver disease

Vergani D, Mieli-Vergani G.
PMID: 31236268
Clin Liver Dis (Hoboken). 2014 Mar 05;3(2):38-41. doi: 10.1002/cld.321. eCollection 2014 Feb.

No abstract available.

A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome.

Journal of translational autoimmunity

Terziroli Beretta-Piccoli B, Mazzucchelli L, Taiana C, Mossi G, Usai C, Vergani D, Mieli-Vergani G.
PMID: 32743518
J Transl Autoimmun. 2019 Dec 17;3:100033. doi: 10.1016/j.jtauto.2019.100033. eCollection 2020.

Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap. A 68-year-old male patient...

Autoimmune Hepatitis: Serum Autoantibodies in Clinical Practice.

Clinical reviews in allergy & immunology

Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D.
PMID: 34491531
Clin Rev Allergy Immunol. 2021 Sep 07; doi: 10.1007/s12016-021-08888-9. Epub 2021 Sep 07.

Circulating autoantibodies are a key diagnostic tool in autoimmune hepatitis (AIH), being positive in 95% of the cases if tested according to dedicated guidelines issued by the International Autoimmune Hepatitis Group. They also allow the distinction between type 1...

Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis.

Hepatology (Baltimore, Md.)

Graham JJ, Mukherjee S, Yuksel M, Sanabria Mateos R, Si T, Huang Z, Huang X, Abu Arqoub H, Patel V, McPhail M, Zen Y, Heaton N, Longhi MS, Heneghan MA, Liberal R, Vergani D, Mieli-Vergani G, Ma Y, Hayee B.
PMID: 34633679
Hepatology. 2021 Oct 11; doi: 10.1002/hep.32193. Epub 2021 Oct 11.

BACKGROUND AND AIMS: The "gut homing" hypothesis suggests the pathogenesis of primary sclerosing cholangitis (PSC) is driven by aberrant hepatic expression of gut adhesion molecules and subsequent recruitment of gut-derived T cells to the liver. However, inconsistencies lie within...

Autoimmmune hepatitis.

Cellular & molecular immunology

Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D.
PMID: 34580437
Cell Mol Immunol. 2021 Sep 27; doi: 10.1038/s41423-021-00768-8. Epub 2021 Sep 27.

Autoimmune hepatitis (AIH) is a T-cell mediated, inflammatory liver disease affecting all ages and characterized by female preponderance, elevated serum transaminase and immunoglobulin G levels, positive circulating autoantibodies, and presence of interface hepatitis at liver histology. AIH type 1,...

ABCB4 variants in adult patients with cholestatic disease are frequent and underdiagnosed.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Avena A, Puggelli S, Morris M, Cerny A, Andrade AR, Pareti E, Bihl F, Cassatella D, Moix I, Merlo E, Rougemont AL, Majno-Hurst P, Vergani D, Mieli-Vergani G, Terziroli Beretta-Piccoli B.
PMID: 33390354
Dig Liver Dis. 2021 Mar;53(3):329-344. doi: 10.1016/j.dld.2020.12.003. Epub 2020 Dec 31.

BACKGROUND: Heterozygous ABCB4 variants are not routinely tested in adults with cholestasis because of their supposed rarity and high costs.METHODS: Nineteen adult patients presenting with unexplained cholestasis, and/or recurrent gallstones were included; genotyping was not done in five due...

Human Leukocyte Antigen Profile Predicts Severity of Autoimmune Liver Disease in Children of European Ancestry.

Hepatology (Baltimore, Md.)

Ma Y, Su H, Yuksel M, Longhi MS, McPhail MJ, Wang P, Bansal S, Wong GW, Graham J, Yang L, J Thompson R, Doherty DG, Hadzic N, Zen Y, Quaglia A, Heneghan MA, Samyn M, Vergani D, Mieli-Vergani G.
PMID: 33971035
Hepatology. 2021 Oct;74(4):2032-2046. doi: 10.1002/hep.31893. Epub 2021 Jun 21.

BACKGROUND AND AIMS: Genetic predisposition to autoimmune hepatitis (AIH) in adults is associated with possession of human leukocyte antigen (HLA) class I (A*01, B*08) and class II (DRB1*03, -04, -07, or -13) alleles, depending on geographic region. Juvenile autoimmune...

Autoimmune hepatitis: From mechanisms to therapy.

Revista clinica espanola

Liberal R, Mieli-Vergani G, Vergani D.
PMID: 27161382
Rev Clin Esp (Barc). 2016 Oct;216(7):372-383. doi: 10.1016/j.rce.2016.04.003. Epub 2016 May 06.

Autoimmune hepatitis (AIH) is a progressive inflammatory hepatopathy and an important cause of end-stage liver disease. Its aetiology remains unknown, though both genetic and environmental factors are involved in its development. The major mechanism of autoimmune liver damage involves...

Showing 13 to 24 of 25 entries