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Wu N, Zheng F, Li N, et al. RND3 attenuates oxidative stress and vascular remodeling in spontaneously hypertensive rat via inhibiting ROCK1 signaling. Redox Biol. 2021;48:102204doi: 10.1016/j.redox.2021.102204.
Wu, N., Zheng, F., Li, N., Han, Y., Xiong, X. Q., Wang, J. J., Chen, Q., Li, Y. H., Zhu, G. Q., & Zhou, Y. B. (2021). RND3 attenuates oxidative stress and vascular remodeling in spontaneously hypertensive rat via inhibiting ROCK1 signaling. Redox biology, 48102204. https://doi.org/10.1016/j.redox.2021.102204
Wu, Nan, et al. "RND3 attenuates oxidative stress and vascular remodeling in spontaneously hypertensive rat via inhibiting ROCK1 signaling." Redox biology vol. 48 (2021): 102204. doi: https://doi.org/10.1016/j.redox.2021.102204
Wu N, Zheng F, Li N, Han Y, Xiong XQ, Wang JJ, Chen Q, Li YH, Zhu GQ, Zhou YB. RND3 attenuates oxidative stress and vascular remodeling in spontaneously hypertensive rat via inhibiting ROCK1 signaling. Redox Biol. 2021 Dec 06;48:102204. doi: 10.1016/j.redox.2021.102204. Epub 2021 Dec 06. PMID: 34883403.
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Redox Biol. 2021 Dec 06;48:102204. doi: 10.1016/j.redox.2021.102204. Epub 2021 Dec 06.

RND3 attenuates oxidative stress and vascular remodeling in spontaneously hypertensive rat via inhibiting ROCK1 signaling.

Redox biology

Nan Wu, Fen Zheng, Na Li, Ying Han, Xiao-Qing Xiong, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Ye-Bo Zhou

Affiliations

  1. Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, and Department of Physiology, Nanjing Medical University, Nanjing, 211166, China.
  2. Department of Pathophysiology, Nanjing Medical University, Nanjing, 211166, China.
  3. Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, and Department of Physiology, Nanjing Medical University, Nanjing, 211166, China; Department of Pathophysiology, Nanjing Medical University, Nanjing, 211166, China. Electronic address: [email protected].
  4. Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, and Department of Physiology, Nanjing Medical University, Nanjing, 211166, China. Electronic address: [email protected].

PMID: 34883403 DOI: 10.1016/j.redox.2021.102204

Abstract

Superoxide and vascular smooth muscle cells (VSMCs) migration and proliferation play crucial roles in the vascular remodeling. Vascular remodeling contributes to the development and complications of hypertension. Rho family GTPase 3 (RND3 or RhoE), an atypical small Rho-GTPase, is known to be involved in cancer development and metastasis. However, the roles of RND3 in superoxide production and cardiovascular remodeling are unknown. Here, we uncovered the critical roles of RND3 in attenuating superoxide production, VSMCs migration and proliferation, and vascular remodeling in hypertension and its underline mechanisms. VSMCs were isolated and prepared from thoracic aorta of Male Wistar-Kyoto rat (WKY) and spontaneously hypertensive rat (SHR). RND3 mRNA and protein expressions in arteries and VSMCs were down-regulated in SHR. RND3 overexpression in VSMCs reduced NAD(P)H oxidase (NOX) activity, NOX1 and NOX2 expressions, mitochondria superoxide generation, and H

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Keywords: Hypertension; Migration; Proliferation; RND3; Superoxide; Vascular remodeling; Vascular smooth muscle cells

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