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Showing 1 to 12 of 43 entries
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The Role of NG2 Proteoglycan in Glioma.

Translational oncology

Yadavilli S, Hwang EI, Packer RJ, Nazarian J.
PMID: 26947882
Transl Oncol. 2016 Feb;9(1):57-63. doi: 10.1016/j.tranon.2015.12.005.

Neuron glia antigen-2 ((NG2), also known as chondroitin sulphate proteoglycan 4, or melanoma-associated chondroitin sulfate proteoglycan) is a type-1 membrane protein expressed by many central nervous system (CNS) cells during development and differentiation and plays a critical role in...

Repetitive concussions in adolescent athletes - translating clinical and experimental research into perspectives on rehabilitation strategies.

Frontiers in neurology

Semple BD, Lee S, Sadjadi R, Fritz N, Carlson J, Griep C, Ho V, Jang P, Lamb A, Popolizio B, Saini S, Bazarian JJ, Prins ML, Ferriero DM, Basso DM, Noble-Haeusslein LJ.
PMID: 25883586
Front Neurol. 2015 Apr 02;6:69. doi: 10.3389/fneur.2015.00069. eCollection 2015.

Sports-related concussions are particularly common during adolescence, a time when even mild brain injuries may disrupt ongoing brain maturation and result in long-term complications. A recent focus on the consequences of repetitive concussions among professional athletes has prompted the...

Which neurotransmitters modulate corneal sensitivity?.

Clinical & experimental optometry

O'Leary DJ, Nazarian J, Millodot M.
PMID: 23714129
Clin Exp Optom. 1986 May;69(3):108-11. doi: 10.1111/j.1444-0938.1986.tb06799.x.

Corneal sensitivity was assessed before and after applying atropine (0.5, 0.05, 0.005% w/v), pilocarpine (1.0, 0.1%), eserine (0.1, 0.01%) and potassium chloride (171mM). Atropine (0.5 - 0.005%) significantly depressed corneal sensitivity; parasympathomimetics, taken together, significantly increased sensitivity. Exposure to...

Defining Acute Traumatic Encephalopathy: Methods of the "HEAD Injury Serum Markers and Multi-Modalities for Assessing Response to Trauma" (HeadSMART II) Study.

Frontiers in neurology

Peacock WF, Kuehl D, Bazarian J, Singer AJ, Cannon C, Rafique Z, d'Etienne JP, Welch R, Clark C, Diaz-Arrastia R.
PMID: 34956041
Front Neurol. 2021 Dec 08;12:733712. doi: 10.3389/fneur.2021.733712. eCollection 2021.

Despite an estimated 2.8 million annual ED visits, traumatic brain injury (TBI) is a syndromic diagnosis largely based on report of loss of consciousness, post-traumatic amnesia, and/or confusion, without readily available objective diagnostic tests at the time of presentation,...

ADHD May Associate With Reduced Tolerance to Acute Subconcussive Head Impacts: A Pilot Case-Control Intervention Study.

Journal of attention disorders

Nowak MK, Ejima K, Quinn PD, Bazarian JJ, Mickleborough TD, Harezlak J, Newman SD, Kawata K.
PMID: 33161816
J Atten Disord. 2022 Jan;26(1):125-139. doi: 10.1177/1087054720969977. Epub 2020 Nov 07.

OBJECTIVE: To test our hypothesis that individuals with ADHD would exhibit reduced resiliency to subconcussive head impacts induced by ten soccer headings.METHOD: We conducted a case-control intervention study in 51 adults (20.6 ± 1.7 years old). Cognitive assessment, using...

Predictive Performance of Traumatic Brain Injury Biomarkers in High-Risk Elderly Patients.

The journal of applied laboratory medicine

Ward MD, Weber A, Merrill VD, Welch RD, Bazarian JJ, Christenson RH.
PMID: 32445348
J Appl Lab Med. 2020 May 01;5(3):608. doi: 10.1093/jalm/jfaa039.

No abstract available.

Addition of Multimodal Immunotherapy to Combination Treatment Strategies for Children with DIPG: A Single Institution Experience.

Medicines (Basel, Switzerland)

Van Gool SW, Makalowski J, Bonner ER, Feyen O, Domogalla MP, Prix L, Schirrmacher V, Nazarian J, Stuecker W.
PMID: 32438648
Medicines (Basel). 2020 May 19;7(5). doi: 10.3390/medicines7050029.

No abstract available.

Transitive Inverse Consistent Rigid Longitudinal Registration of Diffusion Weighted Magnetic Resonance Imaging: A Case Study in Athletes With Repetitive Non-Concussive Head Injuries.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Prajapati HS, Merchant-Borna K, Bazarian JJ, Linte CA, Cahill ND.
PMID: 34892086
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:3906-3911. doi: 10.1109/EMBC46164.2021.9629871.

Significant longitudinal changes in metrics derived from diffusion weighted magnetic resonance (MR) images of the brain have been observed in athletes subject to repetitive non-concussive head injuries (RHIs). Accurate alignment of longitudinal scans of a subject is an important...

Liquid biopsy for pediatric central nervous system tumors.

NPJ precision oncology

Bonner ER, Bornhorst M, Packer RJ, Nazarian J.
PMID: 30588509
NPJ Precis Oncol. 2018 Dec 17;2:29. doi: 10.1038/s41698-018-0072-z. eCollection 2018.

Central nervous system (CNS) tumors are the most common solid tumors in children, and the leading cause of cancer-related death. Over the past decade, molecular profiling has been incorporated into treatment for pediatric CNS tumors, allowing for a more...

Sex Differences in Circulating T-Tau Trajectories After Sports-Concussion and Correlation With Outcome.

Frontiers in neurology

Mondello S, Guedes VA, Lai C, Jeromin A, Bazarian JJ, Gill JM.
PMID: 32733367
Front Neurol. 2020 Jul 07;11:651. doi: 10.3389/fneur.2020.00651. eCollection 2020.

Sex differences in molecular biomarkers after sports-related concussion (SRC) could steadily advance our understanding of injury heterogeneity and complexity, and help capture phenotypic characteristics, by unveiling sex-dependent pathobiological processes and disease mechanisms. Such knowledge will help improve diagnosis, clinical...

A 66-Year-Old Woman with a Progressive, Longitudinally Extensive, Tract Specific, Myelopathy.

Case reports in neurological medicine

O'Keefe E, Schwetye KE, Nazarian J, Perrin R, Schmidt RE, Bucelli R.
PMID: 27990305
Case Rep Neurol Med. 2016;2016:4125294. doi: 10.1155/2016/4125294. Epub 2016 Nov 21.

A 66-year-old woman presented with progressive lancinating pain and sensory deficits attributable to a myelopathy of unclear etiology. Spinal cord magnetic resonance imaging showed a longitudinally extensive T2-hyperintense lesion of the dorsal columns. Comprehensive serum, urine, and cerebrospinal fluid...

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.

Nature medicine

Grasso CS, Tang Y, Truffaux N, Berlow NE, Liu L, Debily MA, Quist MJ, Davis LE, Huang EC, Woo PJ, Ponnuswami A, Chen S, Johung TB, Sun W, Kogiso M, Du Y, Qi L, Huang Y, Hütt-Cabezas M, Warren KE, Le Dret L, Meltzer PS, Mao H, Quezado M, van Vuurden DG, Abraham J, Fouladi M, Svalina MN, Wang N, Hawkins C, Nazarian J, Alonso MM, Raabe EH, Hulleman E, Spellman PT, Li XN, Keller C, Pal R, Grill J, Monje M.
PMID: 26151328
Nat Med. 2015 Jul;21(7):827. doi: 10.1038/nm0715-827a.

No abstract available.

Showing 1 to 12 of 43 entries