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Showing 9541 to 9550 of 9550 entries
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Overcoming Acquired Epigenetic Resistance to BTK Inhibitors.

Blood cancer discovery

Shaffer AL, Phelan JD, Wang JQ, Huang D, Wright GW, Kasbekar M, Choi J, Young RM, Webster DE, Yang Y, Zhao H, Yu X, Xu W, Roulland S, Ceribelli M, Zhang X, Wilson KM, Chen L, McKnight C, Klumpp-Thomas C, Thomas CJ, Häupl B, Oellerich T, Rae Z, Kelly MC, Ahn IE, Sun C, Gaglione EM, Wilson WH, Wiestner A, Staudt LM.
PMID: 34778802
Blood Cancer Discov. 2021 Sep 14;2(6):630-647. doi: 10.1158/2643-3230.BCD-21-0063. eCollection 2021 Nov.

The use of Bruton tyrosine kinase (BTK) inhibitors to block B-cell receptor (BCR)-dependent NF-κB activation in lymphoid malignancies has been a major clinical advance, yet acquired therapeutic resistance is a recurring problem. We modeled the development of resistance to...

Total protein staining with Congo red as an alternative loading control for western blot analysis.

Biotechnic & histochemistry : official publication of the Biological Stain Commission

Wang JL, Li MQ, Zhang JJ, Xu CJ.
PMID: 34903132
Biotech Histochem. 2021 Dec 14;1-11. doi: 10.1080/10520295.2021.2008008. Epub 2021 Dec 14.

For western blot analysis, a housekeeping protein, such as β-actin or glyceraldehyde-3-phosphate dehydrogenase, is used as loading control with the assumption that these proteins are stable. In practice, these internal loading control proteins vary with different cell states and...

Heat Shock Protein 60 Restricts Release of Mitochondrial dsRNA to Suppress Hepatic Inflammation and Ameliorate Non-Alcoholic Fatty Liver Disease in Mice.

International journal of molecular sciences

Huang YH, Wang FS, Wang PW, Lin HY, Luo SD, Yang YL.
PMID: 35009003
Int J Mol Sci. 2022 Jan 05;23(1). doi: 10.3390/ijms23010577.

Non-alcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease, consists of fat deposited (steatosis) in the liver due to causes besides excessive alcohol use. The folding activity of heat shock protein 60 (HSP60) has been...

The Urinary Proteomic Profile Implicates Key Regulators for Urologic Chronic Pelvic Pain Syndrome (UCPPS): A MAPP Research Network Study.

Molecular & cellular proteomics : MCP

Froehlich JW, Wang HS, Logvinenko T, Kostel S, DiMartino S, van Bokhoven A, Moses MA, Lee RS.
PMID: 34774759
Mol Cell Proteomics. 2021 Nov 11;21(1):100176. doi: 10.1016/j.mcpro.2021.100176. Epub 2021 Nov 11.

Urologic chronic pelvic pain syndrome (UCPPS) is a condition of unknown etiology characterized by pelvic pain and urinary frequency and/or urgency. As the proximal fluid of this syndrome, urine is an ideal candidate sample matrix for an unbiased study...

Inhibitory effect of Aphidicolin - a tetracyclic diterpene - on the proliferation and apoptotic induction in human cervical cancer (HeLa) cells.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

Yu EY, Zhao RY, Wang DS.
PMID: 33721476
J BUON. 2021 Jan-Feb;26(1):291.

Retraction of: 'Inhibitory effect of Aphidicolin - a tetracyclic diterpene - on the proliferation and apoptotic induction in human cervical cancer (HeLa) cells', by En-Yan Yu, Rui-Yan Zhao, Dong-Sheng Wang, JBUON 2015;20(6):1480-1486; PMID:26854444. Following the publication of the above...

[Characteristics of Cadmium Enrichment and Pollution Evaluation of a Soil-Crop System in a Typical Karst Area].

Huan jing ke xue= Huanjing kexue

Wang R, Deng H, Jia ZM, Yan MS, Zhou J, Dong JX, Wang JB, Yu F, Pickering AJ, Boehm AB.
PMID: 33742890
Huan Jing Ke Xue. 2021 Feb 08;42(2):941-951. doi: 10.13227/j.hjkx.202008085.

In order to study the characteristics and factors influencing Cd accumulation in surface soils and crops in karst areas, and to provide a theoretical basis for safe land use, 360 surface soil samples, 7 deep soil samples, and 85...

Palliative inter-professional learning via cased based tele-videoconference: Experience from the hospice development stage in Taiwan and China.

Medicine

Lin HR, Wang JH, Hsieh JG, Wang YW.
PMID: 34871275
Medicine (Baltimore). 2021 Nov 05;100(44):e27741. doi: 10.1097/MD.0000000000027741.

ABSTRACT: Palliative care in rural areas can be difficult to assess and, often is of lower quality compared to more densely populated regions. A program of multicenter palliative care discussion forum via tele-videoconference may be a promising tool for...

The biomechanical effect of preexisting different types of disc herniation in cervical hyperextension injury.

Journal of orthopaedic surgery and research

Wang JJ, Xu ML, Zeng HZ, Zheng LD, Zhu SJ, Jin C, Zeng ZL, Cheng LM, Zhu R.
PMID: 34429142
J Orthop Surg Res. 2021 Aug 24;16(1):527. doi: 10.1186/s13018-021-02677-y.

OBJECTIVE: Preexisting severe cervical spinal cord compression is a significant risk factor in cervical hyperextension injury, and the neurological function may deteriorate after a slight force to the forehead. There are few biomechanical studies regarding the influence of pathological...

RND3 attenuates oxidative stress and vascular remodeling in spontaneously hypertensive rat via inhibiting ROCK1 signaling.

Redox biology

Wu N, Zheng F, Li N, Han Y, Xiong XQ, Wang JJ, Chen Q, Li YH, Zhu GQ, Zhou YB.
PMID: 34883403
Redox Biol. 2021 Dec 06;48:102204. doi: 10.1016/j.redox.2021.102204. Epub 2021 Dec 06.

Superoxide and vascular smooth muscle cells (VSMCs) migration and proliferation play crucial roles in the vascular remodeling. Vascular remodeling contributes to the development and complications of hypertension. Rho family GTPase 3 (RND3 or RhoE), an atypical small Rho-GTPase, is...

Is Empiricism Innate? Preference for Nurture Over Nature in People's Beliefs About the Origins of Human Knowledge.

Open mind : discoveries in cognitive science

Wang JJ, Feigenson L.
PMID: 34485789
Open Mind (Camb). 2019 Sep 01;3:89-100. doi: 10.1162/opmi_a_00028. eCollection 2019.

The origins of human knowledge are an enduring puzzle: what parts of what we know require learning, and what depends on intrinsic structure? Although the nature-nurture debate has been a central question for millennia and has inspired much contemporary...

Showing 9541 to 9550 of 9550 entries