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Showing 25 to 36 of 1283 entries
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The oncogenic role of the cochaperone Sgt1.

Oncogenesis

Ogi H, Sakuraba Y, Kitagawa R, Xiao L, Shen C, Cynthia MA, Ohta S, Arnold MA, Ramirez N, Houghton PJ, Kitagawa K.
PMID: 25985210
Oncogenesis. 2015 May 18;4:e149. doi: 10.1038/oncsis.2015.12.

Sgt1/Sugt1, a cochaperone of Hsp90, is involved in several cellular activities including Cullin E3 ubiqutin ligase activity. The high level of Sgt1 expression in colorectal and gastric tumors suggests that Sgt1 is involved in tumorigenesis. Here, we report that...

Fabrication of single cylindrical Au-coated nanopores with non-homogeneous fixed charge distribution exhibiting high current rectifications.

ACS applied materials & interfaces

Nasir S, Ali M, Ramirez P, Gómez V, Oschmann B, Muench F, Tahir MN, Zentel R, Mafe S, Ensinger W.
PMID: 25051046
ACS Appl Mater Interfaces. 2014 Aug 13;6(15):12486-94. doi: 10.1021/am502419j. Epub 2014 Jul 30.

We designed and characterized a cylindrical nanopore that exhibits high electrochemical current rectification ratios at low and intermediate electrolyte concentrations. For this purpose, the track-etched single cylindrical nanopore in polymer membrane was coated with a gold (Au) layer via...

Sitagliptin ameliorates oxidative stress in experimental diabetic nephropathy by diminishing the miR-200a/Keap-1/Nrf2 antioxidant pathway.

Diabetes, metabolic syndrome and obesity : targets and therapy

Civantos E, Bosch E, Ramirez E, Zhenyukh O, Egido J, Lorenzo O, Mas S.
PMID: 28652790
Diabetes Metab Syndr Obes. 2017 Jun 07;10:207-222. doi: 10.2147/DMSO.S132537. eCollection 2017.

BACKGROUND: Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor used in type 2 diabetes therapy, has demonstrated protective effects in diabetic chronic kidney disease, in part due to its pleiotropic actions. However, its potential direct effects on the kidney are still...

Ge-rich graded-index Si1-xGex waveguides with broadband tight mode confinement and flat anomalous dispersion for nonlinear mid-infrared photonics.

Optics express

Ramirez JM, Vakarin V, Frigerio J, Chaisakul P, Chrastina D, Le Roux X, Ballabio A, Vivien L, Isella G, Marris-Morini D.
PMID: 28381003
Opt Express. 2017 Mar 20;25(6):6561-6567. doi: 10.1364/OE.25.006561.

This work explores the use of Ge-rich graded-index Si1-xGex rib waveguides as building blocks to develop integrated nonlinear optical devices for broadband operation in the mid-IR. The vertical Ge gradient concentration in the waveguide core renders unique properties to...

Career Advice: Finding a Job at a Predominantly Undergraduate Institution.

Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience

Ramirez JJ.
PMID: 27385929
J Undergrad Neurosci Educ. 2016 Apr 15;14(2):E15-9. eCollection 2016.

Seeking a teaching job at a predominantly undergraduate college or university can be a daunting proposition. Although reports from the Bureau of Labor Statistics suggest that the job market for teaching positions at postsecondary institutions will be healthy over...

Quantifying biomass consumption and carbon release from the California Rim fire by integrating airborne LiDAR and Landsat OLI data.

Journal of geophysical research. Biogeosciences

Garcia M, Saatchi S, Casas A, Koltunov A, Ustin S, Ramirez C, Garcia-Gutierrez J, Balzter H.
PMID: 28405539
J Geophys Res Biogeosci. 2017 Feb;122(2):340-353. doi: 10.1002/2015JG003315. Epub 2017 Feb 18.

Quantifying biomass consumption and carbon release is critical to understanding the role of fires in the carbon cycle and air quality. We present a methodology to estimate the biomass consumed and the carbon released by the California Rim fire...

Chronic Intermittent Hypoxia Differentially Impacts Different States of Inspiratory Activity at the Level of the preBötzinger Complex.

Frontiers in physiology

Garcia AJ, Dashevskiy T, Khuu MA, Ramirez JM.
PMID: 28936176
Front Physiol. 2017 Aug 28;8:571. doi: 10.3389/fphys.2017.00571. eCollection 2017.

The preBötzinger complex (preBötC) is a medullary brainstem network crucially involved in the generation of different inspiratory rhythms. In the isolated brainstem slice, the preBötC reconfigures to produce different rhythms that we refer to as "fictive eupnea" under baseline...

Role of Salt, Pressure, and Water Activity on Homogeneous Ice Nucleation.

The journal of physical chemistry letters

Espinosa JR, Soria GD, Ramirez J, Valeriani C, Vega C, Sanz E.
PMID: 28876070
J Phys Chem Lett. 2017 Sep 21;8(18):4486-4491. doi: 10.1021/acs.jpclett.7b01551. Epub 2017 Sep 06.

Pure water can be substantially supercooled below the melting temperature without transforming into ice. The achievable supercooling can be enhanced by adding solutes or by applying hydrostatic pressure. Avoiding ice formation is of great importance in the cryopreservation of...

Oil and gas wells and pipelines on U.S. wildlife refuges: challenges for managers.

PloS one

Ramirez P, Mosley SB.
PMID: 25915417
PLoS One. 2015 Apr 27;10(4):e0124085. doi: 10.1371/journal.pone.0124085. eCollection 2015.

The increased demand for oil and gas places a burden on lands set aside for natural resource conservation. Oil and gas development alters the environment locally and on a much broader spatial scale depending on the intensity and extent...

Peripheral inflammatory markers indicate microstructural damage within periventricular white matter hyperintensities in Alzheimer's disease: A preliminary report.

Alzheimer's & dementia (Amsterdam, Netherlands)

Swardfager W, Yu D, Ramirez J, Cogo-Moreira H, Szilagyi G, Holmes MF, Scott CJ, Scola G, Chan PC, Chen J, Chan P, Sahlas DJ, Herrmann N, Lanctôt KL, Andreazza AC, Pettersen JA, Black SE.
PMID: 28275700
Alzheimers Dement (Amst). 2017 Jan 21;7:56-60. doi: 10.1016/j.dadm.2016.12.011. eCollection 2017.

INTRODUCTION: White matter hyperintensities (WMH) presumed to reflect cerebral small vessel disease and increased peripheral inflammatory markers are found commonly in Alzheimer's disease (AD), but their interrelationships remain unclear.METHODS: Inflammatory markers were assayed in 54 elderly participants (RESULTS: Mean...

Real-Time Enrollment Dashboard For Multisite Clinical Trials.

Contemporary clinical trials communications

Mattingly WA, Kelley RR, Wiemken TL, Chariker JH, Peyrani P, Guinn BE, Binford LE, Buckner K, Ramirez J.
PMID: 26878068
Contemp Clin Trials Commun. 2015 Oct 30;1:17-21. doi: 10.1016/j.conctc.2015.09.001.

OBJECTIVE: Achieving patient recruitment goals are critical for the successful completion of a clinical trial. We designed and developed a web-based dashboard for assisting in the management of clinical trial screening and enrollment.MATERIALS AND METHODS: We use the dashboard...

Respiratory rhythm generation: triple oscillator hypothesis.

F1000Research

Anderson TM, Ramirez JM.
PMID: 28299192
F1000Res. 2017 Feb 14;6:139. doi: 10.12688/f1000research.10193.1. eCollection 2017.

Breathing is vital for survival but also interesting from the perspective of rhythm generation. This rhythmic behavior is generated within the brainstem and is thought to emerge through the interaction between independent oscillatory neuronal networks. In mammals, breathing is...

Showing 25 to 36 of 1283 entries