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Showing 25 to 36 of 224 entries
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A comparison of GP, pharmacist and nurse prescriber responses to patients' emotional cues and concerns in primary care consultations.

Patient education and counseling

Riley R, Weiss MC, Platt J, Taylor G, Horrocks S, Taylor A.
PMID: 23246150
Patient Educ Couns. 2013 Apr;91(1):65-71. doi: 10.1016/j.pec.2012.11.009. Epub 2012 Dec 12.

OBJECTIVE: Recognising patients' cues and concerns is an important part of patient centred care. With nurses and pharmacists now able to prescribe in the UK, this study compared the frequency, nature, and professionals' responses to patient cues and concerns...

Achievement of Sustained Net Plasma Heating in a Fusion Experiment with the Optometrist Algorithm.

Scientific reports

Baltz EA, Trask E, Binderbauer M, Dikovsky M, Gota H, Mendoza R, Platt JC, Riley PF.
PMID: 28743898
Sci Rep. 2017 Jul 25;7(1):6425. doi: 10.1038/s41598-017-06645-7.

Many fields of basic and applied science require efficiently exploring complex systems with high dimensionality. An example of such a challenge is optimising the performance of plasma fusion experiments. The highly-nonlinear and temporally-varying interaction between the plasma, its environment...

Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration.

Journal of cell science

El-Remessy AB, Bartoli M, Platt DH, Fulton D, Caldwell RB.
PMID: 27528208
J Cell Sci. 2016 Aug 15;129(16):3203. doi: 10.1242/jcs.195966.

No abstract available.

Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms.

Circulation. Genomic and precision medicine

Lindholm ME, Jimenez-Morales D, Zhu H, Seo K, Amar D, Zhao C, Raja A, Madhvani R, Abramowitz S, Espenel C, Sutton S, Caleshu C, Berry GJ, Motonaga KS, Dunn K, Platt J, Ashley EA, Wheeler MT.
PMID: 34802252
Circ Genom Precis Med. 2021 Nov 22;CIRCGEN121003419. doi: 10.1161/CIRCGEN.121.003419. Epub 2021 Nov 22.

BACKGROUND: ACTN2 (alpha-actinin 2) anchors actin within cardiac sarcomeres. The mechanisms linking METHODS: Patients harboring ACTN2 protein-truncating variants were identified using a custom mutation pipeline. In patient-derived iPSC-cardiomyocytes, we investigated transcriptional profiles using RNA sequencing, contractile properties using video-based...

TNFRSF13B polymorphisms counter microbial adaptation to enteric IgA.

JCI insight

Platt JL, de Mattos Barbosa MG, Huynh D, Lefferts AR, Katta J, Kharas C, Freddolino P, Bassis CM, Wobus C, Geha R, Bram R, Nunez G, Kamada N, Cascalho M.
PMID: 34111031
JCI Insight. 2021 Jul 22;6(14). doi: 10.1172/jci.insight.148208.

TNFRSF13B encodes the transmembrane activator and CAML interactor (TACI) receptor, which drives plasma cell differentiation. Although TNFRSF13B supports host defense, dominant-negative TNFRSF13B alleles are common in humans and other species and only rarely associate with disease. We reasoned that...

Sedimentary pyrite sulfur isotope compositions preserve signatures of the surface microbial mat environment in sediments underlying low-oxygen cyanobacterial mats.

Geobiology

Gomes ML, Klatt JM, Dick GJ, Grim SL, Rico KI, Medina M, Ziebis W, Kinsman-Costello L, Sheldon ND, Fike DA.
PMID: 34331395
Geobiology. 2021 Jul 31; doi: 10.1111/gbi.12466. Epub 2021 Jul 31.

The sedimentary pyrite sulfur isotope (δ

Recommendations for Advancing Research With Sexual and Gender Minority Older Adults.

The journals of gerontology. Series B, Psychological sciences and social sciences

Flatt JD, Cicero EC, Kittle KR, Brennan-Ing M.
PMID: 34216459
J Gerontol B Psychol Sci Soc Sci. 2022 Jan 12;77(1):1-9. doi: 10.1093/geronb/gbab127.

No abstract available.

Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms.

Circulation. Genomic and precision medicine

Lindholm ME, Jimenez-Morales D, Zhu H, Seo K, Amar D, Zhao C, Raja A, Madhvani R, Abramowitz S, Espenel C, Sutton S, Caleshu C, Berry GJ, Motonaga KS, Dunn K, Platt J, Ashley EA, Wheeler MT.
PMID: 34802252
Circ Genom Precis Med. 2021 Dec;14(6):e003419. doi: 10.1161/CIRCGEN.121.003419. Epub 2021 Nov 22.

BACKGROUND: ACTN2 (alpha-actinin 2) anchors actin within cardiac sarcomeres. The mechanisms linking METHODS: Patients harboring ACTN2 protein-truncating variants were identified using a custom mutation pipeline. In patient-derived iPSC-cardiomyocytes, we investigated transcriptional profiles using RNA sequencing, contractile properties using video-based...

Impact of health technology assessment on prescribing patterns of inhaled fixed-dose combination triple therapy in chronic obstructive pulmonary disease.

Journal of market access & health policy

Cook J, Bloom C, Lewis J, Marjenberg Z, Platz JH, Langham S.
PMID: 34122781
J Mark Access Health Policy. 2021 Jun 02;9(1):1929757. doi: 10.1080/20016689.2021.1929757.

No abstract available.

The Immunogenicity and Safety Profile for KM-248, a Combined Measles, Mumps, and Rubella Vaccine, and Its Noninferiority to the Measles Vaccine in Healthy Japanese Children: a Phase 3 Randomized Multicenter Single-Blind Clinical Trial.

Japanese journal of infectious diseases

Platt H, Tochihara S, Oda Y, Ueda K.
PMID: 33518626
Jpn J Infect Dis. 2021 Sep 22;74(5):429-436. doi: 10.7883/yoken.JJID.2020.876. Epub 2021 Jan 29.

The domestic combined measles-mumps-rubella (MMR) vaccine was withdrawn in Japan in 1993 following an outbreak of aseptic meningitis attributed to the mumps component of the cocktail. KM-248 is an MMR vaccine (M-M-R

Durvalumab (MEDI 4736) in combination with extended neoadjuvant regimens in rectal cancer: a study protocol of a randomised phase II trial (PRIME-RT).

Radiation oncology (London, England)

Hanna CR, O'Cathail SM, Graham JS, Saunders M, Samuel L, Harrison M, Devlin L, Edwards J, Gaya DR, Kelly CA, Lewsley LA, Maka N, Morrison P, Dinnett L, Dillon S, Gourlay J, Platt JJ, Thomson F, Adams RA, Roxburgh CSD.
PMID: 34446053
Radiat Oncol. 2021 Aug 26;16(1):163. doi: 10.1186/s13014-021-01888-1.

BACKGROUND: Advances in multi-modality treatment of locally advanced rectal cancer (LARC) have resulted in low local recurrence rates, but around 30% of patients will still die from distant metastatic disease. In parallel, there is increasing recognition that with radiotherapy...

Association of Childhood Adversity With Morbidity and Mortality in US Adults: A Systematic Review.

JAMA pediatrics

Grummitt LR, Kreski NT, Kim SG, Platt J, Keyes KM, McLaughlin KA.
PMID: 34605870
JAMA Pediatr. 2021 Dec 01;175(12):1269-1278. doi: 10.1001/jamapediatrics.2021.2320.

IMPORTANCE: Childhood adversity (CA) is a powerful determinant of long-term physical and mental health that is associated with elevated risk for chronic disease and psychopathology. However, the degree to which CA contributes to mortality as a preventable driver of...

Showing 25 to 36 of 224 entries