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Showing 1 to 12 of 47 entries
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Deep Immune Profiling of an Arginine-Enriched Nutritional Intervention in Patients Undergoing Surgery.

Journal of immunology (Baltimore, Md. : 1950)

Aghaeepour N, Kin C, Ganio EA, Jensen KP, Gaudilliere DK, Tingle M, Tsai A, Lancero HL, Choisy B, McNeil LS, Okada R, Shelton AA, Nolan GP, Angst MS, Gaudilliere BL.
PMID: 28794234
J Immunol. 2017 Aug 09; doi: 10.4049/jimmunol.1700421. Epub 2017 Aug 09.

Application of high-content immune profiling technologies has enormous potential to advance medicine. Whether these technologies reveal pertinent biology when implemented in interventional clinical trials is an important question. The beneficial effects of preoperative arginine-enriched dietary supplements (AES) are highly...

Deleterious and Protective Psychosocial and Stress-Related Factors Predict Risk of Spontaneous Preterm Birth.

American journal of perinatology

Becker M, Mayo JA, Phogat NK, Quaintance CC, Laborde A, King L, Gotlib IH, Gaudilliere B, Angst MS, Shaw GM, Stevenson DK, Aghaeepour N, Dhabhar FS.
PMID: 34015838
Am J Perinatol. 2021 May 20; doi: 10.1055/s-0041-1729162. Epub 2021 May 20.

OBJECTIVES:  The aim of the study was to: (1) Identify (early in pregnancy) psychosocial and stress-related factors that predict risk of spontaneous preterm birth (PTB, gestational age

Use of Patient-Reported Outcome Measures to Assess Outpatient Postpartum Recovery: A Systematic Review.

JAMA network open

Sultan P, Sharawi N, Blake L, Ando K, Sultan E, Aghaeepour N, Carvalho B, Sadana N.
PMID: 34042993
JAMA Netw Open. 2021 May 03;4(5):e2111600. doi: 10.1001/jamanetworkopen.2021.11600.

IMPORTANCE: Outpatient postpartum recovery is an underexplored area of obstetrics. There is currently no consensus regarding which patient-reported outcome measure (PROM) clinicians and researchers should use to evaluate postpartum recovery.OBJECTIVE: To evaluate PROMs of outpatient postpartum recovery using Consensus-Based...

Integrated Single-Cell and Plasma Proteomic Modeling to Predict Surgical Site Complications: A Prospective Cohort Study.

Annals of surgery

Rumer KK, Hedou J, Tsai A, Einhaus J, Verdonk F, Stanley N, Choisy B, Ganio E, Bonham A, Jacobsen D, Warrington B, Gao X, Tingle M, McAllister TN, Fallahzadeh R, Feyaerts D, Stelzer I, Gaudilliere D, Ando K, Shelton A, Morris A, Kebebew E, Aghaeepour N, Kin C, Angst MS, Gaudilliere B.
PMID: 34954754
Ann Surg. 2021 Dec 23; doi: 10.1097/SLA.0000000000005348. Epub 2021 Dec 23.

OBJECTIVE: The aim of this study was to determine whether single-cell and plasma proteomic elements of the host's immune response to surgery accurately identify patients who develop a surgical site complication (SSC) after major abdominal surgery.SUMMARY BACKGROUND DATA: SSCs...

Improvement in Glucose Regulation Using a Digital Tracker and Continuous Glucose Monitoring in Healthy Adults and Those with Type 2 Diabetes.

Diabetes therapy : research, treatment and education of diabetes and related disorders

Dehghani Zahedani A, Shariat Torbaghan S, Rahili S, Karlin K, Scilley D, Thakkar R, Saberi M, Hashemi N, Perelman D, Aghaeepour N, McLaughlin T, Snyder MP.
PMID: 34047962
Diabetes Ther. 2021 Jul;12(7):1871-1886. doi: 10.1007/s13300-021-01081-3. Epub 2021 May 28.

INTRODUCTION: While continuous glucose monitoring (CGM) has been shown to decrease both hyper- and hypoglycemia in insulin-treated diabetes, its value in non-insulin-treated type 2 diabetes (T2D) and prediabetes is unclear. Studies examining the reduction in hyperglycemia with the use...

High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status.

Cell reports

Camiolo MJ, Zhou X, Oriss TB, Yan Q, Gorry M, Horne W, Trudeau JB, Scholl K, Chen W, Kolls JK, Ray P, Weisel FJ, Weisel NM, Aghaeepour N, Nadeau K, Wenzel SE, Ray A.
PMID: 33852838
Cell Rep. 2021 Apr 13;35(2):108974. doi: 10.1016/j.celrep.2021.108974.

Clinical definitions of asthma fail to capture the heterogeneity of immune dysfunction in severe, treatment-refractory disease. Applying mass cytometry and machine learning to bronchoalveolar lavage (BAL) cells, we find that corticosteroid-resistant asthma patients cluster largely into two groups: one...

Author Correction: Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma.

Nature communications

Ganio EA, Stanley N, Lindberg-Larsen V, Einhaus J, Tsai AS, Verdonk F, Culos A, Ghaemi S, Rumer KK, Stelzer IA, Gaudilliere D, Tsai E, Fallahzadeh R, Choisy B, Kehlet H, Aghaeepour N, Angst MS, Gaudilliere B.
PMID: 32883978
Nat Commun. 2020 Sep 03;11(1):4495. doi: 10.1038/s41467-020-18410-y.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Human influenza virus challenge identifies cellular correlates of protection for oral vaccination.

Cell host & microbe

McIlwain DR, Chen H, Rahil Z, Bidoki NH, Jiang S, Bjornson Z, Kolhatkar NS, Martinez CJ, Gaudillière B, Hedou J, Mukherjee N, Schürch CM, Trejo A, Affrime M, Bock B, Kim K, Liebowitz D, Aghaeepour N, Tucker SN, Nolan GP.
PMID: 34784508
Cell Host Microbe. 2021 Dec 08;29(12):1828-1837.e5. doi: 10.1016/j.chom.2021.10.009. Epub 2021 Nov 15.

Developing new influenza vaccines with improved performance and easier administration routes hinges on defining correlates of protection. Vaccine-elicited cellular correlates of protection for influenza in humans have not yet been demonstrated. A phase-2 double-blind randomized placebo and active (inactivated...

Use of Patient-Reported Outcome Measures to Assess Outpatient Postpartum Recovery: A Systematic Review.

JAMA network open

Sultan P, Sharawi N, Blake L, Ando K, Sultan E, Aghaeepour N, Carvalho B, Sadana N.
PMID: 34042993
JAMA Netw Open. 2021 May 03;4(5):e2111600. doi: 10.1001/jamanetworkopen.2021.11600.

IMPORTANCE: Outpatient postpartum recovery is an underexplored area of obstetrics. There is currently no consensus regarding which patient-reported outcome measure (PROM) clinicians and researchers should use to evaluate postpartum recovery.OBJECTIVE: To evaluate PROMs of outpatient postpartum recovery using Consensus-Based...

Purification and partial characterization of a cholesterol oxidase from Streptomyces fradiae.

Enzyme and microbial technology

Yazdi MT, Zahraei M, Aghaepour K, Kamranpour N.
PMID: 11240199
Enzyme Microb Technol. 2001 Mar 08;28(4):410-414. doi: 10.1016/s0141-0229(00)00337-9.

An extracellular cholesterol oxidase from Streptomyces fradiae (PTCC 1121) was purified in one step using DEAE-Sepharose. The purified enzyme had a molecular weight of 60 KDa. The optimum pH and temperature for activity was found to be 7 and...

Genetic characterization of the wboA gene from the predominant biovars of Brucella isolates in Iran.

Electronic physician

Etemady A, Mohammdi M, Esmaelizad M, Alamian S, Vahedi F, Aghaeipour K, Behrozikhah AM, Faghihloo E, Afshar D, Firuzyar S, Rahimi A.
PMID: 26516446
Electron Physician. 2015 Oct 19;7(6):1381-6. doi: 10.14661/1381. eCollection 2015 Oct.

INTRODUCTION: Brucella spp. are gram-negative, facultative intracellular bacteria pathogens responsible for brucellosis, a zoonotic disease that can cause abortion, fetal death, and genital infections in animals and undulant fever in humans. Lipopolysaccharide (LPS) is known as a major virulence...

Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities.

Nature reviews. Neurology

Davis KD, Aghaeepour N, Ahn AH, Angst MS, Borsook D, Brenton A, Burczynski ME, Crean C, Edwards R, Gaudilliere B, Hergenroeder GW, Iadarola MJ, Iyengar S, Jiang Y, Kong JT, Mackey S, Saab CY, Sang CN, Scholz J, Segerdahl M, Tracey I, Veasley C, Wang J, Wager TD, Wasan AD, Pelleymounter MA.
PMID: 32541893
Nat Rev Neurol. 2020 Jul;16(7):381-400. doi: 10.1038/s41582-020-0362-2. Epub 2020 Jun 15.

Pain medication plays an important role in the treatment of acute and chronic pain conditions, but some drugs, opioids in particular, have been overprescribed or prescribed without adequate safeguards, leading to an alarming rise in medication-related overdose deaths. The...

Showing 1 to 12 of 47 entries