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Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in .

Proceedings of the National Academy of Sciences of the United States of America

Skalenko KS, Li L, Zhang Y, Vvedenskaya IO, Winkelman JT, Cope AL, Taylor DM, Shah P, Ebright RH, Kinney JB, Zhang Y, Nickels BE.
PMID: 34187896
Proc Natl Acad Sci U S A. 2021 Jul 06;118(27). doi: 10.1073/pnas.2106388118.

Chemical modifications of RNA 5'-ends enable "epitranscriptomic" regulation, influencing multiple aspects of RNA fate. In transcription initiation, a large inventory of substrates compete with nucleoside triphosphates for use as initiating entities, providing an ab initio mechanism for altering the...

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Skalenko KS, Li L, Zhang Y, et al. Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in . Proc Natl Acad Sci U S A. 2021;118(27)doi: 10.1073/pnas.2106388118.
Skalenko, K. S., Li, L., Zhang, Y., Vvedenskaya, I. O., Winkelman, J. T., Cope, A. L., Taylor, D. M., Shah, P., Ebright, R. H., Kinney, J. B., Zhang, Y., & Nickels, B. E. (2021). Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in . Proceedings of the National Academy of Sciences of the United States of America, 118(27), . https://doi.org/10.1073/pnas.2106388118
Skalenko, Kyle S, et al. "Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in ." Proceedings of the National Academy of Sciences of the United States of America vol. 118,27 (2021). doi: https://doi.org/10.1073/pnas.2106388118
Skalenko KS, Li L, Zhang Y, Vvedenskaya IO, Winkelman JT, Cope AL, Taylor DM, Shah P, Ebright RH, Kinney JB, Zhang Y, Nickels BE. Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in . Proc Natl Acad Sci U S A. 2021 Jul 06;118(27). doi: 10.1073/pnas.2106388118. PMID: 34187896; PMCID: PMC8271711.
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Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms.

Current neuropharmacology

Haidar MA, Ibeh S, Shakkour Z, Reslan MA, Nwaiwu J, Moqidem YA, Sader G, Nickles RG, Babale I, Jaffa AA, Salama M, Shaito A, Kobeissy F.
PMID: 34856905
Curr Neuropharmacol. 2021 Dec 02; doi: 10.2174/1570159X19666211202123322. Epub 2021 Dec 02.

Microglia are the resident immune cells of the brain and play a crucial role in housekeeping and maintaining homeostasis of the brain microenvironment. Upon injury or disease, microglial cells become activated, at least partly, via signals initiated by injured...

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Haidar MA, Ibeh S, Shakkour Z, et al. Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms. Curr Neuropharmacol. 2021;doi: 10.2174/1570159X19666211202123322.
Haidar, M. A., Ibeh, S., Shakkour, Z., Reslan, M. A., Nwaiwu, J., Moqidem, Y. A., Sader, G., Nickles, R. G., Babale, I., Jaffa, A. A., Salama, M., Shaito, A., & Kobeissy, F. (2021). Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms. Current neuropharmacology, . https://doi.org/10.2174/1570159X19666211202123322
Haidar, Muhammad Ali, et al. "Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms." Current neuropharmacology vol. (2021). doi: https://doi.org/10.2174/1570159X19666211202123322
Haidar MA, Ibeh S, Shakkour Z, Reslan MA, Nwaiwu J, Moqidem YA, Sader G, Nickles RG, Babale I, Jaffa AA, Salama M, Shaito A, Kobeissy F. Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms. Curr Neuropharmacol. 2021 Dec 02; doi: 10.2174/1570159X19666211202123322. Epub 2021 Dec 02. PMID: 34856905.
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The Association Between Modifiable Lifestyle Factors and Postoperative Complications of Elective Surgery in Patients With Colorectal Cancer.

Diseases of the colon and rectum

Loogman L, de Nes LCF, Heil TC, Kok DEG, Winkels RM, Kampman E, de Wilt JHW, van Duijnhoven FJB.
PMID: 34082436
Dis Colon Rectum. 2021 Nov 01;64(11):1342-1353. doi: 10.1097/DCR.0000000000001976.

BACKGROUND: Research has demonstrated a possible relation between patients' preoperative lifestyle and postoperative complications.OBJECTIVE: This study aimed to assess associations between modifiable preoperative lifestyle factors and postoperative complications in patients undergoing elective surgery for colorectal cancer.DESIGN: This is a...

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Loogman L, de Nes LCF, Heil TC, et al. The Association Between Modifiable Lifestyle Factors and Postoperative Complications of Elective Surgery in Patients With Colorectal Cancer. Dis Colon Rectum. 2021;64(11):1342-1353doi: 10.1097/DCR.0000000000001976.
Loogman, L., de Nes, L. C. F., Heil, T. C., Kok, D. E. G., Winkels, R. M., Kampman, E., de Wilt, J. H. W., van Duijnhoven, F. J. B. (2021). The Association Between Modifiable Lifestyle Factors and Postoperative Complications of Elective Surgery in Patients With Colorectal Cancer. Diseases of the colon and rectum, 64(11), 1342-1353. https://doi.org/10.1097/DCR.0000000000001976
Loogman, Lisanne, et al. "The Association Between Modifiable Lifestyle Factors and Postoperative Complications of Elective Surgery in Patients With Colorectal Cancer." Diseases of the colon and rectum vol. 64,11 (2021): 1342-1353. doi: https://doi.org/10.1097/DCR.0000000000001976
Loogman L, de Nes LCF, Heil TC, Kok DEG, Winkels RM, Kampman E, de Wilt JHW, van Duijnhoven FJB. The Association Between Modifiable Lifestyle Factors and Postoperative Complications of Elective Surgery in Patients With Colorectal Cancer. Dis Colon Rectum. 2021 Nov 01;64(11):1342-1353. doi: 10.1097/DCR.0000000000001976. PMID: 34082436; PMCID: PMC8492187.
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Green Synthesis of Gold Nanoparticles Using Upland Cress and Their Biochemical Characterization and Assessment.

Nanomaterials (Basel, Switzerland)

Hutchinson N, Wu Y, Wang Y, Kanungo M, DeBruine A, Kroll E, Gilmore D, Eckrose Z, Gaston S, Matel P, Kaltchev M, Nickel AM, Kumpaty S, Hua X, Zhang W.
PMID: 35009978
Nanomaterials (Basel). 2021 Dec 23;12(1). doi: 10.3390/nano12010028.

This research focuses on the plant-mediated green synthesis process to produce gold nanoparticles (Au NPs) using upland cress (Barbarea verna), as various biomolecules within the upland cress act as both reducing and capping agents. The synthesized gold nanoparticles were...

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Hutchinson N, Wu Y, Wang Y, et al. Green Synthesis of Gold Nanoparticles Using Upland Cress and Their Biochemical Characterization and Assessment. Nanomaterials (Basel). 2021;12(1)doi: 10.3390/nano12010028.
Hutchinson, N., Wu, Y., Wang, Y., Kanungo, M., DeBruine, A., Kroll, E., Gilmore, D., Eckrose, Z., Gaston, S., Matel, P., Kaltchev, M., Nickel, A. M., Kumpaty, S., Hua, X., & Zhang, W. (2021). Green Synthesis of Gold Nanoparticles Using Upland Cress and Their Biochemical Characterization and Assessment. Nanomaterials (Basel, Switzerland), 12(1), . https://doi.org/10.3390/nano12010028
Hutchinson, Noah, et al. "Green Synthesis of Gold Nanoparticles Using Upland Cress and Their Biochemical Characterization and Assessment." Nanomaterials (Basel, Switzerland) vol. 12,1 (2021). doi: https://doi.org/10.3390/nano12010028
Hutchinson N, Wu Y, Wang Y, Kanungo M, DeBruine A, Kroll E, Gilmore D, Eckrose Z, Gaston S, Matel P, Kaltchev M, Nickel AM, Kumpaty S, Hua X, Zhang W. Green Synthesis of Gold Nanoparticles Using Upland Cress and Their Biochemical Characterization and Assessment. Nanomaterials (Basel). 2021 Dec 23;12(1). doi: 10.3390/nano12010028. PMID: 35009978; PMCID: PMC8746345.
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Patient-Reported Outcomes for Migraine in the US and Europe: Burden Associated with Multiple Preventive Treatment Failures.

ClinicoEconomics and outcomes research : CEOR

Ford J, Nichols RM, Ye W, Tockhorn-Heidenreich A, Cotton S, Jackson J.
PMID: 34285524
Clinicoecon Outcomes Res. 2021 Jul 14;13:647-660. doi: 10.2147/CEOR.S304158. eCollection 2021.

PURPOSE: To evaluate patient-reported outcomes (PROs) among patients with migraine, including those who were preventive-naïve and preventive-treated.METHODS: This was a point-in-time, real-world study of patients with migraine in the US and EU5 (France, Germany, Spain, Italy, and UK) and...

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Ford J, Nichols RM, Ye W, et al. Patient-Reported Outcomes for Migraine in the US and Europe: Burden Associated with Multiple Preventive Treatment Failures. Clinicoecon Outcomes Res. 2021;13:647-660doi: 10.2147/CEOR.S304158.
Ford, J., Nichols, R. M., Ye, W., Tockhorn-Heidenreich, A., Cotton, S., & Jackson, J. (2021). Patient-Reported Outcomes for Migraine in the US and Europe: Burden Associated with Multiple Preventive Treatment Failures. ClinicoEconomics and outcomes research : CEOR, 13647-660. https://doi.org/10.2147/CEOR.S304158
Ford, Janet, et al. "Patient-Reported Outcomes for Migraine in the US and Europe: Burden Associated with Multiple Preventive Treatment Failures." ClinicoEconomics and outcomes research : CEOR vol. 13 (2021): 647-660. doi: https://doi.org/10.2147/CEOR.S304158
Ford J, Nichols RM, Ye W, Tockhorn-Heidenreich A, Cotton S, Jackson J. Patient-Reported Outcomes for Migraine in the US and Europe: Burden Associated with Multiple Preventive Treatment Failures. Clinicoecon Outcomes Res. 2021 Jul 14;13:647-660. doi: 10.2147/CEOR.S304158. eCollection 2021. PMID: 34285524; PMCID: PMC8286727.
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"The Circle" Predicts Extent of Fusion for Surgical Correction of Cervical Spinal Kyphotic Deformities: Proof of Concept.

World neurosurgery

Li D, Nockels RP.
PMID: 34958989
World Neurosurg. 2021 Dec 24; doi: 10.1016/j.wneu.2021.12.073. Epub 2021 Dec 24.

BACKGROUND: Correction of kyphotic deformities of the spine is a common problem faced by spine surgeons. Unfortunately, there are no clear published guidelines available regarding the extent of spinal fusion required to achieve and maintain lasting deformity correction.OBJECTIVE: The...

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Li D, Nockels RP. "The Circle" Predicts Extent of Fusion for Surgical Correction of Cervical Spinal Kyphotic Deformities: Proof of Concept. World Neurosurg. 2021;doi: 10.1016/j.wneu.2021.12.073.
Li, D., & Nockels, R. P. (2021). "The Circle" Predicts Extent of Fusion for Surgical Correction of Cervical Spinal Kyphotic Deformities: Proof of Concept. World neurosurgery, . https://doi.org/10.1016/j.wneu.2021.12.073
Li, Daphne, and Nockels, Russ P. ""The Circle" Predicts Extent of Fusion for Surgical Correction of Cervical Spinal Kyphotic Deformities: Proof of Concept." World neurosurgery vol. (2021). doi: https://doi.org/10.1016/j.wneu.2021.12.073
Li D, Nockels RP. "The Circle" Predicts Extent of Fusion for Surgical Correction of Cervical Spinal Kyphotic Deformities: Proof of Concept. World Neurosurg. 2021 Dec 24; doi: 10.1016/j.wneu.2021.12.073. Epub 2021 Dec 24. PMID: 34958989.
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The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1.

Cell reports

Walter J, Bolognin S, Poovathingal SK, Magni S, Gérard D, Antony PMA, Nickels SL, Salamanca L, Berger E, Smits LM, Grzyb K, Perfeito R, Hoel F, Qing X, Ohnmacht J, Bertacchi M, Jarazo J, Ignac T, Monzel AS, Gonzalez-Cano L, Krüger R, Sauter T, Studer M, de Almeida LP, Tronstad KJ, Sinkkonen L, Skupin A, Schwamborn JC.
PMID: 34686322
Cell Rep. 2021 Oct 19;37(3):109864. doi: 10.1016/j.celrep.2021.109864.

Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in dopaminergic neurons in a model of Parkinson's disease (PD). We monitor the differentiation of human...

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Walter J, Bolognin S, Poovathingal SK, et al. The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell Rep. 2021;37(3):109864doi: 10.1016/j.celrep.2021.109864.
Walter, J., Bolognin, S., Poovathingal, S. K., Magni, S., Gérard, D., Antony, P. M. A., Nickels, S. L., Salamanca, L., Berger, E., Smits, L. M., Grzyb, K., Perfeito, R., Hoel, F., Qing, X., Ohnmacht, J., Bertacchi, M., Jarazo, J., Ignac, T., Monzel, A. S., Gonzalez-Cano, L., Krüger, R., Sauter, T., Studer, M., de Almeida, L. P., Tronstad, K. J., Sinkkonen, L., Skupin, A., & Schwamborn, J. C. (2021). The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell reports, 37(3), 109864. https://doi.org/10.1016/j.celrep.2021.109864
Walter, Jonas, et al. "The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1." Cell reports vol. 37,3 (2021): 109864. doi: https://doi.org/10.1016/j.celrep.2021.109864
Walter J, Bolognin S, Poovathingal SK, Magni S, Gérard D, Antony PMA, Nickels SL, Salamanca L, Berger E, Smits LM, Grzyb K, Perfeito R, Hoel F, Qing X, Ohnmacht J, Bertacchi M, Jarazo J, Ignac T, Monzel AS, Gonzalez-Cano L, Krüger R, Sauter T, Studer M, de Almeida LP, Tronstad KJ, Sinkkonen L, Skupin A, Schwamborn JC. The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell Rep. 2021 Oct 19;37(3):109864. doi: 10.1016/j.celrep.2021.109864. PMID: 34686322.
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DNA Origami Meets Bottom-Up Nanopatterning.

ACS nano

Martynenko IV, Ruider V, Dass M, Liedl T, Nickels PC.
PMID: 34255962
ACS Nano. 2021 Jul 13; doi: 10.1021/acsnano.1c04297. Epub 2021 Jul 13.

DNA origami has emerged as a powerful molecular breadboard with nanometer resolution that can integrate the world of bottom-up (bio)chemistry with large-scale, macroscopic devices created by top-down lithography. Substituting the top-down patterning with self-assembled colloidal nanoparticles now takes the...

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Martynenko IV, Ruider V, Dass M, et al. DNA Origami Meets Bottom-Up Nanopatterning. ACS Nano. 2021;doi: 10.1021/acsnano.1c04297.
Martynenko, I. V., Ruider, V., Dass, M., Liedl, T., & Nickels, P. C. (2021). DNA Origami Meets Bottom-Up Nanopatterning. ACS nano, . https://doi.org/10.1021/acsnano.1c04297
Martynenko, Irina V, et al. "DNA Origami Meets Bottom-Up Nanopatterning." ACS nano vol. (2021). doi: https://doi.org/10.1021/acsnano.1c04297
Martynenko IV, Ruider V, Dass M, Liedl T, Nickels PC. DNA Origami Meets Bottom-Up Nanopatterning. ACS Nano. 2021 Jul 13; doi: 10.1021/acsnano.1c04297. Epub 2021 Jul 13. PMID: 34255962; PMCID: PMC8320526.
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Dynamics of brain function in patients with chronic pain assessed by microstate analysis of resting-state electroencephalography.

Pain

May ES, Gil Ávila C, Ta Dinh S, Heitmann H, Hohn VD, Nickel MM, Tiemann L, Tölle TR, Ploner M.
PMID: 33863863
Pain. 2021 Dec 01;162(12):2894-2908. doi: 10.1097/j.pain.0000000000002281.

ABSTRACT: Chronic pain is a highly prevalent and severely disabling disease that is associated with substantial changes of brain function. Such changes have mostly been observed when analyzing static measures of resting-state brain activity. However, brain activity varies over...

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May ES, Gil Ávila C, Ta Dinh S, et al. Dynamics of brain function in patients with chronic pain assessed by microstate analysis of resting-state electroencephalography. Pain. 2021;162(12):2894-2908doi: 10.1097/j.pain.0000000000002281.
May, E. S., Gil Ávila, C., Ta Dinh, S., Heitmann, H., Hohn, V. D., Nickel, M. M., Tiemann, L., Tölle, T. R., & Ploner, M. (2021). Dynamics of brain function in patients with chronic pain assessed by microstate analysis of resting-state electroencephalography. Pain, 162(12), 2894-2908. https://doi.org/10.1097/j.pain.0000000000002281
May, Elisabeth S, et al. "Dynamics of brain function in patients with chronic pain assessed by microstate analysis of resting-state electroencephalography." Pain vol. 162,12 (2021): 2894-2908. doi: https://doi.org/10.1097/j.pain.0000000000002281
May ES, Gil Ávila C, Ta Dinh S, Heitmann H, Hohn VD, Nickel MM, Tiemann L, Tölle TR, Ploner M. Dynamics of brain function in patients with chronic pain assessed by microstate analysis of resting-state electroencephalography. Pain. 2021 Dec 01;162(12):2894-2908. doi: 10.1097/j.pain.0000000000002281. PMID: 33863863; PMCID: PMC8600543.
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Surgical correction of pediatric spinal deformities with coexisting intraspinal pathology: A case report and literature review.

Surgical neurology international

Li D, Anderson DE, Nockels RP.
PMID: 34513148
Surg Neurol Int. 2021 Aug 03;12:381. doi: 10.25259/SNI_593_2021. eCollection 2021.

BACKGROUND: Surgical correction of spinal deformities with coexisting intraspinal pathology (SDCIP) requires special consideration to minimize risks of further injury to an already abnormal spinal cord. However, there is a paucity of literature on this topic. Here, the authors...

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Li D, Anderson DE, Nockels RP. Surgical correction of pediatric spinal deformities with coexisting intraspinal pathology: A case report and literature review. Surg Neurol Int. 2021;12:381doi: 10.25259/SNI_593_2021.
Li, D., Anderson, D. E., & Nockels, R. P. (2021). Surgical correction of pediatric spinal deformities with coexisting intraspinal pathology: A case report and literature review. Surgical neurology international, 12381. https://doi.org/10.25259/SNI_593_2021
Li, Daphne, et al. "Surgical correction of pediatric spinal deformities with coexisting intraspinal pathology: A case report and literature review." Surgical neurology international vol. 12 (2021): 381. doi: https://doi.org/10.25259/SNI_593_2021
Li D, Anderson DE, Nockels RP. Surgical correction of pediatric spinal deformities with coexisting intraspinal pathology: A case report and literature review. Surg Neurol Int. 2021 Aug 03;12:381. doi: 10.25259/SNI_593_2021. eCollection 2021. PMID: 34513148; PMCID: PMC8422436.
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Relationship Between Cancer Related Fatigue, Physical Activity Related Health Competence, and Leisure Time Physical Activity in Cancer Patients and Survivors.

Frontiers in sports and active living

Koeppel M, Körbi C, Winkels RM, Schmitz KH, Wiskemann J.
PMID: 34423290
Front Sports Act Living. 2021 Aug 05;3:687365. doi: 10.3389/fspor.2021.687365. eCollection 2021.

No abstract available.

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Koeppel M, Körbi C, Winkels RM, et al. Relationship Between Cancer Related Fatigue, Physical Activity Related Health Competence, and Leisure Time Physical Activity in Cancer Patients and Survivors. Front Sports Act Living. 2021;3:687365doi: 10.3389/fspor.2021.687365.
Koeppel, M., Körbi, C., Winkels, R. M., Schmitz, K. H., & Wiskemann, J. (2021). Relationship Between Cancer Related Fatigue, Physical Activity Related Health Competence, and Leisure Time Physical Activity in Cancer Patients and Survivors. Frontiers in sports and active living, 3687365. https://doi.org/10.3389/fspor.2021.687365
Koeppel, Maximilian, et al. "Relationship Between Cancer Related Fatigue, Physical Activity Related Health Competence, and Leisure Time Physical Activity in Cancer Patients and Survivors." Frontiers in sports and active living vol. 3 (2021): 687365. doi: https://doi.org/10.3389/fspor.2021.687365
Koeppel M, Körbi C, Winkels RM, Schmitz KH, Wiskemann J. Relationship Between Cancer Related Fatigue, Physical Activity Related Health Competence, and Leisure Time Physical Activity in Cancer Patients and Survivors. Front Sports Act Living. 2021 Aug 05;3:687365. doi: 10.3389/fspor.2021.687365. eCollection 2021. PMID: 34423290; PMCID: PMC8374069.
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306.1: Clinical Metrics Predict Defective Physiologic Responses to Hypoglycemia in Long-standing Type 1 Diabetes and May Facilitate Early Consideration of Referral for Beta-Cell Replacement Therapy.

Transplantation

Flatt A, Chen E, Peleckis AJ, Dalton-Bakes C, Nguyen HL, Gallop R, Rickels MR.
PMID: 34908320
Transplantation. 2021 Dec 01;105(12):S18. doi: 10.1097/01.tp.0000804372.45039.8e.

No abstract available.

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Flatt A, Chen E, Peleckis AJ, et al. 306.1: Clinical Metrics Predict Defective Physiologic Responses to Hypoglycemia in Long-standing Type 1 Diabetes and May Facilitate Early Consideration of Referral for Beta-Cell Replacement Therapy. Transplantation. 2021;105(12):S18doi: 10.1097/01.tp.0000804372.45039.8e.
Flatt, A., Chen, E., Peleckis, A. J., Dalton-Bakes, C., Nguyen, H. L., Gallop, R., & Rickels, M. R. (2021). 306.1: Clinical Metrics Predict Defective Physiologic Responses to Hypoglycemia in Long-standing Type 1 Diabetes and May Facilitate Early Consideration of Referral for Beta-Cell Replacement Therapy. Transplantation, 105(12), S18. https://doi.org/10.1097/01.tp.0000804372.45039.8e
Flatt, Anneliese, et al. "306.1: Clinical Metrics Predict Defective Physiologic Responses to Hypoglycemia in Long-standing Type 1 Diabetes and May Facilitate Early Consideration of Referral for Beta-Cell Replacement Therapy." Transplantation vol. 105,12 (2021): S18. doi: https://doi.org/10.1097/01.tp.0000804372.45039.8e
Flatt A, Chen E, Peleckis AJ, Dalton-Bakes C, Nguyen HL, Gallop R, Rickels MR. 306.1: Clinical Metrics Predict Defective Physiologic Responses to Hypoglycemia in Long-standing Type 1 Diabetes and May Facilitate Early Consideration of Referral for Beta-Cell Replacement Therapy. Transplantation. 2021 Dec 01;105(12):S18. doi: 10.1097/01.tp.0000804372.45039.8e. PMID: 34908320.
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