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Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network.

Science advances

Lopez A, Dahiya V, Delhommel F, Freiburger L, Stehle R, Asami S, Rutz D, Blair L, Buchner J, Sattler M.
PMID: 34919431
Sci Adv. 2021 Dec 17;7(51):eabl7295. doi: 10.1126/sciadv.abl7295. Epub 2021 Dec 17.

[Figure: see text].

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Lopez A, Dahiya V, Delhommel F, et al. Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network. Sci Adv. 2021;7(51):eabl7295doi: 10.1126/sciadv.abl7295.
Lopez, A., Dahiya, V., Delhommel, F., Freiburger, L., Stehle, R., Asami, S., Rutz, D., Blair, L., Buchner, J., & Sattler, M. (2021). Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network. Science advances, 7(51), eabl7295. https://doi.org/10.1126/sciadv.abl7295
Lopez, Abraham, et al. "Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network." Science advances vol. 7,51 (2021): eabl7295. doi: https://doi.org/10.1126/sciadv.abl7295
Lopez A, Dahiya V, Delhommel F, Freiburger L, Stehle R, Asami S, Rutz D, Blair L, Buchner J, Sattler M. Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network. Sci Adv. 2021 Dec 17;7(51):eabl7295. doi: 10.1126/sciadv.abl7295. Epub 2021 Dec 17. PMID: 34919431.
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Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2.

International journal of breast cancer

Ghimirey N, Steele C, Czerniecki BJ, Koski GK, Showalter LE.
PMID: 33936816
Int J Breast Cancer. 2021 Apr 14;2021:8818393. doi: 10.1155/2021/8818393. eCollection 2021.

Although immune-based therapies have made remarkable inroads in cancer treatment, they usually must be combined with standard treatment modalities, including cytotoxic drugs, to achieve maximal clinical benefits. As immunotherapies are further advanced and refined, considerable efforts will be required...

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Ghimirey N, Steele C, Czerniecki BJ, et al. Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2. Int J Breast Cancer. 2021;2021:8818393doi: 10.1155/2021/8818393.
Ghimirey, N., Steele, C., Czerniecki, B. J., Koski, G. K., & Showalter, L. E. (2021). Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2. International journal of breast cancer, 20218818393. https://doi.org/10.1155/2021/8818393
Ghimirey, Nirmala, et al. "Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2." International journal of breast cancer vol. 2021 (2021): 8818393. doi: https://doi.org/10.1155/2021/8818393
Ghimirey N, Steele C, Czerniecki BJ, Koski GK, Showalter LE. Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2. Int J Breast Cancer. 2021 Apr 14;2021:8818393. doi: 10.1155/2021/8818393. eCollection 2021. PMID: 33936816; PMCID: PMC8062178.
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A Truncated NRIP1 Mutant Amplifies Microsatellite Instability of Colorectal Cancer by Regulating MSH2/MSH6 Expression, and Is a Prognostic Marker of Stage III Tumors.

Cancers

Palassin P, Lapierre M, Pyrdziak S, Wagner A, Stehle R, Corsini C, Duffour J, Bonnet S, Boulahtouf A, Rodriguez C, Ho-Pun-Cheung A, Lopez-Crapez E, Boissière-Michot F, Bibeau F, Thezenas S, Elarouci N, Selves J, Hoffmann JS, Roepman P, Mazard T, Buhard O, Duval A, Jalaguier S, Cavaillès V, Castet-Nicolas A.
PMID: 34503257
Cancers (Basel). 2021 Sep 03;13(17). doi: 10.3390/cancers13174449.

Microsatellite instability (MSI) is related to the alteration of mismatch repair (MMR) genes and plays a key role in colorectal cancer (CRC) pathogenesis. We previously reported that the transcription factor Nuclear Receptor Interacting Protein 1 (NRIP1) is involved in...

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Palassin P, Lapierre M, Pyrdziak S, et al. A Truncated NRIP1 Mutant Amplifies Microsatellite Instability of Colorectal Cancer by Regulating MSH2/MSH6 Expression, and Is a Prognostic Marker of Stage III Tumors. Cancers (Basel). 2021;13(17)doi: 10.3390/cancers13174449.
Palassin, P., Lapierre, M., Pyrdziak, S., Wagner, A., Stehle, R., Corsini, C., Duffour, J., Bonnet, S., Boulahtouf, A., Rodriguez, C., Ho-Pun-Cheung, A., Lopez-Crapez, E., Boissière-Michot, F., Bibeau, F., Thezenas, S., Elarouci, N., Selves, J., Hoffmann, J. S., Roepman, P., Mazard, T., Buhard, O., Duval, A., Jalaguier, S., Cavaillès, V., & Castet-Nicolas, A. (2021). A Truncated NRIP1 Mutant Amplifies Microsatellite Instability of Colorectal Cancer by Regulating MSH2/MSH6 Expression, and Is a Prognostic Marker of Stage III Tumors. Cancers, 13(17), . https://doi.org/10.3390/cancers13174449
Palassin, Pascale, et al. "A Truncated NRIP1 Mutant Amplifies Microsatellite Instability of Colorectal Cancer by Regulating MSH2/MSH6 Expression, and Is a Prognostic Marker of Stage III Tumors." Cancers vol. 13,17 (2021). doi: https://doi.org/10.3390/cancers13174449
Palassin P, Lapierre M, Pyrdziak S, Wagner A, Stehle R, Corsini C, Duffour J, Bonnet S, Boulahtouf A, Rodriguez C, Ho-Pun-Cheung A, Lopez-Crapez E, Boissière-Michot F, Bibeau F, Thezenas S, Elarouci N, Selves J, Hoffmann JS, Roepman P, Mazard T, Buhard O, Duval A, Jalaguier S, Cavaillès V, Castet-Nicolas A. A Truncated NRIP1 Mutant Amplifies Microsatellite Instability of Colorectal Cancer by Regulating MSH2/MSH6 Expression, and Is a Prognostic Marker of Stage III Tumors. Cancers (Basel). 2021 Sep 03;13(17). doi: 10.3390/cancers13174449. PMID: 34503257; PMCID: PMC8430632.
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An algorithm for safe de-labelling of antibiotic allergy in adult hospital in-patients.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Sneddon J, Cooper L, Ritchie N, Steele C, Spears M, McEwen J, Dempsey Z, Sutherland R, Khatamzas E, Seaton RA.
PMID: 33811406
Clin Exp Allergy. 2021 Sep;51(9):1229-1232. doi: 10.1111/cea.13878. Epub 2021 Apr 12.

No abstract available.

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Sneddon J, Cooper L, Ritchie N, et al. An algorithm for safe de-labelling of antibiotic allergy in adult hospital in-patients. Clin Exp Allergy. 2021;51(9):1229-1232doi: 10.1111/cea.13878.
Sneddon, J., Cooper, L., Ritchie, N., Steele, C., Spears, M., McEwen, J., Dempsey, Z., Sutherland, R., Khatamzas, E., & Seaton, R. A. (2021). An algorithm for safe de-labelling of antibiotic allergy in adult hospital in-patients. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 51(9), 1229-1232. https://doi.org/10.1111/cea.13878
Sneddon, Jacqueline, et al. "An algorithm for safe de-labelling of antibiotic allergy in adult hospital in-patients." Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology vol. 51,9 (2021): 1229-1232. doi: https://doi.org/10.1111/cea.13878
Sneddon J, Cooper L, Ritchie N, Steele C, Spears M, McEwen J, Dempsey Z, Sutherland R, Khatamzas E, Seaton RA. An algorithm for safe de-labelling of antibiotic allergy in adult hospital in-patients. Clin Exp Allergy. 2021 Sep;51(9):1229-1232. doi: 10.1111/cea.13878. Epub 2021 Apr 12. PMID: 33811406.
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Prognostic implications of left atrial dilation in aortic regurgitation due to bicuspid aortic valve.

Heart (British Cardiac Society)

Butcher SC, Fortuni F, Kong W, Vollema EM, Prevedello F, Perry R, Ng ACT, Poh KK, Almeida AG, González-Gómez A, Shen M, Yeo TC, Shanks M, Popescu BA, Galian-Gay L, Fijalkowski M, Liang M, Tay E, Ajmone Marsan N, Selvanayagam JB, Pinto FJ, Zamorano J, Pibarot P, Evangelista A, Bax JJ, Delgado V.
PMID: 33833069
Heart. 2022 Jan;108(2):137-144. doi: 10.1136/heartjnl-2020-318907. Epub 2021 Apr 08.

OBJECTIVE: To investigate the prognostic value of left atrial volume index (LAVI) in patients with moderate to severe aortic regurgitation (AR) and bicuspid aortic valve (BAV).METHODS: 554 individuals (45 (IQR 33-57) years, 80% male) with BAV and moderate or...

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Butcher SC, Fortuni F, Kong W, et al. Prognostic implications of left atrial dilation in aortic regurgitation due to bicuspid aortic valve. Heart. 2021;108(2):137-144doi: 10.1136/heartjnl-2020-318907.
Butcher, S. C., Fortuni, F., Kong, W., Vollema, E. M., Prevedello, F., Perry, R., Ng, A. C. T., Poh, K. K., Almeida, A. G., González-Gómez, A., Shen, M., Yeo, T. C., Shanks, M., Popescu, B. A., Galian-Gay, L., Fijalkowski, M., Liang, M., Tay, E., Ajmone Marsan, N., Selvanayagam, J. B., Pinto, F. J., Zamorano, J., Pibarot, P., Evangelista, A., Bax, J. J., & Delgado, V. (2022). Prognostic implications of left atrial dilation in aortic regurgitation due to bicuspid aortic valve. Heart (British Cardiac Society), 108(2), 137-144. https://doi.org/10.1136/heartjnl-2020-318907
Butcher, Steele C, et al. "Prognostic implications of left atrial dilation in aortic regurgitation due to bicuspid aortic valve." Heart (British Cardiac Society) vol. 108,2 (2022): 137-144. doi: https://doi.org/10.1136/heartjnl-2020-318907
Butcher SC, Fortuni F, Kong W, Vollema EM, Prevedello F, Perry R, Ng ACT, Poh KK, Almeida AG, González-Gómez A, Shen M, Yeo TC, Shanks M, Popescu BA, Galian-Gay L, Fijalkowski M, Liang M, Tay E, Ajmone Marsan N, Selvanayagam JB, Pinto FJ, Zamorano J, Pibarot P, Evangelista A, Bax JJ, Delgado V. Prognostic implications of left atrial dilation in aortic regurgitation due to bicuspid aortic valve. Heart. 2022 Jan;108(2):137-144. doi: 10.1136/heartjnl-2020-318907. Epub 2021 Apr 08. PMID: 33833069.
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Author Correction: Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus.

Scientific reports

Nöldeke ER, Muckenfuss LM, Niemann V, Müller A, Störk E, Zocher G, Schneider T, Stehle T.
PMID: 30573753
Sci Rep. 2018 Dec 21;8(1):18073. doi: 10.1038/s41598-018-37082-9.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

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Nöldeke ER, Muckenfuss LM, Niemann V, et al. Author Correction: Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus. Sci Rep. 2018;8(1):18073doi: 10.1038/s41598-018-37082-9.
Nöldeke, E. R., Muckenfuss, L. M., Niemann, V., Müller, A., Störk, E., Zocher, G., Schneider, T., & Stehle, T. (2018). Author Correction: Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus. Scientific reports, 8(1), 18073. https://doi.org/10.1038/s41598-018-37082-9
Nöldeke, Erik R, et al. "Author Correction: Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus." Scientific reports vol. 8,1 (2018): 18073. doi: https://doi.org/10.1038/s41598-018-37082-9
Nöldeke ER, Muckenfuss LM, Niemann V, Müller A, Störk E, Zocher G, Schneider T, Stehle T. Author Correction: Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus. Sci Rep. 2018 Dec 21;8(1):18073. doi: 10.1038/s41598-018-37082-9. PMID: 30573753; PMCID: PMC6301993.
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Dietary patterns associated with meeting the WHO free sugars intake guidelines.

Public health nutrition

Steele C, Eyles H, Te Morenga L, Ni Mhurchu C, Cleghorn C.
PMID: 32264996
Public Health Nutr. 2020 Jun;23(9):1495-1506. doi: 10.1017/S1368980019004543. Epub 2020 Apr 08.

OBJECTIVE: Emerging evidence suggests that free sugars intake in many countries exceeds that recommended by the WHO. However, information regarding real-world dietary patterns associated with meeting the WHO free sugars guidelines is lacking. The current study aimed to determine...

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Steele C, Eyles H, Te Morenga L, et al. Dietary patterns associated with meeting the WHO free sugars intake guidelines. Public Health Nutr. 2020;23(9):1495-1506doi: 10.1017/S1368980019004543.
Steele, C., Eyles, H., Te Morenga, L., Ni Mhurchu, C., & Cleghorn, C. (2020). Dietary patterns associated with meeting the WHO free sugars intake guidelines. Public health nutrition, 23(9), 1495-1506. https://doi.org/10.1017/S1368980019004543
Steele, Courtney, et al. "Dietary patterns associated with meeting the WHO free sugars intake guidelines." Public health nutrition vol. 23,9 (2020): 1495-1506. doi: https://doi.org/10.1017/S1368980019004543
Steele C, Eyles H, Te Morenga L, Ni Mhurchu C, Cleghorn C. Dietary patterns associated with meeting the WHO free sugars intake guidelines. Public Health Nutr. 2020 Jun;23(9):1495-1506. doi: 10.1017/S1368980019004543. Epub 2020 Apr 08. PMID: 32264996.
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The dynamics of linear polyubiquitin.

Science advances

Jussupow A, Messias AC, Stehle R, Geerlof A, Solbak SMØ, Paissoni C, Bach A, Sattler M, Camilloni C.
PMID: 33055165
Sci Adv. 2020 Oct 14;6(42). doi: 10.1126/sciadv.abc3786. Print 2020 Oct.

Polyubiquitin chains are flexible multidomain proteins, whose conformational dynamics enable them to regulate multiple biological pathways. Their dynamic is determined by the linkage between ubiquitins and by the number of ubiquitin units. Characterizing polyubiquitin behavior as a function of...

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Jussupow A, Messias AC, Stehle R, et al. The dynamics of linear polyubiquitin. Sci Adv. 2020;6(42)doi: 10.1126/sciadv.abc3786.
Jussupow, A., Messias, A. C., Stehle, R., Geerlof, A., Solbak, S. M. �. �., Paissoni, C., Bach, A., Sattler, M., & Camilloni, C. (2020). The dynamics of linear polyubiquitin. Science advances, 6(42), . https://doi.org/10.1126/sciadv.abc3786
Jussupow, Alexander, et al. "The dynamics of linear polyubiquitin." Science advances vol. 6,42 (2020). doi: https://doi.org/10.1126/sciadv.abc3786
Jussupow A, Messias AC, Stehle R, Geerlof A, Solbak SMØ, Paissoni C, Bach A, Sattler M, Camilloni C. The dynamics of linear polyubiquitin. Sci Adv. 2020 Oct 14;6(42). doi: 10.1126/sciadv.abc3786. Print 2020 Oct. PMID: 33055165; PMCID: PMC7556843.
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Implementation of anesthesia quality indicators in Germany : A prospective, national, multicenter quality improvement study.

Der Anaesthesist

Ziemann S, Coburn M, Rossaint R, Van Waesberghe J, Bürkle H, Fries M, Henrich M, Henzler D, Iber T, Karst J, Kunitz O, Löb R, Meißner W, Meybohm P, Mierke B, Pabst F, Schaelte G, Schiff J, Soehle M, Winterhalter M, Kowark A.
PMID: 32377798
Anaesthesist. 2021 Dec;70:38-47. doi: 10.1007/s00101-020-00773-y. Epub 2020 Jul 06.

BACKGROUND: In 2016 the German Society of Anesthesiology and Intensive Care Medicine (DGAI) and the Association of German Anesthetists (BDA) published 10 quality indicators (QI) to compare and improve the quality of anesthesia care in Germany. So far, there...

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Ziemann S, Coburn M, Rossaint R, et al. Implementierung anästhesiologischer Qualitätsindikatoren in Deutschland : Eine prospektive, nationale, multizentrische Qualitätssteigerungsstudie. Implementation of anesthesia quality indicators in Germany : A prospective, national, multicenter quality improvement study. Anaesthesist. 2020;70:38-47doi: 10.1007/s00101-020-00773-y.
Ziemann, S., Coburn, M., Rossaint, R., Van Waesberghe, J., Bürkle, H., Fries, M., Henrich, M., Henzler, D., Iber, T., Karst, J., Kunitz, O., Löb, R., Meißner, W., Meybohm, P., Mierke, B., Pabst, F., Schaelte, G., Schiff, J., Soehle, M., Winterhalter, M., & Kowark, A. (2021). Implementierung anästhesiologischer Qualitätsindikatoren in Deutschland : Eine prospektive, nationale, multizentrische Qualitätssteigerungsstudie. Implementation of anesthesia quality indicators in Germany : A prospective, national, multicenter quality improvement study. Der Anaesthesist, 7038-47. https://doi.org/10.1007/s00101-020-00773-y
Ziemann, S, et al. "Implementierung anästhesiologischer Qualitätsindikatoren in Deutschland : Eine prospektive, nationale, multizentrische Qualitätssteigerungsstudie." Implementation of anesthesia quality indicators in Germany : A prospective, national, multicenter quality improvement study. Der Anaesthesist vol. 70 (2021): 38-47. doi: https://doi.org/10.1007/s00101-020-00773-y
Ziemann S, Coburn M, Rossaint R, Van Waesberghe J, Bürkle H, Fries M, Henrich M, Henzler D, Iber T, Karst J, Kunitz O, Löb R, Meißner W, Meybohm P, Mierke B, Pabst F, Schaelte G, Schiff J, Soehle M, Winterhalter M, Kowark A. Implementierung anästhesiologischer Qualitätsindikatoren in Deutschland : Eine prospektive, nationale, multizentrische Qualitätssteigerungsstudie. Implementation of anesthesia quality indicators in Germany : A prospective, national, multicenter quality improvement study. Anaesthesist. 2021 Dec;70:38-47. doi: 10.1007/s00101-020-00773-y. Epub 2020 Jul 06. PMID: 32377798.
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Moderate aortic stenosis: importance of symptoms and left ventricular ejection fraction.

European heart journal. Cardiovascular Imaging

Stassen J, Ewe SH, Butcher SC, Amanullah MR, Hirasawa K, Singh GK, Sin KYK, Ding ZP, Pio SM, Sia CH, Chew NWS, Kong WKF, Poh KK, Cohen DJ, Généreux P, Leon MB, Marsan NA, Delgado V, Bax JJ.
PMID: 34864942
Eur Heart J Cardiovasc Imaging. 2021 Dec 02; doi: 10.1093/ehjci/jeab242. Epub 2021 Dec 02.

AIMS: The aim of this study is to investigate the independent determinants of survival in patients with moderate aortic stenosis (AS), stratified by severity of symptoms and left ventricular ejection fraction (LVEF).METHODS AND RESULTS: Patients with a first diagnosis...

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Stassen J, Ewe SH, Butcher SC, et al. Moderate aortic stenosis: importance of symptoms and left ventricular ejection fraction. Eur Heart J Cardiovasc Imaging. 2021;doi: 10.1093/ehjci/jeab242.
Stassen, J., Ewe, S. H., Butcher, S. C., Amanullah, M. R., Hirasawa, K., Singh, G. K., Sin, K. Y. K., Ding, Z. P., Pio, S. M., Sia, C. H., Chew, N. W. S., Kong, W. K. F., Poh, K. K., Cohen, D. J., Généreux, P., Leon, M. B., Marsan, N. A., Delgado, V., & Bax, J. J. (2021). Moderate aortic stenosis: importance of symptoms and left ventricular ejection fraction. European heart journal. Cardiovascular Imaging, . https://doi.org/10.1093/ehjci/jeab242
Stassen, Jan, et al. "Moderate aortic stenosis: importance of symptoms and left ventricular ejection fraction." European heart journal. Cardiovascular Imaging vol. (2021). doi: https://doi.org/10.1093/ehjci/jeab242
Stassen J, Ewe SH, Butcher SC, Amanullah MR, Hirasawa K, Singh GK, Sin KYK, Ding ZP, Pio SM, Sia CH, Chew NWS, Kong WKF, Poh KK, Cohen DJ, Généreux P, Leon MB, Marsan NA, Delgado V, Bax JJ. Moderate aortic stenosis: importance of symptoms and left ventricular ejection fraction. Eur Heart J Cardiovasc Imaging. 2021 Dec 02; doi: 10.1093/ehjci/jeab242. Epub 2021 Dec 02. PMID: 34864942.
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Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.

Science advances

Pessoa Rodrigues C, Herman JS, Herquel B, Valsecchi CIK, Stehle T, Grün D, Akhtar A.
PMID: 32671208
Sci Adv. 2020 May 20;6(21):eaaz4815. doi: 10.1126/sciadv.aaz4815. eCollection 2020 May.

Self-renewal and differentiation of hematopoietic stem cells (HSCs) are orchestrated by the combinatorial action of transcription factors and epigenetic regulators. Here, we have explored the mechanism by which histone H4 lysine 16 acetyltransferase MOF regulates erythropoiesis. Single-cell RNA sequencing...

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Pessoa Rodrigues C, Herman JS, Herquel B, et al. Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Sci Adv. 2020;6(21):eaaz4815doi: 10.1126/sciadv.aaz4815.
Pessoa Rodrigues, C., Herman, J. S., Herquel, B., Valsecchi, C. I. K., Stehle, T., Grün, D., & Akhtar, A. (2020). Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Science advances, 6(21), eaaz4815. https://doi.org/10.1126/sciadv.aaz4815
Pessoa Rodrigues, Cecilia, et al. "Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate." Science advances vol. 6,21 (2020): eaaz4815. doi: https://doi.org/10.1126/sciadv.aaz4815
Pessoa Rodrigues C, Herman JS, Herquel B, Valsecchi CIK, Stehle T, Grün D, Akhtar A. Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Sci Adv. 2020 May 20;6(21):eaaz4815. doi: 10.1126/sciadv.aaz4815. eCollection 2020 May. PMID: 32671208; PMCID: PMC7314555.
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Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation.

Frontiers in physiology

Groen M, López-Dávila AJ, Zittrich S, Pfitzer G, Stehle R.
PMID: 32581830
Front Physiol. 2020 Jun 03;11:516. doi: 10.3389/fphys.2020.00516. eCollection 2020.

Length-dependent activation of calcium-dependent myocardial force generation provides the basis for the Frank-Starling mechanism. To directly compare the effects of mutations associated with hypertrophic cardiomyopathy and dilated cardiomyopathy, the native troponin complex in skinned trabecular fibers of guinea pigs...

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Groen M, López-Dávila AJ, Zittrich S, et al. Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation. Front Physiol. 2020;11:516doi: 10.3389/fphys.2020.00516.
Groen, M., López-Dávila, A. J., Zittrich, S., Pfitzer, G., & Stehle, R. (2020). Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation. Frontiers in physiology, 11516. https://doi.org/10.3389/fphys.2020.00516
Groen, Marcel, et al. "Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation." Frontiers in physiology vol. 11 (2020): 516. doi: https://doi.org/10.3389/fphys.2020.00516
Groen M, López-Dávila AJ, Zittrich S, Pfitzer G, Stehle R. Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation. Front Physiol. 2020 Jun 03;11:516. doi: 10.3389/fphys.2020.00516. eCollection 2020. PMID: 32581830; PMCID: PMC7283609.
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Showing 25 to 36 of 182 entries