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Testicular volume in infertile versus fertile white-European men: a case-control investigation in the real-life setting.

Asian journal of andrology

Boeri L, Capogrosso P, Ventimiglia E, Cazzaniga W, Pozzi E, Belladelli F, Pederzoli F, Alfano M, Abbate C, Montanari E, Valsecchi L, Papaleo E, Viganò P, Rovere-Querini P, Minhas S, Montorsi F, Salonia A.
PMID: 33723100
Asian J Androl. 2021 Sep-Oct;23(5):501-509. doi: 10.4103/aja.aja_93_20.

Testicular volume (TV) is considered a good clinical marker of hormonal and spermatogenic function. Accurate reference values for TV measures in infertile and fertile men are lacking. We aimed to assess references values for TV in white-European infertile men...

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Boeri L, Capogrosso P, Ventimiglia E, et al. Testicular volume in infertile versus fertile white-European men: a case-control investigation in the real-life setting. Asian J Androl. 2021;23(5):501-509doi: 10.4103/aja.aja_93_20.
Boeri, L., Capogrosso, P., Ventimiglia, E., Cazzaniga, W., Pozzi, E., Belladelli, F., Pederzoli, F., Alfano, M., Abbate, C., Montanari, E., Valsecchi, L., Papaleo, E., Viganò, P., Rovere-Querini, P., Minhas, S., Montorsi, F., & Salonia, A. (2021). Testicular volume in infertile versus fertile white-European men: a case-control investigation in the real-life setting. Asian journal of andrology, 23(5), 501-509. https://doi.org/10.4103/aja.aja_93_20
Boeri, Luca, et al. "Testicular volume in infertile versus fertile white-European men: a case-control investigation in the real-life setting." Asian journal of andrology vol. 23,5 (2021): 501-509. doi: https://doi.org/10.4103/aja.aja_93_20
Boeri L, Capogrosso P, Ventimiglia E, Cazzaniga W, Pozzi E, Belladelli F, Pederzoli F, Alfano M, Abbate C, Montanari E, Valsecchi L, Papaleo E, Viganò P, Rovere-Querini P, Minhas S, Montorsi F, Salonia A. Testicular volume in infertile versus fertile white-European men: a case-control investigation in the real-life setting. Asian J Androl. 2021 Sep-Oct;23(5):501-509. doi: 10.4103/aja.aja_93_20. PMID: 33723100; PMCID: PMC8451491.
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Country-level factors dynamics and ABO/Rh blood groups contribution to COVID-19 mortality.

Scientific reports

Monaco A, Pantaleo E, Amoroso N, Bellantuono L, Stella A, Bellotti R.
PMID: 34972836
Sci Rep. 2021 Dec 31;11(1):24527. doi: 10.1038/s41598-021-04162-2.

The identification of factors associated to COVID-19 mortality is important to design effective containment measures and safeguard at-risk categories. In the last year, several investigations have tried to ascertain key features to predict the COVID-19 mortality tolls in relation...

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Monaco A, Pantaleo E, Amoroso N, et al. Country-level factors dynamics and ABO/Rh blood groups contribution to COVID-19 mortality. Sci Rep. 2021;11(1):24527doi: 10.1038/s41598-021-04162-2.
Monaco, A., Pantaleo, E., Amoroso, N., Bellantuono, L., Stella, A., & Bellotti, R. (2021). Country-level factors dynamics and ABO/Rh blood groups contribution to COVID-19 mortality. Scientific reports, 11(1), 24527. https://doi.org/10.1038/s41598-021-04162-2
Monaco, Alfonso, et al. "Country-level factors dynamics and ABO/Rh blood groups contribution to COVID-19 mortality." Scientific reports vol. 11,1 (2021): 24527. doi: https://doi.org/10.1038/s41598-021-04162-2
Monaco A, Pantaleo E, Amoroso N, Bellantuono L, Stella A, Bellotti R. Country-level factors dynamics and ABO/Rh blood groups contribution to COVID-19 mortality. Sci Rep. 2021 Dec 31;11(1):24527. doi: 10.1038/s41598-021-04162-2. PMID: 34972836; PMCID: PMC8720090.
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Primary seminoma arising in the posterior mediastinum: a diagnostic challenge.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

Parini S, Spina P, Papalia E, Boldorini R, Abruzzese M, Rena O.
PMID: 34634899
Monaldi Arch Chest Dis. 2021 Oct 11; doi: 10.4081/monaldi.2021.2028. Epub 2021 Oct 11.

Primary mediastinal germ cell tumors are a rare finding, and one third of them are seminomas. Seminomas are found in the anterior mediastinum, whereas they are extremely rare within the posterior compartment. Most clinicians would not consider a primary...

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Parini S, Spina P, Papalia E, et al. Primary seminoma arising in the posterior mediastinum: a diagnostic challenge. Monaldi Arch Chest Dis. 2021;doi: 10.4081/monaldi.2021.2028.
Parini, S., Spina, P., Papalia, E., Boldorini, R., Abruzzese, M., & Rena, O. (2021). Primary seminoma arising in the posterior mediastinum: a diagnostic challenge. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, . https://doi.org/10.4081/monaldi.2021.2028
Parini, Sara, et al. "Primary seminoma arising in the posterior mediastinum: a diagnostic challenge." Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace vol. (2021). doi: https://doi.org/10.4081/monaldi.2021.2028
Parini S, Spina P, Papalia E, Boldorini R, Abruzzese M, Rena O. Primary seminoma arising in the posterior mediastinum: a diagnostic challenge. Monaldi Arch Chest Dis. 2021 Oct 11; doi: 10.4081/monaldi.2021.2028. Epub 2021 Oct 11. PMID: 34634899.
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Prokaryotic Diversity of the Composting Thermophilic Phase: The Case of Ground Coffee Compost.

Microorganisms

Papale M, Romano I, Finore I, Lo Giudice A, Piccolo A, Cangemi S, Di Meo V, Nicolaus B, Poli A.
PMID: 33494462
Microorganisms. 2021 Jan 21;9(2). doi: 10.3390/microorganisms9020218.

Waste biomass coming from a local coffee company, which supplied burnt ground coffee after an incorrect roasting process, was employed as a starting material in the composting plant of the Experimental Station of the University of Naples Federico II...

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Papale M, Romano I, Finore I, et al. Prokaryotic Diversity of the Composting Thermophilic Phase: The Case of Ground Coffee Compost. Microorganisms. 2021;9(2)doi: 10.3390/microorganisms9020218.
Papale, M., Romano, I., Finore, I., Lo Giudice, A., Piccolo, A., Cangemi, S., Di Meo, V., Nicolaus, B., & Poli, A. (2021). Prokaryotic Diversity of the Composting Thermophilic Phase: The Case of Ground Coffee Compost. Microorganisms, 9(2), . https://doi.org/10.3390/microorganisms9020218
Papale, Maria, et al. "Prokaryotic Diversity of the Composting Thermophilic Phase: The Case of Ground Coffee Compost." Microorganisms vol. 9,2 (2021). doi: https://doi.org/10.3390/microorganisms9020218
Papale M, Romano I, Finore I, Lo Giudice A, Piccolo A, Cangemi S, Di Meo V, Nicolaus B, Poli A. Prokaryotic Diversity of the Composting Thermophilic Phase: The Case of Ground Coffee Compost. Microorganisms. 2021 Jan 21;9(2). doi: 10.3390/microorganisms9020218. PMID: 33494462; PMCID: PMC7911569.
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Comparison of the positivity rate of anti-spike and anti-nucleocapsid SARS-CoV-2 IgG in asymptomatic pregnant women.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

Heireman L, Baetens M, Menten B, Dehaene I, Padalko E.
PMID: 34958623
J Obstet Gynaecol. 2021 Dec 27;1-2. doi: 10.1080/01443615.2021.1997960. Epub 2021 Dec 27.

No abstract available.

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Heireman L, Baetens M, Menten B, et al. Comparison of the positivity rate of anti-spike and anti-nucleocapsid SARS-CoV-2 IgG in asymptomatic pregnant women. J Obstet Gynaecol. 2021;1-2doi: 10.1080/01443615.2021.1997960.
Heireman, L., Baetens, M., Menten, B., Dehaene, I., & Padalko, E. (2021). Comparison of the positivity rate of anti-spike and anti-nucleocapsid SARS-CoV-2 IgG in asymptomatic pregnant women. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 1-2. https://doi.org/10.1080/01443615.2021.1997960
Heireman, L, et al. "Comparison of the positivity rate of anti-spike and anti-nucleocapsid SARS-CoV-2 IgG in asymptomatic pregnant women." Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology vol. (2021): 1-2. doi: https://doi.org/10.1080/01443615.2021.1997960
Heireman L, Baetens M, Menten B, Dehaene I, Padalko E. Comparison of the positivity rate of anti-spike and anti-nucleocapsid SARS-CoV-2 IgG in asymptomatic pregnant women. J Obstet Gynaecol. 2021 Dec 27;1-2. doi: 10.1080/01443615.2021.1997960. Epub 2021 Dec 27. PMID: 34958623.
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Immunology and microbiology: how do they affect social cognition and emotion recognition?.

Current opinion in immunology

Barcik W, Chiacchierini G, Bimpisidis Z, Papaleo F.
PMID: 34058687
Curr Opin Immunol. 2021 Aug;71:46-54. doi: 10.1016/j.coi.2021.05.001. Epub 2021 May 28.

Social interactions profoundly influence animals' life. The quality of social interactions and many everyday life decisions are determined by a proper perception, processing and reaction to others' emotions. Notably, alterations in these social processes characterize a number of neurodevelopmental...

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Barcik W, Chiacchierini G, Bimpisidis Z, et al. Immunology and microbiology: how do they affect social cognition and emotion recognition?. Curr Opin Immunol. 2021;71:46-54doi: 10.1016/j.coi.2021.05.001.
Barcik, W., Chiacchierini, G., Bimpisidis, Z., & Papaleo, F. (2021). Immunology and microbiology: how do they affect social cognition and emotion recognition?. Current opinion in immunology, 7146-54. https://doi.org/10.1016/j.coi.2021.05.001
Barcik, Weronika, et al. "Immunology and microbiology: how do they affect social cognition and emotion recognition?." Current opinion in immunology vol. 71 (2021): 46-54. doi: https://doi.org/10.1016/j.coi.2021.05.001
Barcik W, Chiacchierini G, Bimpisidis Z, Papaleo F. Immunology and microbiology: how do they affect social cognition and emotion recognition?. Curr Opin Immunol. 2021 Aug;71:46-54. doi: 10.1016/j.coi.2021.05.001. Epub 2021 May 28. PMID: 34058687.
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Acoustic impact of a wave energy converter in Mediterranean shallow waters.

Scientific reports

Buscaino G, Mattiazzo G, Sannino G, Papale E, Bracco G, Grammauta R, Carillo A, Kenny JM, De Cristofaro N, Ceraulo M, Mazzola S.
PMID: 31270346
Sci Rep. 2019 Jul 03;9(1):9586. doi: 10.1038/s41598-019-45926-1.

In this study, underwater noise from a full-scale wave energy converter system (ISWEC), installed on the coast of Pantelleria Island (central Mediterranean Sea), was characterized. The noise was measured using an autonomous acoustic recorder anchored to the sea bottom...

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Buscaino G, Mattiazzo G, Sannino G, et al. Acoustic impact of a wave energy converter in Mediterranean shallow waters. Sci Rep. 2019;9(1):9586doi: 10.1038/s41598-019-45926-1.
Buscaino, G., Mattiazzo, G., Sannino, G., Papale, E., Bracco, G., Grammauta, R., Carillo, A., Kenny, J. M., De Cristofaro, N., Ceraulo, M., & Mazzola, S. (2019). Acoustic impact of a wave energy converter in Mediterranean shallow waters. Scientific reports, 9(1), 9586. https://doi.org/10.1038/s41598-019-45926-1
Buscaino, Giuseppa, et al. "Acoustic impact of a wave energy converter in Mediterranean shallow waters." Scientific reports vol. 9,1 (2019): 9586. doi: https://doi.org/10.1038/s41598-019-45926-1
Buscaino G, Mattiazzo G, Sannino G, Papale E, Bracco G, Grammauta R, Carillo A, Kenny JM, De Cristofaro N, Ceraulo M, Mazzola S. Acoustic impact of a wave energy converter in Mediterranean shallow waters. Sci Rep. 2019 Jul 03;9(1):9586. doi: 10.1038/s41598-019-45926-1. PMID: 31270346; PMCID: PMC6610649.
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Massive intrasplenic arterial thrombosis in a patient with chronic ITP during the development of an Evans syndrome.

Thrombosis research

Diez-Feijóo R, Rodríguez-Sevilla JJ, Colomo L, Papaleo N, Maiques JM, Gimeno E, Andrade-Campos M, Abella E, Merchan BM, Calvo X, Jimenez C, Román-Bravo OD, Salar A, Sanchez-Gonzalez B.
PMID: 33714615
Thromb Res. 2021 Dec;208:226-229. doi: 10.1016/j.thromres.2021.02.021. Epub 2021 Feb 24.

Long-term safety and efficacy of eltrombopag in adults with persitent/chronic primary immune thrombocytopenia (ITP) evaluated in EXTEND study, showed a high response rate (80%) but, in the clinical safety study, it was observed that 6% of the patients presented...

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Diez-Feijóo R, Rodríguez-Sevilla JJ, Colomo L, et al. Massive intrasplenic arterial thrombosis in a patient with chronic ITP during the development of an Evans syndrome. Thromb Res. 2021;208:226-229doi: 10.1016/j.thromres.2021.02.021.
Diez-Feijóo, R., Rodríguez-Sevilla, J. J., Colomo, L., Papaleo, N., Maiques, J. M., Gimeno, E., Andrade-Campos, M., Abella, E., Merchan, B. M., Calvo, X., Jimenez, C., Román-Bravo, O. D., Salar, A., & Sanchez-Gonzalez, B. (2021). Massive intrasplenic arterial thrombosis in a patient with chronic ITP during the development of an Evans syndrome. Thrombosis research, 208226-229. https://doi.org/10.1016/j.thromres.2021.02.021
Diez-Feijóo, R, et al. "Massive intrasplenic arterial thrombosis in a patient with chronic ITP during the development of an Evans syndrome." Thrombosis research vol. 208 (2021): 226-229. doi: https://doi.org/10.1016/j.thromres.2021.02.021
Diez-Feijóo R, Rodríguez-Sevilla JJ, Colomo L, Papaleo N, Maiques JM, Gimeno E, Andrade-Campos M, Abella E, Merchan BM, Calvo X, Jimenez C, Román-Bravo OD, Salar A, Sanchez-Gonzalez B. Massive intrasplenic arterial thrombosis in a patient with chronic ITP during the development of an Evans syndrome. Thromb Res. 2021 Dec;208:226-229. doi: 10.1016/j.thromres.2021.02.021. Epub 2021 Feb 24. PMID: 33714615.
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Risk Factors for Monozygotic Twins in IVF-ICSI Cycles: a Case-Control Study.

Reproductive sciences (Thousand Oaks, Calif.)

Dallagiovanna C, Vanni VS, Somigliana E, Busnelli A, Papaleo E, Villanacci R, Candiani M, Reschini M.
PMID: 33258063
Reprod Sci. 2021 May;28(5):1421-1427. doi: 10.1007/s43032-020-00406-0. Epub 2020 Nov 30.

In vitro fertilization (IVF) is associated with a higher incidence of monozygotic twin pregnancies, which are known to be burdened by a higher risk of main obstetric complications. The reasons behind this association are still unclear. In the present...

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Dallagiovanna C, Vanni VS, Somigliana E, et al. Risk Factors for Monozygotic Twins in IVF-ICSI Cycles: a Case-Control Study. Reprod Sci. 2020;28(5):1421-1427doi: 10.1007/s43032-020-00406-0.
Dallagiovanna, C., Vanni, V. S., Somigliana, E., Busnelli, A., Papaleo, E., Villanacci, R., Candiani, M., & Reschini, M. (2021). Risk Factors for Monozygotic Twins in IVF-ICSI Cycles: a Case-Control Study. Reproductive sciences (Thousand Oaks, Calif.), 28(5), 1421-1427. https://doi.org/10.1007/s43032-020-00406-0
Dallagiovanna, Chiara, et al. "Risk Factors for Monozygotic Twins in IVF-ICSI Cycles: a Case-Control Study." Reproductive sciences (Thousand Oaks, Calif.) vol. 28,5 (2021): 1421-1427. doi: https://doi.org/10.1007/s43032-020-00406-0
Dallagiovanna C, Vanni VS, Somigliana E, Busnelli A, Papaleo E, Villanacci R, Candiani M, Reschini M. Risk Factors for Monozygotic Twins in IVF-ICSI Cycles: a Case-Control Study. Reprod Sci. 2021 May;28(5):1421-1427. doi: 10.1007/s43032-020-00406-0. Epub 2020 Nov 30. PMID: 33258063.
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Dopamine, Cognitive Impairments and Second-Generation Antipsychotics: From Mechanistic Advances to More Personalized Treatments.

Pharmaceuticals (Basel, Switzerland)

Torrisi SA, Laudani S, Contarini G, De Luca A, Geraci F, Managò F, Papaleo F, Salomone S, Drago F, Leggio GM.
PMID: 33167370
Pharmaceuticals (Basel). 2020 Nov 05;13(11). doi: 10.3390/ph13110365.

The pharmacological treatment of cognitive impairments associated with schizophrenia is still a major unmet clinical need. Indeed, treatments with available antipsychotics generate highly variable cognitive responses among patients with schizophrenia. This has led to the general assumption that antipsychotics...

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Torrisi SA, Laudani S, Contarini G, et al. Dopamine, Cognitive Impairments and Second-Generation Antipsychotics: From Mechanistic Advances to More Personalized Treatments. Pharmaceuticals (Basel). 2020;13(11)doi: 10.3390/ph13110365.
Torrisi, S. A., Laudani, S., Contarini, G., De Luca, A., Geraci, F., Managò, F., Papaleo, F., Salomone, S., Drago, F., & Leggio, G. M. (2020). Dopamine, Cognitive Impairments and Second-Generation Antipsychotics: From Mechanistic Advances to More Personalized Treatments. Pharmaceuticals (Basel, Switzerland), 13(11), . https://doi.org/10.3390/ph13110365
Torrisi, Sebastiano Alfio, et al. "Dopamine, Cognitive Impairments and Second-Generation Antipsychotics: From Mechanistic Advances to More Personalized Treatments." Pharmaceuticals (Basel, Switzerland) vol. 13,11 (2020). doi: https://doi.org/10.3390/ph13110365
Torrisi SA, Laudani S, Contarini G, De Luca A, Geraci F, Managò F, Papaleo F, Salomone S, Drago F, Leggio GM. Dopamine, Cognitive Impairments and Second-Generation Antipsychotics: From Mechanistic Advances to More Personalized Treatments. Pharmaceuticals (Basel). 2020 Nov 05;13(11). doi: 10.3390/ph13110365. PMID: 33167370; PMCID: PMC7694365.
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Substantial hysteresis in emergent temperature sensitivity of global wetland CH.

Nature communications

Chang KY, Riley WJ, Knox SH, Jackson RB, McNicol G, Poulter B, Aurela M, Baldocchi D, Bansal S, Bohrer G, Campbell DI, Cescatti A, Chu H, Delwiche KB, Desai AR, Euskirchen E, Friborg T, Goeckede M, Helbig M, Hemes KS, Hirano T, Iwata H, Kang M, Keenan T, Krauss KW, Lohila A, Mammarella I, Mitra B, Miyata A, Nilsson MB, Noormets A, Oechel WC, Papale D, Peichl M, Reba ML, Rinne J, Runkle BRK, Ryu Y, Sachs T, Schäfer KVR, Schmid HP, Shurpali N, Sonnentag O, Tang ACI, Torn MS, Trotta C, Tuittila ES, Ueyama M, Vargas R, Vesala T, Windham-Myers L, Zhang Z, Zona D.
PMID: 33859182
Nat Commun. 2021 Apr 15;12(1):2266. doi: 10.1038/s41467-021-22452-1.

Wetland methane (CH

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Chang KY, Riley WJ, Knox SH, et al. Substantial hysteresis in emergent temperature sensitivity of global wetland CH. Nat Commun. 2021;12(1):2266doi: 10.1038/s41467-021-22452-1.
Chang, K. Y., Riley, W. J., Knox, S. H., Jackson, R. B., McNicol, G., Poulter, B., Aurela, M., Baldocchi, D., Bansal, S., Bohrer, G., Campbell, D. I., Cescatti, A., Chu, H., Delwiche, K. B., Desai, A. R., Euskirchen, E., Friborg, T., Goeckede, M., Helbig, M., Hemes, K. S., Hirano, T., Iwata, H., Kang, M., Keenan, T., Krauss, K. W., Lohila, A., Mammarella, I., Mitra, B., Miyata, A., Nilsson, M. B., Noormets, A., Oechel, W. C., Papale, D., Peichl, M., Reba, M. L., Rinne, J., Runkle, B. R. K., Ryu, Y., Sachs, T., Schäfer, K. V. R., Schmid, H. P., Shurpali, N., Sonnentag, O., Tang, A. C. I., Torn, M. S., Trotta, C., Tuittila, E. S., Ueyama, M., Vargas, R., Vesala, T., Windham-Myers, L., Zhang, Z., & Zona, D. (2021). Substantial hysteresis in emergent temperature sensitivity of global wetland CH. Nature communications, 12(1), 2266. https://doi.org/10.1038/s41467-021-22452-1
Chang, Kuang-Yu, et al. "Substantial hysteresis in emergent temperature sensitivity of global wetland CH." Nature communications vol. 12,1 (2021): 2266. doi: https://doi.org/10.1038/s41467-021-22452-1
Chang KY, Riley WJ, Knox SH, Jackson RB, McNicol G, Poulter B, Aurela M, Baldocchi D, Bansal S, Bohrer G, Campbell DI, Cescatti A, Chu H, Delwiche KB, Desai AR, Euskirchen E, Friborg T, Goeckede M, Helbig M, Hemes KS, Hirano T, Iwata H, Kang M, Keenan T, Krauss KW, Lohila A, Mammarella I, Mitra B, Miyata A, Nilsson MB, Noormets A, Oechel WC, Papale D, Peichl M, Reba ML, Rinne J, Runkle BRK, Ryu Y, Sachs T, Schäfer KVR, Schmid HP, Shurpali N, Sonnentag O, Tang ACI, Torn MS, Trotta C, Tuittila ES, Ueyama M, Vargas R, Vesala T, Windham-Myers L, Zhang Z, Zona D. Substantial hysteresis in emergent temperature sensitivity of global wetland CH. Nat Commun. 2021 Apr 15;12(1):2266. doi: 10.1038/s41467-021-22452-1. PMID: 33859182; PMCID: PMC8050324.
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The FLUXCOM ensemble of global land-atmosphere energy fluxes.

Scientific data

Jung M, Koirala S, Weber U, Ichii K, Gans F, Camps-Valls G, Papale D, Schwalm C, Tramontana G, Reichstein M.
PMID: 31133670
Sci Data. 2019 May 27;6(1):74. doi: 10.1038/s41597-019-0076-8.

Although a key driver of Earth's climate system, global land-atmosphere energy fluxes are poorly constrained. Here we use machine learning to merge energy flux measurements from FLUXNET eddy covariance towers with remote sensing and meteorological data to estimate global...

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Jung M, Koirala S, Weber U, et al. The FLUXCOM ensemble of global land-atmosphere energy fluxes. Sci Data. 2019;6(1):74doi: 10.1038/s41597-019-0076-8.
Jung, M., Koirala, S., Weber, U., Ichii, K., Gans, F., Camps-Valls, G., Papale, D., Schwalm, C., Tramontana, G., & Reichstein, M. (2019). The FLUXCOM ensemble of global land-atmosphere energy fluxes. Scientific data, 6(1), 74. https://doi.org/10.1038/s41597-019-0076-8
Jung, Martin, et al. "The FLUXCOM ensemble of global land-atmosphere energy fluxes." Scientific data vol. 6,1 (2019): 74. doi: https://doi.org/10.1038/s41597-019-0076-8
Jung M, Koirala S, Weber U, Ichii K, Gans F, Camps-Valls G, Papale D, Schwalm C, Tramontana G, Reichstein M. The FLUXCOM ensemble of global land-atmosphere energy fluxes. Sci Data. 2019 May 27;6(1):74. doi: 10.1038/s41597-019-0076-8. PMID: 31133670; PMCID: PMC6536554.
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