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Showing 13 to 24 of 65 entries
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Determining the frequency of thyroid parameter measurements following rhTSH administration in a healthy, older population.

MethodsX

Zutinic A, Blauw GJ, van Heemst D.
PMID: 34430296
MethodsX. 2021 May 28;8:101400. doi: 10.1016/j.mex.2021.101400. eCollection 2021.

Serial thyroid hormone measurement in blood following recombinant human thyroid stimulating hormone (rhTSH) administration has not been studied extensively in healthy, older populations. Current methods involve measurement of thyroid hormones mostly at 4 to 24 hours following rhTSH administration....

The Association between Adult Weight Gain and Insulin Resistance at Middle Age: Mediation by Visceral Fat and Liver Fat.

Journal of clinical medicine

Verkouter I, Noordam R, le Cessie S, van Dam RM, Lamb HJ, Rosendaal FR, van Heemst D, de Mutsert R.
PMID: 31569345
J Clin Med. 2019 Sep 28;8(10). doi: 10.3390/jcm8101559.

We aimed to investigate the role of the amount of visceral fat and liver fat in the association between adult weight change and insulin resistance at middle age. In the Netherlands Epidemiology of Obesity study, adult weight change was...

Upper airway obstruction in neonates: Does sleep exacerbate symptoms?.

Laryngoscope investigative otolaryngology

Van Heest T, Ebert B, Roby BB, Sidman J.
PMID: 29721538
Laryngoscope Investig Otolaryngol. 2018 Feb 10;3(2):78-81. doi: 10.1002/lio2.137. eCollection 2018 Apr.

OBJECTIVE: Describe the factors that exacerbate upper airway obstructions (UAOs) in neonates.STUDY DESIGN: Retrospective chart review.SETTING: Pediatric tertiary care hospital.SUBJECTS AND METHODS: All neonates hospitalized between 1/1/2010 and 12/31/2014 diagnosed with either: 1) laryngomalacia, 2) Pierre Robin sequence, or...

Comparative Analysis of the Equivital EQ02 Lifemonitor with Holter Ambulatory ECG Device for Continuous Measurement of ECG, Heart Rate, and Heart Rate Variability: A Validation Study for Precision and Accuracy.

Frontiers in physiology

Akintola AA, van de Pol V, Bimmel D, Maan AC, van Heemst D.
PMID: 27708585
Front Physiol. 2016 Sep 21;7:391. doi: 10.3389/fphys.2016.00391. eCollection 2016.

No abstract available.

Thyroid function and risk of anemia: a multivariable-adjusted and Mendelian Randomization analysis in the UK Biobank.

The Journal of clinical endocrinology and metabolism

van Vliet NA, Kamphuis AEP, den Elzen WPJ, Blauw GJ, Gussekloo J, Noordam R, van Heemst D.
PMID: 34514498
J Clin Endocrinol Metab. 2021 Sep 13; doi: 10.1210/clinem/dgab674. Epub 2021 Sep 13.

CONTEXT: Thyroid dysfunction is associated with higher anemia prevalence, though causality remains unclear.OBJECTIVE: To investigate the association between thyroid function and anemia.DESIGN: Cross-sectional and Mendelian Randomization study.SETTING: Europeans from UK Biobank.PARTICIPANTS: 445,482 participants, mean age 56.77 years (SD 8.0)...

Does the Preferred Study Source Impact Orthopedic In-Training Examination Performance?.

Journal of surgical education

Theismann JJ, Solberg EJ, Agel J, Dyer GS, Egol KA, Israelite CL, Karam MD, Kim H, Klein SE, Kweon CY, LaPorte DM, Van Heest A.
PMID: 34509414
J Surg Educ. 2021 Sep 08; doi: 10.1016/j.jsurg.2021.08.021. Epub 2021 Sep 08.

OBJECTIVE: This study examines the role of electronic learning platforms for medical knowledge acquisition in orthopedic surgery residency training. This study hypothesizes that all methods of medical knowledge acquisition will achieve similar levels of improvement in medical knowledge as...

Depression and Inflammatory Bowel Disease: A Bidirectional two-sample Mendelian Randomization Study.

Journal of Crohn's & colitis

Luo J, Xu Z, Noordam R, van Heemst D, Li-Gao R.
PMID: 34739073
J Crohns Colitis. 2021 Nov 05; doi: 10.1093/ecco-jcc/jjab191. Epub 2021 Nov 05.

BACKGROUND AND AIMS: Observational studies have suggested a bidirectional association between depression and inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). However, it remains unclear whether observed associations are casual due to the difficulties of...

High Adiposity Is Associated With Higher Nocturnal and Diurnal Glycaemia, but Not With Glycemic Variability in Older Individuals Without Diabetes.

Frontiers in endocrinology

Noordam R, Huurman NC, Wijsman CA, Akintola AA, Jansen SWM, Stassen S, Beekman M, van de Rest O, Slagboom PE, Mooijaart SP, van Heemst D.
PMID: 29867770
Front Endocrinol (Lausanne). 2018 May 14;9:238. doi: 10.3389/fendo.2018.00238. eCollection 2018.

BACKGROUND: It is well known that adiposity is a risk factor for insulin resistance and type 2 diabetes mellitus. In the present study, we aimed to investigate the associations of measures of adiposity with indices of glycemia and of...

Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes.

Nature communications

Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppälä I, Cordell HJ, Dose J, Amin N, Arnold AM, Ayers KL, Barzilai N, Becker EJ, Beekman M, Blanché H, Christensen K, Christiansen L, Collerton JC, Cubaynes S, Cummings SR, Davies K, Debrabant B, Deleuze JF, Duncan R, Faul JD, Franceschi C, Galan P, Gudnason V, Harris TB, Huisman M, Hurme MA, Jagger C, Jansen I, Jylhä M, Kähönen M, Karasik D, Kardia SLR, Kingston A, Kirkwood TBL, Launer LJ, Lehtimäki T, Lieb W, Lyytikäinen LP, Martin-Ruiz C, Min J, Nebel A, Newman AB, Nie C, Nohr EA, Orwoll ES, Perls TT, Province MA, Psaty BM, Raitakari OT, Reinders MJT, Robine JM, Rotter JI, Sebastiani P, Smith J, Sørensen TIA, Taylor KD, Uitterlinden AG, van der Flier W, van der Lee SJ, van Duijn CM, van Heemst D, Vaupel JW, Weir D, Ye K, Zeng Y, Zheng W, Holstege H, Kiel DP, Lunetta KL, Slagboom PE, Murabito JM.
PMID: 33893282
Nat Commun. 2021 Apr 23;12(1):2463. doi: 10.1038/s41467-021-22613-2.

No abstract available.

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population.

Antioxidants (Basel, Switzerland)

Martens LG, Luo J, Meulmeester FL, Ashrafi N, van Eekelen EW, de Mutsert R, Mook-Kanamori DO, Rosendaal FR, van Dijk KW, Mills K, Noordam R, van Heemst D.
PMID: 33333950
Antioxidants (Basel). 2020 Dec 15;9(12). doi: 10.3390/antiox9121280.

The antioxidant vitamin E (α-tocopherol, α-TOH) protects lipids from oxidation by reactive oxygen species. We hypothesized that lifestyle factors associate with vitamin E metabolism marked by urinary α-tocopheronolactone hydroquinone (α-TLHQ) and α-carboxymethyl-hydroxychroman (α-CEHC levels), as potential reflection of lipid...

Circulating angiopoietin-2 and angiogenic microRNAs associate with cerebral small vessel disease and cognitive decline in older patients reaching end stage renal disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Bijkerk R, Kallenberg MH, Zijlstra LE, van den Berg BM, de Bresser J, Hammer S, Bron EE, Achterberg H, van Buchem MA, Berkhout-Byrne NC, Bos WJW, van Heemst D, Rabelink TJ, van Zonneveld AJ, van Buren M, Mooijaart S.
PMID: 33355649
Nephrol Dial Transplant. 2020 Dec 23; doi: 10.1093/ndt/gfaa370. Epub 2020 Dec 23.

BACKGROUND: The prevalence of end-stage renal disease (ESRD) is increasing worldwide, with the majority of new ESRD cases diagnosed in patients aged >60 years. These older patients are at increased risk for impaired cognitive functioning, potentially through cerebral small...

Associations of metabolomic profiles with circulating vitamin E and urinary vitamin E metabolites in middle-aged individuals.

Nutrition (Burbank, Los Angeles County, Calif.)

Luo J, Hashimoto Y, Martens LG, Meulmeester FL, Ashrafi N, Mook-Kanamori DO, Rosendaal FR, Jukema JW, van Dijk KW, Mills K, le Cessie S, Noordam R, van Heemst D.
PMID: 34534944
Nutrition. 2022 Jan;93:111440. doi: 10.1016/j.nut.2021.111440. Epub 2021 Jul 29.

Vitamin E (α-tocopherol [α-TOH]) is transported in lipoprotein particles in blood, but little is known about the transportation of its oxidized metabolites. In the Netherlands Epidemiology of Obesity Study, we aimed to investigate the associations of 147 circulating metabolomic...

Showing 13 to 24 of 65 entries