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Showing 1 to 6 of 6 entries
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Targeting .

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Gueniot F, Rubin S, Bougaran P, Abelanet A, Morel JL, Bontempi B, Proust C, Dufourcq P, Couffinhal T, Duplàa C.
PMID: 34644209
J Cereb Blood Flow Metab. 2021 Oct 13;271678X211048981. doi: 10.1177/0271678X211048981. Epub 2021 Oct 13.

Blood brain barrier (BBB) disruption is a critical component of the pathophysiology of cognitive impairment of vascular etiology (VCI) and associated with Alzheimer's disease (AD). The Wnt pathway plays a crucial role in BBB maintenance, but there is limited...

Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis.

Cell metabolism

Torrino S, Grasset EM, Audebert S, Belhadj I, Lacoux C, Haynes M, Pisano S, Abélanet S, Brau F, Chan SY, Mari B, Oldham WM, Ewald AJ, Bertero T.
PMID: 34102109
Cell Metab. 2021 Jul 06;33(7):1342-1357.e10. doi: 10.1016/j.cmet.2021.05.009. Epub 2021 Jun 07.

Mechanical signals from the tumor microenvironment modulate cell mechanics and influence cell metabolism to promote cancer aggressiveness. Cells withstand external forces by adjusting the stiffness of their cytoskeleton. Microtubules (MTs) act as compression-bearing elements. Yet how cancer cells regulate...

Decrease of Pdzrn3 is required for heart maturation and protects against heart failure.

Scientific reports

Pernot M, Jaspard-Vinassa B, Abelanet A, Rubin S, Forfar I, Jeanningros S, Cetran L, Yu MH, Balse E, Hatem S, Dufourcq P, Couffinhal T, Duplàa C.
PMID: 34996942
Sci Rep. 2022 Jan 07;12(1):8. doi: 10.1038/s41598-021-03795-7.

Heart failure is the final common stage of most cardiopathies. Cardiomyocytes (CM) connect with others via their extremities by intercalated disk protein complexes. This planar and directional organization of myocytes is crucial for mechanical coupling and anisotropic conduction of...

Decrease of Pdzrn3 is required for heart maturation and protects against heart failure.

Scientific reports

Pernot M, Jaspard-Vinassa B, Abelanet A, Rubin S, Forfar I, Jeanningros S, Cetran L, Yu MH, Balse E, Hatem S, Dufourcq P, Couffinhal T, Duplàa C.
PMID: 34996942
Sci Rep. 2022 Jan 07;12(1):8. doi: 10.1038/s41598-021-03795-7.

Heart failure is the final common stage of most cardiopathies. Cardiomyocytes (CM) connect with others via their extremities by intercalated disk protein complexes. This planar and directional organization of myocytes is crucial for mechanical coupling and anisotropic conduction of...

Decrease of Pdzrn3 is required for heart maturation and protects against heart failure.

Scientific reports

Pernot M, Jaspard-Vinassa B, Abelanet A, Rubin S, Forfar I, Jeanningros S, Cetran L, Yu MH, Balse E, Hatem S, Dufourcq P, Couffinhal T, Duplàa C.
PMID: 34996942
Sci Rep. 2022 Jan 07;12(1):8. doi: 10.1038/s41598-021-03795-7.

Heart failure is the final common stage of most cardiopathies. Cardiomyocytes (CM) connect with others via their extremities by intercalated disk protein complexes. This planar and directional organization of myocytes is crucial for mechanical coupling and anisotropic conduction of...

Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis.

Cell metabolism

Torrino S, Grasset EM, Audebert S, Belhadj I, Lacoux C, Haynes M, Pisano S, Abélanet S, Brau F, Chan SY, Mari B, Oldham WM, Ewald AJ, Bertero T.
PMID: 34102109
Cell Metab. 2021 Jul 06;33(7):1342-1357.e10. doi: 10.1016/j.cmet.2021.05.009. Epub 2021 Jun 07.

Mechanical signals from the tumor microenvironment modulate cell mechanics and influence cell metabolism to promote cancer aggressiveness. Cells withstand external forces by adjusting the stiffness of their cytoskeleton. Microtubules (MTs) act as compression-bearing elements. Yet how cancer cells regulate...

Showing 1 to 6 of 6 entries