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Showing 1 to 12 of 266 entries
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The 1-Particle-per-k-Nucleotides (1PkN) Elastic Network Model of DNA Dynamics with Sequence-Dependent Geometry.

Frontiers in physiology

Kameda T, Isami S, Togashi Y, Nishimori H, Sakamoto N, Awazu A.
PMID: 28382002
Front Physiol. 2017 Mar 14;8:103. doi: 10.3389/fphys.2017.00103. eCollection 2017.

Coarse-grained models of DNA have made important contributions to the determination of the physical properties of genomic DNA, working as a molecular machine for gene regulation. In this study, to analyze the global dynamics of long DNA sequences with...

Transient Fanconi syndrome in two preterm infants with hydronephrosis and urinary tract infection.

CEN case reports

Tominaga T, Sato T, Ichihashi Y, Amano N, Kobayashi Y, Awazu M.
PMID: 28509132
CEN Case Rep. 2017 May;6(1):88-90. doi: 10.1007/s13730-017-0250-9. Epub 2017 Feb 16.

Type IV renal tubular acidosis is known to occur in obstructive uropathy with urinary tract infection. Fanconi syndrome, however, has not been described in these settings. We report two preterm infants who developed Fanconi syndrome associated with hydronephrosis and...

Vaccine Potentiation by Combination Adjuvants.

Vaccines

Levast B, Awate S, Babiuk L, Mutwiri G, Gerdts V, van Drunen Littel-van den Hurk S.
PMID: 26344621
Vaccines (Basel). 2014 Apr 14;2(2):297-322. doi: 10.3390/vaccines2020297.

Adjuvants are crucial components of vaccines. They significantly improve vaccine efficacy by modulating, enhancing, or extending the immune response and at the same time reducing the amount of antigen needed. In contrast to previously licensed adjuvants, current successful adjuvant...

Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles.

Genes

Bharti SK, Awate S, Banerjee T, Brosh RM.
PMID: 27376332
Genes (Basel). 2016 Jul 01;7(7). doi: 10.3390/genes7070031.

Mounting evidence indicates that alternate DNA structures, which deviate from normal double helical DNA, form in vivo and influence cellular processes such as replication and transcription. However, our understanding of how the cellular machinery deals with unusual DNA structures...

Purification and Some Properties of p-Nitrophenyl-β-D-glucoside-hydrolyzing Enzymes in Culture Filtrate of Bacillus circulans KA-304 Grown on Cell-wall Preparation of Schizophyllum commune.

Bioscience, biotechnology, and biochemistry

Mizuno K, Awazu N, Tachiki T.
PMID: 27393352
Biosci Biotechnol Biochem. 1998;62(1):39-43. doi: 10.1271/bbb.62.39.

Hydrolyzing activities toward p-nitrophenyl (p-NP)-β-D-glucoside and laminarin in a culture filtrate of Bacillus circulans KA-304, which has been observed to form protoplasts from Schizophyllum commune mycelia, increased when the bacterium was grown on a cell-wall preparation (CWP) of S....

Effect of baseline HbA1c level on the development of diabetes by lifestyle intervention in primary healthcare settings: insights from subanalysis of the Japan Diabetes Prevention Program.

BMJ open diabetes research & care

Sakane N, Sato J, Tsushita K, Tsujii S, Kotani K, Tominaga M, Kawazu S, Sato Y, Usui T, Kamae I, Yoshida T, Kiyohara Y, Sato S, Tsuzaki K, Takahashi K, Kuzuya H.
PMID: 25452854
BMJ Open Diabetes Res Care. 2014 Apr 23;2(1):e000003. doi: 10.1136/bmjdrc-2013-000003. eCollection 2014.

OBJECTIVES: To determine the effects of a lifestyle intervention on the development of type 2 diabetes mellitus (T2DM) among participants with impaired glucose tolerance (IGT), in particular in the subgroup with baseline glycated hemoglobin (HbA1c) levels ≥5.7%, in primary...

Linking uric acid metabolism to diabetic complications.

World journal of diabetes

Kushiyama A, Tanaka K, Hara S, Kawazu S.
PMID: 25512781
World J Diabetes. 2014 Dec 15;5(6):787-95. doi: 10.4239/wjd.v5.i6.787.

Hyperuricemia have been thought to be caused by the ingestion of large amounts of purines, and prevention or treatment of hyperuricemia has intended to prevent gout. Xanthine dehydrogenase/xanthine oxidase (XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol...

Evaluation of antibiotic prescription in the Lebanese community: a pilot study.

Infection ecology & epidemiology

Saleh N, Awada S, Awwad R, Jibai S, Arfoul C, Zaiter L, Dib W, Salameh P.
PMID: 26112266
Infect Ecol Epidemiol. 2015 Jun 24;5:27094. doi: 10.3402/iee.v5.27094. eCollection 2015.

BACKGROUND: Antibiotics are considered among the most commonly prescribed drug classes in developing countries. Inappropriate prescription of antibiotics is a major public health concern and is related to the development of antimicrobial resistance.OBJECTIVE: This study aimed at assessing the...

Effects of a sodium glucose co-transporter 2 selective inhibitor, ipragliflozin, on the diurnal profile of plasma glucose in patients with type 2 diabetes: A study using continuous glucose monitoring.

Journal of diabetes investigation

Yamada K, Nakayama H, Yoshinobu S, Kawano S, Tsuruta M, Nohara M, Hasuo R, Akasu S, Tokubuchi I, Wada N, Hirao S, Iwata S, Kaku H, Tajiri Y.
PMID: 26543545
J Diabetes Investig. 2015 Nov;6(6):699-707. doi: 10.1111/jdi.12370. Epub 2015 Jun 20.

AIMS/INTRODUCTION: To assess the effects of sodium glucose co-transporter 2 inhibitor therapy on the pathophysiology of type 2 diabetes.MATERIALS AND METHODS: We administered ipragliflozin to 21 inpatients with type 2 diabetes for 7 days, and analyzed the diurnal profiles...

Prenylated Dihydrochalcones from Artocarpus altilis as Antiausterity Agents.

The Enzymes

Nguyen MT, Nguyen NT, Awale S.
PMID: 26298457
Enzymes. 2015;37:95-110. doi: 10.1016/bs.enz.2015.05.005. Epub 2015 Jun 24.

Human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. A novel antiausterity strategy in anticancer drug discovery led to the discovery of agents that preferentially inhibit the survival...

Strain-controlled critical temperature in REBa2Cu3Oy-coated conductors.

Scientific reports

Awaji S, Suzuki T, Oguro H, Watanabe K, Matsumoto K.
PMID: 26063123
Sci Rep. 2015 Jun 11;5:11156. doi: 10.1038/srep11156.

Recently, we succeeded in detwinning REBa2Cu3O7 (RE123, RE = rare-earth elements)-coated conductors by annealing under an external uniaxial strain. Using the untwinned RE123 tapes, the uniaxial-strain dependencies of the critical temperature Tc along the a and b crystal axes...

Screening for adjustment disorders and major depression in otolaryngology patients using the Hospital Anxiety and Depression Scale.

International journal of psychiatry in clinical practice

Hosaka T, Awazu H, Aoki T, Okuyama T, Yamawaki S.
PMID: 24945066
Int J Psychiatry Clin Pract. 1999;3(1):43-8. doi: 10.3109/13651509909024758.

The authors conducted a study to demonstrate the prevalence of psychiatric symptoms among 100 otolaryngology inpatients (50 with non-malignant conditions; 50 with malignancies), and to investigate the efficacy of the Hospital Anxiety and Depression Scale (HADS) as a screening...

Showing 1 to 12 of 266 entries