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Showing 121 to 129 of 129 entries
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Tailoring precision immunotherapy: coming to a clinic soon?.

ESMO open

Han S, Shuen WH, Wang WW, Nazim E, Toh HC.
PMID: 33558033
ESMO Open. 2020;5:e000631. doi: 10.1136/esmoopen-2019-000631. Epub 2020 Sep 30.

Cell-based and antibody-based cancer immunotherapies have been widely tested across increasing numbers of cancers with an unprecedented number of successful practice-changing immunotherapy clinical trials, achieving significant survival outcomes and, characteristically, some very long-term survivors. Still, a sizeable proportion of...

[Ⅴ. Novel Immunotherapies Targeting Tumor-Associated Macrophages].

Gan to kagaku ryoho. Cancer & chemotherapy

Takahashi H.
PMID: 34267027
Gan To Kagaku Ryoho. 2021 Jul;48(7):907-909.

No abstract available.

Tumor Associated Macrophages and TAMs-Based Anti-Tumor Nanomedicines.

Advanced healthcare materials

Cheng Y, Song S, Wu P, Lyu B, Qin M, Sun Y, Sun A, Mu L, Xu F, Zhang L, Wang J, Zhang Q.
PMID: 34292673
Adv Healthc Mater. 2021 Sep;10(18):e2100590. doi: 10.1002/adhm.202100590. Epub 2021 Jul 22.

As an important part of tumor microenvironment, tumor associated macrophages (TAMs) play a vital role in the occurrence, development, invasion, and metastasis of many malignant tumors and can significantly promote the formation of tumor blood vessels and lymphatic vessels,...

Immunotherapies targeting stimulatory pathways and beyond.

Journal of hematology & oncology

Marin-Acevedo JA, Kimbrough EO, Manochakian R, Zhao Y, Lou Y.
PMID: 33980266
J Hematol Oncol. 2021 May 12;14(1):78. doi: 10.1186/s13045-021-01085-3.

Co-stimulatory and co-inhibitory molecules play a critical role in T cell function. Tumor cells escape immune surveillance by promoting immunosuppression. Immunotherapy targeting inhibitory molecules like anti-CTLA-4 and anti-PD-1/PD-L1 were developed to overcome these immunosuppressive effects. These agents have demonstrated...

Introduction to the special issue-Barriers and opportunities to cancer immunotherapy in the tumor immune microenvironment.

Seminars in immunology

Zou W.
PMID: 33308923
Semin Immunol. 2020 Jun;49:101421. doi: 10.1016/j.smim.2020.101421. Epub 2020 Dec 09.

No abstract available.

Combinatorial therapy in tumor microenvironment: Where do we stand?.

Biochimica et biophysica acta. Reviews on cancer

Kumari S, Advani D, Sharma S, Ambasta RK, Kumar P.
PMID: 34224836
Biochim Biophys Acta Rev Cancer. 2021 Dec;1876(2):188585. doi: 10.1016/j.bbcan.2021.188585. Epub 2021 Jul 02.

The tumor microenvironment plays a pivotal role in tumor initiation and progression by creating a dynamic interaction with cancer cells. The tumor microenvironment consists of various cellular components, including endothelial cells, fibroblasts, pericytes, adipocytes, immune cells, cancer stem cells...

[Roles of highly expressed bone-specific genes in bone metastatic prostate cancer PC3 cells: Advances in studies].

Zhonghua nan ke xue = National journal of andrology

Zhou SY, Wang D, Shao JC, You YD.
PMID: 34914272
Zhonghua Nan Ke Xue. 2021 Oct 20;27(10):927-933.

Prostate cancer (PCa) is a maligmancy with high morbidity and mortality. Bone metastasis is the main cause of short survival time and difficulties in the treatment and prevention of PCa. Previous findings of our team showed 155 bone-specific genes...

Mathematical simulation and prediction of tumor volume using RBF artificial neural network at different circumstances in the tumor microenvironment.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

Akbarpour Ghazani M, Saghafian M, Jalali P, Soltani M.
PMID: 34247529
Proc Inst Mech Eng H. 2021 Nov;235(11):1335-1355. doi: 10.1177/09544119211028380. Epub 2021 Jul 10.

Uncontrolled proliferation of cells in a tissue caused by genetic mutations inside a cell is referred to as a tumor. A tumor which grows rapidly encounters a barrier when it grows to a certain size in presence of preexisting...

M2 subtype tumor associated macrophages (M2-TAMs) infiltration predicts poor response rate of immune checkpoint inhibitors treatment for prostate cancer.

Annals of medicine

JiaWei Z, ChunXia D, CunDong L, Yang L, JianKun Y, HaiFeng D, Cheng Y, ZhiPeng H, HongYi W, DeYing L, ZhiJian L, Xiao X, QiZhao Z, KangYi X, WenBing G, Ming X, JunHao Z, JiMing B, ShanChao Z, MingKun C.
PMID: 34032524
Ann Med. 2021 Dec;53(1):730-740. doi: 10.1080/07853890.2021.1924396.

BACKGROUND: Prostate cancer (PCa) is poor response to the immunotherapy for its high heterogeneity of immune microenvironment. In this study, we aim to introduce a new immune subtype for PCa involving M2 tumour associated macrophages METHODS: Three hundred and...

Showing 121 to 129 of 129 entries