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Showing 25 to 36 of 1463 entries
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Enzymatic synthesis and characterization of N(5)-(carboxymethyl)-L-ornithine and N (6)-(carboxymethyl)-L-lysine.

Amino acids

Miller SP, Donkersloot JA, Thompson J.
PMID: 24190788
Amino Acids. 1994 Jun;6(2):189-98. doi: 10.1007/BF00805846.

This report describes the enzyme-catalyzed synthesis, characterization, and chromatographic separation of N(6)-(carboxymethyl)-L-lysine and N(5)-(carboxymethyl)-L-ornithine. The two N (ω) -(carboxyalkyl)amino acids are formed via a reductive condensation between glyoxylate and theε- orδ-amino groups of lysine and ornithine, respectively. Both reactions...

Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A).

ACS medicinal chemistry letters

Hu E, Andrews K, Chmait S, Zhao X, Davis C, Miller S, Hill Della Puppa G, Dovlatyan M, Chen H, Lester-Zeiner D, Able J, Biorn C, Ma J, Shi J, Treanor J, Allen JR.
PMID: 24944747
ACS Med Chem Lett. 2014 Mar 28;5(6):700-5. doi: 10.1021/ml5000993. eCollection 2014 Jun 12.

We report the discovery of novel imidazo[4,5-b]pyridines as potent and selective inhibitors of PDE10A. The investigation began with our recently disclosed ketobenzimidazole 1, which exhibited single digit nanomolar PDE10A activity but poor oral bioavailability. To improve oral bioavailability, we...

Correction: The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis.

PLoS pathogens

Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM.
PMID: 26086393
PLoS Pathog. 2015 Jun 18;11(6):e1004943. doi: 10.1371/journal.ppat.1004943. eCollection 2015 Jun.

No abstract available.

Precise test of internal-conversion theory: transitions measured in five nuclei spanning 50≤Z≤78.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Hardy JC, Nica N, Iacob VE, Miller S, Maguire M, Trzhaskovskaya MB.
PMID: 24326313
Appl Radiat Isot. 2014 May;87:87-91. doi: 10.1016/j.apradiso.2013.11.033. Epub 2013 Nov 26.

In a research program aimed at testing calculated internal-conversion coefficients (ICCs), we have made precise measurements of αK values for transitions in five nuclei, (197)Pt, (193)Ir, (137)Ba, (134)Cs and (119)Sn, which span a wide range of A and Z...

High-throughput neuro-imaging informatics.

Frontiers in neuroinformatics

Miller MI, Faria AV, Oishi K, Mori S.
PMID: 24381556
Front Neuroinform. 2013 Dec 17;7:31. doi: 10.3389/fninf.2013.00031. eCollection 2013.

This paper describes neuroinformatics technologies at 1 mm anatomical scale based on high-throughput 3D functional and structural imaging technologies of the human brain. The core is an abstract pipeline for converting functional and structural imagery into their high-dimensional neuroinformatic...

Biodiversity inventories in high gear: DNA barcoding facilitates a rapid biotic survey of a temperate nature reserve.

Biodiversity data journal

Telfer AC, Young MR, Quinn J, Perez K, Sobel CN, Sones JE, Levesque-Beaudin V, Derbyshire R, Fernandez-Triana J, Rougerie R, Thevanayagam A, Boskovic A, Borisenko AV, Cadel A, Brown A, Pages A, Castillo AH, Nicolai A, Glenn Mockford BM, Bukowski B, Wilson B, Trojahn B, Lacroix CA, Brimblecombe C, Hay C, Ho C, Steinke C, Warne CP, Garrido Cortes C, Engelking D, Wright D, Lijtmaer DA, Gascoigne D, Hernandez Martich D, Morningstar D, Neumann D, Steinke D, Marco DeBruin DD, Dobias D, Sears E, Richard E, Damstra E, Zakharov EV, Laberge F, Collins GE, Blagoev GA, Grainge G, Ansell G, Meredith G, Hogg I, McKeown J, Topan J, Bracey J, Guenther J, Sills-Gilligan J, Addesi J, Persi J, Layton KK, D'Souza K, Dorji K, Grundy K, Nghidinwa K, Ronnenberg K, Lee KM, Xie L, Lu L, Penev L, Gonzalez M, Rosati ME, Kekkonen M, Kuzmina M, Iskandar M, Mutanen M, Fatahi M, Pentinsaari M, Bauman M, Nikolova N, Ivanova NV, Jones N, Weerasuriya N, Monkhouse N, Lavinia PD, Jannetta P, Hanisch PE, McMullin RT, Ojeda Flores R, Mouttet R, Vender R, Labbee RN, Forsyth R, Lauder R, Dickson R, Kroft R, Miller SE, MacDonald S, Panthi S, Pedersen S, Sobek-Swant S, Naik S, Lipinskaya T, Eagalle T, Decaëns T, Kosuth T, Braukmann T, Woodcock T, Roslin T, Zammit T, Campbell V, Dinca V, Peneva V, Hebert PD, deWaard JR.
PMID: 26379469
Biodivers Data J. 2015 Aug 30;(3):e6313. doi: 10.3897/BDJ.3.e6313. eCollection 2015.

BACKGROUND: Comprehensive biotic surveys, or 'all taxon biodiversity inventories' (ATBI), have traditionally been limited in scale or scope due to the complications surrounding specimen sorting and species identification. To circumvent these issues, several ATBI projects have successfully integrated DNA...

Draft Genome Sequence of Alteromonas macleodii Strain MIT1002, Isolated from an Enrichment Culture of the Marine Cyanobacterium Prochlorococcus.

Genome announcements

Biller SJ, Coe A, Martin-Cuadrado AB, Chisholm SW.
PMID: 26316635
Genome Announc. 2015 Aug 27;3(4). doi: 10.1128/genomeA.00967-15.

Alteromonas spp. are heterotrophic gammaproteobacteria commonly found in marine environments. We present here the draft genome sequence of Alteromonas macleodii MIT1002, which was isolated from an enrichment culture of the marine cyanobacterium Prochlorococcus NATL2A. This genome contains a mixture...

Chronic Thoracic Aortic Aneurysm Presenting 29 Years following Trauma.

Case reports in surgery

Miller S, Kumar P, Van den Bosch R, Khanafer A.
PMID: 26351610
Case Rep Surg. 2015;2015:470917. doi: 10.1155/2015/470917. Epub 2015 Aug 13.

Blunt, nonpenetrating injuries of the thoracic aorta are uncommon and associated with a high mortality rate within the first hour. Aortic injury is missed in 1-2% of patients that survive to hospital, and a chronic thoracic aortic aneurysm may...

Providing Palliative Care, and Beyond….

Journal of palliative medicine

Miller SC.
PMID: 27689856
J Palliat Med. 2016 Oct;19(10):1022-1024. doi: 10.1089/jpm.2016.0394.

No abstract available.

A Synergistic Combinatorial and Chiroptical Study of Peptide Catalysts for Asymmetric Baeyer-Villiger Oxidation.

Advanced synthesis & catalysis

Giuliano MW, Lin CY, Romney DK, Miller SJ, Anslyn EV.
PMID: 26543444
Adv Synth Catal. 2015 Jul 06;357(10):2301-2309. doi: 10.1002/adsc.201500230. Epub 2015 Jul 14.

We report an approach to the asymmetric Baeyer-Villiger oxidation utilizing bioinformatics-inspired combinatorial screening for catalyst discovery. Scaled-up validation of our on-bead efforts with a circular dichroism-based assay of alcohols derived from the products of solution-phase reactions established the absolute...

Development and utilization of complementary communication channels for treatment decision making and survivorship issues among cancer patients: The CIS Research Consortium Experience.

Internet interventions

Fleisher L, Wen KY, Miller SM, Diefenbach M, Stanton AL, Ropka M, Morra M, Raich PC.
PMID: 26855885
Internet Interv. 2015 Nov 01;2(4):392-398. doi: 10.1016/j.invent.2015.09.002.

OBJECTIVE: Cancer patients and survivors are assuming active roles in decision-making and digital patient support tools are widely used to facilitate patient engagement. As part of Cancer Information Service Research Consortium's randomized controlled trials focused on the efficacy of...

Network Neurodegeneration in Alzheimer's Disease via MRI Based Shape Diffeomorphometry and High-Field Atlasing.

Frontiers in bioengineering and biotechnology

Miller MI, Ratnanather JT, Tward DJ, Brown T, Lee DS, Ketcha M, Mori K, Wang MC, Mori S, Albert MS, Younes L.
PMID: 26284236
Front Bioeng Biotechnol. 2015 May 15;3:54. doi: 10.3389/fbioe.2015.00054. eCollection 2015.

This paper examines MRI analysis of neurodegeneration in Alzheimer's Disease (AD) in a network of structures within the medial temporal lobe using diffeomorphometry methods coupled with high-field atlasing in which the entorhinal cortex is partitioned into eight subareas. The...

Showing 25 to 36 of 1463 entries