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Showing 1 to 12 of 95 entries
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Molecular pathways associated with aggressiveness of papillary thyroid cancer.

Current genomics

Benvenga S, Koch CA.
PMID: 24955023
Curr Genomics. 2014 Jun;15(3):162-70. doi: 10.2174/1389202915999140404100958.

The most common thyroid malignancy is papillary thyroid cancer (PTC). Mortality rates from PTC mainly depend on its aggressiveness. Geno- and phenotyping of aggressive PTC has advanced our understanding of treatment failures and of potential future therapies. Unraveling molecular...

Personalization of targeted therapy in advanced thyroid cancer.

Current genomics

Fallahi P, Ferrari SM, Mazzi V, Vita R, Benvenga S, Antonelli A.
PMID: 24955027
Curr Genomics. 2014 Jun;15(3):190-202. doi: 10.2174/1389202915999140404101902.

Although generally the prognosis of differentiated thyroid carcinoma (DTC) is good, approximately 5% of people are likely to develop metastases which fail to respond to radioactive iodine, and other traditional therapies, exhibiting a more aggressive behavior. Nowadays, therapy is...

Molecular characterization and chromosomal localization of spermatogenesis related sequences in Torpedo torpedo (Chondrichthyes, Torpediniformes).

Marine genomics

Rocco L, Bencivenga S, Archimandritis A, Stingo V.
PMID: 21798177
Mar Genomics. 2009 Jun;2(2):99-102. doi: 10.1016/j.margen.2009.06.001. Epub 2009 Jun 25.

Cytogenetic data in cartilaginous fishes are currently very inconsistent, considering that the karyotype morphology of only about seventy living species is actually known. Only in the last few years different molecular approaches, first of all physical mapping on metaphase...

LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy.

Frontiers in neuroscience

Fitch TE, Benvenga MJ, Jesudason CD, Zink C, Vandergriff AB, Menezes MM, Schober DA, Rorick-Kehn LM.
PMID: 24478625
Front Neurosci. 2014 Jan 28;8:5. doi: 10.3389/fnins.2014.00005. eCollection 2014.

We describe a novel, potent and selective orexin-2 (OX2)/hypocretin-2 receptor antagonist with in vivo activity in an animal model predictive of antidepressant-like efficacy. N-biphenyl-2-yl-4-fluoro-N-(1H-imidazol-2-ylmethyl) benzenesulfonamide HCl (LSN2424100) binds with high affinity to recombinant human OX2 receptors (Ki = 4.5...

Intracranial Tumour Characterization: Whole Brain Evaluation with MR Perfusion Images and SPECT-CT.

The neuroradiology journal

Aprile I, Bencivenga S, Loreti F, Torni C.
PMID: 24059884
Neuroradiol J. 2011 Dec 30;24(6):838-45. doi: 10.1177/197140091102400602. Epub 2011 Dec 23.

A comparative study between perfusion magnetic resonance (MR) imaging and single photon emission tomography - computed tomography (SPECT-CT) was performed to disclose the indications and limits of the two techniques for brain tumour characterization. We compared these two techniques...

Assessment of serum thyroid hormone autoantibodies in the first trimester of gestation as predictors of postpartum thyroiditis.

Journal of clinical & translational endocrinology

Benvenga S, Vita R, Di Bari F, Lo Re C, Scilipoti A, Giorgianni G, Grasso L, Galletti MR, Mandolfino MG, Le Donne M.
PMID: 31428563
J Clin Transl Endocrinol. 2019 Jul 24;18:100201. doi: 10.1016/j.jcte.2019.100201. eCollection 2019 Dec.

BACKGROUND: Measurement of serum thyroperoxidase autoantibodies (TPOAb) during gestation as a classical marker for the risk of postpartum thyroiditis (PPT) predicts PPT in 1/3 to 1/2 of women. Very few studies have measured serum thyroid hormone Ab (THAb) during...

Coronary Artery Fistula Diagnosed by Echocardiography during NSTEMI: Case Report and Review of Literature.

Case reports in cardiology

Acitelli A, Bencivenga S, Giannico MB, Lanzillo C, Maresca L, Petroni R, Penco M, Calò L, Romano S.
PMID: 31485355
Case Rep Cardiol. 2019 Aug 14;2019:5956806. doi: 10.1155/2019/5956806. eCollection 2019.

Coronary artery fistulas are rare abnormal connections between a coronary artery and a cardiac chamber or a major vessel. Often, they are asymptomatic and the diagnosis is accidental. The case we present is the incidental finding of a fistula...

E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion.

Oncotarget

Benvegnù S, Wahle T, Dotti CG.
PMID: 29163761
Oncotarget. 2017 Aug 10;8(52):89439-89450. doi: 10.18632/oncotarget.20143. eCollection 2017 Oct 27.

Altered processing of the Amyloid Precursor Protein (APP) is a well-recognized central pathogenic mechanism in Alzheimer's Disease (AD), and regulation of APP processing is a major focus of research in the AD field. However, how age-associated cellular and molecular...

Autoimmune Abnormalities of Postpartum Thyroid Diseases.

Frontiers in endocrinology

Di Bari F, Granese R, Le Donne M, Vita R, Benvenga S.
PMID: 28751877
Front Endocrinol (Lausanne). 2017 Jul 13;8:166. doi: 10.3389/fendo.2017.00166. eCollection 2017.

The year following parturition is a critical time for the

The various faces of hyperthyroidism.

Journal of clinical & translational endocrinology

Koch CA, Vita R, Benvenga S.
PMID: 32632358
J Clin Transl Endocrinol. 2020 Jun 05;20:100229. doi: 10.1016/j.jcte.2020.100229. eCollection 2020 Jun.

No abstract available.

Environmental Issues in Thyroid Diseases.

Frontiers in endocrinology

Ferrari SM, Fallahi P, Antonelli A, Benvenga S.
PMID: 28373861
Front Endocrinol (Lausanne). 2017 Mar 20;8:50. doi: 10.3389/fendo.2017.00050. eCollection 2017.

Environmental factors are determinant for the appearance of autoimmune thyroid diseases (AITD) in susceptible subjects. Increased iodine intake, selenium, and vitamin D deficiency, exposure to radiation, from nuclear fallout or due to medical radiation, are environmental factors increasing AITD....

Screening for drugs potentially interfering with MCT8-mediated T.

Journal of endocrinological investigation

Di Cosmo C, De Marco G, Agretti P, Ferrarini E, Dimida A, Falcetta P, Benvenga S, Vitti P, Tonacchera M.
PMID: 34850364
J Endocrinol Invest. 2021 Nov 30; doi: 10.1007/s40618-021-01711-4. Epub 2021 Nov 30.

BACKGROUND: Monocarboxylate transporter 8 (MCT8) is the first thyroid hormone transporter that has been linked to a human disease. Besides genetic alterations other factors might impair MCT8 activity.AIM: This study aimed at investigating whether some common drugs having a...

Showing 1 to 12 of 95 entries