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Exposure to extracellular vesicles from .

Epigenetics

Kyung Lee M, Armstrong DA, Hazlett HF, Dessaint JA, Mellinger DL, Aridgides DS, Christensen BC, Ashare A.
PMID: 33380271
Epigenetics. 2021 Nov;16(11):1187-1200. doi: 10.1080/15592294.2020.1853318. Epub 2020 Dec 31.

Various pathogens use differing strategies to evade host immune response including modulating the host's epigenome. Here, we investigate if EVs secreted from

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Kyung Lee M, Armstrong DA, Hazlett HF, et al. Exposure to extracellular vesicles from . Epigenetics. 2020;16(11):1187-1200doi: 10.1080/15592294.2020.1853318.
Kyung Lee, M., Armstrong, D. A., Hazlett, H. F., Dessaint, J. A., Mellinger, D. L., Aridgides, D. S., Christensen, B. C., & Ashare, A. (2021). Exposure to extracellular vesicles from . Epigenetics, 16(11), 1187-1200. https://doi.org/10.1080/15592294.2020.1853318
Kyung Lee, Min, et al. "Exposure to extracellular vesicles from ." Epigenetics vol. 16,11 (2021): 1187-1200. doi: https://doi.org/10.1080/15592294.2020.1853318
Kyung Lee M, Armstrong DA, Hazlett HF, Dessaint JA, Mellinger DL, Aridgides DS, Christensen BC, Ashare A. Exposure to extracellular vesicles from . Epigenetics. 2021 Nov;16(11):1187-1200. doi: 10.1080/15592294.2020.1853318. Epub 2020 Dec 31. PMID: 33380271.
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Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions.

mBio

O'Toole GA, Crabbé A, Kümmerli R, LiPuma JJ, Bomberger JM, Davies JC, Limoli D, Phelan VV, Bliska JB, DePas WH, Dietrich LE, Hampton TH, Hunter R, Khursigara CM, Price-Whelan A, Ashare A, Cramer RA, Goldberg JB, Harrison F, Hogan DA, Henson MA, Madden DR, Mayers JR, Nadell C, Newman D, Prince A, Rivett DW, Schwartzman JD, Schultz D, Sheppard DC, Smyth AR, Spero MA, Stanton BA, Turner PE, van der Gast C, Whelan FJ, Whitaker R, Whiteson K.
PMID: 34544277
mBio. 2021 Oct 26;12(5):e0176321. doi: 10.1128/mBio.01763-21. Epub 2021 Sep 21.

A recent workshop titled "Developing Models to Study Polymicrobial Infections," sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF)....

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O'Toole GA, Crabbé A, Kümmerli R, et al. Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions. mBio. 2021;12(5):e0176321doi: 10.1128/mBio.01763-21.
O'Toole, G. A., Crabbé, A., Kümmerli, R., LiPuma, J. J., Bomberger, J. M., Davies, J. C., Limoli, D., Phelan, V. V., Bliska, J. B., DePas, W. H., Dietrich, L. E., Hampton, T. H., Hunter, R., Khursigara, C. M., Price-Whelan, A., Ashare, A., Cramer, R. A., Goldberg, J. B., Harrison, F., Hogan, D. A., Henson, M. A., Madden, D. R., Mayers, J. R., Nadell, C., Newman, D., Prince, A., Rivett, D. W., Schwartzman, J. D., Schultz, D., Sheppard, D. C., Smyth, A. R., Spero, M. A., Stanton, B. A., Turner, P. E., van der Gast, C., Whelan, F. J., Whitaker, R., & Whiteson, K. (2021). Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions. mBio, 12(5), e0176321. https://doi.org/10.1128/mBio.01763-21
O'Toole, George A, et al. "Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions." mBio vol. 12,5 (2021): e0176321. doi: https://doi.org/10.1128/mBio.01763-21
O'Toole GA, Crabbé A, Kümmerli R, LiPuma JJ, Bomberger JM, Davies JC, Limoli D, Phelan VV, Bliska JB, DePas WH, Dietrich LE, Hampton TH, Hunter R, Khursigara CM, Price-Whelan A, Ashare A, Cramer RA, Goldberg JB, Harrison F, Hogan DA, Henson MA, Madden DR, Mayers JR, Nadell C, Newman D, Prince A, Rivett DW, Schwartzman JD, Schultz D, Sheppard DC, Smyth AR, Spero MA, Stanton BA, Turner PE, van der Gast C, Whelan FJ, Whitaker R, Whiteson K. Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions. mBio. 2021 Oct 26;12(5):e0176321. doi: 10.1128/mBio.01763-21. Epub 2021 Sep 21. PMID: 34544277; PMCID: PMC8546538.
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Magnitude and associated factors of perceived stress and its consequence among undergraduate students of Salale University, Ethiopia: cross-sectional study.

Psychology, health & medicine

Amhare AF, Jian L, Wagaw LM, Qu C, Han J.
PMID: 32783647
Psychol Health Med. 2021 Dec;26(10):1230-1240. doi: 10.1080/13548506.2020.1808234. Epub 2020 Aug 12.

Excessive stress may have a negative impact on students' performance and learning ability. The aim of this study is to assess the magnitude and associated factors of perceived stress and its consequences among undergraduate students at Salale University, Ethiopia....

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Amhare AF, Jian L, Wagaw LM, et al. Magnitude and associated factors of perceived stress and its consequence among undergraduate students of Salale University, Ethiopia: cross-sectional study. Psychol Health Med. 2020;26(10):1230-1240doi: 10.1080/13548506.2020.1808234.
Amhare, A. F., Jian, L., Wagaw, L. M., Qu, C., & Han, J. (2021). Magnitude and associated factors of perceived stress and its consequence among undergraduate students of Salale University, Ethiopia: cross-sectional study. Psychology, health & medicine, 26(10), 1230-1240. https://doi.org/10.1080/13548506.2020.1808234
Amhare, Abebe Feyissa, et al. "Magnitude and associated factors of perceived stress and its consequence among undergraduate students of Salale University, Ethiopia: cross-sectional study." Psychology, health & medicine vol. 26,10 (2021): 1230-1240. doi: https://doi.org/10.1080/13548506.2020.1808234
Amhare AF, Jian L, Wagaw LM, Qu C, Han J. Magnitude and associated factors of perceived stress and its consequence among undergraduate students of Salale University, Ethiopia: cross-sectional study. Psychol Health Med. 2021 Dec;26(10):1230-1240. doi: 10.1080/13548506.2020.1808234. Epub 2020 Aug 12. PMID: 32783647.
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Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.

Cartilage

Lei J, Deng H, Ran Y, Lv Y, Amhare AF, Wang L, Guo X, Han J, Lammi MJ.
PMID: 32517548
Cartilage. 2021 Dec;13(1):818S-828S. doi: 10.1177/1947603520932199. Epub 2020 Jun 09.

OBJECTIVE: The objective of this study was to investigate the expression of enzymes involved in synthesis and modification of chondroitin sulfate (CS) in knee cartilage tissue of patients with osteoarthritis (OA) and Kashin-Beck disease (KBD).METHODS: The knee articular cartilage...

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Lei J, Deng H, Ran Y, et al. Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease. Cartilage. 2020;13(1):818S-828Sdoi: 10.1177/1947603520932199.
Lei, J., Deng, H., Ran, Y., Lv, Y., Amhare, A. F., Wang, L., Guo, X., Han, J., & Lammi, M. J. (2021). Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease. Cartilage, 13(1), 818S-828S. https://doi.org/10.1177/1947603520932199
Lei, Jian, et al. "Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease." Cartilage vol. 13,1 (2021): 818S-828S. doi: https://doi.org/10.1177/1947603520932199
Lei J, Deng H, Ran Y, Lv Y, Amhare AF, Wang L, Guo X, Han J, Lammi MJ. Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease. Cartilage. 2021 Dec;13(1):818S-828S. doi: 10.1177/1947603520932199. Epub 2020 Jun 09. PMID: 32517548.
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Bedside ultrasound as a simple non-invasive method of assessing intracranial pressure in a limited resource setting.

African journal of emergency medicine : Revue africaine de la medecine d'urgence

Zewdie A, Tesema H, Aklilu AT, Teklemariam TL, Zewdu T, Ashagre Y, Bizuneh Y, Azazh A, Hassen GW.
PMID: 30456086
Afr J Emerg Med. 2016 Sep;6(3):e1-e4. doi: 10.1016/j.afjem.2016.06.002. Epub 2016 Jul 22.

INTRODUCTION: Increased intracranial pressure is usually measured with invasive methods that are not practical in resource-limited countries. However, bedside ultrasound, a non-invasive method, measures the optic nerve sheath diameter and could be a safe and accurate alternative to measure...

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Zewdie A, Tesema H, Aklilu AT, et al. Bedside ultrasound as a simple non-invasive method of assessing intracranial pressure in a limited resource setting. Afr J Emerg Med. 2016;6(3):e1-e4doi: 10.1016/j.afjem.2016.06.002.
Zewdie, A., Tesema, H., Aklilu, A. T., Teklemariam, T. L., Zewdu, T., Ashagre, Y., Bizuneh, Y., Azazh, A., & Hassen, G. W. (2016). Bedside ultrasound as a simple non-invasive method of assessing intracranial pressure in a limited resource setting. African journal of emergency medicine : Revue africaine de la medecine d'urgence, 6(3), e1-e4. https://doi.org/10.1016/j.afjem.2016.06.002
Zewdie, Ayalew, et al. "Bedside ultrasound as a simple non-invasive method of assessing intracranial pressure in a limited resource setting." African journal of emergency medicine : Revue africaine de la medecine d'urgence vol. 6,3 (2016): e1-e4. doi: https://doi.org/10.1016/j.afjem.2016.06.002
Zewdie A, Tesema H, Aklilu AT, Teklemariam TL, Zewdu T, Ashagre Y, Bizuneh Y, Azazh A, Hassen GW. Bedside ultrasound as a simple non-invasive method of assessing intracranial pressure in a limited resource setting. Afr J Emerg Med. 2016 Sep;6(3):e1-e4. doi: 10.1016/j.afjem.2016.06.002. Epub 2016 Jul 22. PMID: 30456086; PMCID: PMC6234191.
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Biomedical application of chondroitin sulfate with nanoparticles in drug delivery systems: systematic review.

Journal of drug targeting

Amhare AF, Lei J, Deng H, Lv Y, Han J, Zhang L.
PMID: 33021406
J Drug Target. 2021 Mar;29(3):259-268. doi: 10.1080/1061186X.2020.1833018. Epub 2020 Oct 14.

Chondroitin sulphate captured an increasing amount of attention in the field of drug delivery systems. Nanoparticles and chondroitin sulphate were combined in different ways to form effective target nanocarriers. The study aimed to evaluate the biomedical application of chondroitin...

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Amhare AF, Lei J, Deng H, et al. Biomedical application of chondroitin sulfate with nanoparticles in drug delivery systems: systematic review. J Drug Target. 2020;29(3):259-268doi: 10.1080/1061186X.2020.1833018.
Amhare, A. F., Lei, J., Deng, H., Lv, Y., Han, J., & Zhang, L. (2021). Biomedical application of chondroitin sulfate with nanoparticles in drug delivery systems: systematic review. Journal of drug targeting, 29(3), 259-268. https://doi.org/10.1080/1061186X.2020.1833018
Amhare, Abebe Feyissa, et al. "Biomedical application of chondroitin sulfate with nanoparticles in drug delivery systems: systematic review." Journal of drug targeting vol. 29,3 (2021): 259-268. doi: https://doi.org/10.1080/1061186X.2020.1833018
Amhare AF, Lei J, Deng H, Lv Y, Han J, Zhang L. Biomedical application of chondroitin sulfate with nanoparticles in drug delivery systems: systematic review. J Drug Target. 2021 Mar;29(3):259-268. doi: 10.1080/1061186X.2020.1833018. Epub 2020 Oct 14. PMID: 33021406.
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Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.

Cartilage

Lei J, Deng H, Ran Y, Lv Y, Amhare AF, Wang L, Guo X, Han J, Lammi MJ.
PMID: 32517548
Cartilage. 2021 Dec;13(1):818S-828S. doi: 10.1177/1947603520932199. Epub 2020 Jun 09.

OBJECTIVE: The objective of this study was to investigate the expression of enzymes involved in synthesis and modification of chondroitin sulfate (CS) in knee cartilage tissue of patients with osteoarthritis (OA) and Kashin-Beck disease (KBD).METHODS: The knee articular cartilage...

Cite
Lei J, Deng H, Ran Y, et al. Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease. Cartilage. 2020;13(1):818S-828Sdoi: 10.1177/1947603520932199.
Lei, J., Deng, H., Ran, Y., Lv, Y., Amhare, A. F., Wang, L., Guo, X., Han, J., & Lammi, M. J. (2021). Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease. Cartilage, 13(1), 818S-828S. https://doi.org/10.1177/1947603520932199
Lei, Jian, et al. "Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease." Cartilage vol. 13,1 (2021): 818S-828S. doi: https://doi.org/10.1177/1947603520932199
Lei J, Deng H, Ran Y, Lv Y, Amhare AF, Wang L, Guo X, Han J, Lammi MJ. Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease. Cartilage. 2021 Dec;13(1):818S-828S. doi: 10.1177/1947603520932199. Epub 2020 Jun 09. PMID: 32517548.
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Factors associated with symptoms of poor mental health among women factory workers in China's supply chain.

International archives of occupational and environmental health

Sznajder KK, Harlow SD, Wang J, Tso L, Ashagre Y, Han C.
PMID: 35001196
Int Arch Occup Environ Health. 2022 Jan 10; doi: 10.1007/s00420-021-01820-w. Epub 2022 Jan 10.

OBJECTIVE: Foreign direct investment (FDI) to China has motivated increased labor migration to export processing zones (EPZs). Work environments with high occupational stress, such as production line jobs typical in EPZs, have been associated with adverse mental health symptoms.METHODS:...

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Sznajder KK, Harlow SD, Wang J, et al. Factors associated with symptoms of poor mental health among women factory workers in China's supply chain. Int Arch Occup Environ Health. 2022;doi: 10.1007/s00420-021-01820-w.
Sznajder, K. K., Harlow, S. D., Wang, J., Tso, L., Ashagre, Y., & Han, C. (2022). Factors associated with symptoms of poor mental health among women factory workers in China's supply chain. International archives of occupational and environmental health, . https://doi.org/10.1007/s00420-021-01820-w
Sznajder, K K, et al. "Factors associated with symptoms of poor mental health among women factory workers in China's supply chain." International archives of occupational and environmental health vol. (2022). doi: https://doi.org/10.1007/s00420-021-01820-w
Sznajder KK, Harlow SD, Wang J, Tso L, Ashagre Y, Han C. Factors associated with symptoms of poor mental health among women factory workers in China's supply chain. Int Arch Occup Environ Health. 2022 Jan 10; doi: 10.1007/s00420-021-01820-w. Epub 2022 Jan 10. PMID: 35001196; PMCID: PMC8743097.
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Protective effect of chondroitin sulfate nano-selenium on chondrocyte of patients with Kashin-Beck disease.

Journal of biomaterials applications

Qiao L, Amhare AF, Deng H, Lv Y, Zhao Y, Liu J, Lei J, Wang L, Chilufya MM, Han J.
PMID: 33487067
J Biomater Appl. 2021 May;35(10):1347-1354. doi: 10.1177/0885328220988427. Epub 2021 Jan 24.

OBJECTIVE: To investigate the protective effect of chondroitin sulfate nano-selenium (SeCS) on chondrocyte of Kashin-Beck disease (KBD).METHODS: Chondrocyte samples were isolated from the cartilage of three male KBD patients (54-57 years old). The chondrocytes were respectively divided into four...

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Qiao L, Amhare AF, Deng H, et al. Protective effect of chondroitin sulfate nano-selenium on chondrocyte of patients with Kashin-Beck disease. J Biomater Appl. 2021;35(10):1347-1354doi: 10.1177/0885328220988427.
Qiao, L., Amhare, A. F., Deng, H., Lv, Y., Zhao, Y., Liu, J., Lei, J., Wang, L., Chilufya, M. M., & Han, J. (2021). Protective effect of chondroitin sulfate nano-selenium on chondrocyte of patients with Kashin-Beck disease. Journal of biomaterials applications, 35(10), 1347-1354. https://doi.org/10.1177/0885328220988427
Qiao, Lichun, et al. "Protective effect of chondroitin sulfate nano-selenium on chondrocyte of patients with Kashin-Beck disease." Journal of biomaterials applications vol. 35,10 (2021): 1347-1354. doi: https://doi.org/10.1177/0885328220988427
Qiao L, Amhare AF, Deng H, Lv Y, Zhao Y, Liu J, Lei J, Wang L, Chilufya MM, Han J. Protective effect of chondroitin sulfate nano-selenium on chondrocyte of patients with Kashin-Beck disease. J Biomater Appl. 2021 May;35(10):1347-1354. doi: 10.1177/0885328220988427. Epub 2021 Jan 24. PMID: 33487067.
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Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence.

mBio

Ross BS, Lofgren LA, Ashare A, Stajich JE, Cramer RA.
PMID: 34465017
mBio. 2021 Aug 31;12(4):e0215321. doi: 10.1128/mBio.02153-21. Epub 2021 Aug 31.

The prevalence of Aspergillus fumigatus colonization in individuals with cystic fibrosis (CF) and subsequent fungal persistence in the lung is increasingly recognized. However, there is no consensus for clinical management of A. fumigatus in CF individuals, due largely to...

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Ross BS, Lofgren LA, Ashare A, et al. Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence. mBio. 2021;12(4):e0215321doi: 10.1128/mBio.02153-21.
Ross, B. S., Lofgren, L. A., Ashare, A., Stajich, J. E., & Cramer, R. A. (2021). Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence. mBio, 12(4), e0215321. https://doi.org/10.1128/mBio.02153-21
Ross, Brandon S, et al. "Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence." mBio vol. 12,4 (2021): e0215321. doi: https://doi.org/10.1128/mBio.02153-21
Ross BS, Lofgren LA, Ashare A, Stajich JE, Cramer RA. Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence. mBio. 2021 Aug 31;12(4):e0215321. doi: 10.1128/mBio.02153-21. Epub 2021 Aug 31. PMID: 34465017; PMCID: PMC8406193.
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Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.

Cartilage

Lei J, Deng H, Ran Y, Lv Y, Amhare AF, Wang L, Guo X, Han J, Lammi MJ.
PMID: 32517548
Cartilage. 2020 Jun 09;1947603520932199. doi: 10.1177/1947603520932199. Epub 2020 Jun 09.

OBJECTIVE: The objective of this study was to investigate the expression of enzymes involved in synthesis and modification of chondroitin sulfate (CS) in knee cartilage tissue of patients with osteoarthritis (OA) and Kashin-Beck disease (KBD).METHODS: The knee articular cartilage...

Cite
Lei J, Deng H, Ran Y, et al. Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease. Cartilage. 2020;1947603520932199doi: 10.1177/1947603520932199.
Lei, J., Deng, H., Ran, Y., Lv, Y., Amhare, A. F., Wang, L., Guo, X., Han, J., & Lammi, M. J. (2020). Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease. Cartilage, 1947603520932199. https://doi.org/10.1177/1947603520932199
Lei, Jian, et al. "Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease." Cartilage vol. (2020): 1947603520932199. doi: https://doi.org/10.1177/1947603520932199
Lei J, Deng H, Ran Y, Lv Y, Amhare AF, Wang L, Guo X, Han J, Lammi MJ. Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease. Cartilage. 2020 Jun 09;1947603520932199. doi: 10.1177/1947603520932199. Epub 2020 Jun 09. PMID: 32517548.
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Characterization and quantification of the fungal microbiome in serial samples from individuals with cystic fibrosis.

Microbiome

Willger SD, Grim SL, Dolben EL, Shipunova A, Hampton TH, Morrison HG, Filkins LM, O'Toole GA, Moulton LA, Ashare A, Sogin ML, Hogan DA.
PMID: 25408892
Microbiome. 2014 Nov 03;2:40. doi: 10.1186/2049-2618-2-40. eCollection 2014.

BACKGROUND: Human-associated microbial communities include fungi, but we understand little about which fungal species are present, their relative and absolute abundances, and how antimicrobial therapy impacts fungal communities. The disease cystic fibrosis (CF) often involves chronic airway colonization by...

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Willger SD, Grim SL, Dolben EL, et al. Characterization and quantification of the fungal microbiome in serial samples from individuals with cystic fibrosis. Microbiome. 2014;2:40doi: 10.1186/2049-2618-2-40.
Willger, S. D., Grim, S. L., Dolben, E. L., Shipunova, A., Hampton, T. H., Morrison, H. G., Filkins, L. M., O'Toole, G. A., Moulton, L. A., Ashare, A., Sogin, M. L., & Hogan, D. A. (2014). Characterization and quantification of the fungal microbiome in serial samples from individuals with cystic fibrosis. Microbiome, 240. https://doi.org/10.1186/2049-2618-2-40
Willger, Sven D, et al. "Characterization and quantification of the fungal microbiome in serial samples from individuals with cystic fibrosis." Microbiome vol. 2 (2014): 40. doi: https://doi.org/10.1186/2049-2618-2-40
Willger SD, Grim SL, Dolben EL, Shipunova A, Hampton TH, Morrison HG, Filkins LM, O'Toole GA, Moulton LA, Ashare A, Sogin ML, Hogan DA. Characterization and quantification of the fungal microbiome in serial samples from individuals with cystic fibrosis. Microbiome. 2014 Nov 03;2:40. doi: 10.1186/2049-2618-2-40. eCollection 2014. PMID: 25408892; PMCID: PMC4236224.
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