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Showing 3361 to 3372 of 3372 entries
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Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells.

Genes & development

Hada M, Miura H, Tanigawa A, Matoba S, Inoue K, Ogonuki N, Hirose M, Watanabe N, Nakato R, Fujiki K, Hasegawa A, Sakashita A, Okae H, Miura K, Shikata D, Arima T, Shirahige K, Hiratani I, Ogura A.
PMID: 34992147
Genes Dev. 2022 Jan 06; doi: 10.1101/gad.348782.121. Epub 2022 Jan 06.

The placenta is a highly evolved, specialized organ in mammals. It differs from other organs in that it functions only for fetal maintenance during gestation. Therefore, there must be intrinsic mechanisms that guarantee its unique functions. To address this...

Gastric Xanthoma Is Related to the Rapid Growth of Gastric Cancer.

Journal of clinical medicine

Miura K, Oshima T, Tamura A, Hara K, Okugawa T, Fukushima M, Tomita T, Fukui H, Miwa H.
PMID: 34884406
J Clin Med. 2021 Dec 05;10(23). doi: 10.3390/jcm10235704.

Early detection of gastric cancer is important. However, rapid growth of gastric cancers that cannot be resected endoscopically occurs even with periodic check-ups. Accordingly, we assessed factors associated with the speed of gastric cancer growth by examining historical endoscopic...

Effects of benzodiazepine and orexin receptor antagonist on cognitive function revealed by auditory event-related potentials.

Journal of psychopharmacology (Oxford, England)

Shiga T, Hoshino H, Ochiai H, Osakabe Y, Kanno K, Horikoshi S, Miura I, Yabe H.
PMID: 34330170
J Psychopharmacol. 2021 Dec;35(12):1488-1495. doi: 10.1177/02698811211035390. Epub 2021 Jul 30.

BACKGROUND: Cognitive decline after oral administration of sedatives, such as benzodiazepines, is a serious side effect. Suvorexant, an orexin receptor antagonist, has a favorable tolerability and a limited side-effect profile.AIM: The purpose of this study was to estimate the...

Assessment of left ventricular dyssynchrony by speckle tracking echocardiography in children with duchenne muscular dystrophy.

The international journal of cardiovascular imaging

Lanot N, Vincenti M, Abassi H, Bredy C, Agullo A, Gamon L, Mura T, Lavastre K, De La Villeon G, Barrea C, Meyer P, Rivier F, Meli AC, Fauconnier J, Cazorla O, Lacampagne A, Amedro P.
PMID: 34905152
Int J Cardiovasc Imaging. 2021 Dec 14; doi: 10.1007/s10554-021-02369-y. Epub 2021 Dec 14.

Prognosis of Duchenne muscular dystrophy (DMD) is related to cardiac dysfunction. Two dimensional-speckle tracking echocardiography (2D-STE) has recently emerged as a non-invasive functional biomarker for early detection of DMD-related cardiomyopathy. This study aimed to determine, in DMD children, the...

Determining the short-term neurological prognosis for acute cervical spinal cord injury using machine learning.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Okimatsu S, Maki S, Furuya T, Fujiyoshi T, Kitamura M, Inada T, Aramomi M, Yamauchi T, Miyamoto T, Inoue T, Yunde A, Miura M, Shiga Y, Inage K, Orita S, Eguchi Y, Ohtori S.
PMID: 34998207
J Clin Neurosci. 2022 Jan 05;96:74-79. doi: 10.1016/j.jocn.2021.11.037. Epub 2022 Jan 05.

It is challenging to predict neurological outcomes of acute spinal cord injury (SCI) considering issues such as spinal shock and injury heterogeneity. Deep learning-based radiomics (DLR) were developed to quantify the radiographic characteristics automatically using a convolutional neural network...

Suppressive effect of dexamethasone on murine Th9 cell-mediated nasal eosinophilic inflammation.

Asia Pacific allergy

Koyama T, Miura K, Yamasaki N, Ogata S, Ito D, Saeki M, Hiroi T, Mori A, Kaminuma O.
PMID: 34386401
Asia Pac Allergy. 2021 Jul 07;11(3):e25. doi: 10.5415/apallergy.2021.11.e25. eCollection 2021 Jul.

BACKGROUND: Th9 cells have been implicated in the development of allergic inflammation, though its contribution to allergic rhinitis and the effect of steroid on Th9 cell-mediated nasal responses are unclear.OBJECTIVE: In this study, allergen-induced nasal inflammatory responses and their...

Influence of Culture Period on Osteoblast Differentiation of Tissue-Engineered Bone Constructed by Apatite-Fiber Scaffolds Using Radial-Flow Bioreactor.

International journal of molecular sciences

Suzuki K, Fukasawa J, Miura M, Lim PN, Honda M, Matsuura T, Aizawa M.
PMID: 34884885
Int J Mol Sci. 2021 Dec 03;22(23). doi: 10.3390/ijms222313080.

With the limitation of autografts, the development of alternative treatments for bone diseases to alleviate autograft-related complications is highly demanded. In this study, a tissue-engineered bone was formed by culturing rat bone marrow cells (RBMCs) onto porous apatite-fiber scaffolds...

Regulatory T Cell as a Biomarker of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia.

Cancers

Fujioka Y, Sugiyama D, Matsumura I, Minami Y, Miura M, Atsuta Y, Ohtake S, Kiyoi H, Miyazaki Y, Nishikawa H, Takahashi N.
PMID: 34885012
Cancers (Basel). 2021 Nov 24;13(23). doi: 10.3390/cancers13235904.

Treatment-free remission (TFR) has become a therapeutic goal in chronic myeloid leukemia (CML), and approximately half of the patients with chronic phase-CML (CML-CP) with deep molecular remission (DMR) by tyrosine-kinase inhibitors (TKIs) have achieved TFR. However, the mechanism of...

Aligned human induced pluripotent stem cell-derived cardiac tissue improves contractile properties through promoting unidirectional and synchronous cardiomyocyte contraction.

Biomaterials

Takada T, Sasaki D, Matsuura K, Miura K, Sakamoto S, Goto H, Ohya T, Iida T, Homma J, Shimizu T, Hagiwara N.
PMID: 34979417
Biomaterials. 2021 Dec 30;281:121351. doi: 10.1016/j.biomaterials.2021.121351. Epub 2021 Dec 30.

Alignment, as seen in the native myocardium, is crucial for the fabrication of functional cardiac tissue. However, it remains unclear whether the control of cardiomyocyte alignment influences cardiac function and the underlying mechanisms. We fabricated aligned human cardiac tissue...

Aligned human induced pluripotent stem cell-derived cardiac tissue improves contractile properties through promoting unidirectional and synchronous cardiomyocyte contraction.

Biomaterials

Takada T, Sasaki D, Matsuura K, Miura K, Sakamoto S, Goto H, Ohya T, Iida T, Homma J, Shimizu T, Hagiwara N.
PMID: 34979417
Biomaterials. 2021 Dec 30;281:121351. doi: 10.1016/j.biomaterials.2021.121351. Epub 2021 Dec 30.

Alignment, as seen in the native myocardium, is crucial for the fabrication of functional cardiac tissue. However, it remains unclear whether the control of cardiomyocyte alignment influences cardiac function and the underlying mechanisms. We fabricated aligned human cardiac tissue...

Accelerated decline in lung function in adults with a history of remitted childhood asthma.

The European respiratory journal

Miura S, Iwamoto H, Omori K, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Fujitaka K, Hamada H, Yokoyama A, Hattori N.
PMID: 34588191
Eur Respir J. 2022 Jan 13;59(1). doi: 10.1183/13993003.00305-2021. Print 2022 Jan.

BACKGROUND: A significant number of children with asthma show remission in adulthood. Although these adults are often diagnosed with COPD in later life, the effect of clinically remitted childhood asthma on the decline in lung function during adulthood is...

Optimizing Detection of Lymphatic Invasion in Primary Cutaneous Melanoma With the Use of D2-40 and a Paired Melanocytic Marker.

The American Journal of dermatopathology

Straker RJ, Taylor LA, Neuwirth MG, Sinnamon AJ, Shannon AB, Abbott J, Miura JT, Chu EY, Xu X, Karakousis GC.
PMID: 34231497
Am J Dermatopathol. 2022 Jan 01;44(1):21-27. doi: 10.1097/DAD.0000000000002018.

ABSTRACT: Dual immunohistochemical (IHC) staining with D2-40 and S100 improves detection of lymphatic invasion (LI) in primary cutaneous melanoma. However, limited data exist evaluating this technique using other melanocytic markers, and thus, the optimal marker for detection of LI...

Showing 3361 to 3372 of 3372 entries